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Article: Change in Hepatitis B Surface Antibody Titers After Chemotherapy in Patients With Hematological Malignancies.

Unver Ulusoy, Tülay / Tıglıoglu, Pınar / Demirköse, Hacer / Albayrak, Murat / Şencan, İrfan

2024 Volume 16, Issue 1, Page(s) e51572

Abstract: Background The change in hepatitis B surface antibody (anti-HBs) titers after chemotherapy (CT) in patients with hematological malignancy, affecting factors, and its clinical implications have not been sufficiently understood. Therefore, we aim to ... ...

Abstract	Background The change in hepatitis B surface antibody (anti-HBs) titers after chemotherapy (CT) in patients with hematological malignancy, affecting factors, and its clinical implications have not been sufficiently understood. Therefore, we aim to evaluate the change in anti-HBs titers and hepatitis B virus reactivation (HBVr) after CT. Methods This retrospective study enrolled patients with hematological malignancies who received CT between 2013 and 2021. All patients were followed up for HBVr and a change in anti-HBs titers for one year. Results Overall, 192 patients were included. In total, 33.9% of the patients were anti-HBs (+) and 26% of the patients were anti-HBc (+) ± anti-HBs (+). Hepatitis B virus (HBV) prophylaxis was given to 35 (70%) of 50 Anti-HBc (+) patients. Tenofovir disoproxil fumarate and entecavir prophylaxis were initiated in 25 (71.4%) and 10 (28.6%) patients, respectively. A significant decrease was found in anti-HBs titers of all patients (p=0.017). A significant decrease was also found in anti-HBs titers of HBc IgG (+) patients and those who received four or more courses of CT (p=0.025; p=0.041). HBVr was not diagnosed in any of the patients. Conclusion Chemotherapeutic agents administered for hematological malignancy have serious immunosuppression effects. In these patients, anti-HBs titers may decrease or become negative one year after CT. Anti-HBs titer before CT or its change after CT may not constitute a risk for HBVr patients who received HBV prophylaxis in line with current guidelines and these recommendations.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51572
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Article ; Online: Global health emergencies during the pandemic and their solutions

Şencan, Irfan / Bulut, Dilek / Şencan, Ismail Hakki / Ağalar, Canan

Turkish journal of medical sciences

2021 Volume 51, Issue SI-1, Page(s) 3194–3206

Abstract: In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care ... ...

Abstract	In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well as health system policies.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Emergencies ; Global Health ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
Language	English
Publishing date	2021-12-17
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2106-183
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Article ; Online: Global threat of COVID 19 and evacuation of the citizens of different countries

Şencan, Irfan / Kuzi, Semanur

Turkish journal of medical sciences

2020 Volume 50, Issue SI-1, Page(s) 534–543

Abstract: Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and has been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of ... ...

Abstract	Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and has been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of the pandemic, many countries evacuated their citizens from affected regions and combined the evacuation with quarantine process. Some examples of these countries who evacuated their citizens are Germany, Italy, Spain, and USA. In further times, during the course of pandemic, according to spread, other countries evacuated their citizens from these countries too. Despite being the origin of the pandemic, in later times Wuhan was also a place where people were evacuated to. Evacuation and quarantine have caused social and psychological impacts on people and some of them took place in mainstream media. In this review article, evacuation and quarantine processes as well as the society’s reactions to these, have been compiled.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Quarantine/methods ; SARS-CoV-2 ; Travel
Keywords	covid19
Language	English
Publishing date	2020-04-21
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2004-21
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Article: Comparative Analysis of Demographic and Clinical Findings in Spontaneous, Peritoneal Dialysis-Related, and Secondary Bacterial Peritonitis.

Unver Ulusoy, Tülay / Karakoç Parlayan, Hanife Nur / Altın, Nilgün / Sarıkaya, Büşra / Öztürk, Büşra / Şencan, İrfan

Cureus

2024 Volume 16, Issue 3, Page(s) e55445

Abstract: Background This study aims to contribute to peritonitis management strategies by comparing the demographic, clinical, and laboratory characteristics of patients diagnosed with spontaneous bacterial peritonitis (SBP), peritoneal dialysis-related ... ...

