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Article ; Online: Synthesis of (+/-)-likonide B (smenochromene D) using a regioselective Claisen rearrangement, separation of the enantiomers and stereochemical assignment.

Bruder, Marjorie / Smith, Stephen J / Blake, Alexander J / Moody, Christopher J

2009 Volume 7, Issue 10, Page(s) 2127–2134

Abstract: ... smenochromene D and (+)-likonide B. ... A synthesis of the unusual ansa-bridged farnesyl hydroquinone derivative likonide B in racemic form ... is described. The natural product, also known as smenochromene D, was obtained from geranylacetone ...

Abstract	A synthesis of the unusual ansa-bridged farnesyl hydroquinone derivative likonide B in racemic form is described. The natural product, also known as smenochromene D, was obtained from geranylacetone by a route in which the key steps are a regioselective microwave-mediated Claisen rearrangement of an aryl propargyl ether to deliver the chromene ring, and macrocyclization via an intramolecular Mitsunobu reaction. Subsequent HPLC on a chiral stationary phase gave the pure (+)- and (-)-enantiomers, that were studied by CD spectroscopy, thereby shedding some light on the true stereochemical nature of the two natural products (-)-smenochromene D and (+)-likonide B.
MeSH term(s)	Biological Products/chemistry ; Hydroquinones/chemical synthesis ; Hydroquinones/chemistry ; Microwaves ; Molecular Structure ; Stereoisomerism
Chemical Substances	Biological Products ; Hydroquinones ; likonide B
Language	English
Publishing date	2009-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/b901358j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synthesis of (±)-Smenochromene D (Likonide B) Using a Regioselective Claisen Rearrangement

Bruder, Marjorie / Moody, Christopher J.

Synlett

2008 Volume 2008, Issue 04, Page(s) 575–577

Abstract: A synthesis of the unusual ansa farnesyl hydroquinone smenochromene D (likonide B) is described ...

Abstract	A synthesis of the unusual ansa farnesyl hydroquinone smenochromene D (likonide B) is described, in which the key steps are a regioselective microwave-mediated Claisen rearrangement of an aryl propargyl ether to deliver the chromene ring, and macrocyclisation via an intramolecular Mitsunobu reaction.
Keywords	natural products ; rearrangements ; chromenes
Language	English
Publishing date	2008-02-12
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/s-2008-1032090
Database	Thieme publisher's database

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Article ; Online: Synthesis of N-protected nortopsentins B and D

Christopher J. Moody / Jonathan R. A. Roffey

ARKIVOC, Vol 2000, Iss 3, Pp 393-

2000 Volume 401

Keywords	Organic chemistry ; QD241-441
Language	English
Publishing date	2000-08-01T00:00:00Z
Publisher	Arkat USA, Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Automated Deep Learning Segmentation of Cardiac Inflammatory FDG PET.

Poitrasson-Rivière, Alexis / Vanderver, Michael D / Hagio, Tomoe / Arida-Moody, Liliana / Moody, Jonathan B / Renaud, Jennifer M / Ficaro, Edward P / Murthy, Venkatesh L

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Fluorodeoxyglucose positron emission tomography (FDG PET) with glycolytic metabolism suppression plays a pivotal role in diagnosing cardiac sarcoidosis. Reorientation of images to match perfusion datasets is critical and myocardial ... ...

