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  1. Book ; Online: Targeting Monocytes/Macrophages to Treat Atherosclerotic Inflammation

    Corti, Alessandro / Gaucher, Caroline / Pompella, Alfonso

    2020  

    Keywords Science: general issues ; Pharmacology ; monocytes/macrophages ; inflammation ; foam cell formation ; smooth muscle cells ; atherosclerosis progression
    Size 1 electronic resource (127 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230114
    ISBN 9782889635993 ; 2889635996
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The changing faces of glutathione, a cellular protagonist

    Corti, Alessandro / Pompella, Alfonso

    2015  

    Abstract: Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been ... ...

    Abstract Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism (S-glutathionylation) in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH-and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase-can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell's health, disease and death
    Keywords Therapeutics. Pharmacology ; Science (General)
    Size 1 electronic resource (142 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091023
    ISBN 9782889195954 ; 2889195953
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Redox Mechanisms in Cisplatin Resistance of Cancer Cells: The Twofold Role of Gamma-Glutamyltransferase 1 (GGT1).

    Pompella, Alfonso / Corti, Alessandro / Visvikis, Athanase

    Frontiers in oncology

    2022  Volume 12, Page(s) 920316

    Abstract: Cisplatin (CDDP) is currently employed for the treatment of several solid tumors, but cellular heterogeneity and the onset of drug resistance dictate that suitable biomarkers of CDDP sensitivity are established. Studies on triple-negative breast cancer ( ... ...

    Abstract Cisplatin (CDDP) is currently employed for the treatment of several solid tumors, but cellular heterogeneity and the onset of drug resistance dictate that suitable biomarkers of CDDP sensitivity are established. Studies on triple-negative breast cancer (TNBC) have recently confirmed the involvement of gamma-glutamyltransferase 1 (GGT1), whose enzyme activity expressed at the cell surface favors the cellular resupply of antioxidant glutathione (GSH) thus offering cancer cells protection against the prooxidant effects of CDDP. However, an additional well-established mechanism depends on GGT1-mediated matabolism of extracellular GSH. It was in fact shown that glycyl-cysteine - the dipeptide originated by GGT1-mediated GSH metabolism at the cell surface - can promptly form adducts with exogenous CDDP, thus hindering its access to the cell, interactions with DNA and overall cytotoxicity. Both mechanisms: mainainance of intracellular GSH levels
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.920316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy.

    Corti, Alessandro / Dominici, Silvia / Piaggi, Simona / Pompella, Alfonso

    BioFactors (Oxford, England)

    2022  Volume 49, Issue 2, Page(s) 405–414

    Abstract: Ferroptosis is a form of regulated cell death (RCD) characterized by intracellular iron ion accumulation and reactive oxygen species (ROS)-induced lipid peroxidation. Ferroptosis in cancer and ferroptosis-related anticancer drugs have recently gained ... ...

    Abstract Ferroptosis is a form of regulated cell death (RCD) characterized by intracellular iron ion accumulation and reactive oxygen species (ROS)-induced lipid peroxidation. Ferroptosis in cancer and ferroptosis-related anticancer drugs have recently gained interest in the field of cancer treatment. Boron is an essential trace element playing an important role in several biological processes. Recent studies have described contrasting effects of boric acid (BA) in cancer cells, ranging from protective/mitogenic to damaging/antiproliferative. Interestingly, boron has been shown to interfere with critical factors involved in ferroptosis-intracellular glutathione and lipid peroxidation in the first place. Thus, the present study was aimed to verify the ability of boron to modulate the ferroptotic process in HepG2 cells, a model of hepatocellular carcinoma. Our results indicate that-when used at high, pharmacological concentrations-BA can increase intracellular ROS, glutathione, and TBARS levels, and enhance ferroptosis induced by RSL3 and erastin. Also, high BA concentrations can directly induce ferroptosis, and such BA-induced ferroptosis can add to the cytotoxic effects of anticancer drugs sorafenib, doxorubicin and cisplatin. These observations suggest that BA could be exploited as a chemo-sensitizer agent in order to overcome cancer drug resistance in selected conditions. However, the possibility of reaching suitably high concentrations of BA in the tumor microenvironment will need to be further investigated.
    MeSH term(s) Humans ; Ferroptosis ; Cell Death ; Reactive Oxygen Species/metabolism ; Boron/pharmacology ; Boron/therapeutic use ; Lipid Peroxidation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Liver Neoplasms/drug therapy ; Glutathione/metabolism ; Tumor Microenvironment
    Chemical Substances boric acid (R57ZHV85D4) ; Reactive Oxygen Species ; Boron (N9E3X5056Q) ; Antineoplastic Agents ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-12-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.1919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2473: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Gamma-glutamyltransferase (GGT) in tumor progression, drug resistance and targeted therapies.

    Pompella, A / Corti, A

    Journal of biological regulators and homeostatic agents

    2019  Volume 32, Issue 4 Suppl. 1, Page(s) 27–28

    MeSH term(s) Drug Resistance, Neoplasm ; Humans ; Neoplasms/enzymology ; Neoplasms/therapy ; gamma-Glutamyltransferase
    Chemical Substances gamma-Glutamyltransferase (EC 2.3.2.2)
    Language English
    Publishing date 2019-02-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 639196-5
    ISSN 1724-6083 ; 0393-974X
    ISSN (online) 1724-6083
    ISSN 0393-974X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Positive Effects of UV-Photofunctionalization of Titanium Oxide Surfaces on the Survival and Differentiation of Osteogenic Precursor Cells-An In Vitro Study.

