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  1. Article: Biological properties of andrographolide, an active ingredient of

    Vetvicka, Vaclav / Vannucci, Luca

    Annals of translational medicine

    2021  Volume 9, Issue 14, Page(s) 1186

    Abstract: Andrographolide is a labdane diterpenoid isolated ... ...

    Abstract Andrographolide is a labdane diterpenoid isolated from
    Language English
    Publishing date 2021-08-21
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-20-7830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Review: β-glucans as Effective Antibiotic Alternatives in Poultry.

    Schwartz, Betty / Vetvicka, Vaclav

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 12

    Abstract: The occurrence of microbial challenges in commercial poultry farming causes significant economic losses. Antibiotics have been used to control diseases involving bacterial infection in poultry. As the incidence of antibiotic resistance turns out to be a ... ...

    Abstract The occurrence of microbial challenges in commercial poultry farming causes significant economic losses. Antibiotics have been used to control diseases involving bacterial infection in poultry. As the incidence of antibiotic resistance turns out to be a serious problem, there is increased pressure on producers to reduce antibiotic use. With the reduced availability of antibiotics, poultry producers are looking for feed additives to stimulate the immune system of the chicken to resist microbial infection. Some β-glucans have been shown to improve gut health, to increase the flow of new immunocytes, increase macrophage function, stimulate phagocytosis, affect intestinal morphology, enhance goblet cell number and mucin-2 production, induce the increased expression of intestinal tight-junctions, and function as effective anti-inflammatory immunomodulators in poultry. As a result, β-glucans may provide a new tool for producers trying to reduce or eliminate the use of antibiotics in fowl diets. The specific activity of each β-glucan subtype still needs to be investigated. Upon knowledge, optimal β-glucan mixtures may be implemented in order to obtain optimal growth performance, exert anti-inflammatory and immunomodulatory activity, and optimized intestinal morphology and histology responses in poultry. This review provides an extensive overview of the current use of β glucans as additives and putative use as antibiotic alternative in poultry.
    MeSH term(s) Animal Feed ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Humans ; Immunologic Factors/pharmacology ; Meat ; Poultry ; beta-Glucans/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Immunologic Factors ; beta-Glucans
    Language English
    Publishing date 2021-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26123560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Endometrial cancer-is our knowledge changing?

    Králíčková, Milena / Vetvicka, Vaclav / Laganà, Antonio Simone

    Translational cancer research

    2022  Volume 9, Issue 12, Page(s) 7734–7745

    Abstract: In developed countries, endometrial cancer (EC) is the most frequent gynecologic malignancy in postmenopausal women. At the same time, EC has become one of the most common cancers in numerous developing countries, probably influenced by global epidemic ... ...

    Abstract In developed countries, endometrial cancer (EC) is the most frequent gynecologic malignancy in postmenopausal women. At the same time, EC has become one of the most common cancers in numerous developing countries, probably influenced by global epidemic of obesity. The majority of patients have low-grade endometrioid cancer with a high 5-year survival rate, but with high-risk EC, the survival rates are still rather low. However, despite intensive research in last decades, our knowledge of the mechanisms, risk factors, diagnosis and treatment have not significantly improved. The standard treatment of all types of EC is still a traditional combination of surgery, irradiation and/or chemotherapy, despite the fact that each of these options is not without having some negative side effects. Despite the fact that on the molecular level, EC is relatively well-studied, but the efforts to transform these findings into either diagnosis or therapies of EC remain elusive. In addition, some research into risk factors involved in the development or progression of EC seems to be more a fishing expedition than a well thought-out approach. The purpose of this review is to summarize the most recent developments in the search for biomarkers and prognostic markers and to discuss the progress in EC treatment.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-1720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Delayed ejaculation in men with depressive disorders.

    Fiala, Ludek / Lenz, Jiri / Havelka, Pavel / Vetvicka, Vaclav

    Andrologia

    2022  Volume 54, Issue 6, Page(s) e14412

    Abstract: Delayed ejaculation belongs to the group of sexual disorders in men. The causes of delayed ejaculation or anejaculation are not exactly known. It is assumed that it can be caused by psychogenic or organic influences or their combinations. One of the ... ...