Abstract	Background: Fluorodeoxyglucose positron emission tomography (FDG PET) with glycolytic metabolism suppression plays a pivotal role in diagnosing cardiac sarcoidosis. Reorientation of images to match perfusion datasets is critical and myocardial segmentation enables consistent image scaling and quantification. However, both are challenging and labor intensive. We developed a 3D U-Net deep learning (DL) algorithm for automated myocardial segmentation in cardiac sarcoidosis FDG PET. Methods: The DL model was trained on 316 patients' FDG PET scans, and left ventricular contours derived from perfusion datasets. Qualitative analysis of clinical readability was performed to compare DL segmentation with the current automated method on a 50-patient test subset. Additionally, left ventricle displacement and angulation, as well as SUVmax sampling were compared to inter-user reproducibility results. Results: DL segmentation enhanced readability scores in over 90% of cases compared to the standard segmentation currently used in the software. DL segmentation performed similarly to a trained technologist, surpassing standard segmentation for left ventricle displacement and angulation, as well as correlation of SUVmax. Conclusion: The DL-based automated segmentation tool presents a marked improvement in the processing of cardiac sarcoidosis FDG PET, promising enhanced clinical workflow. This tool holds significant potential for accelerating clinical practice and improving consistency and quality. Further research with varied datasets is warranted to broaden its applicability.
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.31.24302113
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Article: Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System.

Yin, Xing / Harmancey, Romain / Frierson, Brion / Wu, Jean G / Moody, Melanie R / McPherson, David D / Huang, Shao-Ling

Pharmaceutics

2024 Volume 16, Issue 3

Abstract: ... labeled decoy oligodeoxynucleotide against nuclear factor kappa B (ELIP-NF-κB-FITC) were used ...

Abstract	Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic liposomes (ELIP) containing a fluorescein isothiocyanate-labeled decoy oligodeoxynucleotide against nuclear factor kappa B (ELIP-NF-κB-FITC) were used both in vitro on mouse neonatal ventricular myocytes and in vivo on rat hearts to assess gene delivery efficacy with or without ultrasound. In vitro analysis was then repeated with ELIP containing Cas9-sg-IL1RL1 (interleukin 1 receptor-like 1) RNA to determine the efficiency of gene knockdown. ELIP-NF-κB-FITC without ultrasound showed limited gene delivery in vitro and in vivo, but ultrasound combined with ELIP notably improved penetration into heart cells and tissues. When ELIP was used to deliver Cas9-sg-IL1RL1 RNA, gene editing was successful and enhanced by ultrasound. This innovative approach shows promise for heart disease gene therapy using CRISPR technology.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16030343
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Article: Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations.

Beutler, Bryce David / Moody, Alastair E / Thomas, Jerry Mathew / Sugar, Benjamin Phillip / Ulanja, Mark B / Antwi-Amoabeng, Daniel / Tsikitas, Lucas Anthony

World journal of radiology

2024 Volume 16, Issue 1, Page(s) 1–8

Abstract: Anti-N-methyl-D-aspartate receptor-associated encephalitis (NMDARE) is a rare immune-mediated ...

Abstract	Anti-N-methyl-D-aspartate receptor-associated encephalitis (NMDARE) is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic dysfunction. The mechanism of pathogenesis remains incompletely understood, but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic pathways. Young adults are most frequently affected; the median age at diagnosis is 21 years. There is a strong female predilection with a female sex predominance of 4:1. NMDARE often develops as a paraneoplastic process and is most commonly associated with ovarian teratoma. However, NMDARE has also been described in patients with small cell lung cancer, clear cell renal carcinoma, and other benign and malignant neoplasms. Diagnosis is based on correlation of the clinical presentation, electroencephalography, laboratory studies, and imaging. Computed tomography, positron emission tomography, and magnetic resonance imaging are essential to identify an underlying tumor, exclude clinicopathologic mimics, and predict the likelihood of long-term functional impairment. Nuclear imaging may be of value for prognostication and to assess the response to therapy. Treatment may involve high-dose corticosteroids, intravenous immunoglobulin, and plasma exchange. Herein, we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria, treatment regimens, and proposed pathogenetic mechanisms.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573705-3
ISSN	1949-8470
ISSN	1949-8470
DOI	10.4329/wjr.v16.i1.1
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Article ; Online: Anaesthesia and orphan disease: A patient with neuromyotonia undergoing single lung ventilation.