    Roy, Marco / Corti, Alessandro / Dorocka-Bobkowska, Barbara / Pompella, Alfonso

    Journal of functional biomaterials

    2022  Volume 13, Issue 4

    Abstract: Introduction: The UVC-irradiation ("UV-photofunctionalization") of titanium dental implants has proved to be capable of removing carbon contamination and restoring the ability of titanium surfaces to attract cells involved in the process of ... ...

    Abstract Introduction: The UVC-irradiation ("UV-photofunctionalization") of titanium dental implants has proved to be capable of removing carbon contamination and restoring the ability of titanium surfaces to attract cells involved in the process of osteointegration, thus significantly enhancing the biocompatibility of implants and favoring the post-operative healing process. To what extent the effect of UVC irradiation is dependent on the type or the topography of titanium used, is still not sufficiently established.
    Objective: The present study was aimed at analyzing the effects of UV-photofunctionalization on the TiO
    Methodology: The analysis of the surface roughness was performed by atomic force microscopy (AFM) on machined surface grade 2, and sand-blasted/acid-etched surface grades 2 and 4 titanium specimens. The expression of the genes related with the process of healing and osteogenesis was studied in the MC3T3-E1 pre-osteoblastic murine cells, as well as in MSC murine stem cells, before and after exposure to differently treated TiO
    Results: The AFM determinations showed that the surface topographies of titanium after the sand-blasting and acid-etching procedures, look very similar, independently of the grade of titanium. The UVC-irradiation of the TiO
    Conclusion: Overall, our findings expand and further support the current view that UV-photofunctionalization can indeed restore biocompatibility and osteointegration of TiO
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb13040265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells-An Issue Still Open.

    Paties Montagner, Giulia / Dominici, Silvia / Piaggi, Simona / Pompella, Alfonso / Corti, Alessandro

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Boric acid (BA) is the dominant form of boron in plasma, playing a role in different physiological mechanisms such as cell replication. Toxic effects have been reported, both for high doses of boron and its deficiency. Contrasting results were, however, ... ...

    Abstract Boric acid (BA) is the dominant form of boron in plasma, playing a role in different physiological mechanisms such as cell replication. Toxic effects have been reported, both for high doses of boron and its deficiency. Contrasting results were, however, reported about the cytotoxicity of pharmacological BA concentrations on cancer cells. The aim of this review is to briefly summarize the main findings in the field ranging from the proposed mechanisms of BA uptake and actions to its effects on cancer cells.
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Targeting Monocytes/Macrophages to Treat Atherosclerotic Inflammation.

    Corti, Alessandro / Gaucher, Caroline / Pompella, Alfonso

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 86

    Language English
    Publishing date 2020-02-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.00086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Phenotypic Modulation of Macrophages and Vascular Smooth Muscle Cells in Atherosclerosis-Nitro-Redox Interconnections.

    Bonetti, Justine / Corti, Alessandro / Lerouge, Lucie / Pompella, Alfonso / Gaucher, Caroline

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 4

    Abstract: Monocytes/macrophages and vascular smooth muscle cells (vSMCs) are the main cell types implicated in atherosclerosis development, and unlike other mature cell types, both retain a remarkable plasticity. In mature vessels, differentiated vSMCs control the ...

    Abstract Monocytes/macrophages and vascular smooth muscle cells (vSMCs) are the main cell types implicated in atherosclerosis development, and unlike other mature cell types, both retain a remarkable plasticity. In mature vessels, differentiated vSMCs control the vascular tone and the blood pressure. In response to vascular injury and modifications of the local environment (inflammation, oxidative stress), vSMCs switch from a contractile to a secretory phenotype and also display macrophagic markers expression and a macrophagic behaviour. Endothelial dysfunction promotes adhesion to the endothelium of monocytes, which infiltrate the sub-endothelium and differentiate into macrophages. The latter become polarised into M1 (pro-inflammatory), M2 (anti-inflammatory) or Mox macrophages (oxidative stress phenotype). Both monocyte-derived macrophages and macrophage-like vSMCs are able to internalise and accumulate oxLDL, leading to formation of "foam cells" within atherosclerotic plaques. Variations in the levels of nitric oxide (NO) can affect several of the molecular pathways implicated in the described phenomena. Elucidation of the underlying mechanisms could help to identify novel specific therapeutic targets, but to date much remains to be explored. The present article is an overview of the different factors and signalling pathways implicated in plaque formation and of the effects of NO on the molecular steps of the phenotypic switch of macrophages and vSMCs.
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10040516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans.

    Piaggi, Simona / Lorenzini, Evelina / Pratesi, Federico / Migliorini, Paola / Pompella, Alfonso / Bruschi, Fabrizio / Corti, Alessandro

    Clinical and experimental immunology

    2022  Volume 209, Issue 3, Page(s) 305–310

    Abstract: Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in the serum of patients with esophageal ... ...

    Abstract Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in the serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our findings show that anti-GSTO1-1 antibodies can be found in a variety of inflammatory diseases, including autoimmune rheumatoid arthritis, infectious SARS-CoV-2, and trichinellosis. Our findings strongly suggest that anti-GSTO1-1 antibodies may be a marker of tissue damage/inflammation rather than a specific tumor-associated biomarker.
    MeSH term(s) Biomarkers, Tumor ; COVID-19 ; Esophageal Neoplasms ; Esophageal Squamous Cell Carcinoma ; Glutathione Transferase ; Humans ; Inflammation ; SARS-CoV-2
    Chemical Substances Biomarkers, Tumor ; GSTO1 protein, human (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18)
    Language English
    Publishing date 2022-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxac060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 337: Show issues Location:
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