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  1. Article ; Online: Revealing the secret behind Epstein-Barr virus-specific tumor immune contexture.

    Deng, Chu-Xia

    Cancer communications (London, England)

    2024  Volume 44, Issue 4, Page(s) 491–494

    MeSH term(s) Humans ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/pathology ; Neoplasms
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The global battle against SARS-CoV-2 and COVID-19 at the third year.

    Deng, Chu-Xia

    International journal of biological sciences

    2022  Volume 18, Issue 12, Page(s) 4792–4794

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-07-13
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.76035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The continued global battle against SARS-CoV-2 and COVID-19.

    Deng, Chu-Xia

    International journal of biological sciences

    2021  Volume 17, Issue 6, Page(s) 1440–1442

    MeSH term(s) COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/prevention & control ; Disease Outbreaks ; Humans ; Pandemics ; SARS-CoV-2/isolation & purification
    Language English
    Publishing date 2021-04-10
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.60639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Glucocorticoids save lives in COVID-19 patients.

    Deng, Chu-Xia

    International journal of biological sciences

    2020  Volume 16, Issue 13, Page(s) 2477–2478

    Abstract: Recent studies showed that glucocorticoid drugs, which are easily available as pills on pharmacy shelves worldwide, could save lives of COVID-19 patients. With the swiftly increasing infections of the SARS-CoV-2 pandemic at a lethality rate of about 4.7% ...

    Abstract Recent studies showed that glucocorticoid drugs, which are easily available as pills on pharmacy shelves worldwide, could save lives of COVID-19 patients. With the swiftly increasing infections of the SARS-CoV-2 pandemic at a lethality rate of about 4.7% countless lives may be saved globally.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Glucocorticoids ; Humans ; Interleukin-6 ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Glucocorticoids ; Interleukin-6 ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.49125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The global battle against SARS-CoV-2 and COVID-19.

    Deng, Chu-Xia

    International journal of biological sciences

    2020  Volume 16, Issue 10, Page(s) 1676–1677

    MeSH term(s) Animals ; Antibodies, Neutralizing/therapeutic use ; Autophagy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Endocytosis ; Health Knowledge, Attitudes, Practice ; Health Personnel ; Humans ; Medicine, Chinese Traditional ; Mental Health ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Public Health ; SARS-CoV-2 ; Virus Shedding ; Zoonoses/virology
    Chemical Substances Antibodies, Neutralizing
    Keywords covid19
    Language English
    Publishing date 2020-03-15
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.45587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Glucocorticoids save lives in COVID-19 patients

    Deng, Chu-Xia

    Int J Biol Sci

    Abstract: Recent studies showed that glucocorticoid drugs, which are easily available as pills on pharmacy shelves worldwide, could save lives of COVID-19 patients. With the swiftly increasing infections of the SARS-CoV-2 pandemic at a lethality rate of about 4.7% ...

    Abstract Recent studies showed that glucocorticoid drugs, which are easily available as pills on pharmacy shelves worldwide, could save lives of COVID-19 patients. With the swiftly increasing infections of the SARS-CoV-2 pandemic at a lethality rate of about 4.7% countless lives may be saved globally.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #695546
    Database COVID19

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    Inter-library loan at ZB MED

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  8. Article ; Online: SRC-3, a Steroid Receptor Coactivator

    Licen Li / Chu-Xia Deng / Qiang Chen

    International Journal of Molecular Sciences, Vol 22, Iss 4760, p

    Implication in Cancer

    2021  Volume 4760

    Abstract: Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the ... ...

    Abstract Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.
    Keywords SRC-3 ; AIB1 ; coactivator ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: Sirt6 ablation in the liver causes fatty liver that increases cancer risky by upregulating Serpina12.

    Li, Licen / Zeng, Jianming / Zhang, Xin / Feng, Yangyang / Lei, Josh Haipeng / Xu, Xiaoling / Chen, Qiang / Deng, Chu-Xia

    EMBO reports

    2024  Volume 25, Issue 3, Page(s) 1361–1386

    Abstract: Non-alcoholic fatty liver disease is a chronic liver abnormality that exhibits high variability and can lead to liver cancer in advanced stages. Hepatic ablation of SIRT6 results in fatty liver disease, yet the potential mechanism of SIRT6 deficiency, ... ...

    Abstract Non-alcoholic fatty liver disease is a chronic liver abnormality that exhibits high variability and can lead to liver cancer in advanced stages. Hepatic ablation of SIRT6 results in fatty liver disease, yet the potential mechanism of SIRT6 deficiency, particularly in relation to downstream mediators for NAFLD, remains elusive. Here we identify Serpina12 as a key gene regulated by Sirt6 that plays a crucial function in energy homeostasis. Specifically, Sirt6 suppresses Serpina12 expression through histone deacetylation at its promoter region, after which the transcription factor, Cebpα, binds to and regulates its expression. Sirt6 deficiency results in an increased expression of Serpina12 in hepatocytes, which enhances insulin signaling and promotes lipid accumulation. Importantly, CRISPR-Cas9 mediated Serpina12 knockout in the liver ameliorated fatty liver disease caused by Sirt6 ablation. Finally, we demonstrate that Sirt6 functions as a tumor suppressor in the liver, and consequently, deletion of Sirt6 in the liver leads to not only the spontaneous development of tumors but also enhanced tumorigenesis in response to DEN treatment or under conditions of obesity.
    MeSH term(s) Humans ; Sirtuins/metabolism ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/genetics ; Hepatocytes/metabolism ; Liver Neoplasms/metabolism
    Chemical Substances Sirtuins (EC 3.5.1.-) ; SIRT6 protein, human (EC 3.5.1.-)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-024-00071-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance.

    Zhang, Aiping / Miao, Kai / Sun, Heng / Deng, Chu-Xia

    International journal of biological sciences

    2022  Volume 18, Issue 7, Page(s) 3019–3033

    Abstract: Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure. Mechanically, tumor heterogeneity either directly affects ... ...

    Abstract Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure. Mechanically, tumor heterogeneity either directly affects therapeutic targets or shapes the tumor microenvironment (TME) by defining transcriptomic and phenotypic profiles to influence drug resistance. Tumor heterogeneity evolves spatially and temporally during tumor development, leading to the constant reprogramming of the TME. Advances in molecular profiling technologies and precision oncology platforms have allowed us to uncover the impact of tumor heterogeneity on drug resistance in the context of the TME. In this review, we focus on the processes during which genomic mutations drive tumor heterogeneity and the mechanisms through which tumor heterogeneity reprograms the TME to affect drug resistance and patient prognosis.
    MeSH term(s) Drug Resistance ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Precision Medicine ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2022-04-24
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.72534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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