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Article ; Online: Glucocorticoid-Induced Bacterial Endocarditis in COVID-19 Pneumonia　- Something to Be Concerned About?

Regazzoni, Valentina / Loffi, Marco / Garini, Alberto / Danzi, Gian Battista

Circulation journal : official journal of the Japanese Circulation Society

2020 Volume 84, Issue 10, Page(s) 1887

MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Betacoronavirus ; Coinfection/chemically induced ; Coinfection/drug therapy ; Coinfection/virology ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Echocardiography, Transesophageal ; Endocarditis, Bacterial/chemically induced ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis, Bacterial/drug therapy ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/therapeutic use ; Magnetic Resonance Imaging ; Male ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Staphylococcal Infections/chemically induced ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/isolation & purification ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Glucocorticoids ; Hydroxychloroquine (4QWG6N8QKH)
Keywords	covid19
Language	English
Publishing date	2020-08-07
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-20-0462
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Article: Glucocorticoid-Induced Bacterial Endocarditis in COVID-19 Pneumoniaã- Something to Be Concerned About?

Regazzoni, Valentina / Loffi, Marco / Garini, Alberto / Danzi, Gian Battista

Circ J

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696548
Database	COVID19

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Article ; Online: Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection.

Moschini, Luigi / Loffi, Marco / Regazzoni, Valentina / Di Tano, Giuseppe / Gherbesi, Elisa / Danzi, Gian Battista

Heart and vessels

2020 Volume 36, Issue 1, Page(s) 115–120

Abstract: Introduction: Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc).: Objective: To evaluate the effects of an association therapy of ... ...

Abstract	Introduction: Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc). Objective: To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals. Methods: At the beginning of COVID-19 pandemic patients admitted to our hospital were treated with the empiric association of HY/RD; one week later the therapeutic protocol was modified with the combination of HY/AZ. Patients underwent an ECG at baseline, then 3 and 7 days after starting therapy. We prospectively enrolled 113 patients (61 in the HY/RD group-52 in the HY/AZ group). Results: A significant increase in median QTc was reported after seven days of therapy in both groups: from 438 to 452 ms in HY/RD patients; from 433 to 440 ms in HY/AZ patients (p = 0.001 for both). 23 patients (21.2%) had a QTc > 500 ms at 7 days. The risk of developing a QTc > 500 ms was greater in patients with prolonged baseline QTc values (≥ 440 ms for female and ≥ 460 ms for male patients) (OR 7.10 (95% IC 1.88-26.81); p = 0.004) and in patients with an increase in the QTc > 40 ms 3 days after onset of treatment (OR 30.15 (95% IC 6.96-130.55); p = 0.001). One patient per group suffered a malignant ventricular arrhythmia. Conclusion: Hydroxychloroquine with both ritonavir/darunavir or azithromycin therapy significantly increased the QTc-interval at 7 days. The risk of developing malignant arrhythmias remained relatively low when these drugs were administered for a limited period of time.
MeSH term(s)	Aged ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/adverse effects ; Azithromycin/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; Darunavir/adverse effects ; Darunavir/therapeutic use ; Electrocardiography/drug effects ; Enzyme Inhibitors/therapeutic use ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Long QT Syndrome/chemically induced ; Long QT Syndrome/physiopathology ; Male ; Middle Aged ; Ritonavir/adverse effects ; Ritonavir/therapeutic use ; SARS-CoV-2
Chemical Substances	Anti-Bacterial Agents ; Enzyme Inhibitors ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Ritonavir (O3J8G9O825) ; Darunavir (YO603Y8113)
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-020-01671-4
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Article ; Online: Echocardiographic findings in subjects with an amyloidogenic apolipoprotein A1 pathogenic variant.

Tomasoni, Daniela / Aimo, Alberto / Adamo, Marianna / Nardi, Matilde / Lombardi, Carlo Mario / Regazzoni, Valentina / De Angelis, Maria Grazia / Fabiani, Iacopo / Merlini, Giampaolo / Mussinelli, Roberta / Obici, Laura / Panichella, Giorgia / Vergaro, Giuseppe / Passino, Claudio / Scolari, Francesco / Perlini, Stefano / Emdin, Michele / Metra, Marco

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2023 Volume 30, Issue 3, Page(s) 335–345

Abstract: Background: Very small case series of patients with apolipoprotein A1 (ApoA1) amyloidosis are available.: Methods: We described the clinical and echocardiographic characteristics of individuals with the pathogenic : Results: We enrolled 189 ... ...

