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Article ; Online: Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.

Takumida, Masaya / Anniko, Matti

2019 Volume 139, Issue 11, Page(s) 948–952

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Ear, Inner/metabolism ; Melatonin/metabolism ; Mice, Inbred C57BL ; Receptor, Melatonin, MT1/metabolism ; Receptor, Melatonin, MT2/metabolism
Chemical Substances	Receptor, Melatonin, MT1 ; Receptor, Melatonin, MT2 ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2019-09-06
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2019.1655587
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Article ; Online: Gastric-type H

Takumida, Masaya / Takumida, Hiroshi / Anniko, Matti

Acta oto-laryngologica

2017 Volume 137, Issue 5, Page(s) 455–459

Abstract: Conclusion: Gastric type H: Objective: To analyze the expression of gastric-type H: Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H: Results: In the vestibular end organs, ... ...

Abstract	Conclusion: Gastric type H Objective: To analyze the expression of gastric-type H Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H Results: In the vestibular end organs, H
MeSH term(s)	Animals ; H(+)-K(+)-Exchanging ATPase/isolation & purification ; H(+)-K(+)-Exchanging ATPase/metabolism ; Meniere Disease/drug therapy ; Mice, Inbred CBA ; Proton Pump Inhibitors/therapeutic use ; Vestibule, Labyrinth/enzymology
Chemical Substances	Proton Pump Inhibitors ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10)
Language	English
Publishing date	2017-05
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2016.1245865
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Book ; Thesis: Dynamic properties of the endolymphatic sac

Takumida, Masaya

a morhological and histochemical analysis of secretory and absorptive mechanisms

1988

Size	Getr. Zählung : Ill.
Publishing country	Sweden
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Stockhom, Karolinska Inst., Diss., 1988
HBZ-ID	HT003290106
ISBN	91-7900-468-7 ; 978-91-7900-468-2
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
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Article ; Online: Localization of sirtuins (SIRT1-7) in the aged mouse inner ear.

Takumida, Masaya / Takumida, Hiroshi / Katagiri, Yoshiaki / Anniko, Matti

Acta oto-laryngologica

2016 Volume 136, Issue 2, Page(s) 120–131

Abstract: Conclusion: The expression of sirtuin in vestibular end organs and cochlea responds differently to age-related changes. Down-regulation of SIRT1, 3, and 5 in the cochlea may weaken the protective activity regarding degeneration of the organ of Corti as ... ...

Abstract	Conclusion: The expression of sirtuin in vestibular end organs and cochlea responds differently to age-related changes. Down-regulation of SIRT1, 3, and 5 in the cochlea may weaken the protective activity regarding degeneration of the organ of Corti as well as of spiral ganglion cells, resulting in the development of age-related hearing loss. An increase in SIRT 1, 4, or 5 in vestibular tissue could indicate an increased need of detoxification of reactive oxygen species and an increased anti-ageing potential. Objective: To analyse the expression of sirtuins (SIRT1-7) in the normal young and old mouse inner ears. Methods: Young (8 weeks) and old (22 months) CBA/J mice were used in this study. Localization of SIRT1-7 in the inner ear, i.e. cochlea, vestibular end organs, and vestibular ganglion, was investigated using real-time PCR and immunohistochemistry. Results: In the vestibular end organs, the expression of SIRT1, 2, 4, 5 (both mRNA and protein), SIRT6, and 7 (only mRNA) was found to be increased, while a slightly decreased immunoreactivity was observed in SIRT3. In the cochlea, the expression of SIRT1, 3, and 5 (both mRNA and protein) was decreased in the old mice, whereas no noticeable difference was observed regarding SIRT2, 4, 6, or 7.
MeSH term(s)	Aging/genetics ; Animals ; Ear, Inner/diagnostic imaging ; Ear, Inner/growth & development ; Ear, Inner/metabolism ; Gene Expression Regulation, Developmental ; Immunohistochemistry ; Mice ; Mice, Inbred CBA ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Sirtuin 1/metabolism ; Sirtuin 3/biosynthesis ; Sirtuin 3/genetics ; Sirtuins/biosynthesis ; Sirtuins/genetics ; Tomography, X-Ray Computed
Chemical Substances	RNA, Messenger ; SIRT5 protein, mouse ; Sirt3 protein, mouse ; Sirt1 protein, mouse (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; Sirtuin 3 (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.3109/00016489.2015.1093172
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Article ; Online: Localization of histamine (H1, H2, H3 and H4) receptors in mouse inner ear.

Takumida, Masaya / Takumida, Hiroshi / Anniko, Matti

Acta oto-laryngologica

2016 Volume 136, Issue 6, Page(s) 537–544

Abstract: Conclusion The present findings show that all four types of histamine receptors (H1R, H2R, H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine plays a physiological role in the inner ear. Objective To analyse the ... ...

