LIVIVO - Search results -

Search results

Result 1 - 10 of total 94

Search options

Article ; Online: Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens' Infectivity?

Hardy, Eugenio / Sarker, Hassan / Fernandez-Patron, Carlos

2023 Volume 12, Issue 13

Abstract: We advance the notion that much like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria, and other microorganisms) may also acquire a biomolecular corona upon entering the ...

Abstract	We advance the notion that much like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria, and other microorganisms) may also acquire a biomolecular corona upon entering the blood circulation of an organism. We view this biomolecular corona as a component of a much broader non-cellular blood interactome that can be highly specific to the organism, akin to components of the innate immune response to an invading pathogen. We review published supporting data and generalize these notions from artificial nanoparticles to viruses and bacteria. Characterization of the non-cellular blood interactome of an organism may help explain apparent differences in the susceptibility to pathogens among individuals. The non-cellular blood interactome is a candidate therapeutic target to treat infectious and non-infectious conditions.
MeSH term(s)	Humans ; Immunity, Innate ; Nanoparticles ; Viruses
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12131699
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity?

Eugenio Hardy / Hassan Sarker / Carlos Fernandez-Patron

Cells, Vol 12, Iss 1699, p

2023 Volume 1699

Abstract	We advance the notion that much like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria, and other microorganisms) may also acquire a biomolecular corona upon entering the blood circulation of an organism. We view this biomolecular corona as a component of a much broader non-cellular blood interactome that can be highly specific to the organism, akin to components of the innate immune response to an invading pathogen. We review published supporting data and generalize these notions from artificial nanoparticles to viruses and bacteria. Characterization of the non-cellular blood interactome of an organism may help explain apparent differences in the susceptibility to pathogens among individuals. The non-cellular blood interactome is a candidate therapeutic target to treat infectious and non-infectious conditions.
Keywords	nanoparticles ; virus ; bacteria ; protein corona ; glucocorticoid ; innate immunity ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Potential of dissimilarity measure-based computation of protein thermal stability data for determining protein interactions.

Teitz, Joshua / Sander, Joerg / Sarker, Hassan / Fernandez-Patron, Carlos

Briefings in bioinformatics

2023 Volume 24, Issue 3

Abstract: Determining the interacting proteins in multiprotein complexes can be technically challenging. An emerging biochemical approach to this end is based on the 'thermal proximity co-aggregation' (TPCA) phenomenon. Accordingly, when two or more proteins ... ...

Abstract	Determining the interacting proteins in multiprotein complexes can be technically challenging. An emerging biochemical approach to this end is based on the 'thermal proximity co-aggregation' (TPCA) phenomenon. Accordingly, when two or more proteins interact to form a complex, they tend to co-aggregate when subjected to heat-induced denaturation and thus exhibit similar melting curves. Here, we explore the potential of leveraging TPCA for determining protein interactions. We demonstrate that dissimilarity measure-based information retrieval applied to melting curves tends to rank a protein-of-interest's interactors higher than its non-interactors, as shown in the context of pull-down assay results. Consequently, such rankings can reduce the number of confirmatory biochemical experiments needed to find bona fide protein-protein interactions. In general, rankings based on dissimilarity measures generated through metric learning further reduce the required number of experiments compared to those based on standard dissimilarity measures such as Euclidean distance. When a protein mixture's melting curves are obtained in two conditions, we propose a scoring function that uses melting curve data to inform how likely a protein pair is to interact in one condition but not another. We show that ranking protein pairs by their scores is an effective approach for determining condition-specific protein-protein interactions. By contrast, clustering melting curve data generally does not inform about the interacting proteins in multiprotein complexes. In conclusion, we report improved methods for dissimilarity measure-based computation of melting curves data that can greatly enhance the determination of interacting proteins in multiprotein complexes.
MeSH term(s)	Proteins ; Multiprotein Complexes
Chemical Substances	Proteins ; Multiprotein Complexes
Language	English
Publishing date	2023-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbad143
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6262: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prevalence and identification of caprine pasteurellosis in pneumonic goats in Bangladesh.

Rahman, Md Habibur / Akther, Sonia / Alam, Md Shahin / Hassan, Md Zakir / Sarker, Md Samun / Ali, Md Zulfekar / Giasuddin, Md / Ahmed, Sadek

Journal of advanced veterinary and animal research

2023 Volume 10, Issue 3, Page(s) 538–544

Abstract: Objective: This research aimed to assess the prevalence of caprine pasteurellosis, isolate and identify pasteurellosis (: Materials and methods: One hundred and five samples (94 nasal swabs and 11 lung tissues) from goats suspected of having ... ...

Abstract	Objective: This research aimed to assess the prevalence of caprine pasteurellosis, isolate and identify pasteurellosis ( Materials and methods: One hundred and five samples (94 nasal swabs and 11 lung tissues) from goats suspected of having pneumonia were taken and transferred aseptically to the laboratory. Following the processing of the collected samples, Results: From the 105 clinically suspicious samples, 51 (48.57%) were identified to be Conclusion: The present study revealed that
Language	English
Publishing date	2023-09-30
Publishing country	Bangladesh
Document type	Journal Article ; Review
ZDB-ID	2766493-4
ISSN	2311-7710 ; 2311-7710
ISSN (online)	2311-7710
ISSN	2311-7710
DOI	10.5455/javar.2023.j707
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts.