Abstract	Background: Very small case series of patients with apolipoprotein A1 (ApoA1) amyloidosis are available. Methods: We described the clinical and echocardiographic characteristics of individuals with the pathogenic Results: We enrolled 189 subjects, 54% men, median age 55 years (interquartile range 42-67), 39% with concomitant renal disease and 31% with liver disease. Median left ventricular ejection fraction was 60% (55-66). Overall, these subjects did not show overt diastolic dysfunction nor left ventricular (LV) hypertrophy. Age correlated with interventricular septal (IVS) thickness ( Conclusions: Subjects with the
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Stroke Volume ; Apolipoprotein A-I/genetics ; Ventricular Function, Left ; Echocardiography ; Hypertrophy, Left Ventricular/complications ; Amyloidosis/pathology
Chemical Substances	Apolipoprotein A-I
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1205246-2
ISSN	1744-2818 ; 1350-6129
ISSN (online)	1744-2818
ISSN	1350-6129
DOI	10.1080/13506129.2023.2190003
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Article ; Online: Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection

Moschini, Luigi / Loffi, Marco / Regazzoni, Valentina / Di Tano, Giuseppe / Gherbesi, Elisa / Danzi, Gian Battista

Heart and Vessels ; ISSN 0910-8327 1615-2573

2020

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s00380-020-01671-4
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection

Moschini, Luigi / Loffi, Marco / Regazzoni, Valentina / Di Tano, Giuseppe / Gherbesi, Elisa / Danzi, Gian Battista

Heart vessels

Abstract: INTRODUCTION: Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc). OBJECTIVE: To evaluate the effects of an association therapy of ... ...

Abstract	INTRODUCTION: Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc). OBJECTIVE: To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals. METHODS: At the beginning of COVID-19 pandemic patients admitted to our hospital were treated with the empiric association of HY/RD; one week later the therapeutic protocol was modified with the combination of HY/AZ. Patients underwent an ECG at baseline, then 3 and 7 days after starting therapy. We prospectively enrolled 113 patients (61 in the HY/RD group-52 in the HY/AZ group). RESULTS: A significant increase in median QTc was reported after seven days of therapy in both groups: from 438 to 452 ms in HY/RD patients; from 433 to 440 ms in HY/AZ patients (p = 0.001 for both). 23 patients (21.2%) had a QTc > 500 ms at 7 days. The risk of developing a QTc > 500 ms was greater in patients with prolonged baseline QTc values (≥ 440 ms for female and ≥ 460 ms for male patients) (OR 7.10 (95% IC 1.88-26.81); p = 0.004) and in patients with an increase in the QTc > 40 ms 3 days after onset of treatment (OR 30.15 (95% IC 6.96-130.55); p = 0.001). One patient per group suffered a malignant ventricular arrhythmia. CONCLUSION: Hydroxychloroquine with both ritonavir/darunavir or azithromycin therapy significantly increased the QTc-interval at 7 days. The risk of developing malignant arrhythmias remained relatively low when these drugs were administered for a limited period of time.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #649079
Database	COVID19

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Article ; Online: Patient-reported outcome and cognitive measures to be used in vascular and brain tumor surgery: proposal for a minimum set.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022 Volume 43, Issue 8, Page(s) 5143–5151

Abstract: Background: The standardization of outcome measures is needed for comparing studies and using common measures in clinical practice. We aimed to identify cognitive and patient-reported outcomes and timing of assessment for glioma, meningioma, and ... ...

Abstract	Background: The standardization of outcome measures is needed for comparing studies and using common measures in clinical practice. We aimed to identify cognitive and patient-reported outcomes and timing of assessment for glioma, meningioma, and vascular surgery. Method: A consensus study was conducted. Participants selected cognitive and patient-reported measures among a list of instruments identified through a literature search. Results: Seventeen cognitive tests for the glioma and meningioma's evaluation, 8 for the vascular diseases, and one questionnaire on quality of life and one on emotional distress were identified. The timing of outcome assessment selected was before surgery, at discharge, and after 3 and 12 months for glioma; before surgery and after 3 months for meningioma; before surgery, at discharge, and after 6 months for vascular diseases. Conclusion: The identification of common outcome measures is the first step toward a shared data collection improving the quality and comparability of future studies.
MeSH term(s)	Brain Neoplasms/surgery ; Cognition ; Glioma ; Humans ; Meningeal Neoplasms ; Meningioma/surgery ; Patient Reported Outcome Measures ; Quality of Life ; Vascular Diseases
Language	English
Publishing date	2022-06-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06162-0
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Article: Spontaneous pneumomediastinum in COVID-19 pneumonia.

Loffi, Marco / Regazzoni, Valentina / Sergio, Pietro / Martinelli, Enrico / Stifani, Italo / Quinzani, Filippo / Robba, Debora / Cotugno, Annunziata / Dede, Meghi / Danzi, Gian Battista

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2020 Volume 90, Issue 4

Abstract: Spontaneous pneumomediastinum is a benign entity but can worsen the underlying condition with which it is associated. We evaluated the incidence and the clinical relevance of spontaneous pneumomediastinum in a consecutive series of 102 patients with ... ...