    Abstract Delayed ejaculation belongs to the group of sexual disorders in men. The causes of delayed ejaculation or anejaculation are not exactly known. It is assumed that it can be caused by psychogenic or organic influences or their combinations. One of the causes of delayed ejaculation may be elevated prolactin levels, which may be increased by psychosocial stress, pituitary disorders or also treatment with selective serotonin reuptake inhibitors in the treatment of depression. We tested a selected group of 50 men who were diagnosed with a depressive disorder and whose antidepressant treatment lasted for at least 24 weeks. These patients reported long-term delayed ejaculation or, in some cases, anejaculation as comorbidity. The results showed significant Spearman's correlation between elevated prolactin levels and intravaginal ejaculation latency values (R = 0.45), as well as between Beck's Depression-II inventory and intravaginal ejaculation latency and latency values (R = 0.48).
    MeSH term(s) Depressive Disorder ; Ejaculation ; Humans ; Male ; Premature Ejaculation/etiology ; Prolactin ; Serotonin Uptake Inhibitors/pharmacology ; Serotonin Uptake Inhibitors/therapeutic use ; Sexual Dysfunction, Physiological/etiology
    Chemical Substances Serotonin Uptake Inhibitors ; Prolactin (9002-62-4)
    Language English
    Publishing date 2022-03-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 7280-1
    ISSN 1439-0272 ; 0303-4569
    ISSN (online) 1439-0272
    ISSN 0303-4569
    DOI 10.1111/and.14412
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 665: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Glucan-many faces of one molecule.

    Vetvicka, Vaclav

    Annals of translational medicine

    2014  Volume 2, Issue 2, Page(s) 11

    Language English
    Publishing date 2014-07-14
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.3978/j.issn.2305-5839.2014.02.08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Review

    Betty Schwartz / Vaclav Vetvicka

    Molecules, Vol 26, Iss 3560, p

    β-glucans as Effective Antibiotic Alternatives in Poultry

    2021  Volume 3560

    Abstract: The occurrence of microbial challenges in commercial poultry farming causes significant economic losses. Antibiotics have been used to control diseases involving bacterial infection in poultry. As the incidence of antibiotic resistance turns out to be a ... ...

    Abstract The occurrence of microbial challenges in commercial poultry farming causes significant economic losses. Antibiotics have been used to control diseases involving bacterial infection in poultry. As the incidence of antibiotic resistance turns out to be a serious problem, there is increased pressure on producers to reduce antibiotic use. With the reduced availability of antibiotics, poultry producers are looking for feed additives to stimulate the immune system of the chicken to resist microbial infection. Some β-glucans have been shown to improve gut health, to increase the flow of new immunocytes, increase macrophage function, stimulate phagocytosis, affect intestinal morphology, enhance goblet cell number and mucin-2 production, induce the increased expression of intestinal tight-junctions, and function as effective anti-inflammatory immunomodulators in poultry. As a result, β-glucans may provide a new tool for producers trying to reduce or eliminate the use of antibiotics in fowl diets. The specific activity of each β-glucan subtype still needs to be investigated. Upon knowledge, optimal β-glucan mixtures may be implemented in order to obtain optimal growth performance, exert anti-inflammatory and immunomodulatory activity, and optimized intestinal morphology and histology responses in poultry. This review provides an extensive overview of the current use of β glucans as additives and putative use as antibiotic alternative in poultry.
    Keywords β-glucans ; poultry ; immunomodulatory ; antibiotics ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Anti-infectious and Anti-tumor Activities of β-glucans.

    Vetvicka, Vaclav / Vetvickova, Jana

    Anticancer research

    2020  Volume 40, Issue 6, Page(s) 3139–3145

    Abstract: Background/aim: The aim of this study was to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans.: Materials and methods: We used five different glucans isolated from algae, yeast, bacteria, oat, and ... ...