Moody, Alastair E / Beutler, Bryce D / Moody, Catriona E / Chang, Carina / Ulanja, Mark B / Gullapalli, Nageshwara / Moody, Eric J

European journal of anaesthesiology

2020 Volume 37, Issue 8, Page(s) 731–733

MeSH term(s)	Anesthesia, General/adverse effects ; Anesthesiology ; Humans ; Isaacs Syndrome ; One-Lung Ventilation ; Rare Diseases ; Respiration, Artificial
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000001233
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Article ; Online: Subtract Before You Add: Toward the Development of a De-Implementation Approach in School-Based Speech Sound Therapy.

Farquharson, Kelly / Cabbage, Kathryn L / Reed, Anne C / Moody, Mary Allison

Language, speech, and hearing services in schools

2023 Volume 54, Issue 4, Page(s) 1052–1065

Abstract: ... based survey research: (a) overreliance on speech sound norms for eligibility determinations, (b ... and (d) the use of only one treatment approach for all children with SSDs.: Conclusions: De ...

Abstract	Purpose: It is often difficult for school-based speech-language pathologists (SLPs) to prioritize implementing new practices for children with speech sound disorders (SSDs), given burgeoning caseloads and the myriad of other workload tasks. We propose that de-implementation science is equally as important as implementation science. De-implementation science is the recognition and identification of areas that are of "low-value and wasteful." Critically, the idea of de-implementation suggests that we first remove something from a clinician's workload before requesting that they learn and implement something new. Method: Situated within the Sustainability in Healthcare by Allocating Resources Effectively (SHARE) framework, we review de-implementation science and current speech sound therapy literature to understand the mechanisms behind continuous use of practices that are no longer supported by science or legislation. We use vignettes to highlight real-life examples that clinicians may be facing in school-based settings and to provide hypothetical solutions, resources, and/or next steps to these common challenges. Results: By focusing on Phase 1 of the SHARE framework, we identified four primary practices that can be de-implemented to make space for new evidence-based techniques and approaches. These four practices were determined based on an in-depth review of SLP-based survey research: (a) overreliance on speech sound norms for eligibility determinations, (b) the omission of phonological processing skills within evaluations, (c) homogeneity of service delivery factors, and (d) the use of only one treatment approach for all children with SSDs. Conclusions: De-implementation will take work and may lead to some difficult discussions. Implementing a framework, such as SHARE, can guide SLPs toward a reduction in workloads and improved outcomes for children with SSDs.
MeSH term(s)	Child ; Humans ; Phonetics ; Speech-Language Pathology/methods ; Speech Therapy/methods ; Communication Disorders ; Speech Sound Disorder/therapy ; Speech
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2067619-0
ISSN	1558-9129 ; 0161-1461
ISSN (online)	1558-9129
ISSN	0161-1461
DOI	10.1044/2023_LSHSS-22-00176
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Article ; Online: Innovations in HIV-1 Vaccine Design.

Jones, Letitia D / Moody, M Anthony / Thompson, Amelia B

Clinical therapeutics

2020 Volume 42, Issue 3, Page(s) 499–514

Abstract: Purpose: The field of HIV-1 vaccinology has evolved during the last 30 years from the first viral vector HIV gene insert constructs to vaccination regimens using a myriad of strategies. These strategies now include germline-targeting, lineage-based, and ...

