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  1. Article ; Online: Mera Costas, Pilar, 18 de julio de 1936. El día que empezó la Guerra Civil, Barcelona, Taurus, 2021, 239 págs., ISBN

    Sergio Vaquero Martínez

    Hispania, Vol 83, Iss

    978-84-306-2269-6.

    2023  Volume 274

    Keywords Social Sciences ; H
    Language Spanish
    Publishing date 2023-12-01T00:00:00Z
    Publisher Consejo Superior de Investigaciones Científicas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Pityriasis Rubra Pilar and hypothyroidism.

    Franzotti, Aline Martinez / Avelar, Juliana Centofanti Dentello / Cardoso, Thaís Abrão / Pires, Mario Cesar / Vidigal, Maria do Rosário

    Anais brasileiros de dermatologia

    2014  Volume 89, Issue 3, Page(s) 497–500

    Abstract: Pityriasis Rubra Pilaris (PRP) is a chronic and rare papulosquamous disorder. Treatment ... of Pityriasis Rubra Pilaris is based on empiric evidence because of several doubts regarding its etiology and also ... of vitamin A is involved in pathogenesis. We report a case of Pityriasis Rubra Pilaris associated ...

    Abstract Pityriasis Rubra Pilaris (PRP) is a chronic and rare papulosquamous disorder. Treatment of Pityriasis Rubra Pilaris is based on empiric evidence because of several doubts regarding its etiology and also because of its relative rarity, making randomized studies difficult to perform. Some factors suggest that the metabolism of vitamin A is involved in pathogenesis. We report a case of Pityriasis Rubra Pilaris associated with autoimmune hypothyroidism which presented rapid and complete response after thyroid hormone replacement, without any association with other systemic treatment. In literature there are only three other reports of significant improvement of the lesions after hormonal correction. Deficiency of thyroid hormone inhibits the conversion of carotene into vitamin A, which would be responsible for the occurrence of Pityriasis Rubra Pilaris in this patient.
    MeSH term(s) Adult ; Hormone Replacement Therapy ; Humans ; Hypothyroidism/complications ; Hypothyroidism/drug therapy ; Male ; Pityriasis Rubra Pilaris/drug therapy ; Pityriasis Rubra Pilaris/etiology ; Thyroid Hormones/therapeutic use ; Thyroxine/therapeutic use ; Treatment Outcome ; Vitamin A/therapeutic use ; Vitamin A Deficiency/complications
    Chemical Substances Thyroid Hormones ; Vitamin A (11103-57-4) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2014-06-14
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/abd1806-4841.20142994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 344: Show issues

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  3. Book: ¡Empatamos, Pilar!

    Cerisola, Mariví / Martínez Torres, José

    cuentos de futbol

    (La escritura invisible ; 21)

    2009  

    Author's details compilación de Mariví Cerisola y José Martínez Torres
    Series title La escritura invisible ; 21
    Keywords Short stories, Mexican ; Soccer/Fiction
    Language Spanish
    Size 141 S, 21 cm
    Edition 1a ed
    Publisher Ed. Terracota
    Publishing place Mexico, D.F
    Document type Book
    ISBN 6077616370 ; 9786077616375
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Online ; E-Book: The Handbook of Language in Public Health and Healthcare

    Ortega, Pilar / Martínez, Glenn / Lor, Maichou / Martínez, A. Susana

    (Blackwell Handbooks in Linguistics Series)

    2024  

    Series title Blackwell Handbooks in Linguistics Series
    Language English
    Size 1 online resource (589 pages)
    Edition 1st ed.
    Publisher John Wiley & Sons, Incorporated
    Publishing place Newark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-85383-4 ; 1-119-85381-8 ; 1-119-85382-6 ; 978-1-119-85383-1 ; 978-1-119-85381-7 ; 978-1-119-85382-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: MOGOLLÓN CANO-CORTÉS, Pilar. José Menéndez-Pidal Álvarez. Arquitecto conservador-restaurador. Colección Arquitectura, Urbanismo y Restauración. Editorial Universidad de Granada, Granada, 2020.

    Miguel Martínez-Monedero / Jaime Vergara-Muñoz

    E-RPH, Iss

    2021  Volume 28

    Abstract: ... por la profesora Pilar García Cuetos de la Universidad de Oviedo que, gracias a un elenco de brillantes ...