    Abstract Background/aim: The aim of this study was to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans.
    Materials and methods: We used five different glucans isolated from algae, yeast, bacteria, oat, and mushroom. We compared their effects on the stimulation of phagocytosis of blood cells, on the secretion of IL-2, and on the inhibition of melanoma and breast and lung cancers. In addition, we evaluated the effects of glucan supplementation on two experimental models of infection.
    Results: Most of the tested glucans stimulated phagocytosis and IL-2 secretion, reduced cancer growth, and ameliorated some effects of experimental infections.
    Conclusion: Glucans can produce significant pleiotropic effects, but the activity varies among individual samples.
    MeSH term(s) Animals ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Cell Line ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Phagocytosis/drug effects ; beta-Glucans/pharmacology ; beta-Glucans/therapeutic use
    Chemical Substances Anti-Infective Agents ; beta-Glucans
    Language English
    Publishing date 2020-06-02
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.14295
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Beta-glucans induce cellular immune training and changes in intestinal morphology in poultry.

    Bar-Dagan, Hadar / Gover, Ofer / Cohen, Natalie Avital / Vetvicka, Vaclav / Rozenboim, Israel / Schwartz, Betty

    Frontiers in veterinary science

    2023  Volume 9, Page(s) 1092812

    Abstract: Introduction: Beta-glucans are known as biological response modifiers due to their ability to activate the immune system. This research aimed to determine the efficacy and safety of feeding beta-glucans from various sources on the immune status and ... ...

    Abstract Introduction: Beta-glucans are known as biological response modifiers due to their ability to activate the immune system. This research aimed to determine the efficacy and safety of feeding beta-glucans from various sources on the immune status and intestinal morphology of chickens.
    Methods: To this end we used
    Results: In the
    Discussion: In conclusion, dietary supplementation of poultry with beta-glucan exerts significant and positive effects on immune activity and the intestinal morphology in poultry.
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.1092812
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  9. Book: Immunology of annelids

    Větvička, Václav

    1994  

    Author's details Václav Větvička
    Keywords Annelida / immunology ; Ringelwürmer ; Immunologie
    Subject Klinische Immunologie ; Gliederwürmer ; Annelida
    Language English
    Size 299 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006742386
    ISBN 0-8493-4909-5 ; 978-0-8493-4909-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 4204 order for loan Magazin

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  10. Article: Effects of β-glucan on some environmental toxins: An overview.

    Vetvicka, Vaclav

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2014  Volume 158, Issue 1, Page(s) 1–4

    Abstract: Background: Beta-glucans are naturally occurring polysaccharides and constituents of the cell wall of certain pathogenic bacteria and fungi. They have proven healing and immunostimulating properties, linked to enhanced macrophage and natural killer cell ...

    Abstract Background: Beta-glucans are naturally occurring polysaccharides and constituents of the cell wall of certain pathogenic bacteria and fungi. They have proven healing and immunostimulating properties, linked to enhanced macrophage and natural killer cell function which likely involves specific interaction with several cell surface receptors, such as lactosylceramide, selected scavenger receptors, and dectin-1 (betaGR). In particular, glucan reduces the immunosuppressive effects of a number of agents including chemo therapy and radiation. More recent studies suggest a positive function for glucan in the immunosuppression caused by toxic agents in the environment.
    Aim: An overview of the effects of glucan on the mycotoxin, aflotoxin and other environmental toxins (mercury-thimerosal, depleted uranium).
    Conclusion: Glucan is effective as a natural immunomodulator and could be used as an inexpensive solution to reducing the adverse effects of some environmental toxins.
    MeSH term(s) Adsorption/drug effects ; Environmental Pollutants/antagonists & inhibitors ; Environmental Pollutants/toxicity ; Immunosuppression ; Mercury/metabolism ; Mercury/toxicity ; Mycotoxins/antagonists & inhibitors ; Mycotoxins/metabolism ; Mycotoxins/toxicity ; Oxidative Stress/drug effects ; Uranium/metabolism ; Uranium/toxicity ; beta-Glucans/immunology ; beta-Glucans/pharmacology
    Chemical Substances Environmental Pollutants ; Mycotoxins ; beta-Glucans ; Uranium (4OC371KSTK) ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2014
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2013.090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6675: Show issues Location:
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