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  1. Article ; Online: Efficacy and potential therapeutic mechanism of Weiwei decoction on Spasmolytic polypeptide-expressing metaplasia in Helicobacter pylori-infected and Atp4a-knockout mice.

    Hong, Xinxin / Li, Haiwen / Lin, Yandan / Luo, Liuru / Xu, Weijun / Kang, Jianyuan / Li, Jingwei / Huang, Bin / Xu, Yifei / Pan, Huafeng / Guo, Shaoju

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117062

    Abstract: ... when accompanied with an increase in transcripts associated with intestinal-type gastric cancer. Weiwei decoction ...

    Abstract Ethnopharmacological relevance: Spasmolytic polypeptide-expressing metaplasia (SPEM) is characterized by mucus cell morphologies at the base of gastric glands, which is considered advanced SPEM when accompanied with an increase in transcripts associated with intestinal-type gastric cancer. Weiwei decoction (WWD) was modified from "Si-Jun-Zi Tang," which has been used for thousands of years in China against gastric atrophy and metaplasia.
    Aim of the study: To investigate the effects and potential mechanisms of WWD against advanced SPEM.
    Materials and methods: Liquid chromatography-mass spectrometry was employed to analyze the constituents of WWD. Five-month-infected Helicobacter pylori (H. pylori) Sydney strain 1 C57BL/6J mice and 6-week-old ATPase H
    Results: WWD demonstrated beneficial effects on gastric mucosal pathology and mucus secretion. In H. pylori-infected mice, WWD effectively reduced the expression of GSII and inhibited the mRNA levels of key markers associated with advanced SPEM, including Clu, Cftr, Wfdc2, Dmbt1, and Gpx2. Similarly, in Atp4a
    Conclusion: WWD exerted protective effects against SPEM in H. pylori-infected and Atp4a
    MeSH term(s) Animals ; Mice ; Helicobacter pylori/genetics ; Peptides/pharmacology ; Peptides/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Mice, Knockout ; Mice, Inbred C57BL ; Gastric Mucosa/pathology ; Stomach Neoplasms/pathology ; Metaplasia/complications ; Metaplasia/metabolism ; Metaplasia/pathology ; RNA, Messenger/metabolism ; Helicobacter Infections/complications ; WAP Four-Disulfide Core Domain Protein 2/metabolism
    Chemical Substances spasmolytic polypeptide ; Peptides ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; RNA, Messenger ; Wfdc2 protein, mouse ; WAP Four-Disulfide Core Domain Protein 2
    Language English
    Publishing date 2023-08-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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  2. Article ; Online: The effect of pterygium on front and back corneal astigmatism and aberrations in natural-light and low-light conditions.

    Xu, Weiwei / Li, Xia

    BMC ophthalmology

    2024  Volume 24, Issue 1, Page(s) 7

    Abstract: Background: To investigate the effect of different sizes of pterygium on the front and back corneal topography, refractive changes and aberrations in natural-light and low-light conditions.: Methods: Sixty subjects with unilateral primary nasal ... ...

    Abstract Background: To investigate the effect of different sizes of pterygium on the front and back corneal topography, refractive changes and aberrations in natural-light and low-light conditions.
    Methods: Sixty subjects with unilateral primary nasal pterygium were enrolled in this study. All the patients' uncorrected, best spectacle-corrected visual acuity, corneal topographic aberration data in 3 mm and 7 mm areas were collected. The pterygium size was evaluated by the slit-lamp photography and Sirius Scheimpflug Analyzer.
    Results: The front topographic astigmatism values, corneal total aberrations, and higher-order aberrations in 3 mm and 7 mm areas were higher in the pterygium group than those in the control group. The pterygium horizontal length and thickness were moderately to strongly correlated with astigmatism and RMS of aberrations, while pterygium vertical length showed no or just mild correlation with the corneal astigmatism and aberrations. Compared to the readings in 3 mm area, the front and back corneal astigmatism and aberrations were larger in 7 mm area.
    Conclusions: Pterygium led to visual impairment by inducing astigmatism and aberrations. In low-light condition, the visual function worsened due to increased corneal astigmatism values and aberrations.
    MeSH term(s) Humans ; Pterygium/complications ; Pterygium/diagnosis ; Astigmatism/diagnosis ; Visual Acuity ; Cornea ; Corneal Topography ; Corneal Diseases
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-023-03270-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Biosynthesis and regulation of plant specialized metabolisms.