Abstract	Conclusion The present findings show that all four types of histamine receptors (H1R, H2R, H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine plays a physiological role in the inner ear. Objective To analyse the presence of histamine receptors in the normal mouse inner ear. Methods CBA/J mice were used in this study. The localization of H1R, H2R, H3R, and H4R in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion, and endolymphatic sac, was studied by real-time PCR and immunohistochemistry. Results The mRNA for each receptor sub-type was detected in the inner ear. In the immunohistochemical study, the organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory epithelium, and endolymphatic sac cells showed an immunofluorescent reaction to all histamine receptors.
MeSH term(s)	Animals ; Ear, Inner/metabolism ; Immunohistochemistry ; Mice, Inbred CBA ; Real-Time Polymerase Chain Reaction ; Receptors, Histamine/metabolism
Chemical Substances	Receptors, Histamine
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.3109/00016489.2015.1136433
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Article ; Online: Localization of sirtuins in the mouse inner ear.

Takumida, Masaya / Takumida, Hiroshi / Anniko, Matti

Acta oto-laryngologica

2014 Volume 134, Issue 4, Page(s) 331–338

Abstract: Conclusion: It is suggested that SIRT1 and 3, and probably SIRT4 and 5, play an important role in the neuroprotection of the inner ear. SIRT2 may be related to neuroprotection and myelin sheath formation, while SIRT6 seems to have a significant role in ... ...

Abstract	Conclusion: It is suggested that SIRT1 and 3, and probably SIRT4 and 5, play an important role in the neuroprotection of the inner ear. SIRT2 may be related to neuroprotection and myelin sheath formation, while SIRT6 seems to have a significant role in maintaining the energy balance by metabolic regulation. Objective: To analyze the expression of sirtuins (SIRT1-7) in the normal mouse inner ear. Methods: CBA/J mice were used for this study. The localization of SIRT1-7 in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated using real-time PCR and immunohistochemistry. Results: We found high levels of mRNA of all seven sirtuins in the inner ear. In the immunohistochemical study, SIRT1-7 were abundant in many inner ear structures, i.e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, vestibular dark and transitional cells, and the endolymphatic sac.
MeSH term(s)	Animals ; Ear, Inner/cytology ; Ear, Inner/enzymology ; Gene Expression Regulation ; Immunohistochemistry ; Mice ; Mice, Inbred CBA ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Sirtuins/biosynthesis ; Sirtuins/genetics ; Tomography, Optical Coherence
Chemical Substances	RNA, Messenger ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.3109/00016489.2013.861928
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Article ; Online: Sustained coronavirus disease 2019-related organizing pneumonia successfully treated with corticosteroid.

Takumida, Hiroshi / Izumi, Shinyu / Sakamoto, Keita / Hashimoto, Masao / Ishii, Satoru / Suzuki, Manabu / Takasaki, Jin / Tanaka, Mariko / Igari, Toru / Hojo, Masayuki

Respiratory investigation

2021 Volume 59, Issue 3, Page(s) 377–381

Abstract: A 70-year-old Japanese man contracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and required oxygen to maintain oxygen saturation (>90%), 5 weeks after onset of coronavirus disease 2019 (COVID-19) symptoms. Transbronchial ... ...

Abstract	A 70-year-old Japanese man contracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and required oxygen to maintain oxygen saturation (>90%), 5 weeks after onset of coronavirus disease 2019 (COVID-19) symptoms. Transbronchial lung cryobiopsy revealed pathological features of organizing pneumonia with alveolar epithelial injury, and prednisolone administration led to alleviation of respiratory symptoms and recovery of respiratory function. This case report is the first to demonstrate the use of corticosteroids to successfully treat post-COVID-19 respiratory failure in a patient with biopsy-proven organizing pneumonia. We propose that steroid treatment be considered for patients with persistent respiratory dysfunction as COVID-19 pneumonia sequelae.
MeSH term(s)	Administration, Oral ; Aged ; Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/pathology ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Oxygen Inhalation Therapy ; Prednisolone/administration & dosage ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Biomarkers ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2021-01-21
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2020.12.005
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Article ; Online: Examination of micro-superficial lesions of up to 5 mm in size in the pharyngolaryngeal region.

Ueda, T / Yumii, K / Urabe, Y / Chikuie, N / Takumida, M / Taruya, T / Kono, T / Hamamoto, T / Hattori, M / Oka, S / Tanaka, S / Ishino, T / Takeno, S

The Journal of laryngology and otology

2022 Volume 137, Issue 7, Page(s) 749–756

Abstract: Objective: For low-grade intraepithelial neoplasia cases, pharyngolaryngeal lesions equal to or less than 5 mm in size do not generally progress to invasive carcinoma. However, micro-superficial lesions equal to or less than 5 mm that showed rapid ... ...

