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Article ; Online: Effect of Single-Crystal TiO

Chen, Xiangtian / Pasanen, Hannu P / Khan, Ramsha / Tkachenko, Nikolai V / Janáky, Csaba / Samu, Gergely Ferenc

The journal of physical chemistry letters

2024 Volume 15, Issue 7, Page(s) 2057–2065

Abstract: The kinetics of electron extraction at the electron transfer layer/perovskite interface strongly affects the efficiency of a perovskite solar cell. By combining transient absorption and time-resolved photoluminescence spectroscopy, the electron ... ...

Abstract	The kinetics of electron extraction at the electron transfer layer/perovskite interface strongly affects the efficiency of a perovskite solar cell. By combining transient absorption and time-resolved photoluminescence spectroscopy, the electron extraction process between FA
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03536
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Article ; Online: Impact of Reaction Parameters and Water Matrices on the Removal of Organic Pollutants by TiO 2 /LED and ZnO/LED Heterogeneous Photocatalysis Using 365 and 398 nm Radiation

Máté Náfrádi / Tünde Alapi / Gábor Bencsik / Csaba Janáky

Nanomaterials, Vol 12, Iss 5, p

2022 Volume 5

Abstract: ... The transformation of COU was slower for LED 398nm than for LED 365nm , but r 0 7-HC /r 0 COU ratio was significantly ... almost doubled the r 0 7-HC and contributes to the conversion of neonicotinoids by altering the product ...

Abstract	In this work, the application of high-power LED 365nm and commercial, low-price LED 398nm for heterogeneous photocatalysis with TiO 2 and ZnO photocatalysts are studied and compared, focusing on the effect of light intensity, photon energy, quantum yield, electrical energy consumption, and effect of matrices and inorganic components on radical formation. Coumarin (COU) and its hydroxylated product (7-HC) were used to investigate operating parameters on the • OH formation rate. In addition to COU, two neonicotinoids, imidacloprid and thiacloprid, were also used to study the effect of various LEDs, matrices, and inorganic ions. The transformation of COU was slower for LED 398nm than for LED 365nm , but r 0 7-HC /r 0 COU ratio was significantly higher for LED 398nm . The COU mineralization rate was the same for both photocatalysts using LED 365nm , but a significant difference was observed using LED 398nm . The impact of matrices and their main inorganic components Cl − and HCO 3 − were significantly different for ZnO and TiO 2 . The negative effect of HCO 3 − was evident, however, in the case of high-power LED 365nm and TiO 2 , and the formation of CO 3 •− almost doubled the r 0 7-HC and contributes to the conversion of neonicotinoids by altering the product distribution and mineralization rate.
Keywords	hydroxyl radical ; carbonate radical ; matrix effect ; coumarin ; neonicotinoid ; Chemistry ; QD1-999
Subject code	333 ; 290
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Cluster headache and kynurenines.

Tuka, Bernadett / Körtési, Tamás / Nánási, Nikolett / Tömösi, Ferenc / Janáky, Tamás / Veréb, Dániel / Szok, Délia / Tajti, János / Vécsei, László

The journal of headache and pain

2023 Volume 24, Issue 1, Page(s) 35

Abstract: ... a moderate, negative correlation between disease duration and interbout QUINA levels (p < 0.048, R = - 0.459 ... the interbout KYN concentrations (p < 0.024, R = - 0.516). Linear regression models revealed negative ...

