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Article ; Online: Predictability of fossil fuel CO

Miyazaki, Kazuyuki / Bowman, Kevin

2023 Volume 14, Issue 1, Page(s) 1604

Abstract: Quantifying the coevolution of greenhouse gases and air quality pollutants can provide insight into underlying anthropogenic processes enabling predictions of their emission trajectories. Here, we classify the dynamics of historic emissions in terms of a ...

Abstract	Quantifying the coevolution of greenhouse gases and air quality pollutants can provide insight into underlying anthropogenic processes enabling predictions of their emission trajectories. Here, we classify the dynamics of historic emissions in terms of a modified Environmental Kuznets Curve (MEKC), which postulates the coevolution of fossil fuel CO
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37264-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Predictability of fossil fuel CO2 from air quality emissions

Kazuyuki Miyazaki / Kevin Bowman

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 13

Abstract: The historical changes in country emissions of greenhouse gases and air quality pollutants are classified together as a function of economic development, providing valuable guidance to emission scenario development. ...

Abstract	The historical changes in country emissions of greenhouse gases and air quality pollutants are classified together as a function of economic development, providing valuable guidance to emission scenario development.
Keywords	Science ; Q
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Protein S-nitrosylation is involved in valproic acid-promoted neuronal differentiation of adipose tissue-derived stem cells.

Kurokawa, Kenta / Sogawa, Kazuyuki / Suzuki, Takehito / Miyazaki, Yoko / Tanaka, Kazuaki / Usami, Makoto / Takizawa, Tatsuya

Nitric oxide : biology and chemistry

2024 Volume 145, Page(s) 21–32

Abstract: Neuronal differentiation of adipose tissue-derived stem cells (ASCs) is greatly promoted by valproic acid (VPA) with cAMP elevating agents thorough NO signaling pathways, but its mechanism is not fully understood. In the present study, we investigate the ...

Abstract	Neuronal differentiation of adipose tissue-derived stem cells (ASCs) is greatly promoted by valproic acid (VPA) with cAMP elevating agents thorough NO signaling pathways, but its mechanism is not fully understood. In the present study, we investigate the involvement of protein S-nitrosylation in the VPA-promoted neuronal differentiation of ASCs. The whole amount of S-nitrosylated protein was increased by the treatment with VPA alone for three days in ASCs. An inhibitor of thioredoxin reductase (TrxR), auranofin, further increased the amount of S-nitrosylated protein and enhances the VPA-promoted neuronal differentiation in ASCs. On the contrary, another inhibitor of TrxR, dinitrochlorobenzene, inhibited the VPA-promoted neuronal differentiation in ASCs even with cAMP elevating agents, which was accompanied by unexpectedly decreased S-nitrosylated protein. It was considered from these results that increased protein S-nitrosylation is involved in VPA-promoted neuronal differentiation of ASCs. By the proteomic analysis of S-nitrosylated protein in VPA-treated ASCs, no identified proteins could be specifically related to VPA-promoted neuronal differentiation. The identified proteins, however, included those involved in the metabolism of substances regulating neuronal differentiation, such as aspartate and glutamate.
MeSH term(s)	Valproic Acid/pharmacology ; Neurons/metabolism ; Proteomics ; Stem Cells/metabolism ; Adipose Tissue
Chemical Substances	Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2024.02.004
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Zs.A 4677: Show issues

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Article ; Online: The worldwide COVID-19 lockdown impacts on global secondary inorganic aerosols and radiative budget.

Sekiya, Takashi / Miyazaki, Kazuyuki / Eskes, Henk / Bowman, Kevin / Sudo, Kengo / Kanaya, Yugo / Takigawa, Masayuki

Science advances

2023 Volume 9, Issue 30, Page(s) eadh2688

Abstract: Global lockdown measures to prevent the spread of the coronavirus disease 2019 (COVID-19) led to air pollutant emission reductions. While the COVID-19 lockdown impacts on both trace gas and total particulate pollutants have been widely investigated, ... ...