Abstract	Purpose: The field of HIV-1 vaccinology has evolved during the last 30 years from the first viral vector HIV gene insert constructs to vaccination regimens using a myriad of strategies. These strategies now include germline-targeting, lineage-based, and structure-guided immunogen design. This narrative review outlines the historical context of HIV vaccinology and subsequently highlights the scientific discoveries during the last 6 years that promise to propel the field forward. Methods: We conducted a search of 2 electronic databases, PubMed and EMBASE, for experimental studies that involved new HIV immunogen designs between 2013 and 2019. During the title and abstract reviews, publications were excluded if they were written in language other than English and/or were a letter to the editor, a commentary, or a conference-only presentation. We then used ClinicalTrials.gov to identify completed and ongoing clinical trials using these strategies. Findings: The HIV vaccinology field has undergone periods of significant growth during the last 3 decades. Findings elucidated in preclinical studies have revealed the importance of the interaction between the cellular and humoral immune system. As a result, several new rationally designed vaccine strategies have been developed and explored in the last 6 years, including native-like envelope trimers, nanoparticle, and mRNA vaccine design strategies among others. Several of these strategies have shown enough promise in animal models to progress toward first-in-human Phase I clinical trials. Implications: Rapid developments in preclinical and early-phase clinical studies suggest that a tolerable and effective HIV vaccine may be on the horizon.
MeSH term(s)	AIDS Vaccines ; Animals ; Clinical Trials as Topic ; HIV Infections/immunology ; HIV Infections/prevention & control ; HIV Infections/virology ; Humans
Chemical Substances	AIDS Vaccines
Keywords	covid19
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	603113-4
ISSN	1879-114X ; 0149-2918
ISSN (online)	1879-114X
ISSN	0149-2918
DOI	10.1016/j.clinthera.2020.01.009
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Article ; Online: Shortages of antiseizure medications in Australia and the association with patient switching, and adherence in a community setting.

Welton, Jeremy / Stratton, Giles / Schoeninger, Brittany / Low, Min Hui / Moody, Anita / D'Souza, Wendyl

Epilepsy & behavior : E&B

2023 Volume 141, Page(s) 109145

Abstract: Purpose: To quantify sponsor-reported shortages of oral antiseizure medications in Australia, estimate the number of patients impacted, and the association between shortages and brand or formulation switching, and changes in adherence.: Methods: A ... ...

Abstract	Purpose: To quantify sponsor-reported shortages of oral antiseizure medications in Australia, estimate the number of patients impacted, and the association between shortages and brand or formulation switching, and changes in adherence. Methods: A retrospective cohort study of sponsor-reported shortages (defined as where the supply of a medicine will not or will not be likely to meet the demand over a 6-month period) of antiseizure medications reported to the Medicine Shortages Reports Database (Therapeutic Goods Administration, Australia); cross-referencing shortages to the IQVIA-NostraData Dispensing Data (LRx) database, a deidentified, population-level dataset collecting longitudinal dispensation data on individual patients from ∼75% of Australian community pharmacy scripts. Results: Ninety-seven sponsor-reported ASM shortages were identified between 2019 and 2020; of those, 90 (93%) were shortages of generic ASM brands. Of 1,247,787 patients dispensed ≥1 ASMs, 242,947 (19.5%) were impacted by shortages. Sponsor-reported shortages occurred more frequently before the COVID-19 pandemic versus during the pandemic, however, shortages were estimated to affect more patients during the pandemic than before the pandemic. An estimated 330,872 patient-level shortage events were observed, and 98.5% were associated with shortages of generic ASM brands. Shortages occurred at a rate of 41.06 shortages per 100 person-years in patients on generic ASM brands versus 0.83 shortages per 100 person-years in patients on originator ASM brands. In patients taking a formulation of levetiracetam affected by a shortage, 67.6% switched to a different levetiracetam brand or formulation during shortages compared with 46.6% in non-shortage periods. Conclusions: Approximately 20% of patients on ASMs were estimated to have been impacted by an ASM shortage in Australia. The rate of patient-level shortages was approximately 50 times higher for patients on generic ASM brands versus originator brands. Shortages of levetiracetam were associated with formulation and brand switching. Improved supply chain management amongst sponsors of generic ASMs is needed to maintain the continuity of supply in Australia.
MeSH term(s)	Humans ; Levetiracetam ; Pandemics ; Retrospective Studies ; Australia ; COVID-19 ; Pharmaceutical Preparations ; Drugs, Generic/therapeutic use ; Anticonvulsants/therapeutic use
Chemical Substances	Levetiracetam (44YRR34555) ; Pharmaceutical Preparations ; Drugs, Generic ; Anticonvulsants
Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2023.109145
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