Rahman, Tanjilur / Das, Ayan / Abir, Mehedy Hasan / Nafiz, Iqbal Hossain / Mahmud, Aar Rafi / Sarker, Md Rifat / Emran, Talha Bin / Hassan, Mohammad Mahmudul

Cytokine

2023 Volume 169, Page(s) 156268

Abstract: Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for ... ...

Abstract	Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for the regulation of immune responses. Cytokine studies have resulted in the establishment of newer therapies which are being utilized for the treatment of several malignant diseases. The advancement of these therapies has occurred from two distinct strategies. The first strategy involves administrating the recombinant and purified cytokines, and the second strategy involves administrating the therapeutics which inhibits harmful effects of endogenous and overexpressed cytokines. Colony stimulating factors and interferons are two exemplary therapeutics of cytokines. An important effect of cytokine receptor antagonist is that they can serve as anti-inflammatory agents by altering the treatments of inflammation disorder, therefore inhibiting the effects of tumour necrosis factor. In this article, we have highlighted the research behind the establishment of cytokines as therapeutics and vaccine adjuvants, their role of immunotolerance, and their limitations.
MeSH term(s)	Cytokines/metabolism ; Adjuvants, Vaccine ; Interferons/physiology ; Immunologic Factors ; Interleukins/physiology ; Immunotherapy
Chemical Substances	Cytokines ; Adjuvants, Vaccine ; Interferons (9008-11-1) ; Immunologic Factors ; Interleukins
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2023.156268
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2840: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Digitalized to reach and track: a retrospective comparison between traditional and conditional estimate of vaccination coverage and dropout rates using e-Tracker data below one-year children in Bangladesh during-COVID and pre-COVID period.

Saha, Avijit / Sarker, Malabika / Hossen, Md Tanvir / Hassan, Zahid / Adhikari, Jucy Merina / Latif, Mahbub A H M

The Lancet regional health. Southeast Asia

2023 Volume 16, Page(s) 100252

Abstract: Background: With an impressive track record in expanding childhood immunization and an inclination to adopt digitalization in healthcare service delivery, Expanded Program on Immunization (EPI) Bangladesh piloted the e-Tracker intervention in ... ...

Abstract	Background: With an impressive track record in expanding childhood immunization and an inclination to adopt digitalization in healthcare service delivery, Expanded Program on Immunization (EPI) Bangladesh piloted the e-Tracker intervention in Moulvibazar district and Dhaka South City Corporation (Zone-5) from 2019 till the end of 2021. Methods: We retrieved and analyzed the digitalized e-Tracker data of 114,194 infants born between January 1, 2019 and December 31, 2020, with help from Health Management Information System (HMIS) and UNICEF Bangladesh. Childhood vaccination coverage and dropout rates were determined using a 'Traditional approach' traditionally used by WHO and a 'Conditional technique' with a modified denominator. Using a multiple logistic regression model, we examined the effects of COVID-19, birth-cohorts, mother education, and location on vaccination rates (coverages & dropouts) to aid with informed decision-making by the policymakers. Findings: The conditional estimation method yielded a lower full vaccination coverage during pre-COVID period than the national and global reported coverage derived using the 'traditional method' (73.4% vs. 89.0% & 81.0%). As expected, while the coverage has decreased, the dropout rate increased "during-COVID" compared to the "pre-COVID" period. However, dropouts were estimated lower in the 'conditional method.' The average age (in months) for getting BCG was higher in Moulvibazar (∼2.5 months) than that in Dhaka (∼1.4 months). All birth-cohorts from 'the during-COVID period had about 30% lower odds of getting fully vaccinated than those from the 'pre-COVID' period. Interpretations: Age-cohort-specific analysis showed a decline in coverage rates before and during COVID, but e-Tracker didn't have enough data to draw additional conclusions. The server only stored the child's gender, the caregiver's monthly salary, and the mother's education. It didn't track any other factors related to dropout rates. The e-Tracker is an excellent tool for measuring real coverage and should be scaled nationwide. Funding: UNICEF, Bangladesh.
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ISSN	2772-3682
ISSN (online)	2772-3682
DOI	10.1016/j.lansea.2023.100252
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Audio / Video ; Online: Cactus is catching up in India

Hassan, S. / Louhaichi, Mounir / Sarker, A.

2020

Keywords	animal feeding ; scrub ; livestock
Language	English
Publishing date	2020-08-06T10:22:00Z
Publisher	International Center for Agricultural Research in the Dry Areas
Publishing country	fr
Document type	Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Response of cactus pear (Opuntia ficus-indica Mill.) to boron and farmyard manure application under arid soils conditions in Kutch, Gujarat

Naorem, Anandkumar / Patel, Sachin / Hassan, Sawsan / Louhaichi, Mounir / Sarker, Ashutosh

Acta Horticulturae

2022

Abstract: As livestock is an important component of livelihoods in the arid regions of Kutch in Gujarat, India, smallholder farmers have difficulties in cultivating fodder crops during the driest seasons of the year. Water scarcity in arid regions can negatively ... ...