Abstract	Global lockdown measures to prevent the spread of the coronavirus disease 2019 (COVID-19) led to air pollutant emission reductions. While the COVID-19 lockdown impacts on both trace gas and total particulate pollutants have been widely investigated, secondary aerosol formation from trace gases remains unclear. To that end, we quantify the COVID-19 lockdown impacts on NO
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Air Pollution/analysis ; Particulate Matter/analysis ; Nitrates ; Communicable Disease Control ; Respiratory Aerosols and Droplets ; Air Pollutants/analysis ; Sulfates ; Environmental Monitoring
Chemical Substances	Particulate Matter ; Nitrates ; Air Pollutants ; Sulfates
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adh2688
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Article ; Online: Bloodstream infection caused by Wickerhamiella pararugosa in a patient with intestinal obstruction: A case report.

Murata, Satoshi / Mimura, Kazuyuki / Kawamura, Takayuki / Saito, Hiroyuki / Ohno, Hideaki / Tsujii, Emi / Shinohara, Takayuki / Miyazaki, Yoshitsugu / Ohki, Takao

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2024

Abstract: The fungus Wickerhamiella pararugosa (Candida pararugosa) has been detected in various human organs but has rarely caused bloodstream infections. This report presents a case of central venous catheter-related bloodstream infection (CRBSI) of W. ... ...

Abstract	The fungus Wickerhamiella pararugosa (Candida pararugosa) has been detected in various human organs but has rarely caused bloodstream infections. This report presents a case of central venous catheter-related bloodstream infection (CRBSI) of W. pararugosa in an adult. A female patient in her 80s was admitted to our facility for intestinal obstruction caused by colorectal cancer. The patient's ability to consume food was hindered, necessitating the insertion of a central venous catheter (CVC) into the internal jugular vein. On day 3 after admission, the patient developed a fever, prompting blood and CVC tip cultures to be performed. On day 5, yeast-like fungi were discovered in the blood cultures, and fosfluconazole (fluconazole [FLCZ] pro-drug) treatment was initiated. On day 8, yeast-like fungi were identified in both the blood and CVC tip cultures, leading to a diagnosis of CRBSI. The fungus was identified as W. pararugosa through biochemical and genetic characterization. This finding justified the use of micafungin (MCFG) for combination therapy. On day 17, the minimum inhibitory concentrations (MIC) for FLCZ and MCFG were 4-8 and 0.06 μg/mL, respectively. Accordingly, the treatment was changed to monotherapy with MCFG. After a 21-day treatment regimen, the patient was discharged on day 31. We present a case of CRBSI caused by W. pararugosa in an adult with intestinal obstruction. The notable increase in the MIC of FLCZ necessitated monotherapy with MCFG, which resulted in successful recovery of the patient.
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2024.02.014
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Zs.A 5236: Show issues

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Article ; Online: Simple relation between frustration and transition points in diluted spin glasses.

Miyazaki, Ryoji / Kudo, Yuta / Ohzeki, Masayuki / Tanaka, Kazuyuki

Physical review. E

2020 Volume 102, Issue 1-1, Page(s) 12135

Abstract: ... Our result supports the suggestion from R. Miyazaki [J. Phys. Soc. Jpn. 82, 094001 (2013)JUPSAU0031-901510 ...

Abstract	We investigate a possible relation between frustration and phase-transition points in two-dimensional spin glasses at zero temperature. The relation consists of a condition on the average number of frustrated plaquettes and was reported to provide very good predictions for the critical points at zero temperature, for several two-dimensional lattices. Although there has been no proof of the relation, the good correspondence in several lattices suggests the validity of the relation and an important role of frustration in the phase transitions. To examine the relation further, we present a natural extension of the relation to diluted lattices and verify its effectiveness for bond-diluted square lattices. We then confirm that the resulting points are in good agreement with the phase-transition points in a wide range of dilution rate. Our result supports the suggestion from R. Miyazaki [J. Phys. Soc. Jpn. 82, 094001 (2013)JUPSAU0031-901510.7566/JPSJ.82.094001] for nondiluted lattices on the importance of frustration to the phase transition of two-dimensional spin glasses at zero temperature.
Language	English
Publishing date	2020-08-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.102.012135
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Article ; Online: Notch signaling genes and CD8