    Zhang, Weiwei / Xu, Feng / Kwon, Moonhyuk

    Frontiers in plant science

    2023  Volume 14, Page(s) 1319666

    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1319666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape.

    Zheng, Weiwei / Wang, Linchao / Geng, Shang / Xu, Tianjun

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 91

    Abstract: It is known that about 10 circular RNAs (circRNAs) can encode functional polypeptides in higher mammals. However, it is not clear whether the functional polypeptides that can be translated by circRNAs are only the products of the evolution of higher ... ...

    Abstract It is known that about 10 circular RNAs (circRNAs) can encode functional polypeptides in higher mammals. However, it is not clear whether the functional polypeptides that can be translated by circRNAs are only the products of the evolution of higher animals, or also widely exist in other lower organisms. In addition, it is also unclear whether the two ways of translating polypeptides using IRES and m
    MeSH term(s) Animals ; Humans ; RNA, Circular/genetics ; Peptides/genetics ; Mammals/genetics
    Chemical Substances RNA, Circular ; Peptides
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05148-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Effect and mechanisms of quercetin on the treatment of osteoarthritis: A preliminary pre-clinical study.

    Xu, Bin / Huang, Weiwei

    Asian journal of surgery

    2022  Volume 46, Issue 5, Page(s) 2132–2134

    MeSH term(s) Humans ; Quercetin/therapeutic use ; Osteoarthritis/drug therapy
    Chemical Substances Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2022-11-23
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.11.056
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  6. Article ; Online: Observation of the effect of predictive nursing intervention on the care of complications in patients with nephrotic syndrome.

    Xu, Yongjuan / Wang, Weiwei / Li, Mei

    Minerva gastroenterology

    2023  Volume 69, Issue 3, Page(s) 440–442

    MeSH term(s) Humans ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/nursing
    Language English
    Publishing date 2023-03-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062713-8
    ISSN 2724-5365
    ISSN (online) 2724-5365
    DOI 10.23736/S2724-5985.23.03365-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.51: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Subchorionic hematoma: Research status and pathogenesis (Review).

    Xu, Tiantian / Lun, Weiwei / He, Yuanfang

    Medicine international

    2024  Volume 4, Issue 2, Page(s) 10

    Abstract: Subchorionic hematoma (SCH) is a hematoma in which blood accumulates between the chorion and decidua basalis due to the separation of the chorion and decidua basalis. It is common in patients with threatened abortion in early pregnancy and is mainly ... ...

    Abstract Subchorionic hematoma (SCH) is a hematoma in which blood accumulates between the chorion and decidua basalis due to the separation of the chorion and decidua basalis. It is common in patients with threatened abortion in early pregnancy and is mainly detected by ultrasound. SCH mainly manifests as an hypoechoic or anechoic crescent-shaped fluid dark area on ultrasound images. Although there are numerous studies on SCH, its pathogenesis and etiology remain unclear, and its influence on pregnancy outcomes is also controversial; there are also no uniform clinical treatment guidelines. Current studies suggest that the occurrence of SCH may be related to several factors, such as abnormal coagulation function, autoimmune factors of pregnant women, assisted reproduction, drug use during pregnancy and reproductive tract infection; however, its exact etiology remains unclear. Some studies suggest that SCH is associated with adverse pregnancy outcomes such as miscarriage, preterm birth, preeclampsia and fetal growth restriction, although other studies have found that SCH does not increase the risk of adverse pregnancy outcomes. Therefore, the present review mainly discusses the pathogenesis, etiology and treatment of SCH in an aim to provide a reference for the clinical treatment of this condition in pregnant women.
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-1304
    ISSN (online) 2754-1304
    DOI 10.3892/mi.2024.134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Prediction model of death risk in patients with sepsis and screening of biomarkers for prognosis of patients with myocardial injury.