    Abstract El libro “José Menéndez-Pidal Álvarez, arquitecto conservador-restaurador” editado por la Universidad de Granada dentro de la prestigiosa colección: Arquitectura, Urbanismo y Restauración, arroja luz sobre un importante personaje de la arquitectura española del siglo XX. Un arquitecto que aún no había recibido la atención que merecía. Su investigación llena un vacío, no el único aún pendiente, pero que se añade, con solvencia y rigor, a la historiografía y crítica de arquitectura sobre este periodo reciente de la arquitectura en España. Este trabajo se sitúa dentro de los resultados del proyecto de investigación nacional: “Los arquitectos restauradores en la España del franquismo. De la continuidad de la Ley de 1933 a la recepción de la teoría europea”. El cual se enmarca en la reconocida línea de investigación “Los arquitectos restauradores en la España del franquismo”, de amplia trayectoria. Una línea de investigación, dirigida por la profesora Pilar García Cuetos de la Universidad de Oviedo que, gracias a un elenco de brillantes investigadoras (Esther Almarcha, Ascensión Hernández, Belén Castro y otros), está protagonizando la crítica hacia las restauraciones arquitectónicas que se realizaron en aquellos años.
    Keywords Historia ; patrimonio monumental ; restauración arquitectónica ; siglo XX ; franquismo ; Andalucía oriental ; Extremadura ; Islas Canarias ; República Dominicana ; Colombia ; History of the arts ; NX440-632 ; History (General) and history of Europe ; D
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Editorial Universidad de Granada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: PILAR is a novel modulator of human T-cell expansion.

    Huarte, Eduardo / Cubillos-Ruiz, Juan R / Nesbeth, Yolanda C / Scarlett, Uciane K / Martinez, Diana G / Engle, Xavier A / Rigby, William F / Pioli, Patricia A / Guyre, Paul M / Conejo-Garcia, Jose R

    Blood

    2008  Volume 112, Issue 4, Page(s) 1259–1268

    Abstract: ... proliferation-induced lymphocyte-associated receptor (PILAR). Surface PILAR is markedly up-regulated on CD4 and ... to a lesser extent, on CD8 T cells on T-cell receptor engagement. In absence of CD28 costimulation, PILAR ... These effects are abrogated by PILAR blockade with specific antibodies, which decrease surface levels of CD28 ...

    Abstract Robust T-cell responses without autoimmunity are only possible through a fine balance between activating and inhibitory signals. We have identified a novel modulator of T-cell expansion named proliferation-induced lymphocyte-associated receptor (PILAR). Surface PILAR is markedly up-regulated on CD4 and, to a lesser extent, on CD8 T cells on T-cell receptor engagement. In absence of CD28 costimulation, PILAR signaling through CD161 supports CD3 antibody-dependent and antigen-specificT-cell proliferation by increasing the expression of antiapoptotic Bcl-xL and induces secretion of T helper type 1 cytokines. These effects are abrogated by PILAR blockade with specific antibodies, which decrease surface levels of CD28. In contrast, PILAR induces apoptotic death on naive and early activated T cells if CD161 engagement is blocked. PILAR is expressed by approximately 7% to 10% of CD4 T cells in 2 samples of inflammatory synovial fluid, suggesting a potential role in the pathogenesis of joint inflammation. In addition, in the ovarian cancer microenvironment, effector T cells express PILAR, but not CD161, although expression of both can be augmented ex vivo. Our results indicate that PILAR plays a central role in modulating the extent of T-cell expansion. Manipulation of PILAR signaling may be important for treatment of autoimmune diseases and cancer.
    MeSH term(s) Antigens, Surface/metabolism ; Autoimmune Diseases/immunology ; Cell Proliferation ; Cells, Cultured ; Chromosomes, Human, Pair 12 ; Female ; Humans ; Immunity, Cellular ; Inflammation/immunology ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Lectins, C-Type/physiology ; Lymphocyte Activation/immunology ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; NK Cell Lectin-Like Receptor Subfamily B ; Ovarian Neoplasms/immunology ; Signal Transduction ; Synovial Fluid/immunology ; T-Lymphocytes/chemistry ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Up-Regulation/genetics
    Chemical Substances Antigens, Surface ; CLEC2A protein, human ; KLRB1 protein, human ; Lectins, C-Type ; Membrane Proteins ; NK Cell Lectin-Like Receptor Subfamily B
    Language English
    Publishing date 2008-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2007-12-130773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
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  7. Book ; Online: New Approaches in Social, Environmental Management and Policy to Address SDGs

    Martinez-Nuñez, Margarita / Latorre-Martínez, Mª Pilar / Latorre-Martínez, Mª Pilar