Abstract	As livestock is an important component of livelihoods in the arid regions of Kutch in Gujarat, India, smallholder farmers have difficulties in cultivating fodder crops during the driest seasons of the year. Water scarcity in arid regions can negatively affect feed intake, digestion and body weight of animals. The cactus pear [Opuntia ficus-indica (L.) Mill.] has gained attention in Kutch because it serves as a good green fodder. To understand the plant growth response of Opuntia-ficus indica Mill. to inorganic fertilizers and organic manures, a field experiment was conducted with 12 treatment combinations, three levels of farmyard manure and four levels of boron and compared in a randomized complete block design with three replications over two years. The results showed substantial increases in cactus pear growth after applying farmyard manure during the first year and second year of planting. Boron contributed to significant changes in cactus pear growth only during the second year of planting. The integrated application of both farmyard manure and boron can enhance cactus pear growth during the second year of planting
Keywords	nutrition ; fodder ; cladodes ; goal 13 climate action ; borax ; climate adaptation and mitigation ; circumference
Language	English
Publishing date	2022-12-06T21:56:36Z
Publisher	International Society for Horticultural Science
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs.

Sarker, Hassan / Haimour, Ayman / Toor, Ravneet / Fernandez-Patron, Carlos

Biomolecules

2021 Volume 11, Issue 4

Abstract: Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs. ... ...

Abstract	Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs. Conversely, many diseases (such as atherosclerosis, arthritis, bacterial infections (tuberculosis), viral infections (COVID-19), and cancer), cholesterol-lowering drugs (such as statins), and tetracycline-class antibiotics (such as doxycycline) alter MMP activity through transcriptional, translational, and post-translational mechanisms. In this review, we summarize evidence that the aforementioned diseases and drugs exert significant epigenetic pressure on genes encoding MMPs, tissue inhibitors of MMPs, and factors that transcriptionally regulate the expression of MMPs. Our understanding of human pathologies associated with alterations in the proteolytic activity of MMPs must consider that these pathologies and their medicinal treatments may impose epigenetic pressure on the expression of MMP genes. Whether the epigenetic mechanisms affecting the activity of MMPs can be therapeutically targeted warrants further research.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/genetics ; Bone Diseases/drug therapy ; Bone Diseases/genetics ; COVID-19/drug therapy ; COVID-19/genetics ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/genetics ; Drug Discovery ; Epigenesis, Genetic/drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Matrix Metalloproteinases/genetics ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Tetracyclines/pharmacology ; Tetracyclines/therapeutic use ; Virus Diseases/drug therapy ; Virus Diseases/genetics
Chemical Substances	Anti-Bacterial Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Tetracyclines ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2021-04-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11040578
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2.

Sarker, Hassan / Panigrahi, Rashmi / Hardy, Eugenio / Glover, J N Mark / Elahi, Shokrollah / Fernandez-Patron, Carlos

Frontiers in immunology

2022 Volume 13, Page(s) 906687

Abstract: Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocorticoids, such as cortisol, biochemically interact with SARS-CoV-2 spike 1 protein (S1), or its cellular receptor ACE2, is unknown. Using molecular ... ...

Abstract	Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocorticoids, such as cortisol, biochemically interact with SARS-CoV-2 spike 1 protein (S1), or its cellular receptor ACE2, is unknown. Using molecular dynamics (MD) simulations and binding energy calculations, we identified 162 druggable pockets in various conformational states of S1 and all possible binding pockets for cortisol and dexamethasone. Through biochemical binding studies, we confirmed that cortisol and dexamethasone bind to S1. Limited proteolysis and mass spectrometry analyses validated several MD identified binding pockets for cortisol and dexamethasone on S1. Interaction assays indicated that cortisol and dexamethasone separately and cooperatively disrupt S1 interaction with ACE2, through direct binding to S1, without affecting ACE2 catalytic activity. Cortisol disrupted the binding of the mutant S1 Beta variant (E484K, K417N, N501Y) to ACE2. Delta and Omicron variants are mutated in or near identified cortisol-binding pockets in S1, which may affect cortisol binding to them. In the presence of cortisol, we find increased inhibition of S1 binding to ACE2 by an anti-SARS-CoV-2 S1 human chimeric monoclonal antibody against the receptor binding domain. Whether glucocorticoid/S1 direct interaction is an innate defence mechanism that may have contributed to mild or asymptomatic SARS-CoV-2 infection deserves further investigation.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Antibodies, Viral ; COVID-19/drug therapy ; Dexamethasone/pharmacology ; Glucocorticoids/pharmacology ; Humans ; Hydrocortisone ; Peptidyl-Dipeptidase A/metabolism ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; Glucocorticoids ; Dexamethasone (7S5I7G3JQL) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.906687
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito