LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 222

Search options

  1. Article ; Online: Reply to: Flaws in the meta-analysis of comparison between different types of exercise training in patients with type 2 diabetes mellitus: A letter to the editor.

    Mannucci, Edoardo / Monami, Matteo

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2022  Volume 32, Issue 7, Page(s) 1810

    MeSH term(s) Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/therapy ; Exercise ; Humans ; Meta-Analysis as Topic
    Language English
    Publishing date 2022-04-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety, and Economic Evaluation.

    Ragghianti, Benedetta / Berardi, Bianca Maria / Mannucci, Edoardo / Monami, Matteo

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Background: diabetic foot ulcers (DFU) represent the main cause of major amputations and hospitalisations in diabetic patients. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of peripheral blood mononuclear ... ...

    Abstract Background: diabetic foot ulcers (DFU) represent the main cause of major amputations and hospitalisations in diabetic patients. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of peripheral blood mononuclear cells (PBMNCs) in diabetic patients with no-option chronic limb-threatening ischemia (CLTI) and small artery disease (SAD).
    Methods: a retrospective study was carried out on a series of type 2 diabetic patients with DFU grade Texas 3 and no-option CLTI and SAD. All patients had undergone at least a previous revascularization and were allocated to a surgery waiting list for major amputation. The principal endpoint evaluated at 90 days was a composite of TcPO
    Results: the composite endpoint was achieved in nine patients (60.0%); one patient (6.7%) healed within ninety days and 26.7% and 46.7% showed TcPO
    Conclusions: the use of PBMNCs implants in no-option CLTI diabetic patients with SAD seems to be of help in reducing the risk of major amputation.
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12124148
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers

    Benedetta Ragghianti / Bianca Maria Berardi / Edoardo Mannucci / Matteo Monami

    Journal of Clinical Medicine, Vol 12, Iss 4148, p

    Efficacy, Safety, and Economic Evaluation

    2023  Volume 4148

    Abstract: Background: diabetic foot ulcers (DFU) represent the main cause of major amputations and hospitalisations in diabetic patients. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of peripheral blood mononuclear ... ...

    Abstract Background: diabetic foot ulcers (DFU) represent the main cause of major amputations and hospitalisations in diabetic patients. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of peripheral blood mononuclear cells (PBMNCs) in diabetic patients with no-option chronic limb-threatening ischemia (CLTI) and small artery disease (SAD). Methods: a retrospective study was carried out on a series of type 2 diabetic patients with DFU grade Texas 3 and no-option CLTI and SAD. All patients had undergone at least a previous revascularization and were allocated to a surgery waiting list for major amputation. The principal endpoint evaluated at 90 days was a composite of TcPO 2 values at the first toe ≥30 mmHg and/or TcPO 2 increase of at least 50% from baseline and/or ulcer healing. Secondary endpoints were individual components of the primary endpoint, any serious and non-serious adverse events, and direct costs at one year. Results: the composite endpoint was achieved in nine patients (60.0%); one patient (6.7%) healed within ninety days and 26.7% and 46.7% showed TcPO 2 ≥ 30 mmHg and a TcPO 2 increase of at least 50% at ninety days, respectively. At one year, three (20.0%) patients underwent a major amputation (all diagnosed SAD grade III). One patient died after seven months, and seven patients (46.7%) healed. The overall median and mean cost per patient were EUR 8238 ± 7798 and EUR 4426 (3798; 8262), respectively. Conclusions: the use of PBMNCs implants in no-option CLTI diabetic patients with SAD seems to be of help in reducing the risk of major amputation.
    Keywords diabetes mellitus ; foot ulcer ; cell therapy ; small artery disease ; chronic limb-threatening ischemia ; economic evaluation ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: Metformin may not reduce cardiovascular risk or all-cause mortality.

    Monami, Matteo

    Evidence-based medicine

    2013  Volume 18, Issue 2, Page(s) e13

    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Diabetic Angiopathies/mortality ; Humans ; Metformin/therapeutic use ; Outcome Assessment (Health Care)
    Chemical Substances Metformin (9100L32L2N)
    Language English
    Publishing date 2013-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1324346-9
    ISSN 1473-6810 ; 1356-5524
    ISSN (online) 1473-6810
    ISSN 1356-5524
    DOI 10.1136/eb-2012-100836
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Saturation of critical care capacity and mortality in patients with the novel coronavirus (COVID-19) in Italy.

    Mannucci, Edoardo / Silverii, Giovanni Antonio / Monami, Matteo

    Trends in anaesthesia & critical care

    2020  Volume 33, Page(s) 33–34

    Language English
    Publishing date 2020-05-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-8467
    ISSN (online) 2210-8467
    DOI 10.1016/j.tacc.2020.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials.

    Mannucci, Edoardo / Bonifazi, Allegra / Monami, Matteo

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2021  Volume 31, Issue 7, Page(s) 1985–1992

    Abstract: Aim: Aim of the present meta-analysis and network metanalysis (NMA) is the assessment of the effects of physical exercise on glucose control and cardiovascular risk factors in type 2 diabetes.: Data synthesis: This metanalysis includes all available ... ...

    Abstract Aim: Aim of the present meta-analysis and network metanalysis (NMA) is the assessment of the effects of physical exercise on glucose control and cardiovascular risk factors in type 2 diabetes.
    Data synthesis: This metanalysis includes all available trials exploring the effects of different exercise modalities in type 2 diabetes, with a duration of ≥3 months. The standardized difference in means (SDM) with 95% Confidence Intervals were calculated. Data were analyzed using MetaXL and Rev Man 5.0. Primary endpoint was the effect of exercise versus no exercise on HbA1c and fasting plasma glucose (FPG) at endpoint. Secondary endpoints were body weight and fat, waist circumference, and blood pressure. A comparison of different exercise training modalities (aerobic, resistance and combined) for the same endpoints was also performed, choosing 'no exercise' as the reference for indirect comparisons. We included 25 trials fulfilling all inclusion criteria. Physical exercise versus no exercise produced a small, but significant, improvement of HbA1c, body fat, and systolic blood pressure at endpoint (-0.3 [-0.1;-0.4]%, -1.44 [-2.22, -0.66]%, and -5.6 [-9.5, -1.6] mmHg, respectively). Combined, supervised aerobic and resistance exercise were associated with a significantly greater reduction of HbA1c (SDM, -0.4 [-0.6;-0.3], -0.2 [-0.4;-0.1], and -0.2 [-0.3;-0.1]%, respectively), but not of FPG, in comparison with no exercise.
    Conclusions: Physical exercise produces small, but detectable, advantages on glycemic control and cardiovascular risk factors and should be suggested in type 2 diabetes. Combined aerobic/resistance training seems to be superior to aerobic training alone, but differences are small and the reliability of supporting evidence limited.
    MeSH term(s) Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/therapy ; Exercise Therapy/methods ; Female ; Glycated Hemoglobin A/metabolism ; Glycemic Control/methods ; Humans ; Male ; Middle Aged ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Resistance Training ; Treatment Outcome
    Chemical Substances Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2021-03-20
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2021.02.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Prostanoids in patients with diabetes and chronic limb-threatening ischemia: a meta-analysis of randomized clinical trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome.

    Monami, Matteo / Silverii, Antonio / Miranda, Cesare / Monge, Luca / Uccioli, Luigi / Scevola, Germano / Stabile, Eugenio / Gargiulo, Mauro / Scatena, Alessia / Ragghianti, Benedetta / Vermigli, Cristiana

    Acta diabetologica

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-024-02260-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Potential Impact of Climate on Novel Corona Virus (COVID-19) Epidemic.

    Monami, Matteo / Silverii, Antonio / Mannucci, Edoardo

    Journal of occupational and environmental medicine

    2020  Volume 62, Issue 7, Page(s) e371–e372

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Temperature
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000001885
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Sodium-glucose co-transporter-2 inhibitors and all-cause mortality: A meta-analysis of randomized controlled trials.

    Silverii, Giovanni Antonio / Monami, Matteo / Mannucci, Edoardo

    Diabetes, obesity & metabolism

    2020  Volume 23, Issue 4, Page(s) 1052–1056

    Abstract: The present meta-analysis is aimed at assessing the effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on all-cause mortality and differences across different trials and molecules of the class. We included all randomized clinical trials with a ...

    Abstract The present meta-analysis is aimed at assessing the effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on all-cause mortality and differences across different trials and molecules of the class. We included all randomized clinical trials with a duration of treatment longer than 52 weeks, enrolling at least 100 patients in each arm, and comparing an SGLT2 inhibitor with any comparator or placebo. Out of 139, 235 and 145 items identified, 21 trials were selected, enrolling 39 593 and 30 771 patients in SGLT2 inhibitor and comparator arms, respectively, with a median duration of 104 weeks, and reporting 2474 and 2298 deaths for SGLT2 inhibitors and comparators, respectively. No relevant heterogeneity was found (I
    MeSH term(s) Benzhydryl Compounds ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Glucosides ; Humans ; Hypoglycemic Agents/therapeutic use ; Randomized Controlled Trials as Topic ; Sodium ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Symporters
    Chemical Substances Benzhydryl Compounds ; Glucosides ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Symporters ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.14286
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Glucagon-like peptide-1 and diabetes.

    Monami, Matteo

    Experimental diabetes research

    2011  Volume 2011, Page(s) 901954

    MeSH term(s) Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Glucagon-Like Peptide 1/physiology ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/physiopathology ; Incretins/therapeutic use ; Insulin/metabolism ; Signal Transduction/physiology
    Chemical Substances Blood Glucose ; Incretins ; Insulin ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2011-12-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2465179-5
    ISSN 1687-5303 ; 1687-5214
    ISSN (online) 1687-5303
    ISSN 1687-5214
    DOI 10.1155/2011/901954
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top