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Article ; Online: Culinary Medicine Experiences for Medical Students and Residents in the U.S. and Canada: A Scoping Review.

Hildebrand, Caitlin A / Patel, Meghana B / Tenney, Alyssa B / Logan, Julia A / Luong, Khanh H / Crouch, Miranda J / Osta, Amanda E / DeRoo, Courtney / Gilliland, Kurt O / Harlan, Timothy S / Ammerman, Alice S

Teaching and learning in medicine

2024 , Page(s) 1–27

Abstract: Phenomenon: Despite the importance of diet in the prevention and management of many common chronic diseases, nutrition training in medicine is largely inadequate in medical school and residency. The emerging field of culinary medicine offers an ... ...

Abstract	Phenomenon: Despite the importance of diet in the prevention and management of many common chronic diseases, nutrition training in medicine is largely inadequate in medical school and residency. The emerging field of culinary medicine offers an experiential nutrition learning approach with the potential to address the need for improved nutrition training of physicians. Exploring this innovative nutrition training strategy, this scoping review describes the nature of culinary medicine experiences for medical students and resident physicians, their impact on the medical trainees, and barriers and facilitators to their implementation. Approach: This scoping review used the Joanna Briggs Institute methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR) checklist as guides. Eligible publications described the nature, impact, facilitators, and/or barriers of nutrition and food preparation learning experiences for medical students and/or residents. Additional inclusion criteria were location (U.S. or Canada), allopathic or osteopathic, English, human subjects, and publication year (2002 or later). The search strategy included 4 electronic databases. Two reviewers independently screened titles/abstracts and a third reviewer resolved discrepancies. The full-text review consisted of 2 independent reviews with discrepancies resolved by a third reviewer or by consensus if needed, and the research team extracted data from the included articles based on the nature, impact, barriers, and facilitators of culinary medicine experiences for medical trainees. Findings: The publication search resulted in 100 publications describing 116 experiences from 70 institutions. Thirty-seven publications described pilot experiences. Elective/extracurricular and medical student experiences were more common than required and resident experiences, respectively. Experiences varied in logistics, instruction, and curricula. Common themes of tailored culinary medicine experiences included community engagement/service-based learning, interprofessional education, attention to social determinants of health, trainee well-being, and cultural considerations. Program evaluations commonly reported the outcome of experiences on participant attitudes, knowledge, skills, confidence, and behaviors. Frequent barriers to implementation included time, faculty, cost/funding, kitchen space, and institutional support while common facilitators of experiences included funding/donations, collaboratives and partnerships, teaching kitchen access, faculty and institutional support, and trainee advocacy. Insights: Culinary medicine is an innovative approach to address the need and increased demand for improved nutrition training in medicine. The findings from this review can guide medical education stakeholders interested in developing or modifying culinary medicine experiences. Despite barriers to implementation, culinary medicine experiences can be offered in a variety of ways during undergraduate and graduate medical education and can be creatively designed to fulfill some accreditation standards.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038640-3
ISSN	1532-8015 ; 1040-1334
ISSN (online)	1532-8015
ISSN	1040-1334
DOI	10.1080/10401334.2024.2340977
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Article ; Online: Conformability of the GORE EXCLUDER iliac branch endoprosthesis is associated with freedom from adverse iliac events.

DeRoo, Elise / Harris, Donald / Olson, Sydney / Panthofer, Annalise / Meadows, Wendy / Pauli, Thomas / Peterson, Brian / Schneider, Darren / Matsumura, Jon

Journal of vascular surgery

2021 Volume 74, Issue 5, Page(s) 1558–1564.e1

Abstract: Objective: The GORE EXCLUDER iliac branch endoprosthesis (IBE; W.L. Gore & Associates, Flagstaff, Ariz) is designed to preserve internal iliac artery (IIA) patency during endovascular treatment of aneurysms involving the common iliac artery. The device ... ...

Abstract	Objective: The GORE EXCLUDER iliac branch endoprosthesis (IBE; W.L. Gore & Associates, Flagstaff, Ariz) is designed to preserve internal iliac artery (IIA) patency during endovascular treatment of aneurysms involving the common iliac artery. The device is intended to conform to iliac tortuosity, which may decrease adverse iliac events (AIE). The objective of this study was to evaluate risk factors for AIE after IBE implantation. Methods: This was a post hoc analysis of the prospective, multicenter GORE 12-04 IBE pivotal trial. Patients with preoperative and postoperative axial imaging were included, with analysis based on each treated iliac system. An independent core laboratory performed all scan measurements, including iliac diameters, lengths, and tortuosity. Conformability was analyzed by the changes in tortuosity after IBE deployment, with less change indicating greater conformation. The end point was AIE, defined as ipsilateral radiographic or clinical complications. Critical nonconformation was defined as a threshold change in tortuosity associated with a significant increase in AIE. Results: We included 98 patients with 101 treated iliac systems. There were eight AIE (8%; six IIA component occlusions, one iliac branch component occlusion, and one EIA dissection requiring reintervention). Patients with AIE had smaller IIA diameters and less IBE conformability. After multivariable logistic regression analysis, an IIA diameter of less than 10 mm and a change in total iliac tortuosity beyond -15% were independently associated with AIE (odds ratio, 12 [interquartile range, 1.4-110] and odds ratio, 8.2 [interquartile range, 1.5-46], respectively), and the latter was used to define critical nonconformation. Critical nonconformation occurred in 11% of treated systems, and was associated with a high rate of AIE (36% vs 4%; P = .004). Conclusions: Endograft conformation is a novel device property and technical outcome that, along with a larger IIA diameter, is associated with freedom from AIE after IBE deployment. An evaluation of these risk factors may better inform the management of patients with iliac aneurysmal disease. Further research on endograft conformation and patient outcomes is warranted, particularly for those with challenging anatomy undergoing complex procedures.
MeSH term(s)	Aged ; Aged, 80 and over ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Female ; Humans ; Iliac Aneurysm/diagnostic imaging ; Iliac Aneurysm/physiopathology ; Iliac Aneurysm/surgery ; Iliac Artery/diagnostic imaging ; Iliac Artery/physiopathology ; Iliac Artery/surgery ; Male ; Middle Aged ; Prosthesis Design ; Time Factors ; Treatment Outcome ; United States ; Vascular Patency
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2021.05.026
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Zs.A 1933: Show issues

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Article ; Online: Medical Malpractice Analysis in Radiation Oncology: A Decade of Results From a National Comparative Benchmarking System.

Royce, Trevor J / Dwyer, Kathy / Yu-Moe, C Winnie / DeRoo, Courtney / Jacobson, Joseph O / Tishler, Roy B

International journal of radiation oncology, biology, physics

2018 Volume 103, Issue 4, Page(s) 801–808

Abstract: Purpose: Medical errors in radiation oncology (RO) practice have received significant national attention over the last decade. Medical errors can lead to malpractice cases. Better characterizing these events can educate providers with the goal of ... ...

Abstract	Purpose: Medical errors in radiation oncology (RO) practice have received significant national attention over the last decade. Medical errors can lead to malpractice cases. Better characterizing these events can educate providers with the goal of improving patient care. Methods and materials: The Controlled Risk Insurance Company Strategies' Comparative Benchmarking System (CBS) represents approximately 30% of all closed US malpractice cases and includes the experience of more than 30 academic hospitals. Registered nurses trained as clinical taxonomy specialists code each case, and individual case-level details are available. Practicing radiation oncologists extracted all closed RO cases from years 2005 to 2014 and subgrouped them by patient allegation category, clinical injury severity, care setting and academic affiliation, disease site and natural history, treatment modality, and contributing factor. Within categories, χ Results: RO was the primary service in 102 closed cases (0.2% of all cases in the CBS), accounting for $13,323,578 in indemnity payments (0.1% of all payments in the CBS). The median indemnity payment was $100,000. Head-and-neck and central nervous system tumors accounted for 23.9% and 10.9% of all RO cases, respectively, and 41.3% and 31.4% of all indemnity payments, respectively. Benign diseases and brachytherapy were involved in 12.0% and 15.2% of cases, respectively. Cases involving benign disease (P = .009), treatment of the wrong site (P = .001), or treatment using the wrong dose (P < .001) were all associated with indemnity payments. The top 5 most expensive cases accounted for nearly 80% of all indemnity payments, and all involved head-and-neck, central nervous system, benign, or brachytherapy cases. Conclusions: We found that although closed malpractice cases involving RO are rare events, certain populations may be overrepresented in closed claims. These data can help inform providers and systems with the goal of ultimately improving patient safety.
MeSH term(s)	Benchmarking ; Female ; Humans ; Male ; Malpractice/statistics & numerical data ; Middle Aged ; Radiation Oncology
Language	English
Publishing date	2018-11-13
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2018.11.009
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Zs.A 1218: Show issues

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Article ; Online: Management of primary graft failure after heart transplantation: Preoperative risks, perioperative events, and postoperative decisions.

Truby, Lauren K / DeRoo, Scott / Spellman, Jessica / Jennings, Douglas L / Takeda, Koji / Fine, Barry / Restaino, Susan / Farr, Maryjane

Clinical transplantation

2019 Volume 33, Issue 6, Page(s) e13557

Abstract: Primary graft failure (PGF) after heart transplantation (HT) is a devastating and unexpected event characterized by failure of the graft to adequately support recipient circulation necessitating high doses of vasopressors and inotropes and/or temporary ... ...

Abstract	Primary graft failure (PGF) after heart transplantation (HT) is a devastating and unexpected event characterized by failure of the graft to adequately support recipient circulation necessitating high doses of vasopressors and inotropes and/or temporary mechanical circulatory support. Although it represents an increasingly common event in the current era, there remains a high degree of variability in prevalence, reported risk factors, and approach to this clinical entity. The purpose of the current review is to highlight preoperative considerations including known incidence and risk factors, perioperative issues involving the identification and management of PGF, and postoperative decisions related to weaning of mechanical circulatory support and titration of immunosuppressive therapy. Lastly, we highlight future directions in PGF research, involving basic and translational research, that have the potential to uncover novel strategies of risk stratification and treatment. CASE: Our patient is a 53-year-old man with end-stage non-ischemic dilated cardiomyopathy complicated by ventricular tachycardia (VT), post-capillary pulmonary hypertension, and renal insufficiency. After progressing to NYHA Class IV symptoms, he underwent implantation of a durable left ventricular assist device (LVAD) as bridge to transplant (BTT). On device support, he developed recurrent VT resulting in multiple defibrillator discharges and hospital admission for intravenous anti-arrhythmic therapy. He is subsequently upgraded to a higher status on the waiting list. A suitable donor is identified, with an appropriate predicted heart mass and an anticipated ischemic time of <4 hours. He is taken to the operating room, where at the time of anesthesia induction he develops vasodilatory shock, requiring high-dose vasopressors, and cardiopulmonary bypass (CPB) support for dissection. After surgical anastomosis, cross clamp removal and reperfusion, graft function is extremely poor, there is significant bradycardia requiring pacing, and the patient is unable to be weaned successfully from CPB. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is initiated, and the patient is transferred to the intensive care unit. Retrospective flow crossmatch is negative. This patient is suffering from severe primary graft failure.
MeSH term(s)	Disease Management ; Extracorporeal Membrane Oxygenation/methods ; Follow-Up Studies ; Graft Rejection/etiology ; Graft Rejection/pathology ; Graft Rejection/therapy ; Graft Survival ; Heart Failure/surgery ; Heart Transplantation/adverse effects ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Perioperative Care ; Postoperative Complications/etiology ; Postoperative Complications/pathology ; Postoperative Complications/prevention & control ; Preoperative Care ; Prognosis ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2019-04-23
Publishing country	Denmark
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.13557
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Zs.A 2204: Show issues

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Article ; Online: Breast cancer and exposure to tobacco smoke during potential windows of susceptibility.

White, Alexandra J / D'Aloisio, Aimee A / Nichols, Hazel B / DeRoo, Lisa A / Sandler, Dale P

Cancer causes & control : CCC

2017 Volume 28, Issue 7, Page(s) 667–675

Abstract: Purpose: An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco ... ...

Abstract	Purpose: An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life. Methods: Sister study participants (n = 50,884) aged 35-74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they were breast cancer-free but had a sister with breast cancer. Participants completed questionnaires on smoking and environmental tobacco smoke (ETS) exposure. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for breast cancer risk. Results: During follow-up (mean = 6.4 years), 1,843 invasive breast cancers were diagnosed. Neither active smoking nor adult ETS was associated with breast cancer risk. However, never smoking women exposed to ETS throughout their childhood had a 17% higher risk of breast cancer (95% CI 1.00-1.36) relative to those with no exposure. In utero ETS exposure was also associated with breast cancer (HR = 1.16, 95% CI 1.01-1.32) and the HR was most elevated for women born in earlier birth cohorts (<1940, HR = 1.44, 95% CI 1.02-2.02; 1940-1949, HR = 1.28, 95% CI 1.01-1.62). Conclusion: In utero ETS and ETS exposure during childhood and adolescence were associated with increased risk of breast cancer and associations varied by birth cohort.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alcohol Drinking/epidemiology ; Breast Neoplasms/epidemiology ; Child ; Disease Susceptibility ; Female ; Humans ; Middle Aged ; Pregnancy ; Prenatal Exposure Delayed Effects ; Proportional Hazards Models ; Prospective Studies ; Puerto Rico ; Risk ; Smoking/epidemiology ; Surveys and Questionnaires ; Tobacco Smoke Pollution/adverse effects ; United States
Chemical Substances	Tobacco Smoke Pollution
Language	English
Publishing date	2017-05-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-017-0903-1
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Zs.A 3375: Show issues

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Article ; Online: Expression of extracellular matrix components is disrupted in the immature and adult estrogen receptor β-null mouse ovary.

Zalewski, Alexandra / Cecchini, Erin L / Deroo, Bonnie J

PloS one

2012 Volume 7, Issue 1, Page(s) e29937

Abstract: ... regulates granulosa cell gene expression ovary prior to puberty, and b) that ERβ regulates expression of ECM ...

Abstract	Within the ovary, Estrogen Receptor β (ERβ) is localized to the granulosa cells of growing follicles. 17β-estradiol (E2) acting via ERβ augments the actions of follicle stimulating hormone in granulosa cells, leading to granulosa cell differentiation and formation of a preovulatory follicle. Adult ERβ-null females are subfertile and possess ovaries with reduced numbers of growing follicles and corpora lutea. Because the majority of E2 production by granulosa cells occurs once puberty is reached, a role for ERβ in the ovary prior to puberty has not been well examined. We now provide evidence that lack of ERβ disrupts gene expression as early as post-natal day (PND) 13, and in particular, we identify a number of genes of the extracellular matrix (ECM) that are significantly higher in ERβ-null follicles than in wildtype (WT) follicles. Considerable changes occur to the ECM occur during normal folliculogenesis to allow for the dramatic growth, cellular differentiation, and reorganization of the follicle from the primary to preovulatory stage. Using quantitative PCR and immunofluorescence, we now show that several ECM genes are aberrantly overexpressed in ERβ-null follicles. We find that Collagen11a1, a protein highly expressed in cartilage, is significantly higher in ERβ-null follicles than WT follicles as early as PND 13, and this heightened expression continues through PND 23-29 into adulthood. Similarly, Nidogen 2, a highly conserved basement membrane glycoprotein, is elevated in ERβ-null follicles at PND 13 into adulthood, and is elevated specifically in the ERβ-null focimatrix, a basal lamina-like matrix located between granulosa cells. Focimatrix laminin and Collagen IV expression were also higher in ERβ-null ovaries than in WT ovaries at various ages. Our findings suggest two novel observations: a) that ERβ regulates granulosa cell gene expression ovary prior to puberty, and b) that ERβ regulates expression of ECM components in the mouse ovary.
MeSH term(s)	Aging/genetics ; Aging/metabolism ; Animals ; Estrogen Receptor beta/deficiency ; Estrogen Receptor beta/metabolism ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Female ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Ovary/metabolism ; Ovary/pathology ; Protein Transport
Chemical Substances	Estrogen Receptor beta ; Extracellular Matrix Proteins
Language	English
Publishing date	2012-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0029937
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Article: Chromatin modulation of glucocorticoid and progesterone receptor activity.

Archer, T K / Deroo, B J / Fryer, C J

Trends in endocrinology and metabolism: TEM

2008 Volume 8, Issue 10, Page(s) 384–390

Abstract: Steroid hormone receptors are ligand-activated transcription factors that enhance or repress gene expression. They act by binding to target sites within the promoters of genes assembled as chromatin. Chromatin structure is modified in response to steroid ...

Abstract	Steroid hormone receptors are ligand-activated transcription factors that enhance or repress gene expression. They act by binding to target sites within the promoters of genes assembled as chromatin. Chromatin structure is modified in response to steroid hormones and represents a critical step in steroid receptor signaling. Recent experiments demonstrate that the progesterone and glucocorticoid receptors are differentially influenced by this arrangement of DNA and histones. One of the most important developments in the steroid hormone receptor field has been the identification of coactivators and cointegrators, some of which are histone acetyltransferases. These proteins appear to play an important role in mediating ligand activation of transcription, although their exact role on chromatin templates is undefined.
Language	English
Publishing date	2008-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/s1043-2760(97)00159-8
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Zs.A 2999: Show issues

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Article: Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin.

Deroo, B J / Archer, T K

Molecular biology of the cell

2001 Volume 12, Issue 11, Page(s) 3365–3374

Abstract: ... structure of the glucocorticoid-responsive I kappa B alpha gene promoter, the inhibitor of the ubiquitous ... transcription factor, nuclear factor kappa B (NF kappa B). Glucocorticoids inhibit NF kappa B activity in some tissues ... by elevating the levels of I kappa B alpha. We found that glucocorticoids activated the I kappa B alpha ...

Abstract	The glucocorticoid receptor (GR) is a ligand-activated transcription factor that induces expression of many genes. The GR has been useful for understanding how chromatin structure regulates steroid-induced transcription in model systems. However, the effect of glucocorticoids on chromatin structure has been examined on few endogenous mammalian promoters. We investigated the effect of glucocorticoids on the in vivo chromatin structure of the glucocorticoid-responsive I kappa B alpha gene promoter, the inhibitor of the ubiquitous transcription factor, nuclear factor kappa B (NF kappa B). Glucocorticoids inhibit NF kappa B activity in some tissues by elevating the levels of I kappa B alpha. We found that glucocorticoids activated the I kappa B alpha promoter in human T47D/A1-2 cells containing the GR. We then investigated the chromatin structure of the I kappa B alpha promoter in the absence and presence of glucocorticoids with the use of micrococcal nuclease, restriction enzyme, and deoxyribonuclease (DNaseI) analyses. In untreated cells, the promoter assembles into regularly positioned nucleosomes, and glucocorticoid treatment did not alter nucleosomal position. Restriction enzyme accessiblity studies indicated that the I kappa B alpha promoter is assembled as phased nucleosomes that adopt an "open" chromatin architecture in the absence of hormone. However, glucocorticoids may be required for transcription factor binding, because DNaseI footprinting studies suggested that regulatory factors bind to the promoter upon glucocorticoid treatment.
MeSH term(s)	Chromatin ; DNA Footprinting ; DNA-Binding Proteins/genetics ; Deoxyribonuclease I ; Glucocorticoids/metabolism ; Glucocorticoids/pharmacology ; Humans ; I-kappa B Proteins ; NF-KappaB Inhibitor alpha ; NF-kappa B/antagonists & inhibitors ; Nucleosomes ; Promoter Regions, Genetic ; Receptors, Glucocorticoid/metabolism ; Transcriptional Activation ; Tumor Cells, Cultured
Chemical Substances	Chromatin ; DNA-Binding Proteins ; Glucocorticoids ; I-kappa B Proteins ; NF-kappa B ; NFKBIA protein, human ; Nucleosomes ; Receptors, Glucocorticoid ; NF-KappaB Inhibitor alpha (139874-52-5) ; Deoxyribonuclease I (EC 3.1.21.1)
Language	English
Publishing date	2001-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
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Zs.A 2853: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Glucocorticoid receptor-mediated chromatin remodeling in vivo.

Deroo, B J / Archer, T K

Oncogene

2001 Volume 20, Issue 24, Page(s) 3039–3046

Abstract: The compaction of DNA into chromatin provides an additional level of gene regulation in eukaryotes that may not be available to prokaryotes. When packaged as chromatin, most promoters are transcriptionally repressed, and transcription factors have ... ...

Abstract	The compaction of DNA into chromatin provides an additional level of gene regulation in eukaryotes that may not be available to prokaryotes. When packaged as chromatin, most promoters are transcriptionally repressed, and transcription factors have reduced access to their binding sites. The glucocorticoid receptor (GR) is a ligand-activated transcription factor that regulates the activity of genes involved in many physiological processes. To regulate eukaryotic genes, the GR binds to target sites within promoter regions of genes assembled as chromatin. This interaction alters the nucleosomal architecture to allow binding of other transcription factors, and formation of the preinitiation complex. The mouse mammary tumor virus (MMTV) promoter has been used extensively as a model to explore the processes by which the GR remodels chromatin and activates transcription. Significant progress has been made in our understanding of the mechanisms used by the GR to modify chromatin structure, and the limits placed on the GR by post-translational modifications of histones. We will describe recent developments in the processes used by the GR to activate transcription in vivo via chromatin remodeling complexes, histone H1 phosphorylation, and recruitment of diverse coactivators.
MeSH term(s)	Animals ; Chromatin/genetics ; Chromatin/metabolism ; Gene Expression Regulation ; Histones/metabolism ; Humans ; Mammary Tumor Virus, Mouse/genetics ; Mice ; Models, Biological ; Phosphorylation ; Promoter Regions, Genetic/genetics ; Receptors, Glucocorticoid/physiology
Chemical Substances	Chromatin ; Histones ; Receptors, Glucocorticoid
Language	English
Publishing date	2001-05-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/sj.onc.1204328
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Article ; Online: Gérer des inondations par des ouvrages dispersés sur le bassin versant

C. POULARD / P. ROYET / E. LEBLOIS / J.B. FAURE / P. BREIL / S. PROUST / L. DEROO

Sciences, Eaux & Territoires, Iss

principes et méthodes de diagnostic d'efficacité probabiliste

2017 Volume 23

Abstract: Pour dimensionner ou diagnostiquer le fonctionnement d'un ensemble d'ouvrages de prévention des inondations, qu'ils soient petits ou grands, il faut étudier leur fonctionnement à l'échelle du bassin versant, et donc définir des scénarios d'apport (en ... ...

Abstract	Pour dimensionner ou diagnostiquer le fonctionnement d'un ensemble d'ouvrages de prévention des inondations, qu'ils soient petits ou grands, il faut étudier leur fonctionnement à l'échelle du bassin versant, et donc définir des scénarios d'apport (en pluie, en débit) à cette échelle. L'approche qui consiste à définir indépendamment pour chaque tronçon du réseau hydrographique étudié des crues de projet « monofréquences », représentative chacune d'une crue de période de retour donnée, est prise en défaut dès lors qu'on introduit des ouvrages. En effet, il est difficile de répercuter l'effet d'un ouvrage sur les quantiles de débit des tronçons aval. Or, ces cartographies probabilistes sont nécessaires pour calculer des dommages probabilisés, puis les dommages moyens annualisés (DMA). Il faut aussi les estimer en présence d'ouvrages projetés pour évaluer les DMA dit résiduels. La différence entre les DMA de référence et résiduels représente la réduction du risque, à verser dans une analyse coût-bénéfice pour évaluer le projet. Nous allons décrire des méthodes pour obtenir ces cartes probabilistes en présence d'ouvrage(s), et présenterons des développements en cours. Evidemment, la réduction des dommages n'est qu'un indicateur parmi d'autres : protection des personnes, impacts sur la géomorphologie et les écosystèmes. La définition de stratégies intégrées, multi-objectifs et donc multicritères, pose donc de nouveaux challenges que nous ne pourrons qu'évoquer.
Keywords	inondation ; ouvrage de protection ; modèle probabiliste ; analyse coût-bénéfice ; prévention des risques ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350
Language	French
Publishing date	2017-05-01T00:00:00Z
Publisher	Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAE)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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