    Qian, Weiwei / Han, Cunqiao / Xie, Shenglong / Xu, Shuyun

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27209

    Abstract: This study aimed to create a robust prediction model for sepsis patient mortality and identify key biomarkers in those with myocardial injury. A retrospective analysis of 261 sepsis inpatients was conducted, with 44 deaths and 217 recoveries. Key factors ...

    Abstract This study aimed to create a robust prediction model for sepsis patient mortality and identify key biomarkers in those with myocardial injury. A retrospective analysis of 261 sepsis inpatients was conducted, with 44 deaths and 217 recoveries. Key factors were assessed via univariate and multivariate analyses, revealing myocardial injury, shock, and pulmonary infection as independent mortality risk factors. Using LASSO regression, a reliable prediction model was developed and internally validated. Additionally, procalcitonin (PCT) emerged as a sensitive biomarker for myocardial injury prediction in sepsis patients. In summary, this study highlights myocardial injury, shock, and pulmonary infection as independent risk factors for sepsis-related deaths. The LASSO-based prediction model effectively forecasts the prognosis of septic patients with myocardial injury, with PCT showing promise as a predictive biomarker.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fast algorithms for singular value decomposition and the inverse of nearly low-rank matrices.

    Xu, Chen / Xu, Weiwei / Jing, Kaili

    National science review

    2023  Volume 10, Issue 6, Page(s) nwad083

    Abstract: This perspective focuses on the fast algorithm design for singular value decomposition and inverse computation of nearly low-rank matrices that are potentially of big sizes. ...

    Abstract This perspective focuses on the fast algorithm design for singular value decomposition and inverse computation of nearly low-rank matrices that are potentially of big sizes.
    Language English
    Publishing date 2023-03-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 2745465-4
    ISSN 2053-714X ; 2053-714X
    ISSN (online) 2053-714X
    ISSN 2053-714X
    DOI 10.1093/nsr/nwad083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The communication of artificial intelligence and deep learning in computer tomography image recognition of epidemic pulmonary infectious diseases.

    Wang, Weiwei / Zhao, Xinjie / Jia, Yanshu / Xu, Jiali

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297578

    Abstract: The objectives are to improve the diagnostic efficiency and accuracy of epidemic pulmonary infectious diseases and to study the application of artificial intelligence (AI) in pulmonary infectious disease diagnosis and public health management. The ... ...

    Abstract The objectives are to improve the diagnostic efficiency and accuracy of epidemic pulmonary infectious diseases and to study the application of artificial intelligence (AI) in pulmonary infectious disease diagnosis and public health management. The computer tomography (CT) images of 200 patients with pulmonary infectious disease are collected and input into the AI-assisted diagnosis software based on the deep learning (DL) model, "UAI, pulmonary infectious disease intelligent auxiliary analysis system", for lesion detection. By analyzing the principles of convolutional neural networks (CNN) in deep learning (DL), the study selects the AlexNet model for the recognition and classification of pulmonary infection CT images. The software automatically detects the pneumonia lesions, marks them in batches, and calculates the lesion volume. The result shows that the CT manifestations of the patients are mainly involved in multiple lobes and density, the most common shadow is the ground-glass opacity. The detection rate of the manual method is 95.30%, the misdetection rate is 0.20% and missed diagnosis rate is 4.50%; the detection rate of the DL-based AI-assisted lesion method is 99.76%, the misdetection rate is 0.08%, and the missed diagnosis rate is 0.08%. Therefore, the proposed model can effectively identify pulmonary infectious disease lesions and provide relevant data information to objectively diagnose pulmonary infectious disease and manage public health.
    MeSH term(s) Humans ; Artificial Intelligence ; Deep Learning ; Tomography, X-Ray Computed/methods ; Pneumonia ; Computers ; Communicable Diseases ; Communication
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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