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Article ; Online: Relationship between Biodistribution and Tracer Kinetics of 11 C-Erlotinib, 18 F-Afatinib and 11 C-Osimertinib and Image Quality Evaluation Using Pharmacokinetic/Pharmacodynamic Analysis in Advanced Stage Non-Small Cell Lung Cancer Patients

Eveline Annette van de Stadt / Maqsood Yaqub / Robert C. Schuit / Imke H. Bartelink / Anke F. Leeuwerik / Lothar A. Schwarte / Adrianus J. de Langen / Harry Hendrikse / Idris Bahce

Diagnostics, Vol 12, Iss 883, p

2022 Volume 883

Abstract: ... F-afatinib and 11 C-osimertinib. Methods: Data of three prospective studies and 1 ongoing study were ... for 18 F-afatinib (EGFRm and EGFR wild type) and four patients for 11 C-osimertinib (EGFRm). From dynamic ... for 11 C-osimertinib and to a lesser extent for 18 F-afatinib. For EGFRm, 11 C-erlotinib and 18 F ...

Abstract	Background: Patients with non-small cell lung cancer (NSCLC) driven by activating epidermal growth factor receptor (EGFR) mutations are best treated with therapies targeting EGFR, i.e., tyrosine kinase inhibitors (TKI). Radiolabeled EGFR-TKI and PET have been investigated to study EGFR-TKI kinetics and its potential role as biomarker of response in NSCLC patients with EGFR mutations (EGFRm). In this study we aimed to compare the biodistribution and kinetics of three different EGFR-TKI, i.e., 11 C-erlotinib, 18 F-afatinib and 11 C-osimertinib. Methods: Data of three prospective studies and 1 ongoing study were re-analysed; data from thirteen patients (EGFRm) were included for 11 C-erlotinib, seven patients for 18 F-afatinib (EGFRm and EGFR wild type) and four patients for 11 C-osimertinib (EGFRm). From dynamic and static scans, SUV and tumor-to-blood (TBR) values were derived for tumor, lung, spleen, liver, vertebra and, if possible, brain tissue. AUC values were calculated using dynamic time-activity-curves. Parent fraction, plasma-to-blood ratio and SUV values were derived from arterial blood data. Tumor-to-lung contrast was calculated, as well as (background) noise to assess image quality. Results: 11 C-osimertinib showed the highest SUV and TBR (AUC) values in nearly all tissues. Spleen uptake was notably high for 11 C-osimertinib and to a lesser extent for 18 F-afatinib. For EGFRm, 11 C-erlotinib and 18 F-afatinib demonstrated the highest tumor-to-lung contrast, compared to an inverse contrast observed for 11 C-osimertinib. Tumor-to-lung contrast and spleen uptake of the three TKI ranked accordingly to the expected lysosomal sequestration. Conclusion: Comparison of biodistribution and tracer kinetics showed that 11 C-erlotinib and 18 F-afatinib demonstrated the highest tumor-to-background contrast in EGFRm positive tumors. Image quality, based on contrast and noise analysis, was superior for 11 C-erlotinib and 18 F-afatinib (EGFRm) scans compared to 11 C-osimertinib and 18 F-afatinib (EGFR wild type) scans.
Keywords	non-small cell lung cancer ; EGFR TKI PET/CT ; biodistribution ; 11 C-erlotinib ; 18 F-afatinib ; 11 C-osimertinib ; Medicine (General) ; R5-920
Subject code	333
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response to 'What is the cause of increased mortality in normothermic patients with suspected infection?' by Schinkel et al.

Schuttevaer, Romy / Brink, Anniek / Alsma, Jelmer / de Steenwinkel, Jurriaan E M / Verbon, Annelies / Schuit, Stephanie C E / Lingsma, Hester F

European journal of emergency medicine : official journal of the European Society for Emergency Medicine

2022 Volume 29, Issue 4, Page(s) 317–318

Language	English
Publishing date	2022-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1233544-7
ISSN	1473-5695 ; 0969-9546
ISSN (online)	1473-5695
ISSN	0969-9546
DOI	10.1097/MEJ.0000000000000948
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Article ; Online: Prediction of fetal and neonatal outcomes after preterm manifestations of placental insufficiency: systematic review of prediction models.