Abstract	Background This study aims to contribute to peritonitis management strategies by comparing the demographic, clinical, and laboratory characteristics of patients diagnosed with spontaneous bacterial peritonitis (SBP), peritoneal dialysis-related peritonitis (PDrP), and secondary peritonitis. Methods This study included 86 patients diagnosed with peritonitis between 2016 and 2022. Patients were categorized and compared as SBP, PDrP, and secondary peritonitis. Results SBP was diagnosed in 36% of patients, secondary peritonitis in 36% and PDrP in 28%. The mean age of patients with PDrP is 43.71 ± 14.74, which is significantly lower compared to those with SBP and secondary peritonitis (p<0.001). Patients with hypertension (HT), chronic kidney disease (CKD), and those undergoing dialysis most commonly have PDrP whereas those without HT, without CKD, and not undergoing dialysis are most often diagnosed with secondary peritonitis (p=0.002, p<0.001, p<0.001). In peritoneal fluid cultures, the growth of Gram-positive bacteria was most commonly identified in patients with PDrP, while the growth of Gram-negative bacteria was most frequently seen in patients with secondary peritonitis (p=0.018). CRP levels and sedimentation rates were found to be higher in patients with secondary peritonitis (p<0.001, p=0.003). Conclusion The distinct characteristics observed across different types of peritonitis underscore the importance of tailored approaches to diagnosis and treatment. Parameters such as CRP levels, sedimentation rates, and patient age could serve as valuable indicators in discerning between various types of peritonitis. When selecting empirical antibiotic therapy, it's crucial to consider coverage for Gram-positive pathogens in cases of PDrP and Gram-negative pathogens in secondary peritonitis.
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55445
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Article ; Online: Can patients who apply to tertiary care with headache for the first time be managed in primary care? - a cross-sectional study

Hündür Doğan, Esra / Şencan, Irfan / Doğan, Hasan / Özkara, Adem

Turkish journal of medical sciences

2021 Volume 51, Issue 4, Page(s) 1857–1864

Abstract: Background/aim: Headaches are one of the most common neurological symptoms. They adversely affect daily life, reduces the workforce, and have high health costs. Managing this symptom in primary care will free up secondary and tertiary health services to ...

Abstract	Background/aim: Headaches are one of the most common neurological symptoms. They adversely affect daily life, reduces the workforce, and have high health costs. Managing this symptom in primary care will free up secondary and tertiary health services to better treat patients who need follow-up by specialists. In the present study, we aim to show the rate at which this problem can be solved in primary care for patients who applied tertiary care services with a headache for the first time. Materials and methods: Our research is a cross-sectional study of 207 patients who applied to the neurology clinics for the first time with headache. Two questionnaires were prepared by the researchers. IBM SPSS v: 21.0 was used for statistical analysis, and the level of significance was p < 0.05. Results: The opinions of the patients on the evaluability of headache in primary care were compared. Family physicians and neurologists gave similar responses about the disease management, at a rate of 96.6%, this was found to be statistically significant and shows strong agreement. Both groups of physicians thought that 70% of patients, on average, who applied to the neurology clinics with headache for the first time could be managed in primary care. However, only 9.2% of the patients share this opinion with physicians. Primary headache cases constitute most of the cases that are thought to be solved in primary care. It was revealed that the number of patients seeking primary care with this complaint was lower than expected. Conclusion: Patients with headache applied tertiary care instead of primary care for different reasons. Both neurologists and family physicians stated that most patients evaluated in tertiary care could be managed in primary care.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Headache/diagnosis ; Headache/epidemiology ; Headache/therapy ; Humans ; Middle Aged ; Physicians, Family ; Primary Health Care ; Referral and Consultation/statistics & numerical data ; Surveys and Questionnaires ; Tertiary Healthcare ; Young Adult
Language	English
Publishing date	2021-08-30
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2010-237
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Article ; Online: Global threat of COVID 19 and evacuation of the citizens of different countries

ŞENCAN, İrfan / KUZİ, Semanur

Volume: 50, Issue: 534-543 ; 1300-0144 ; 1303-6165 ; Turkish Journal of Medical Sciences

2020

Abstract	Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and has been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of the pandemic, many countries evacuated their citizens from affected regions and combined the evacuation with quarantine process. Some examples of these countries who evacuated their citizens are Germany, Italy, Spain, and USA. In further times, during the course of pandemic, according to spread, other countries evacuated their citizens from these countries too. Despite being the origin of the pandemic, in later times Wuhan was also a place where people were evacuated to. Evacuation and quarantine have caused social and psychological impacts on people and some of them took place in mainstream media. In this review article, evacuation and quarantine processes as well as the society's reactions to these, have been compiled.
Keywords	Quarantine,evacuation ; covid19
Language	English
Publishing date	2020-04-21T00:00:00Z
Publisher	TÜBİTAK
Publishing country	tr
Document type	Article ; Online
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Article ; Online: Implementation of the EUCAST rapid antimicrobial susceptibility test (RAST) directly from positive blood culture bottles without the advanced identification systems.