Ogi, Kazuhiro / Iwamoto, Takahiro / Sasaya, Takashi / Nishiyama, Koyo / Tokura, Takaaki / Sasaki, Takanori / Dehari, Hironari / Arihara, Yohei / Murase, Kazuyuki / Saito, Masato / Someya, Masanori / Takada, Kohichi / Miyazaki, Akihiro

Cancer medicine

2024 Volume 13, Issue 5, Page(s) e6985

Abstract: Background: Aberrant Notch signaling pathway has been related with the tumorigenesis in head and neck region, involving oral cavity. Here, we report the correlation between mutations in the Notch signaling pathway and CD8: Methods: This retrospective ...

Abstract	Background: Aberrant Notch signaling pathway has been related with the tumorigenesis in head and neck region, involving oral cavity. Here, we report the correlation between mutations in the Notch signaling pathway and CD8 Methods: This retrospective study analyzed the results of immunohistochemical staining for PD-L1 and CD8 Results: Four of 10 patients were positive for PD-L1 and CD8
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/metabolism ; Retrospective Studies ; B7-H1 Antigen/metabolism ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; CD8-Positive T-Lymphocytes ; Head and Neck Neoplasms/pathology
Chemical Substances	Immune Checkpoint Inhibitors ; B7-H1 Antigen
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6985
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Book ; Online: Measurement report

Shogrin, Madison J. / Payne, Vivienne H. / Kulawik, Susan S. / Miyazaki, Kazuyuki / Fischer, Emily V.

eISSN: 1680-7324

Spatiotemporal variability of peroxy acyl nitrates (PANs) over Mexico City from TES and CrIS satellite measurements

2023

Abstract: Peroxy acyl nitrates (PANs) are photochemical pollutants with implications for health and atmospheric oxidation capacity. PANs are formed via the oxidation of non-methane volatile organic compounds (NMVOCs) in the presence of nitrogen oxide radicals (NO ... ...

Abstract	Peroxy acyl nitrates (PANs) are photochemical pollutants with implications for health and atmospheric oxidation capacity. PANs are formed via the oxidation of non-methane volatile organic compounds (NMVOCs) in the presence of nitrogen oxide radicals (NO x = NO + NO 2 ). While urban environments are large sources of PANs, in situ observations in urban areas are limited. Here we use satellite measurements of PANs from the Tropospheric Emission Spectrometer (TES) and the Suomi National Polar-orbiting Partnership (S-NPP) Cross-track Infrared Sounder (CrIS) to evaluate the spatiotemporal variability of PANs over and around Mexico City. Monthly mean maxima in PANs over the Mexico City Metropolitan Area (MCMA) occur during spring months (March–May). This time of year coincides with a peak in local photochemistry and more frequent air stagnation. Local fire activity also typically peaks between February and May, which leads to strong interannual variability of PANs over the MCMA. We use S-NPP CrIS data to probe the spatial outflow pattern of PANs produced within urban Mexico City during the month with the largest mixing ratios of PANs (April). Peak outflow in April occurs to the northeast of the city and over the mountains south of the city. Outflow to the northwest appears infrequently. Using observations during 2018 versus 2019, we also show that PANs were not significantly reduced during a year, with a significant decrease in NO x over Mexico City. Our analysis demonstrates that the space-based observations provided by CrIS and TES can increase understanding of the spatiotemporal variability of PANs over and surrounding Mexico City.
Subject code	333
Language	English
Publishing date	2023-02-27
Publishing country	de
Document type	Book ; Online
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Article ; Online: Secondary central nervous system involvement in patients with diffuse large B-cell lymphoma treated with rituximab combined CHOP therapy - a supplementary analysis of JCOG0601.

