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  1. Book: Functional reconstructive nasal surgery

    Huizing, Egbert H. / Groot, John A. M. de

    2015  

    Author's details Egbert H. Huizing ; John A. M. de Groot
    Keywords Rhinoplasty / methods ; Reconstructive Surgical Procedures ; Nose / surgery ; Recovery of Function ; Nasenchirurgie ; Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren ; Nase
    Language English
    Size XII, 413 S. : zahlr. Ill., graph. Darst.
    Edition 2. ed.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018614479
    ISBN 978-3-13-129412-8 ; 3-13-129412-4 ; 9783131641229 ; 3131641223
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 1434 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma.

    Mandel, Jacob J / de Groot, John F

    JAMA oncology

    2023  Volume 9, Issue 7, Page(s) 1006

    MeSH term(s) Humans ; Glioblastoma/drug therapy ; Brain Neoplasms/therapy ; Research Design ; Data Analysis
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Clinical Trial ; Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.1066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 'Case of the Month' from The University of Texas MD Anderson Cancer Center, Houston, Texas, USA: ependymoma of the urinary bladder.

    Myers, Amanda A / Tan, Wei Shen / de Groot, John / Westney, Ouida Lenaine / Kamat, Ashish M

    BJU international

    2024  

    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 13: Show issues

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  4. Article: Preclinical Models of Low-Grade Gliomas.

    Dasgupta, Pushan / Balasubramanyian, Veerakumar / de Groot, John F / Majd, Nazanin K

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Diffuse infiltrating low-grade glioma (LGG) is classified as WHO grade 2 astrocytoma with isocitrate dehydrogenase (IDH) mutation and oligodendroglioma with IDH1 mutation and 1p/19q codeletion. Despite their better prognosis compared with glioblastoma, ... ...

    Abstract Diffuse infiltrating low-grade glioma (LGG) is classified as WHO grade 2 astrocytoma with isocitrate dehydrogenase (IDH) mutation and oligodendroglioma with IDH1 mutation and 1p/19q codeletion. Despite their better prognosis compared with glioblastoma, LGGs invariably recur, leading to disability and premature death. There is an unmet need to discover new therapeutics for LGG, which necessitates preclinical models that closely resemble the human disease. Basic scientific efforts in the field of neuro-oncology are mostly focused on high-grade glioma, due to the ease of maintaining rapidly growing cell cultures and highly reproducible murine tumors. Development of preclinical models of LGG, on the other hand, has been difficult due to the slow-growing nature of these tumors as well as challenges involved in recapitulating the widespread genomic and epigenomic effects of IDH mutation. The most recent WHO classification of CNS tumors emphasizes the importance of the role of IDH mutation in the classification of gliomas, yet there are relatively few IDH-mutant preclinical models available. Here, we review the in vitro and in vivo preclinical models of LGG and discuss the mechanistic challenges involved in generating such models and potential strategies to overcome these hurdles.
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Challenges and strategies for successful clinical development of immune checkpoint inhibitors in glioblastoma.

    Majd, Nazanin / de Groot, John

    Expert opinion on pharmacotherapy

    2019  Volume 20, Issue 13, Page(s) 1609–1624

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antineoplastic Agents, Immunological/administration & dosage ; Brain Neoplasms/therapy ; Glioblastoma/therapy ; Humans ; Immunotherapy/methods ; T-Lymphocytes/immunology
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2019-07-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2019.1621840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Strategies to Improve Drug Delivery Across the Blood-Brain Barrier for Glioblastoma.

    Narsinh, Kazim H / Perez, Edgar / Haddad, Alexander F / Young, Jacob S / Savastano, Luis / Villanueva-Meyer, Javier E / Winkler, Ethan / de Groot, John

    Current neurology and neuroscience reports

    2024  Volume 24, Issue 5, Page(s) 123–139

    Abstract: Purpose of review: Glioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has been a dearth of effective new treatments. New approaches to drug delivery and clinical trial design are ... ...

    Abstract Purpose of review: Glioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has been a dearth of effective new treatments. New approaches to drug delivery and clinical trial design are needed.
    Recent findings: We discuss how the blood-brain barrier and tumor microenvironment pose challenges for development of effective therapies for glioblastoma. Next, we discuss treatments in development that aim to overcome these barriers, including novel drug designs such as nanoparticles and antibody-drug conjugates, novel methods of drug delivery, including convection-enhanced and intra-arterial delivery, and novel methods to enhance drug penetration, such as blood-brain barrier disruption by focused ultrasound and laser interstitial thermal therapy. Lastly, we address future opportunities, positing combination therapy as the best strategy for effective treatment, neoadjuvant and window-of-opportunity approaches to simultaneously enhance therapeutic effectiveness with interrogation of on-treatment biologic endpoints, and adaptive platform and basket trials as imperative for future trial design. New approaches to GBM treatment should account for the blood-brain barrier and immunosuppression by improving drug delivery, combining treatments, and integrating novel clinical trial designs.
    MeSH term(s) Humans ; Blood-Brain Barrier/pathology ; Glioblastoma/drug therapy ; Antineoplastic Agents/therapeutic use ; Brain Neoplasms/drug therapy ; Drug Delivery Systems ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-024-01338-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Relationships between cardiovascular disease risk, neuropathic pain, mental health, and autonomic function in chronic spinal cord injury.