Abstract	Spontaneous pneumomediastinum is a benign entity but can worsen the underlying condition with which it is associated. We evaluated the incidence and the clinical relevance of spontaneous pneumomediastinum in a consecutive series of 102 patients with COVID-19 pneumonia. Six cases of pneumomediastinum were identified by high-resolution chest CT-scan. Three patients required early intubation, and one of them died, while in in the remaining subjects the clinical course was benign. The presence of pneumomediastinum required some changes in the management of mechanical ventilation. In conclusion, spontaneous pneumomediastinum is a possible complication of severe COVID-19 pneumonia that can affect patient management and clinical outcomes.
MeSH term(s)	Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/therapy ; Female ; Humans ; Incidence ; Italy ; Male ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/epidemiology ; Mediastinal Emphysema/therapy ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/therapy ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2020.1399
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Article ; Online: Stressed degradation studies of domiphen bromide by LC-ESI-MS/MS identify a novel promising antimicrobial agent.

Fumagalli, Laura / Regazzoni, Luca Giovanni / Straniero, Valentina / Valoti, Ermanno / Aldini, Giancarlo / Vistoli, Giulio / Carini, Marina / Picozzi, Claudia

Journal of pharmaceutical and biomedical analysis

2018 Volume 159, Page(s) 224–228

Abstract: Nowadays, parabens have been replaced by domiphen bromide, which is widely used in pharmaceutical and cosmetic products. The main aim of this study was to investigate stressed degradation products of domiphen bromide by mean of a rapid, specific and ... ...

Abstract	Nowadays, parabens have been replaced by domiphen bromide, which is widely used in pharmaceutical and cosmetic products. The main aim of this study was to investigate stressed degradation products of domiphen bromide by mean of a rapid, specific and reliable LC-ESI MS/MS since phenyl bromination may occur due to the oxidation of bromide counter ion under oxidative conditions. LC-ESI-MS/MS have characterized a new compound, p-bromodomiphen, as the only degradation product and structure elucidation was also confirmed by the synthesis of the standard. Notably, the resulting p-bromodomiphen bromide is more stable then domiphen bromide in oxidizing conditions since no di-bromoderivatives were detected by MS studies; both domiphen and its p-bromo derivative were tested for antibacterial activity and were more effective on Gram positive (Staphylococcus aureus ATCC25923 and Bacillus cereus DSM31) compared to Gram negative bacteria (Escherichia coli ATCC25922 and Pseudomonas aeruginosa DSM22644). In conclusion, stressed degradation studies by LC-ESI-MS/MS have characterized a new compound that comprises an alternative to domiphen bromide since its antimicrobial activity is comparable to, if not better than, the parental compound.
MeSH term(s)	Anti-Infective Agents/analysis ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Bacillus cereus/drug effects ; Bacillus cereus/metabolism ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Quaternary Ammonium Compounds/analysis ; Quaternary Ammonium Compounds/metabolism ; Quaternary Ammonium Compounds/pharmacology ; Spectrometry, Mass, Electrospray Ionization/methods ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/metabolism ; Tandem Mass Spectrometry/methods
Chemical Substances	Anti-Infective Agents ; Quaternary Ammonium Compounds ; domiphen (4AZL56CU0F)
Language	English
Publishing date	2018-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2018.06.055
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Article ; Online: School and family-based interventions for promoting a healthy lifestyle among children and adolescents in Italy: a systematic review.

Gorga, Elio / Regazzoni, Valentina / Bansilal, Sameer / Carubelli, Valentina / Trichaki, Eleftheria / Gavazzoni, Mara / Lombardi, Carlo / Raddino, Riccardo / Metra, Marco

Journal of cardiovascular medicine (Hagerstown, Md.)

2016 Volume 17, Issue 8, Page(s) 547–555

Abstract: Aims: Cardiovascular diseases affect adult population but risk factors develop as a result of known or assumed behavior since childhood. In Italy, up to 22.2% of children are overweight, 10.6% are obese, and 2.5% have severe obesity.: Methods: We ... ...

Abstract	Aims: Cardiovascular diseases affect adult population but risk factors develop as a result of known or assumed behavior since childhood. In Italy, up to 22.2% of children are overweight, 10.6% are obese, and 2.5% have severe obesity. Methods: We performed a systematic review of the literature to identify studies and initiatives addressing health promotion among children in Italy. Given the high heterogeneity of interventions and outcomes assessed we opted to perform a qualitative synthesis of the results. We described also nonrandomized trial where the intervention of primary prevention was very innovative, explained in detail, and reached an improving outcome for participants. Results: We identified 11 projects since 1983, only five were randomized control trials. Three involved children and teachers of primary and secondary schools and were based on specific curricular lectures about health. One was based on a game developed for high schools with the purpose to promote healthy lifestyle and physical activity. The fifth project was based on an enhanced physical activity program. Conclusion: Our results show that school and family should be considered as the privileged places for health promotion. In Italy, the development of scientific-validated lifestyle interventions for children is still an unmet need.
MeSH term(s)	Adolescent ; Cardiovascular Diseases/prevention & control ; Child ; Exercise ; Family ; Health Promotion/methods ; Healthy Lifestyle ; Humans ; Italy/epidemiology ; Obesity/epidemiology ; Primary Prevention/methods ; Randomized Controlled Trials as Topic ; Risk Factors ; Schools
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000404
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