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  1. Article: The Risks of Phosphate Enemas in Toddlers: A Life-Threatening Unawareness.

    Zago, Alessandro / Occhipinti, Alessandro Agostino / Bramuzzo, Matteo / Ceconi, Viola / Colacino, Vincenzo / Barbi, Egidio / Poropat, Federico

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 3

    Abstract: Background: While oral laxatives represent the first-line treatment of fecal impaction, enemas are frequently used in clinical practice in pediatric emergency departments (PEDs) and by family pediatricians (FPs).: Objectives: Phosphate-containing ... ...

    Abstract Background: While oral laxatives represent the first-line treatment of fecal impaction, enemas are frequently used in clinical practice in pediatric emergency departments (PEDs) and by family pediatricians (FPs).
    Objectives: Phosphate-containing enemas (PcEs) are commonly employed, even causing the risk of rare but lethal toxicity. We investigated pediatricians' awareness of PcE risks.
    Methods: We conducted an online survey by sending a multiple-choice questionnaire to the referents of 51 PEDs and 101 FPs. We collected and compared the answers with recommendations reported by the Italian Drug Agency (AIFA) and the available literature about PcE administration.
    Results: Of the institutions and pediatricians receiving the questionnaire, 23 PEDs (45%) and 63 FP (62.3%) participated in the survey. Of PEDs, 95% and 33.0% of FPs treated fecal impaction with PcE. Moreover, 54% of PEDs and 86.0% of FPs did not provide treatment according to the AIFA recommendations for the daily dose.
    Conclusions: This study shows limited pediatricians' awareness of the potential risks related to PcE.
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11030349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pioglitazone, a PPAR-y agonist, as one of the new therapeutic candidates for C3 glomerulopathy.

    Balestra, Elia / Barbi, Egidio / Ceconi, Viola / Di Maso, Vittorio / Conversano, Ester / Pennesi, Marco

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 39, Issue 1, Page(s) 309–314

    Abstract: Background: C3-glomerulopathy (C3G) is a rare pediatric kidney disease characterised by dysregulation of the alternative complement pathway, with glomerular deposition of C3. C3G may often present as a steroid-resistant nephrotic syndrome (SRNS), and ... ...

    Abstract Background: C3-glomerulopathy (C3G) is a rare pediatric kidney disease characterised by dysregulation of the alternative complement pathway, with glomerular deposition of C3. C3G may often present as a steroid-resistant nephrotic syndrome (SRNS), and there is no established effective therapy: the usual treatment involves corticosteroids and immunosuppressive drugs. Pioglitazone, a PPAR-γ agonist with a protective action on podocytes, was reported in a few cases as helpful in reducing proteinuria when combined with steroids.
    Case-diagnosis/treatment: We report the case of a 13-year-old girl with silent past medical history who presented with SRNS. A kidney biopsy showed findings indicative of C3G. A low sodium diet and angiotensin-converting enzyme inhibitor were started; immunosuppressive treatment with mycophenolate mofetil (MMF) was administered due to the cortico-resistance. Because of poor response to the immunosuppressant, a trial with eculizumab was attempted without significant response and persistence of proteinuria in the nephrotic range. A further therapeutic trial was performed with tacrolimus with no disease remission. Due to a severe deterioration in her condition, the girl was hospitalized and treated with high-dose steroid bolus. A daily dose of oral prednisone and MMF were re-started without benefit with persistent levels of nephrotic range proteinuria. The administration of pioglitazone consistently lowered proteinuria levels for the first time since the onset of the disease, with a maintenance of the effect and normalization (< 0.15 g/24 h) at the 10-month follow-up.
    Conclusions: In this patient affected by C3G, pioglitazone proved effective in reducing proteinuria levels.
    MeSH term(s) Adolescent ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Mycophenolic Acid/therapeutic use ; Nephrotic Syndrome/drug therapy ; Peroxisome Proliferator-Activated Receptors/therapeutic use ; Pioglitazone/therapeutic use ; Prednisone/therapeutic use ; Proteinuria/drug therapy ; Proteinuria/etiology ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T) ; Peroxisome Proliferator-Activated Receptors ; Pioglitazone (X4OV71U42S) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2023-07-26
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06088-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
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  3. Article: Effectiveness and safety of a one-yearly elongation approach of growing rods in the treatment of early-onset scoliosis: A case series of 40 patients with definitive fusion.