Kleuskens, D G / Van Veen, C M C / Groenendaal, F / Ganzevoort, W / Gordijn, S J / Van Rijn, B B / Lely, A T / Schuit, E / Kooiman, J

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2023 Volume 62, Issue 5, Page(s) 644–652

Abstract: ... morbidity. Discriminative properties were reported for 27/41 models (c-statistic between 0.6 and 0.9). Only ...

Abstract	Objectives: To identify all prediction models for fetal and neonatal outcomes in pregnancies with preterm manifestations of placental insufficiency (gestational hypertension, pre-eclampsia, HELLP syndrome or fetal growth restriction with its onset before 37 weeks' gestation) and to assess the quality of the models and their performance on external validation. Methods: A systematic literature search was performed in PubMed, Web of Science and EMBASE. Studies describing prediction models for fetal/neonatal mortality or significant neonatal morbidity in patients with preterm placental insufficiency disorders were included. Data extraction was performed using the CHARMS checklist. Risk of bias was assessed using PROBAST. Literature selection and data extraction were performed by two researchers independently. Results: Our literature search yielded 22 491 unique publications. Fourteen were included after full-text screening of 218 articles that remained after initial exclusions. The studies derived a total of 41 prediction models, including four models in the setting of pre-eclampsia or HELLP, two models in the setting of fetal growth restriction and/or pre-eclampsia and 35 models in the setting of fetal growth restriction. None of the models was validated externally, and internal validation was performed in only two studies. The final models contained mainly ultrasound (Doppler) markers as predictors of fetal/neonatal mortality and neonatal morbidity. Discriminative properties were reported for 27/41 models (c-statistic between 0.6 and 0.9). Only two studies presented a calibration plot. The risk of bias was assessed as unclear in one model and high for all other models, mainly owing to the use of inappropriate statistical methods. Conclusions: We identified 41 prediction models for fetal and neonatal outcomes in pregnancies with preterm manifestations of placental insufficiency. All models were considered to be of low methodological quality, apart from one that had unclear methodological quality. Higher-quality models and external validation studies are needed to inform clinical decision-making based on prediction models. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; Fetal Growth Retardation/diagnostic imaging ; Pre-Eclampsia/prevention & control ; Placental Insufficiency/diagnostic imaging ; Placenta ; Prenatal Care
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.26245
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Article ; Online: Crossover shortage in potato is caused by StMSH4 mutant alleles and leads to either highly uniform unreduced pollen or sterility.

Clot, Corentin R / Klein, Dennis / Koopman, Joey / Schuit, Cees / Engelen, Christel J M / Hutten, Ronald C B / Brouwer, Matthijs / Visser, Richard G F / Jurani, Martina / van Eck, Herman J

Genetics

2023 Volume 226, Issue 1

Abstract: The balanced segregation of homologous chromosomes during meiosis is essential for fertility and is mediated by crossovers (COs). A strong reduction of CO number leads to the unpairing of homologous chromosomes after the withdrawal of the synaptonemal ... ...