Abstract	Background: The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but also in the neuroinflammation, the oxidative stress and the mitochondrial dysfunctions. Previously we identified a depressed peripheral Trp metabolism in interictal period of episodic migraineurs, which prompted us to examine this pathway in patients with episodic cluster headache (CH) as well. Our aims were to compare the concentrations of compounds both in headache-free and attack periods, and to find correlations between Trp metabolism and the clinical features of CH. Levels of 11 molecules were determined in peripheral blood plasma of healthy controls (n = 22) and interbout/ictal periods of CH patients (n = 24) by neurochemical measurements. Findings: Significantly decreased L-kynurenine (KYN, p < 0.01), while increased quinolinic acid (QUINA, p < 0.005) plasma concentrations were detected in the interbout period of CH patients compared to healthy subjects. The levels of KYN are further reduced during the ictal period compared to the controls (p < 0.006). There was a moderate, negative correlation between disease duration and interbout QUINA levels (p < 0.048, R = - 0.459); and between the total number of CH attacks experienced during the lifetime of patients and the interbout KYN concentrations (p < 0.024, R = - 0.516). Linear regression models revealed negative associations between age and levels of Trp, kynurenic acid, 3-hdyroxyanthranilic acid and QUINA in healthy control subjects, as well as between age and ictal level of anthranilic acid. Conclusions: Our results refer to a specifically altered Trp metabolism in CH patients. The onset of metabolic imbalance can be attributed to the interbout period, where the decreased KYN level is unable to perform its protective functions, while the concentration of QUINA, as a toxic compound, increases. These processes can trigger CH attacks, which may be associated with glutamate excess induced neurotoxicity, neuroinflammation and oxidative stress. Further studies are needed to elucidate the exact functions of these molecular alterations that can contribute to identify new, potential biomarkers in the therapy of CH.
MeSH term(s)	Humans ; Kynurenine/metabolism ; Cluster Headache ; Neuroinflammatory Diseases ; Tryptophan/metabolism ; Kynurenic Acid
Chemical Substances	Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Kynurenic Acid (H030S2S85J)
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2036768-5
ISSN	1129-2377 ; 1129-2369
ISSN (online)	1129-2377
ISSN	1129-2369
DOI	10.1186/s10194-023-01570-9
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Article ; Online: Heart-cutting two-dimensional liquid chromatography coupled to quadrupole-orbitrap high resolution mass spectrometry for determination of N,N-dimethyltryptamine in rat plasma and brain; Method development and application.

Körmöczi, Tímea / Szabó, Írisz / Farkas, Eszter / Penke, Botond / Janáky, Tamás / Ilisz, István / Berkecz, Róbert

Journal of pharmaceutical and biomedical analysis

2020 Volume 191, Page(s) 113615

Abstract: The orthogonal heart-cutting liquid chromatography (LC) modes coupled to high-resolution tandem mass spectrometry (HRMS/MS) provide a number of possibilities to enhance selectivity and sensitivity for the determination of targeted compounds in complex ... ...

Abstract	The orthogonal heart-cutting liquid chromatography (LC) modes coupled to high-resolution tandem mass spectrometry (HRMS/MS) provide a number of possibilities to enhance selectivity and sensitivity for the determination of targeted compounds in complex biological matricies. Here we report the development of a new fast 2D-LC-(HRMS/MS) method and its successful application for quantitative determination of the level of plasma and brain N,N-dimethyltriptamine (DMT) using α-methyltryptamine (AMT) as internal standard in an experimental model of cerebral ischemia/reperfusion using DMT administration. The 2D-LC separation was carried out by a combination of hydrophilic interaction liquid chromatography (HILIC) in the first dimension followed by second-dimensional reversed-phase (RP) chromatography within a total run time of 10 min. The enrichment of HILIC effluent of interest containing DMT was performed using a C18 trapping column. During method development several parameters of sample preparation procedures, chromatographic separation and mass spectrometric detection were optimised to achieve high DMT recovery (plasma: 90 %, brain: 88 %) and sensitivity (plasma: 0.108 ng/mL of LOD, brain: 0.212 ng/g of LOD) applying targeted analytical method with strict LC and HRMSMS confirmatory criteria. Concerning rat plasma sample, the concentration of DMT before hypoxia (49.3-114.3 ng/mL plasma) was generally higher than that after hypoxia (10.6-96.1 ng/mL plasma). After treatment, the concentration of DMT in brain was elevated up to the range of 2-6.1 ng/g. Overall, our analytical approach is suitable to detect and confirm the presence of DMT administered to experimental animals with therapeutic purpose in a reliable manner.
MeSH term(s)	Animals ; Brain ; Chromatography, Liquid ; Chromatography, Reverse-Phase ; N,N-Dimethyltryptamine ; Rats ; Tandem Mass Spectrometry
Chemical Substances	N,N-Dimethyltryptamine (WUB601BHAA)
Language	English
Publishing date	2020-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113615
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Article ; Online: Cluster headache and kynurenines

Bernadett Tuka / Tamás Körtési / Nikolett Nánási / Ferenc Tömösi / Tamás Janáky / Dániel Veréb / Délia Szok / János Tajti / László Vécsei

The Journal of Headache and Pain, Vol 24, Iss 1, Pp 1-

2023 Volume 11

Abstract: ... correlation between disease duration and interbout QUINA levels (p < 0.048, R = − 0.459); and between ... concentrations (p < 0.024, R = − 0.516). Linear regression models revealed negative associations between age and ...

Abstract	Abstract Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but also in the neuroinflammation, the oxidative stress and the mitochondrial dysfunctions. Previously we identified a depressed peripheral Trp metabolism in interictal period of episodic migraineurs, which prompted us to examine this pathway in patients with episodic cluster headache (CH) as well. Our aims were to compare the concentrations of compounds both in headache-free and attack periods, and to find correlations between Trp metabolism and the clinical features of CH. Levels of 11 molecules were determined in peripheral blood plasma of healthy controls (n = 22) and interbout/ictal periods of CH patients (n = 24) by neurochemical measurements. Findings Significantly decreased L-kynurenine (KYN, p < 0.01), while increased quinolinic acid (QUINA, p < 0.005) plasma concentrations were detected in the interbout period of CH patients compared to healthy subjects. The levels of KYN are further reduced during the ictal period compared to the controls (p < 0.006). There was a moderate, negative correlation between disease duration and interbout QUINA levels (p < 0.048, R = − 0.459); and between the total number of CH attacks experienced during the lifetime of patients and the interbout KYN concentrations (p < 0.024, R = − 0.516). Linear regression models revealed negative associations between age and levels of Trp, kynurenic acid, 3-hdyroxyanthranilic acid and QUINA in healthy control subjects, as well as between age and ictal level of anthranilic acid. Conclusions Our results refer to a specifically altered Trp metabolism in CH patients. The onset of metabolic imbalance can be attributed to the interbout period, where the decreased KYN level is unable to perform its protective functions, while the concentration of QUINA, as a toxic ...
Keywords	Episodic cluster headache ; Interbout and ictal periods ; Plasma kynurenine metabolites ; Clinical features ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Case Report of a Rare Intracranial Tumour

PP Sathi / Janaky Ramakrishnan / Bimal Govind

Journal of Clinical and Diagnostic Research, Vol 16, Iss 7, Pp ED06-ED

2022 Volume 08

Abstract: A meningeal Solitary Fibrous Tumour (SFT), also called haemangiopericytoma is a fibroblastic type of mesenchymal tumour. These tumours often show a rich, well-branched vascular pattern that encompasses a histological spectrum of tumours which was ... ...

Abstract	A meningeal Solitary Fibrous Tumour (SFT), also called haemangiopericytoma is a fibroblastic type of mesenchymal tumour. These tumours often show a rich, well-branched vascular pattern that encompasses a histological spectrum of tumours which was previously classified separately as meningeal SFT and haemangiopericytoma. Discovery of NAB2-STAT6 fusion in a vast majority of haemangiopericytomas and solitary fibrous tumours indicates a possibility of morphological continuum. Herein, authors report a case 65-year-old female known case of hypertension and type II diabetes mellitus, presented with complaint of headache since two months and left side weakness since three weeks. On clinical examination, she was found to have motor weakness of left upper limb and lower limb with no sensory deficit. Magnetic Resonance Imaging (MRI) showed an extra axial, right frontoparietal convexity, solidly enhancing tumour with transosseous invasion and the imaging features were suggestive of atypical meningioma. After craniotomy, immunohistochemical evaluation showed tumour cells were strongly positive for CD34 and STAT-6 exhibited the characteristic nuclear localisation. The case was reported as SFT/Haemangiopericytoma-grade II. The patient was advised adjuvant radiotherapy but deferred treatment. Regular follow-up after two years post surgery has shown that the patient is disease free.
Keywords	craniotomy ; haemangiopericytoma ; solitary fibrous tumour ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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Article ; Online: Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal administration.

Sipos, Bence / Bella, Zsolt / Gróf, Ilona / Veszelka, Szilvia / Deli, Mária A / Szűcs, Kálmán F / Sztojkov-Ivanov, Anita / Ducza, Eszter / Gáspár, Róbert / Kecskeméti, Gábor / Janáky, Tamás / Volk, Balázs / Budai-Szűcs, Mária / Ambrus, Rita / Szabó-Révész, Piroska / Csóka, Ildikó / Katona, Gábor

International journal of pharmaceutics

2023 Volume 632, Page(s) 122594

Abstract: In our present series of experiments, we investigated the nasal applicability of the previously developed Soluplus® - meloxicam polymeric micelle formulation. Utilizing the nasal drug investigations, moderately high mucoadhesion was experienced in nasal ... ...

Abstract	In our present series of experiments, we investigated the nasal applicability of the previously developed Soluplus® - meloxicam polymeric micelle formulation. Utilizing the nasal drug investigations, moderately high mucoadhesion was experienced in nasal conditions which alongside the appropriate physicochemical properties in liquid state, contributed to rapid drug absorption through human RPMI 2650 cell line. Ex vivo studies also confirmed that higher nasal mucosal permeation could be expected with the polymeric micelle nanoformulation compared to a regular MEL suspension. Also, the nanoformulation met the requirements to provide rapid drug permeation in less 1 h of our measurement. The non-toxic, non-cell barrier damaging formulation also proved to provide a successful passive transport across excides human nasal mucosa. Based on our in vivo investigations, it can be concluded that the polymeric micelle formulation provides higher meloxicam transport to the central nervous system followed by a slow and long-lasting elimination process compared to prior results where physical particle size reduction methods were applied. With these results, a promising solution and nanocarrier is proposed for the successful transport of non-steroidal anti-inflammatory drugs with acidic character to the brain.
MeSH term(s)	Humans ; Administration, Intranasal ; Meloxicam/metabolism ; Micelles ; Nasal Mucosa/metabolism ; Polymers/chemistry ; Brain/metabolism
Chemical Substances	Meloxicam (VG2QF83CGL) ; polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer ; Micelles ; Polymers
Language	English
Publishing date	2023-01-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.122594
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Article ; Online: Solution Combustion Synthesis and Characterization of Magnesium Copper Vanadates.

Rawat, Abhishek / Clark, Laura / Zhang, Chuzhong / Cavin, John / Sangwan, Vinod K / Toth, Peter S / Janáky, Csaba / Ananth, Riddhi / Goldfine, Elise / Bedzyk, Michael J / Weiss, Emily A / Rondinelli, James M / Hersam, Mark C / Meletis, Efstathios I / Rajeshwar, Krishnan

Inorganic chemistry

2023 Volume 62, Issue 23, Page(s) 8903–8913

Abstract: Magnesium vanadate ( ... ...

Abstract	Magnesium vanadate (MgV
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c00452
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Article ; Online: A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis.

Tömösi, Ferenc / Kecskeméti, Gábor / Cseh, Edina Katalin / Szabó, Elza / Rajda, Cecília / Kormány, Róbert / Szabó, Zoltán / Vécsei, László / Janáky, Tamás

Journal of pharmaceutical and biomedical analysis

2020 Volume 185, Page(s) 113246

Abstract: The simultaneous quantitative estimation of tryptophan (TRP) and its metabolites represents a great challenge because of their diverse chemical properties, e.g., presence of acidic, basic, and nonpolar functional groups and their immensely different ... ...

Abstract	The simultaneous quantitative estimation of tryptophan (TRP) and its metabolites represents a great challenge because of their diverse chemical properties, e.g., presence of acidic, basic, and nonpolar functional groups and their immensely different concentrations in biological matrices. A short ultra high-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS) method was validated for targeted analysis of TRP and its 11 most important metabolites derived via both kynurenine (KYN) and serotonin (SERO) pathways in human serum and cerebrospinal fluid (CSF): SERO, KYN, 3-hydroxyanthranilic acid, 5-hydroxyindoleacetic acid, anthranilic acid, kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), xanthurenic acid, melatonin, picolinic acid (PICA), and quinolinic acid (QUIN). After selecting the "best" reversed-phase column and organic modifier, DryLab®4 was used to optimize the gradient time and temperature in chromatographic separation. To achieve absolute quantification, deuterium-labeled internal standards were used. Among all compounds, 3 were analyzed in derivatized (butyl ester) forms (3-HK, PICA, and QUIN) and the remaining 9 in underivatized forms. Validation was performed in accordance with the ICH and FDA guidelines to determine the intraday and interday precision, accuracy, sensitivity, and recovery. To demonstrate the applicability of the developed UHPLC-MS/MS method, the aforementioned metabolites were analyzed in serum and CSF samples from patients with multiple sclerosis (multiple sclerosis group) and those with symptomatic or noninflammatory neurological diseases (control group). The concentration of QUIN dramatically increased, whereas that of KYNA slightly decreased in the multiple sclerosis group, resulting in a significantly increased QUIN/KYNA ratio and significantly decreased PICA/QUIN ratio.
MeSH term(s)	Adult ; Biomarkers/analysis ; Biomarkers/metabolism ; Calibration ; Case-Control Studies ; Chromatography, High Pressure Liquid/instrumentation ; Chromatography, High Pressure Liquid/methods ; Chromatography, High Pressure Liquid/standards ; Female ; Humans ; Kynurenic Acid/analysis ; Kynurenic Acid/metabolism ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/blood ; Multiple Sclerosis, Relapsing-Remitting/cerebrospinal fluid ; Multiple Sclerosis, Relapsing-Remitting/diagnosis ; Picolinic Acids/analysis ; Picolinic Acids/metabolism ; Quinolinic Acid/analysis ; Quinolinic Acid/metabolism ; Reference Standards ; Tandem Mass Spectrometry/instrumentation ; Tandem Mass Spectrometry/methods ; Tandem Mass Spectrometry/standards ; Tryptophan/analysis ; Tryptophan/metabolism ; Young Adult
Chemical Substances	Biomarkers ; Picolinic Acids ; Tryptophan (8DUH1N11BX) ; Quinolinic Acid (F6F0HK1URN) ; Kynurenic Acid (H030S2S85J) ; picolinic acid (QZV2W997JQ)
Language	English
Publishing date	2020-03-09
Publishing country	England
Document type	Journal Article ; Observational Study ; Validation Study
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113246
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Article ; Online: Comparative Analysis of Immunohistochemistry of Hormone Receptors in Breast Cancer by Conventional and Microwave Tissue Processing Methods

Janaky Ramakrishnan / Asiq N Sideeque / Reslin A Khader

Journal of Clinical and Diagnostic Research, Vol 15, Iss 10, Pp EC34-EC

2021 Volume 38

Abstract: Introduction: Rapid histopathological processing of neoplastic biopsies is crucial for initiating early therapy in patients. Microwave processing shortens the time to diagnosis and is less labour intensive. Aim: To compare the quality of ... ...

Abstract	Introduction: Rapid histopathological processing of neoplastic biopsies is crucial for initiating early therapy in patients. Microwave processing shortens the time to diagnosis and is less labour intensive. Aim: To compare the quality of immunohistochemical staining of Estrogen Receptors (ER) and Progesterone Receptors (PR) on paired breast samples using microwave processing versus conventional processing. Materials and Methods: A cross-sectional study was conducted at a tertiary care hospital in Kerala, India, from February 2014 to September 2015. A total of 44 paired samples from breast carcinoma patients were taken. Baseline characteristics of the patients such as age and type of carcinoma were noted. Haematoxylin and Eosin (H&E) stain was used. One slide of the pair was processed conventionally and the other using a microwave. The stained slides were observed by three pathologists. The validity of ER and PR receptor status was evaluated with sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV). Kappa statistics and Spearman’s correlation test was used to denote the agreement between them. Results: The mean age was 51.32±11.16 years. There was agreement (Cohen k=0.902) between the microwave processed and conventionally processed paired breast samples for ER. The sensitivity and specificity of microwave processing in ER evaluation was 87.5% and 100% while that of PR evaluation was 92.9% and 100% respectively. The PPV was 100% and NPV was 93.3% for ER evaluation by microwave processing. Conclusion: Microwave aided tissue processing had significant advantages over conventional methods for providing a rapid diagnosis, being less laborious and had effective staining, which makes it a better choice.
Keywords	breast carcinoma ; estrogen receptors ; progesterone receptors ; rapid histopathology ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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