Shimada, Kazuyuki / Ohmachi, Ken / Machida, Ryunosuke / Ota, Shuichi / Itamura, Hidekazu / Tsujimura, Hideki / Takayama, Nobuyuki / Shimada, Takaki / Kurosawa, Mitsutoshi / Tabayashi, Takayuki / Shimoyama, Tatsu / Ohshima, Koichi / Miyazaki, Kana / Maruyama, Dai / Kinoshita, Tomohiro / Ando, Kiyoshi / Hotta, Tomomitsu / Tsukasaki, Kunihiro / Nagai, Hirokazu

Annals of hematology

2024

Abstract: Secondary central nervous system involvement (sCNSi) in diffuse large B-cell lymphoma (DLBCL) is fatal. However, its features in patients with sCNSi who are categorized as lower risk by international prognostic index (IPI) or CNS-IPI are not yet fully ... ...

Abstract	Secondary central nervous system involvement (sCNSi) in diffuse large B-cell lymphoma (DLBCL) is fatal. However, its features in patients with sCNSi who are categorized as lower risk by international prognostic index (IPI) or CNS-IPI are not yet fully understood. In the present analysis, we evaluated DLBCL patients who developed sCNSi at their first progression and who participated in JCOG0601, most of whom were lower risk by IPI. Of 409 patients, 21 (5.1%) developed sCNSi during a median follow-up of 4.9 years. Five-year cumulative incidence of sCNSi were 5.1%; and 4.0%, 5.3%, and 11.5% at low, intermediate, and high risk of CNS-IPI, respectively. The most common locations of extranodal lesions at the time of registration in patients with sCNSi were the stomach (n = 4), paranasal cavity (n = 3), and bone marrow (n = 2). In univariable analysis, paranasal cavity lesion was a high-risk factor for sCNSi (subdistribution hazard ratio, 4.34 [95% confidence interval 1.28-14.73]). Median overall survival after sCNSi was 1.3 years, with a 2-year overall survival rate of 39.3%. The incidence of sCNSi in DLBCL patients at lower risk of CNS-IPI was low, as previously reported, but paranasal cavity lesion might indicate high risk for organ involvement. CLINICAL TRIAL REGISTRATION: JCOG0601 was registered in the UMIN Clinical Trials Registry (UMIN000000929, date of registration; December 04, 2007) and the Japan Registry of Clinical Trials (jRCTs031180139, date of registration; February 20, 2019).
Language	English
Publishing date	2024-01-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-024-05620-3
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Article ; Online: A new methodology for inferring surface ozone from multispectral satellite measurements

Nadia Colombi / Kazuyuki Miyazaki / Kevin W Bowman / Jessica L Neu / Daniel J Jacob

Environmental Research Letters, Vol 16, Iss 10, p

2021 Volume 105005

Abstract: Over the past two decades, satellite instruments have provided unprecedented information on global air quality, and yet the remote sensing of surface ozone remains elusive. Here we propose a new method to infer spatial variability in surface ozone by ... ...

Abstract	Over the past two decades, satellite instruments have provided unprecedented information on global air quality, and yet the remote sensing of surface ozone remains elusive. Here we propose a new method to infer spatial variability in surface ozone by combining multispectral ozone retrievals using radiances from the tropospheric emission spectrometer thermal infrared instrument and the ozone monitoring instrument ultratraviolet/visible instrument with a chemical reanalysis. We find that our inferred surface ozone in summertime China and the United States has regional biases of less than 4 ppb and a high spatial correlation when validated against independent surface measurements. Over the broader Asia region, our analysis results in a spatial pattern of summertime surface ozone that can largely be explained by a combination of the Asian monsoon circulation and ${\textrm{NO}}_x$ emissions. Our results show the potential of combining satellite measurements and chemical reanalyses to provide critical air quality information in regions of limited surface networks, thereby enhancing the global air quality observing system.
Keywords	ozone ; air quality ; satellites ; chemical reanalysis ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
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