    Dorton, Matthew C / Kramer, John K / de Groot, Sonja / Post, Marcel W M / Claydon, Victoria E

    Spinal cord

    2023  Volume 61, Issue 10, Page(s) 548–555

    Abstract: Study design: Multicentre, cross-sectional study.: Objectives: To determine if clinical measures of poor mental health (MH-) and neuropathic pain (NP) are related to increased CVD risk in individuals with chronic spinal cord injury (SCI), and further ...

    Abstract Study design: Multicentre, cross-sectional study.
    Objectives: To determine if clinical measures of poor mental health (MH-) and neuropathic pain (NP) are related to increased CVD risk in individuals with chronic spinal cord injury (SCI), and further elucidate the relationships between CVD risk, autonomic function, NP, and MH-.
    Setting: Eight SCI rehabilitation centres in the Netherlands.
    Methods: Individuals (n = 257) with a traumatic, chronic (≥10 yrs) SCI, with age at injury between 18-35 years, completed a self-report questionnaire and a one-day visit to a rehabilitation centre for testing. CVD risk was calculated using Framingham risk score. NP was inferred using The Douleur Neuropathique 4 clinical examination, and MH- was assessed using the five-item Mental Health Inventory questionnaire. Cardiovascular autonomic function was determined from peak heart rate during maximal exercise (HR
    Results: There was a high prevalence of both NP (39%) and MH- (45%) following SCI. MH- was significantly correlated with an adverse CVD risk profile (r = 0.174; p = 0.01), increased the odds of adverse 30-year CVD risk by 2.2 (CI 0.92-2.81, p = 0.02), and is an important variable in determining CVD risk (importance=0.74, p = 0.05). Females (p = 0.05) and those with a higher HR
    Conclusions: Clinical measures of MH-, but not NP, are important factors for increased CVD risk following SCI. NP tended to be more prevalent in those with more preserved cardiovascular autonomic function. The interrelationships between secondary consequences of SCI are complex and need further exploration.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/epidemiology ; Mental Health ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/complications ; Cross-Sectional Studies ; Neuralgia/complications
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1316161-1
    ISSN 1476-5624 ; 1362-4393
    ISSN (online) 1476-5624
    ISSN 1362-4393
    DOI 10.1038/s41393-023-00933-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma.

    Sooreshjani, Moloud / Tripathi, Shashwat / Dussold, Corey / Najem, Hinda / de Groot, John / Lukas, Rimas V / Heimberger, Amy B

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Cytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of ... ...

    Abstract Cytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of cancer cell-intrinsic and extrinsic characteristics pose a barrier to effective treatments including cytokines. Recent studies using gene and cell therapy offer new opportunities for targeting cytokines or their receptors, demonstrating that they are actionable targets. Current efforts such as virotherapy, systemic cytokine therapy, and cellular and gene therapy have provided novel strategies that incorporate cytokines as potential therapeutic strategies for glioblastoma. Ongoing research on characterizing the tumor microenvironment will be informative for prioritization and combinatorial strategies of cytokines for future clinical trials. Unique therapeutic opportunities exist at the convergence of cytokines that play a dual role in tumorigenesis and immune modulation. Here, we discuss the underlying strategies in pre- and clinical trials aiming to enhance treatment outcomes in glioblastoma patients.
    Language English
    Publishing date 2023-07-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Functional reconstructive nasal surgery

    Huizing, Egbert H. / Groot, John A. M. de

    23 tables

    2003  

    Author's details Egbert H. Huizing ; John A. M. de Groot
    Keywords Nasenchirurgie ; Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren ; Nase
    Language English
    Size XIV, 386 S. : Ill., graph. Darst.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013553338
    ISBN 3-13-129411-6 ; 1-58890-081-9 ; 978-3-13-129411-1 ; 978-1-58890-081-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 315 order for loan Magazin

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  10. Article ; Online: Isocitrate Dehydrogenase Wild-type Glial Tumors, Including Glioblastoma.

    Galanis, Evanthia / Wen, Patrick Y / de Groot, John F / Weller, Michael

    Hematology/oncology clinics of North America

    2021  Volume 36, Issue 1, Page(s) 113–132

    Abstract: Isocitrate dehydrogenase (IDH) 1 and 2 mutations represent essential components for the diagnosis of diffuse astrocytic tumors and oligodendroglioma. IDH wild-type glial tumors include a wide spectrum of tumors with differences in prognosis and ... ...

    Abstract Isocitrate dehydrogenase (IDH) 1 and 2 mutations represent essential components for the diagnosis of diffuse astrocytic tumors and oligodendroglioma. IDH wild-type glial tumors include a wide spectrum of tumors with differences in prognosis and recommended therapeutic approaches. Tumors characterized as molecular glioblastoma in the World Health Organization 2021 classification should be treated according to the glioblastoma therapeutic principles and included in glioblastoma trials. Improving on existing treatments options including targeted and immunotherapy approaches is imperative for most patients with IDH wild-type glial tumors, and enrollment in clinical trials is encouraged.
    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Glioblastoma/genetics ; Glioblastoma/therapy ; Glioma ; Humans ; Isocitrate Dehydrogenase/genetics ; Oligodendroglioma
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2021-10-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2021.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1077: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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