Tayşi, Muhammet Rıdvan / Şentürk, Gönül Çiçek / Çalişkan, Elif / Öcal, Duygu / Miroglu, Gülşah / Şencan, İrfan

The Journal of antimicrobial chemotherapy

2022 Volume 77, Issue 4, Page(s) 1020–1026

Abstract: Objectives: EUCAST published its recommendations for rapid antimicrobial susceptibility tests (RASTs) directly from positive signal blood culture (BC) bottles. The objective of the present study was to investigate the accuracy and applicability of the ... ...

Abstract	Objectives: EUCAST published its recommendations for rapid antimicrobial susceptibility tests (RASTs) directly from positive signal blood culture (BC) bottles. The objective of the present study was to investigate the accuracy and applicability of the predicted RAST (p-RAST) method without using automated identification systems, and the effects of the results obtained with this method on the treatment decision of the clinician. Methods: The RAST procedure was applied to positive BC samples between November 2020 and June 2021. The categorical results of the method were obtained by comparing the p-RAST results obtained at 4, 6 and 8 h of incubation according to predicted bacterial species with conventional methods and standard disc diffusion results. The effects of these results on the treatment decision of the clinician were evaluated retrospectively. The actual categorical results of the EUCAST RAST [standard RAST (s-RAST)] method were identified. Results: The p-RAST and s-RAST results were analysed according to 145 and 111 isolates, respectively. The p-RAST total error rates were 3.0%, 3.1% and 2.8% at 4, 6 and 8 h of incubation, respectively, and the s-RAST total error rates were determined as 2.7%, 3.3% and 3.2%, respectively. With p-RAST's results, it was observed that effective escalation was performed in the antimicrobial treatment for 45 patients, and effective de-escalation could be performed in 32 patients, but it was recommended not to perform de-escalation. Conclusions: Even in a microbiology laboratory with limited facilities, reliable antimicrobial susceptibility test results can be obtained in a short time with the p-RAST method without using automated systems and antimicrobial choice can be guided in a shorter time.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; Blood Culture ; Humans ; Microbial Sensitivity Tests ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2022-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkac003
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Article ; Online: Prognostic nutritional index: Is it associated with the prognosis of Crimean Congo hemorrhagic fever.

Ünver Ulusoy, Tülay / Hekimoğlu, Can H / Kayhan, Sanem / Altın, Nilgün / Şencan, İrfan

Journal of medical virology

2022 Volume 94, Issue 10, Page(s) 4910–4917

Abstract: Introduction: The prognostic nutritional index (PNI) is calculated using total serum lymphocyte counts and albumin levels. We aimed to analyze the role of PNI in predicting intensive care unit (ICU) referral and mortality in patients with Crimean Congo ... ...

Abstract	Introduction: The prognostic nutritional index (PNI) is calculated using total serum lymphocyte counts and albumin levels. We aimed to analyze the role of PNI in predicting intensive care unit (ICU) referral and mortality in patients with Crimean Congo hemorrhagic fever (CCHF). Materials and methods: Our target population was adult (age >18) patients who presented between March 2015 and October 2021 within 5 days of symptom emergence and were diagnosed with CCHF. The predictive value of PNI was analyzed by the receiver operating curve analysis. The patients were categorized based on the severity grading scores (SGS) as mild, moderate, and severe. The relationship between PNI and ICU referral and mortality was analyzed by logistic regression analysis. Results: Overall, 115 patients with the diagnosis of CCHF were included. 13.9% (n = 16) of the patients were referred to ICU while 11.3% (n = 13) died. A comparison of the patients with different SGS grades revealed that they were significantly different regarding PNI (p < 0.001). There was a significant negative correlation between PNI and SGS (r = -0.662; p < 0.001). PNI had a PV regarding ICU referral and mortality ([area under the curve [AUC] = 0.723, 95% confidence interval [CI]: 0.609-0.836, p = 0.004 [AUC = 0.738, 95% CI: 0.613-0.863, p = 0.005]). The PNI threshold was 36.1 for ICU referral and mortality. The rates of female patients, hospitalization periods longer than 1 week, platelet apheresis replacement, diabetes mellitus, bleeding history, ICU admission, and mortality were significantly higher in patients with a PNI of lower than 36.1 (p < 0.05). Conclusion: PNI can predict ICU referral and mortality in patients admitted due to CCHF.
MeSH term(s)	Adult ; Female ; Hemorrhagic Fever Virus, Crimean-Congo ; Hemorrhagic Fever, Crimean/epidemiology ; Humans ; Nutrition Assessment ; Prognosis ; Severity of Illness Index
Language	English
Publishing date	2022-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27947
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Article: Family planning practices and opinions on population growth of family planning healthcare providers in Turkey.