Abstract	The balanced segregation of homologous chromosomes during meiosis is essential for fertility and is mediated by crossovers (COs). A strong reduction of CO number leads to the unpairing of homologous chromosomes after the withdrawal of the synaptonemal complex. This results in the random segregation of univalents during meiosis I and ultimately to the production of unbalanced and sterile gametes. However, if CO shortage is combined with another meiotic alteration that restitutes the first meiotic division, then uniform and balanced unreduced male gametes, essentially composed of nonrecombinant homologs, are produced. This mitosis-like division is of interest to breeders because it transmits most of the parental heterozygosity to the gametes. In potato, CO shortage, a recessive trait previously referred to as desynapsis, was tentatively mapped to chromosome 8. In this article, we have fine-mapped the position of the CO shortage locus and identified StMSH4, an essential component of the class I CO pathway, as the most likely candidate gene. A 7 base-pair insertion in the second exon of StMSH4 was found to be associated with CO shortage in our mapping population. We also identified a second allele with a 3,820 base-pair insertion and confirmed that both alleles cannot complement each other. Such nonfunctional alleles appear to be common in potato cultivars. More than half of the varieties we tested are carriers of mutational load at the StMSH4 locus. With this new information, breeders can choose to remove alleles associated with CO shortage from their germplasm to improve fertility or to use them to produce highly uniform unreduced male gametes in alternative breeding schemes.
MeSH term(s)	Alleles ; Solanum tuberosum/genetics ; Plant Breeding ; Meiosis/genetics ; Pollen/genetics ; Infertility/genetics
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyad194
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Article ; Online: The association of body temperature with antibiotic therapy and mortality in patients attending the emergency department with suspected infection.

Schuttevaer, Romy / Brink, Anniek / Alsma, Jelmer / de Steenwinkel, Jurriaan E M / Verbon, Annelies / Schuit, Stephanie C E / Lingsma, Hester F

European journal of emergency medicine : official journal of the European Society for Emergency Medicine

2021 Volume 28, Issue 6, Page(s) 440–447

Abstract: Background and importance: Previous studies found that septic patients with normothermia have higher mortality than patients with fever. We hypothesize that antibiotic therapy is less frequently initiated if infectious patients present with normothermia ...

Abstract	Background and importance: Previous studies found that septic patients with normothermia have higher mortality than patients with fever. We hypothesize that antibiotic therapy is less frequently initiated if infectious patients present with normothermia to the emergency department (ED). Objectives: To examine the association of body temperature with the initiation of antibiotic therapy in patients attending the ED with suspected and proven infection. Additionally, the association of temperature with 30-day mortality was assessed. Design, settings and participants: We conducted a retrospective cohort study between 2012 and 2016 at a tertiary university hospital. Adult patients attending the ED with a blood culture taken (i.e. suspected infection) and a positive blood culture (i.e. proven bacteremia) were included. Exposure: Tympanic temperature at arrival was categorized as hypothermia (<36.1°C), normothermia (36.1-38.0°C) or hyperthermia (>38.0°C). Outcome measures and analysis: Primary outcome was the initiation of antibiotic therapy. A secondary outcome was 30-day mortality. Multivariable logistic regression was used to control for covariates. Main results: Of 5997 patients with a suspected infection, 45.8% had normothermia, 44.6% hyperthermia and 5.6% hypothermia. Patients with hyperthermia received more often antibiotic therapy (53.5%) compared to normothermic patients (27.6%, adjusted odds ratio [95% confidence interval], 2.59 [2.27-2.95]). Patients with hyperthermia had lower mortality (4.7%) than those with normothermia (7.4%, adjusted odds ratio [95% confidence interval], 0.50 [0.39-0.64]). Sensitivity analyses in patients with proven bacteremia (n = 934) showed similar results. Conclusion: Normothermia in patients presenting with infection was associated with receiving less antibiotic therapy in the ED compared to presentations with hyperthermia. Moreover, normothermia was associated with a higher mortality risk than hyperthermia.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Body Temperature ; Emergency Service, Hospital ; Humans ; Retrospective Studies ; Temperature
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1233544-7
ISSN	1473-5695 ; 0969-9546
ISSN (online)	1473-5695
ISSN	0969-9546
DOI	10.1097/MEJ.0000000000000817
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Article ; Online: Androgen Deprivation therapy for Oligo-recurrent Prostate cancer in addition to radioTherapy (ADOPT): study protocol for a randomised phase III trial.

Janssen, J / Staal, F H E / Brouwer, C L / Langendijk, J A / de Jong, I J / van Moorselaar, R J A / Schuit, E / Verzijlbergen, J F / Smeenk, R J / Aluwini, S

BMC cancer

2022 Volume 22, Issue 1, Page(s) 482

Abstract: Background: More than 60% of oligo-recurrent prostate cancer (PCa) patients treated with metastasis-directed radiotherapy (MDRT) develop biochemical recurrence within 2 years. This recurrence rate emphasises the need for improved treatment and patient ... ...

Abstract	Background: More than 60% of oligo-recurrent prostate cancer (PCa) patients treated with metastasis-directed radiotherapy (MDRT) develop biochemical recurrence within 2 years. This recurrence rate emphasises the need for improved treatment and patient selection. In line with the treatment of primary PCa, the efficacy of MDRT may be enhanced when combined with androgen-deprivation therapy (ADT). Furthermore, the availability of PSMA PET/CT offers an excellent tool for optimal patient selection for MDRT. This phase III randomised controlled trial will investigate the role of the addition of ADT to MDRT in oligo-recurrent PCa patients selected with PSMA PET/CT to enhance oncological outcome. Methods: Two hundred and eighty patients will be randomised in a 1:1 ratio to the standard treatment arm (MDRT alone) or the experimental arm (MDRT + 6 months ADT). Patients with biochemical recurrence after primary treatment of PCa presenting with ≤ 4 metastases will be included. The primary endpoint is the 2.5-year metastases progression-free survival (MPFS). Secondary endpoints are acute and late toxicity, quality of life, biochemical progression-free survival, overall survival, and the sensitivity of the PSMA PET/CT for detecting oligometastases at low PSA-levels. So far, between March 2020 and December 2021, one hundred patients have been included. Discussion: This phase III randomised controlled trial will assess the possible benefit of the addition of 6 months ADT to MDRT on metastases progression-free survival, toxicity, QoL and survival in PCa patients with 1-4 recurrent oligometastatic lesions. Trial registration: ClinicalTrials.gov, NCT04302454 . Registered 10 March 2020.
MeSH term(s)	Androgen Antagonists/therapeutic use ; Androgens ; Chronic Disease ; Clinical Trials, Phase III as Topic ; Humans ; Male ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/radiotherapy ; Quality of Life ; Randomized Controlled Trials as Topic
Chemical Substances	Androgen Antagonists ; Androgens
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-09523-2
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Article ; Online: Phase III randomised controlled trial on PSMA PET/CT guided hypofractionated salvage prostate bed radiotherapy of biochemical failure after radical prostatectomy for prostate cancer (PERYTON-trial): study protocol.

Staal, F H E / Janssen, J / Brouwer, C L / Langendijk, J A / Ng Wei Siang, K / Schuit, E / de Jong, I J / Verzijlbergen, J F / Smeenk, R J / Aluwini, S

BMC cancer

2022 Volume 22, Issue 1, Page(s) 416

Abstract: Background: Salvage external beam radiotherapy (sEBRT) for patients with a biochemical recurrence (BCR) after radical prostatectomy provides a 5-year biochemical progression-free survival up to 60%. Multiple studies have shown that dose escalation to ... ...

Abstract	Background: Salvage external beam radiotherapy (sEBRT) for patients with a biochemical recurrence (BCR) after radical prostatectomy provides a 5-year biochemical progression-free survival up to 60%. Multiple studies have shown that dose escalation to the primary prostate tumour improves treatment outcome. However, data is lacking on the role of dose escalation in the recurrent salvage setting. The main objective of the PERYTON-trial is to investigate whether treatment outcome of sEBRT for patients with a BCR after prostatectomy can be improved by increasing the biological effective radiation dose using hypofractionation. Moreover, patients will be staged using the PSMA PET/CT scan, which is superior to conventional imaging modalities in detecting oligometastases. Methods: The PERYTON-study is a prospective multicentre open phase III randomised controlled trial. We aim to include 538 participants (269 participants per treatment arm) with a BCR after prostatectomy, a PSA-value of < 1.0 ng/mL and a recent negative PSMA PET/CT scan. Participants will be randomised in a 1:1 ratio between the conventional fractionated treatment arm (35 × 2 Gy) and the experimental hypofractionated treatment arm (20 × 3 Gy). The primary endpoint is the 5-year progression-free survival after treatment. The secondary endpoints include toxicity, quality of life and disease specific survival. Discussion: Firstly, the high rate of BCR after sEBRT may be due to the presence of oligometastases, for which local sEBRT is inappropriate. With the use of the PSMA PET/CT before sEBRT, patients with oligometastases will be excluded from intensive local treatment to avoid unnecessary toxicity. Secondly, the currently applied radiation dose for sEBRT may be too low to achieve adequate local control, which may offer opportunity to enhance treatment outcome of sEBRT by increasing the biologically effective radiotherapy dose to the prostate bed. Trial registration: This study is registered at ClinicalTrials.gov (Identifier: NCT04642027 ). Registered on 24 November 2020 - Retrospectively registered. The study protocol was approved by the accredited Medical Ethical Committee (METc) of all participating hospitals (date METc review: 23-06-2020, METc registration number: 202000239). Written informed consent will be obtained from all participants.
MeSH term(s)	Clinical Trials, Phase III as Topic ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Male ; Multicenter Studies as Topic ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/surgery ; Positron Emission Tomography Computed Tomography/methods ; Prospective Studies ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatectomy/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Quality of Life ; Radiation Dose Hypofractionation ; Randomized Controlled Trials as Topic ; Salvage Therapy/methods
Chemical Substances	Gallium Isotopes ; Gallium Radioisotopes ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-09493-5
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Article ; Online: Waterpipe smoking: not as innocent as it may seem.

Verweij, B G F / Rood, P P M / Schuit, S C E / Bouwhuis, M G

The Netherlands journal of medicine

2019 Volume 77, Issue 4, Page(s) 156–159

Abstract: Introduction: Waterpipe (hookah) smoking is popular; in Dutch surveys, 26% of the respondents have smoked a waterpipe at least once. However, waterpipe smoking is not without risk. We present a series of carbon monoxide (CO) poisonings after waterpipe ... ...

Abstract	Introduction: Waterpipe (hookah) smoking is popular; in Dutch surveys, 26% of the respondents have smoked a waterpipe at least once. However, waterpipe smoking is not without risk. We present a series of carbon monoxide (CO) poisonings after waterpipe smoking and discuss the etiology and treatment of CO intoxication after waterpipe smoking. Case descriptions: We present three patients who presented with syncopial episodes and a variety of other neurological and circulatory symptoms after smoking a waterpipe. All patients had significantly elevated carboxyhaemoglobin levels (26%, 19% and 26%). Patients were treated with oxygen, following Dutch guidelines; one patient was admitted for eight hours of oxygen therapy. The other two patients were observed shortly, diverging from the guidelines because symptoms passed and the carboxyhaemoglobin normalised. Discussion: Reviewing combustion chemistry, the formation of CO is a logical consequence of using burning coals as a heat source. This is due to CO2 reduction with carbon. This chemical process has not previously been related to waterpipe smoking. Dutch guidelines advise eight hours of oxygen therapy. The research this guideline is based on, justifies therapy directed at symptom relief and carboxyhaemoglobin normalisation. This strategy may prevent unnecessary hospital admissions and exposure to high-dose oxygen. Conclusion: We described three cases of CO intoxication after waterpipe smoking and argue why this may not be an incidental finding. Greater awareness of this risk is urgently needed. We conclude that the literature does not firmly support a fixed treatment duration.
MeSH term(s)	Adolescent ; Carbon Monoxide Poisoning/blood ; Carbon Monoxide Poisoning/etiology ; Carbon Monoxide Poisoning/therapy ; Carboxyhemoglobin/analysis ; Female ; Humans ; Male ; Oxygen Inhalation Therapy ; Water Pipe Smoking/adverse effects ; Young Adult
Chemical Substances	Carboxyhemoglobin (9061-29-4)
Language	English
Publishing date	2019-09-09
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	193149-0
ISSN	1872-9061 ; 0300-2977
ISSN (online)	1872-9061
ISSN	0300-2977
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Article ; Online: The effect of emergency department pharmacists on drug overuse and drug underuse in patients with an ADE-related hospitalisation: a controlled intervention study.