    2022  

    Keywords Development economics & emerging economies ; ecological footprint ; environmental performance of SMEs ; 2030 Agenda ; sustainable development goals (SDGs) ; systemic sustainability analysis ; SDG targets prioritization ; sustainability ; project management ; scheduling ; public infrastructures ; Z-fuzzy number ; sustainable development goals ; facilitating factors ; implementation ; regional and local planning ; Norway ; capability assessment ; business incubator ; maturity model ; Thailand ; agro-food business ; small and medium enterprise (SME) ; Food and Agriculture Organization (FAO) ; Agenda 2030 ; regime analysis ; United Nations Sustainable Development Goals ; ecosystem services ; forest ; forestry ; management practices ; European Green Deal ; sustainable development ; financing ; impact fund ; sustainable urban drainage systems ; green infrastructures ; stormwater green infrastructure ; Mediterranean climate ; arid climate ; template climate ; Spain ; hazardous waste shipment ; network analysis ; gross domestic product per capita ; disposal ; proximity principle ; self-sufficiency principle ; complex systems ; industrial ecology ; urban-industrial symbiosis ; urban-industrial systems ; urban metabolism ; ecosystem service ; observational scale ; trade-off ; hot/cold-spot ; Ussuri watershed ; country risk ; developing economies ; governance ; institutional quality ; low-income countries ; SDGs ; community empowerment ; energy transition ; rural depopulation ; Sustainable Development Goals (SDGs)
    Language 0|e
    Size 1 electronic resource (250 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021611358
    ISBN 9783036529509 ; 3036529500
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Isolation of Hepatic and Adipose-Tissue-Derived Extracellular Vesicles Using Density Gradient Separation and Size Exclusion Chromatography.

    Martínez-Greene, Juan Alfonso / Gómez-Chavarín, Margarita / Ramos-Godínez, María Del Pilar / Martínez-Martínez, Eduardo

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: In recent years, the study of extracellular vesicles (EVs) in the context of various diseases has dramatically increased due to their diagnostic and therapeutic potential. Typically, EVs are isolated in vitro from the cell culture of primary cells or ... ...

    Abstract In recent years, the study of extracellular vesicles (EVs) in the context of various diseases has dramatically increased due to their diagnostic and therapeutic potential. Typically, EVs are isolated in vitro from the cell culture of primary cells or cell lines or from bodily fluids. However, these cell culture methods do not represent the whole complexity of an in vivo microenvironment, and bodily fluids contain a high heterogeneous population of vesicles since they originate from different tissues. This highlights the need to develop new methods to isolate EVs directly from tissue samples. In the present study, we established a protocol for isolating EVs from hepatic and adipose tissue of mice, using a combination of ultracentrifugation and iodixanol-sucrose density gradient separation. EV isolation was confirmed with EV protein marker enrichment in Western blot assays, total protein quantification, and transmission electron microscopy. Regarding the liver tissue, we additionally implemented size exclusion chromatography (SEC) to further increase the purity grade of the EVs. The successful isolation of EVs from tissue samples will allow us to uncover a more precise molecular composition and functions, as well as their role in intercellular communication in an in vivo microenvironment.
    MeSH term(s) Animals ; Mice ; Extracellular Vesicles ; Chromatography, Gel ; Liver ; Adipose Tissue ; Blotting, Western
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparative study of in vitro activity of tedizolid and linezolid against Mycobacterium avium complex.

    Marfil, Eduardo / Ruiz, Pilar / Martínez-Martínez, Luis / Causse, Manuel

    Journal of global antimicrobial resistance

    2022  Volume 30, Page(s) 395–398

    Abstract: Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a ...

    Abstract Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a macrodilution assay with the Bactec-MGIT-960.
    Methods: A total of 37 clinical isolates of MAC were included in the study. Reference broth microdilution was performed according to CLSI guidelines in a range of concentrations from 64 to 0.064 mg/L. Macrodilution was performed with the Bactec-MGIT-960 system. The cut-off points defined by CLSI for linezolid (resistant: > 16 mg/L, intermediate: 16 mg/L, susceptible: <16 mg/L) were used to define clinical categories of this drug. Essential agreement for both linezolid and tedizolid and categorical agreement for linezolid were defined following FDA criteria.
    Results: The MIC
    Conclusions: Tedizolid showed higher in vitro activity than linezolid against the tested MAC isolates. Macrodilution using the BD Bactec-MGIT-960 system is a practical approach to determine the susceptibility of MAC strains to tedizolid.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Humans ; Linezolid/pharmacology ; Mycobacterium avium Complex ; Mycobacterium avium-intracellulare Infection ; Organophosphates/pharmacology ; Oxazoles/pharmacology ; Oxazolidinones ; Tetrazoles
    Chemical Substances Anti-Bacterial Agents ; Organophosphates ; Oxazoles ; Oxazolidinones ; Tetrazoles ; tedizolid (97HLQ82NGL) ; Linezolid (ISQ9I6J12J)
    Language English
    Publishing date 2022-07-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pilar GARCÍA ROJAS; Jordi GUSSINYER; Miquel ÍZARD; Javier LAVIÑA; Ricardo PIQUERAS; Miritxell TOUS; M.ª Teresa ZUBIRI (coords.) “Estrategias de poder en América Latina”. Barcelona

    María del Mar MARTÍNEZ ROSÓN

    América Latina Hoy, Vol 29, Iss 0, Pp 188-

    Universitat de Barcelona, 2000. 203 pp.

    2010  Volume 189

    Keywords Reseñas ; Political science (General) ; JA1-92
    Language Spanish
    Publishing date 2010-07-01T00:00:00Z
    Publisher Ediciones Universidad de Salamanca
    Document type Article ; Online
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