Abstract	Objective: For low-grade intraepithelial neoplasia cases, pharyngolaryngeal lesions equal to or less than 5 mm in size do not generally progress to invasive carcinoma. However, micro-superficial lesions equal to or less than 5 mm that showed rapid growth have been recently encountered. This study aimed to identify the characteristics of preferential progression of lesions equal to or less than 5 mm in size. Method: Gross findings, endoscopic findings and pathological results of 55 lesions measuring equal to or less than 5 mm in diameter were retrospectively reviewed to identify factors that distinguish squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions. Results: The overall sensitivity, specificity, accuracy, and positive and negative predictive value of background colouration and intrapapillary capillary loop pattern in differentiation of squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions were all 100 per cent. Conclusion: Diagnosis based on background colouration and the intrapapillary capillary loop pattern on narrow-band imaging facilitates the pathological examination of lesions measuring equal to or less than 5 mm.
MeSH term(s)	Humans ; Retrospective Studies ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Narrow Band Imaging/methods ; Predictive Value of Tests ; Carcinoma in Situ/diagnostic imaging ; Carcinoma in Situ/pathology
Language	English
Publishing date	2022-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215122001761
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Article: Functional morphology of the crista ampullaris: with special interests in sensory hairs and cupula: a review.

Takumida, M

Uchu Seibutsu Kagaku

2002 Volume 15, Issue 4, Page(s) 356–358

Abstract: The functional significance of the ciliary interconnections and cupula has been reviewed. The ciliary interconnecting systems are divided into 2 types, i.e. side links and tip links. The side links acts to maintain the regular distance between the cilia ... ...

Abstract	The functional significance of the ciliary interconnections and cupula has been reviewed. The ciliary interconnecting systems are divided into 2 types, i.e. side links and tip links. The side links acts to maintain the regular distance between the cilia thereby keeping the geometrical arrangement of the entire sensory hair bundle intact as well as to prevent close contact between neighbouring cilia. The tip links, stretching upwards from the tips of the shorter stereocilia to their taller neighbouring shafts, are actually involved in mechanoelectrical transduction. The cupula is composed of the cupula and subcupular meshwork. The subcupular meshwork consists of long branching filaments cross-bridged to one another. The cupula would function as a rigid plate and equally distribute the shear force of the cupula to all the ciliary bundles. The subcupular meshwork may play a role in the transmission of the shear strain force of the cupula to the ciliary bundle and may also exert an additional damping effect in order to prevent unwanted vibrations.
MeSH term(s)	Animals ; Cilia/drug effects ; Cilia/physiology ; Gentamicins/pharmacology ; Glycocalyx/physiology ; Guinea Pigs ; Hair Cells, Vestibular/drug effects ; Hair Cells, Vestibular/physiology ; Hair Cells, Vestibular/ultrastructure ; Microscopy, Electron, Scanning ; Semicircular Canals/physiology ; Semicircular Canals/ultrastructure ; Signal Transduction/physiology
Chemical Substances	Gentamicins
Language	English
Publishing date	2002-04-25
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2217379-1
ISSN	1349-967X ; 0914-9201
ISSN (online)	1349-967X
ISSN	0914-9201
DOI	10.2187/bss.15.356
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Article ; Online: Determining Invasion Depth in Superficial Pharyngeal Carcinoma by Transoral Ultrasonography.

Yumii, Kouhei / Ueda, Tsutomu / Urabe, Yuji / Fukuhara, Motomitsu / Chikuie, Nobuyuki / Taruya, Takayuki / Kono, Takashi / Hamamoto, Takao / Hattori, Minoru / Takumida, Masaya / Ishino, Takashi / Takeno, Sachio

The Laryngoscope

2022 Volume 133, Issue 9, Page(s) 2192–2197

Abstract: Objectives: To examine the clinical usefulness of transoral ultrasonography (US) in determining the invasion depth of superficial pharyngeal carcinoma (SPC). Determining the invasion depth of SPC is crucial for transoral surgery including determining ... ...

Abstract	Objectives: To examine the clinical usefulness of transoral ultrasonography (US) in determining the invasion depth of superficial pharyngeal carcinoma (SPC). Determining the invasion depth of SPC is crucial for transoral surgery including determining treatment strategy. This study aimed to examine the usefulness of transoral US in determining the invasion depth of SPC. Methods: Forty-six patients with 51 lesions who underwent both magnifying endoscopy with narrow-band imaging (ME-NBI) and transoral US were included. The primary outcomes were the sensitivity, specificity, positive (PPV), and negative predictive values (NPV) of ME-NBI and transoral US findings for pathological tumor depth in SPCs. Results: The accuracy (82.4%), sensitivity (85.2%), PPV (82.1%), and NPV (82.6%) rates of US for subepithelial propria (SEP) were higher than those of ME-NBI and macroscopic classification, indicating that transoral US is superior to ME-NBI in determining the invasion depth. All cases where the SEP was clearly invaded (SEP deep) could be diagnosed as SEP by transoral US. Conclusions: Transoral US may be useful in determining the invasion depth of SPCs. Level of evidence: 3 Laryngoscope, 133:2192-2197, 2023.
MeSH term(s)	Humans ; Retrospective Studies ; Neoplasm Invasiveness/pathology ; Endoscopy ; Pharyngeal Neoplasms/diagnostic imaging ; Pharyngeal Neoplasms/surgery ; Carcinoma, Squamous Cell/pathology ; Ultrasonography ; Narrow Band Imaging
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30483
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