    Vittoria, Francesca / Ceconi, Viola / Fantina, Lisa / Barbi, Egidio / Carbone, Marco

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 895065

    Abstract: Background: Early onset scoliosis (EOS) can lead to marked spine and chest wall deformity and often to profound cardiopulmonary compromise. Nowadays, treatment benefits from the possibility of a growth-friendly surgical approach to avoid early spinal ... ...

    Abstract Background: Early onset scoliosis (EOS) can lead to marked spine and chest wall deformity and often to profound cardiopulmonary compromise. Nowadays, treatment benefits from the possibility of a growth-friendly surgical approach to avoid early spinal fusion. Growing rod spinal implants allow maximizing spine and thorax growth during childhood, performing lengthening procedures traditionally approximately every 6 months.
    Methods: We retrospectively evaluated 40 patients affected by EOS who underwent growing rod implantations from 2000 to 2020. A 1-year interval between lengthening procedures was adopted. Data about the age at the first and final surgeries, T1-T12 length pre- and post-surgery, T1-S1 pre- and post-surgery, major coronal curve, pre- and post-surgery rate of complications, and unplanned surgeries were collected and compared with those reported in the literature to determinate the effectiveness and safety of this long period between distractions.
    Results: The lengthening procedures were performed, on average, every 12.3 months; children underwent an average of 4.6 lengthening procedures each. Major curve pre-first surgery was 78°, post-first surgery 45°, pre-final surgery 55°, and post-final surgery 43°. The mean absolute difference between pre-initial to post-final major curve was 35°, representing a mean relative difference of 42%. On average, the T1-T12 segment measured 15 cm before the first surgery and 24 cm after the final surgery, while the T1-S1 segment was 25 cm before the growing rods implantation and reached 37 cm after treatment. During treatment, the adverse events affected 27 of the 40 total patients (67%) who experienced at least one complication. No differences were shown concerning both outcomes and complications, comparing these data with the available literature concerning most frequent elongations. This approach avoided four to five surgical procedures in this population.
    Conclusion: Our results related to deformity correction and complication rate are comparable with those found in the literature, where lengthening procedures are performed approximately every 6 months rather than with a 1-year interval between distractions. We also demonstrate a higher risk of complications for patients with implants before the age of 6.
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.895065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Glycemic control in type 1 diabetes mellitus and COVID-19 lockdown: What comes after a "quarantine"?

    Ceconi, Viola / Barbi, Egidio / Tornese, Gianluca

    Journal of diabetes

    2020  Volume 12, Issue 12, Page(s) 946–948

    Abstract: Highlights A stable or even improved glycemic control was found in adolescents with T1DM using hybrid closed loop system not only during COVID-19 lockdown but also in the weeks after, when daily activities slowly resumed. Although the slowing down of ... ...

    Abstract Highlights A stable or even improved glycemic control was found in adolescents with T1DM using hybrid closed loop system not only during COVID-19 lockdown but also in the weeks after, when daily activities slowly resumed. Although the slowing down of routine daily activities might still have an influence, we believe that the continuation of the health care professional assistance through telemedicine during lockdown might have led to a "dragging effect" in these patients also after its suspension.
    MeSH term(s) Adolescent ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19/virology ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 1/virology ; Female ; Glycemic Control/methods ; Humans ; Male ; Quarantine ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Telemedicine/methods
    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country Australia
    Document type Letter
    ZDB-ID 2503337-2
    ISSN 1753-0407 ; 1753-0393
    ISSN (online) 1753-0407
    ISSN 1753-0393
    DOI 10.1111/1753-0407.13110
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6791: Show issues Location:
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  5. Article ; Online: Accuracy and consequences of reported target height.

    Ceconi, Viola / Grigoletto, Veronica / Pellegrin, Maria Chiara / Faleschini, Elena / Barbi, Egidio / Tornese, Gianluca

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 110, Issue 5, Page(s) 1513–1515

    MeSH term(s) Body Height ; Growth Disorders ; Human Growth Hormone ; Humans
    Chemical Substances Human Growth Hormone (12629-01-5)
    Language English
    Publishing date 2020-12-06
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15690
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    Um IV Zs.95: Show issues Location:
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  6. Article ; Online: Glycemic control in type 1 diabetes mellitus and COVID ‐19 lockdown

    Ceconi, Viola / Barbi, Egidio / Tornese, Gianluca

    Journal of Diabetes ; ISSN 1753-0393 1753-0407

    What comes after a “quarantine”?

    2020  

    Keywords Endocrinology, Diabetes and Metabolism ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/1753-0407.13110
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Glycemic control in type 1 diabetes mellitus and COVID-19 lockdown: What comes after a "quarantine"?

    Ceconi, Viola / Barbi, Egidio / Tornese, Gianluca

    J. diabetes (Online)

    Abstract: A stable or even improved glycemic control was found in adolescents with T1DM using hybrid closed loop system not only during COVID-19 lockdown but also in the weeks after, when daily activities slowly resumed. Although the slowing down of routine daily ... ...

    Abstract A stable or even improved glycemic control was found in adolescents with T1DM using hybrid closed loop system not only during COVID-19 lockdown but also in the weeks after, when daily activities slowly resumed. Although the slowing down of routine daily activities might still have an influence, we believe that the continuation of the health care professional assistance through telemedicine during lockdown might have led to a "dragging effect" in these patients also after its suspension.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #751883
    Database COVID19

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  8. Article ; Online: Glycemic Control in Type 1 Diabetes Mellitus During COVID-19 Quarantine and the Role of In-Home Physical Activity.

    Tornese, Gianluca / Ceconi, Viola / Monasta, Lorenzo / Carletti, Claudia / Faleschini, Elena / Barbi, Egidio

    Diabetes technology & therapeutics

    2020  Volume 22, Issue 6, Page(s) 462–467

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Betacoronavirus ; Blood Glucose/analysis ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/prevention & control ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 1/virology ; Exercise/physiology ; Female ; Humans ; Italy/epidemiology ; Male ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/prevention & control ; Quarantine ; Retrospective Studies ; SARS-CoV-2 ; Self-Management/methods
    Chemical Substances Blood Glucose
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1452816-2
    ISSN 1557-8593 ; 1520-9156
    ISSN (online) 1557-8593
    ISSN 1520-9156
    DOI 10.1089/dia.2020.0169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5269: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Glycemic Control in Type 1 Diabetes Mellitus During COVID-19 Quarantine and the Role of In-Home Physical Activity

    Tornese, Gianluca / Ceconi, Viola / Monasta, Lorenzo / Carletti, Claudia / Faleschini, Elena / Barbi, Egidio

    Diabetes Technology & Therapeutics

    2020  Volume 22, Issue 6, Page(s) 462–467

    Keywords Endocrinology, Diabetes and Metabolism ; Medical Laboratory Technology ; Endocrinology ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1452816-2
    ISSN 1520-9156
    ISSN 1520-9156
    DOI 10.1089/dia.2020.0169
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5269: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Glycemic Control in Type 1 Diabetes Mellitus During COVID-19 Quarantine and the Role of In-Home Physical Activity

    Tornese, Gianluca / Ceconi, Viola / Monasta, Lorenzo / Carletti, Claudia / Faleschini, Elena / Barbi, Egidio

    Diabetes Technol Ther

    Abstract: Background: To limit the spread of coronavirus disease 2019 (COVID-19), governments have ordered a series of restrictions that may affect glycemic control in individuals with type 1 diabetes mellitus (T1DM), since physical activity (PA) was not allowed ... ...

    Abstract Background: To limit the spread of coronavirus disease 2019 (COVID-19), governments have ordered a series of restrictions that may affect glycemic control in individuals with type 1 diabetes mellitus (T1DM), since physical activity (PA) was not allowed outside home. Methods: We retrospectively evaluated glycemic control of individuals with T1DM using hybrid closed loop (HCL) system in the period before the SARS-CoV-2 outbreak in Italy (February 10-23, 2020-Time 1), when movements were only reduced (February 24-March 8, 2020-Time 2) and during complete lockdown (March 9-22, 2020-Time 3). Information about regular PA (at least 3 h per week) prior and during the quarantine was collected. Results: The study included 13 individuals with a median age of 14.2 years and a good glycemic control at baseline (glucose management indicator of 7%, time in range [TIR] of 68%, time below range [TBR] of 2%). All individuals continued to show good glycemic control throughout the study period. There was an increase in TIR during the study period (+3%) and TIR was significantly higher during Time 3 (72%) than during Time 2 (66%). TBR was significantly lower during Time 3 (1%) both compared with Time 1 and Time 2 (2%). A meaningful variance in TIR at Time 3 between individuals who performed or not PA during quarantine and a significant increase in TIR between Time 2 and Time 3 in individuals both doing PA at baseline and during quarantine was found. At logistic regression, only the presence of PA during quarantine significantly predicted a TIR >70%. Conclusions: Glycemic control of T1DM in adolescents using HCL system did not worsen during the restrictions due to COVID-19 pandemics and further improved in those who continued PA during the quarantine. Maintaining regular PA in a safe home environment is an essential strategy for young individuals with T1DM during the COVID-19 crisis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #291217
    Database COVID19

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