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  1. Article: Glycosylation, ligand binding sites and antigenic variations between membrane glycoprotein of COVID-19 and related coronaviruses.

    Dawood, Ali A

    Vacunas

    2020  Volume 22, Issue 1, Page(s) 1–9

    Abstract: A new coronavirus strain has wreaked havoc on human lives so the WHO was declared as a pandemic since 20th March 2020. The Membrane glycoprotein MP spans the viral envelope and it has a highly conserved glycosylation sequence.: Aim: Our study goal was ...

    Abstract A new coronavirus strain has wreaked havoc on human lives so the WHO was declared as a pandemic since 20th March 2020. The Membrane glycoprotein MP spans the viral envelope and it has a highly conserved glycosylation sequence.
    Aim: Our study goal was to find out the N-glycosylation, ligand binding sites, and antigenic variations between COVID-19 and other associated viruses.
    Methods: We performed
    Results: We detected high similarity in sequence alignment for >89% between COVID-19 MP and other MP of CoVs. Prediction of N-glycosylation and cytotoxic T-cell epitopes, we identified precisely sites between SARS-CoV-2 MP and Pangolin CoV MP 100%. We also didn't obtain any similarity in ligand binding site residues between MP sequences. Our study didn't reveal any similarity in CTL epitope predication between coronaviruses under study using the CTLPred server.
    Conclusions: Our results exhibit that the membrane glycoprotein of SARS-CoV-2 is closely associated with predecessor SARS-CoVs specifically Pngolin CoV. Prediction of novel CTL epitopes may substantial scopes for the expansion of a peptide-based vaccine for the inhibition virion assembly of SARS-CoV-2.
    Keywords covid19
    Language English
    Publishing date 2020-10-03
    Publishing country Spain
    Document type Journal Article
    ISSN 1576-9887
    ISSN 1576-9887
    DOI 10.1016/j.vacun.2020.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mutated COVID-19, May Foretells Mankind in a Great Risk in the Future

    Dawood, Ali

    New microbes and new infections, In Press

    2020  

    Abstract: Corona virus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe of respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The highly prevalence of COVID-19 is due to the lack onset of symptoms. ... ...

    Abstract Corona virus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe of respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The highly prevalence of COVID-19 is due to the lack onset of symptoms. Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. Conduct the differences of whole genome sequence and some viral proteins to determine the gap and the change alternation of nucleotides and amino acids sequences. We evaluate 11 complete genome sequence of different coronavirus using BAST and MAFFT software. We also selected 7 types of structural proteins. We were conclude that COVID-19 might be created new mutations specifically in glycoproteins hence requires caution and complete preparation by health authorities.
    Keywords COVID-19 ; Zoonotic ; MERS ; SARS ; Outbreaks ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Evaluation of phytoremediation potential and resistance of Gladiolus grandiflora L. against cadmium stress.

    Bukhari, Syed Ali Qasim / Nawaz, Aamir / Dawood, Muhammad

    Environmental geochemistry and health

    2023  Volume 45, Issue 7, Page(s) 5231–5244

    Abstract: Although irrigation water is a fundamental need for plant growth, it is also a source of pollutants if contaminated with harmful materials like cadmium (Cd). Irrigation water possessing abundant Cd causes damage to soil, plants, animals and ultimately ... ...

    Abstract Although irrigation water is a fundamental need for plant growth, it is also a source of pollutants if contaminated with harmful materials like cadmium (Cd). Irrigation water possessing abundant Cd causes damage to soil, plants, animals and ultimately human beings through the food chain. A pot experiment was conducted to evaluate the gladiolus (Gladiolus grandiflora L.) potential of Cd accumulation and the capability of the plant to be an economically beneficial choice in presence of high Cd irrigation water supply. Artificially prepared four levels of Cd irrigation water were applied to the plants viz., 30, 60, 90 and 120 mg L
    MeSH term(s) Humans ; Cadmium/toxicity ; Cadmium/analysis ; Biodegradation, Environmental ; Soil Pollutants/toxicity ; Soil Pollutants/analysis ; Water ; Soil ; Plant Roots/chemistry
    Chemical Substances Cadmium (00BH33GNGH) ; Soil Pollutants ; