Article: Effect of acupuncture on arthritic pathological injury in rats with type Ⅱ collagen-induced rheumatoid arthritis.
Zhen ci yan jiu = Acupuncture research
2023 Volume 48, Issue 11, Page(s) 1103–1110
Abstract: Objectives: To observe the effect of acupuncture stimulation of "Yanglingquan"(GB34), "Zusanli"(ST36) and "Xuanzhong" (GB39) on arthritis index (AI), joint synovial membrane pathology, serum-related immunoinflammatory factors, and expressions of tumor ... ...
| Title translation | 针刺改善Ⅱ型胶原蛋白诱导性关节炎大鼠炎性反应的机制研究. |
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| Abstract | Objectives: To observe the effect of acupuncture stimulation of "Yanglingquan"(GB34), "Zusanli"(ST36) and "Xuanzhong" (GB39) on arthritis index (AI), joint synovial membrane pathology, serum-related immunoinflammatory factors, and expressions of tumor suppressor gene mt-p53, nuclear factor kappa B (NF-κB) and peroxisome proliferator activated receptor gamma (PPARγ) in knee joint synovial tissue of rats with type Ⅱ collagen-induced arthritis (CIA), so as to explore its possible mechanisms underlying improvement of rheumatoid arthritis (RA). Methods: Male SD rats were used in the present study. The CIA model was established by subcutaneous injection of collagen emulsion (200 μL/rat) in the tail root region on the first day and repeat (100 μL/rat) once on the 9 Results: Compared with the normal control group, the AI scores at different time-points after modeling, contents of serum TNF-α, IL-6 and IL-17, expression levels of mt-p53, NF-κB p65, PPARγ proteins and mRNAs were significantly increased in the model group ( Conclusions: Acupuncture stimulation can improve the degree of joint inflammation and swelling in CIA rats, which may be related to its effects in inhibiting the overexpression of immunoinflammatory factors in serum and regulating expression of mt-p53, NF-κB p65, PPARγ mRNAs and proteins in the synovial tissue. |
| MeSH term(s) | Rats ; Male ; Animals ; NF-kappa B/metabolism ; Collagen Type II/genetics ; Collagen Type II/metabolism ; Interleukin-17/genetics ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Tumor Suppressor Protein p53/adverse effects ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/therapy ; Arthritis, Rheumatoid/chemically induced ; Acupuncture Therapy ; Arthritis, Experimental/genetics ; Arthritis, Experimental/therapy ; RNA, Messenger |
| Chemical Substances | NF-kappa B ; Collagen Type II ; Interleukin-17 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; PPAR gamma ; Tumor Suppressor Protein p53 ; RNA, Messenger |
| Language | Chinese |
| Publishing date | 2023-11-19 |
| Publishing country | China |
| Document type | Journal Article |
| ZDB-ID | 1283179-7 |
| ISSN | 1000-0607 |
| ISSN | 1000-0607 |
| DOI | 10.13702/j.1000-0607.20221180 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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