Bahadir, Adem / Yilmaz, Tarık E / Bülbül, İskender / Yilmaz, Tuğba / Kasim, İsmail / Şencan, İrfan / Ozkara, Adem

African journal of reproductive health

2023 Volume 25, Issue 2, Page(s) 65–75

Abstract: The purpose of this study was to investigate the opinions of health professionals (HPs) who provide family planning counselling (FPC) within the scope of primary health care services since they are perceived as role models by the society. The number of ... ...

Abstract	The purpose of this study was to investigate the opinions of health professionals (HPs) who provide family planning counselling (FPC) within the scope of primary health care services since they are perceived as role models by the society. The number of HPs providing family planning counselling in primary health services in Turkey was 43,000 and 40,000 of these individuals were invited to participate in this observational, cross-sectional study via e-mail and social media. There were 740 responders and all were included in the study. Physicians providing FPC within the scope of primary health care services consisted of 45.1% of the responders and the remaining were nurses. Among all HPs, 59.7% had insufficient awareness regarding Turkey's population growth. Most of the HPs (52.4%) believed that the ideal number of children was 2 or less. The abortion rate was 9.1% in all pregnancies of HPs. The rate of caesarean section was 56% in all live births. According to responses, 75.6% of all pregnancies experienced by HPs were planned. According to 42.1% of the HPs, abortion must be performed if there is a life-threatening situation for the mother or if the fetus has some abnormalities. The most common method of birth control used by married HPs between the ages of 18 and 49 was male condoms (39.9%), while the pull-out method ranked first in the general population (25.5%). It was found that HPs, who had different opinions and practices about family planning than the general population, had insufficient awareness regarding population growth. Increased awareness of demography and FPC among HPs will likely contribute to the quality of service and the general wellbeing of the population.
Language	English
Publishing date	2023-08-14
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	2111906-5
ISSN	1118-4841
ISSN	1118-4841
DOI	10.29063/ajrh2021/v25i2.6
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Article ; Online: Comparison of the Distribution of Healthcare-Associated Infections and Causative Agents Between Intensive Care Units and Other Clinics.

Ulusoy, Tulay Unver / Hekimoglu, Can Huseyin / Parlayan, Hanife Nur Karakoc / Altin, Nilgun / Senturk, Gonul Cicek / Sencan, Irfan

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2024 Volume 34, Issue 2, Page(s) 172–177

Abstract: Objective: To compare the trends in the distribution of healthcare associated infectious (HAIs) and causative agents in intensive care units (ICUs) and other clinics.: Study design: Descriptive study. Place and Duration of the Study: Department of ... ...

Abstract	Objective: To compare the trends in the distribution of healthcare associated infectious (HAIs) and causative agents in intensive care units (ICUs) and other clinics. Study design: Descriptive study. Place and Duration of the Study: Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkiye, from 2015 to 2022. Methodology: The study included patients who were diagnosed with HAIs and admitted to both the ICUs and the clinics. The data of HAIs identified between 2015-2022 were accessed and analysed retrospectively from the surveillance records of the IPC committee between 28.05.2023-07.08.2023. Results: There was a decreasing trend observed in both ICU and clinics regarding the ratio of patients developing HAIs and the overall HAI rate (all p-values <0.001). These two measures were found to be significantly lower in the years 2019-2022 compared to the years 2015-2018. Over the years, particularly after 2020, a significant increasing trend in carbapenem resistance was observed in E. coli, K. pneumoniae, and P. aeruginosa (p=0.009, p<0.001, and p<0.001, respectively). The ratio of patients developing HAIs in the ICUs was higher than in the clinics (p<0.001). There was an increasing trend in the ratio of pneumonia and bloodstream infection (BSI) in ICUs. Conclusion: The increasing ratio of BSI and pneumonia in ICUs highlighted the need to review infection control bundles. Carbapenem resistance has been increasing over the years, suggesting that antimicrobial description and consumption practices should be re-evaluated, especially in the context of the COVID-19 pandemic. Key words: Intensive Care Unit, Healthcare-Associated Infections, Surveillance, Infection prevention and control, Antibiotic resistance.
MeSH term(s)	Humans ; Retrospective Studies ; Escherichia coli ; Pandemics ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Sepsis/epidemiology ; Intensive Care Units ; Klebsiella pneumoniae ; Pneumonia ; Delivery of Health Care ; Carbapenems
Chemical Substances	Carbapenems
Language	English
Publishing date	2024-02-11
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2024.02.172
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