Rahman, R N / Nikolik, B / de Ridder, M A J / Hoek, A E / Janssen, M J A / Schuit, S C E / Karapinar-Çarkit, F / van den Bemt, P M L A

BMC health services research

2022 Volume 22, Issue 1, Page(s) 1363

Abstract: Background: Drug overuse or drug underuse are the most common causes of adverse drug events and can lead to hospital admissions. Using clinical pharmacists in the emergency department may improve patient safety as they are specialised in recognising of ... ...

Abstract	Background: Drug overuse or drug underuse are the most common causes of adverse drug events and can lead to hospital admissions. Using clinical pharmacists in the emergency department may improve patient safety as they are specialised in recognising of adverse drug events and tackling drug overuse and drug underuse. This study tested the effect of an emergency department pharmacist on the number of medication changes for drug overuse and drug underuse taking place in patients with an adverse drug event-related hospitalisation following an emergency department visit. Methods: A multicenter prospective non-randomized controlled intervention study was conducted in a university hospital and a general teaching hospital. Trained emergency department pharmacists included patients in the intervention group with a hospital admission related to an adverse drug event. The interdisciplinary intervention consisted of a pharmacist-led medication review, patient counselling regarding medication, and information transmission to general practitioners and community pharmacies after discharge. The control patients were also admitted after an emergency department visit and received the usual care. The primary outcome was the number of medication changes for drug overuse and drug underuse that took place during hospital admission and persisted 6 months thereafter. Poisson regression analysis was used to estimate the difference in these medication changes between the intervention group and the control group. Results: A total of 216 patients were included (intervention group 104, control group 112). In the intervention group, 156 medication changes for drug overuse and drug underuse persisted 6 months after admission compared to 59 in the control group (adjusted rate ratio 1.22 [95%CI 1.01-1.49] p = 0.039). Conclusion: Emergency department pharmacists do contribute to reduction of drug overuse and drug underuse of medication in patients with a hospitalisation related to adverse drug events after an emergency department visit.
MeSH term(s)	Humans ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Emergency Service, Hospital ; Hospitalization ; Hospitals, University ; Medication Errors/prevention & control ; Pharmacists ; Prospective Studies ; Prescription Drug Overuse
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Clinical Trial ; Controlled Clinical Trial ; Multicenter Study ; Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-08696-7
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Article: Relationship between Biodistribution and Tracer Kinetics of

van de Stadt, Eveline Annette / Yaqub, Maqsood / Schuit, Robert C / Bartelink, Imke H / Leeuwerik, Anke F / Schwarte, Lothar A / de Langen, Adrianus J / Hendrikse, Harry / Bahce, Idris

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: Background: Patients with non-small cell lung cancer (NSCLC) driven by activating epidermal growth factor receptor (EGFR) mutations are best treated with therapies targeting EGFR, i.e., tyrosine kinase inhibitors (TKI). Radiolabeled EGFR-TKI and PET ... ...

Abstract	Background: Patients with non-small cell lung cancer (NSCLC) driven by activating epidermal growth factor receptor (EGFR) mutations are best treated with therapies targeting EGFR, i.e., tyrosine kinase inhibitors (TKI). Radiolabeled EGFR-TKI and PET have been investigated to study EGFR-TKI kinetics and its potential role as biomarker of response in NSCLC patients with EGFR mutations (EGFRm). In this study we aimed to compare the biodistribution and kinetics of three different EGFR-TKI, i.e., Methods: Data of three prospective studies and 1 ongoing study were re-analysed; data from thirteen patients (EGFRm) were included for Results: 11 Conclusion: Comparison of biodistribution and tracer kinetics showed that
Language	English
Publishing date	2022-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12040883
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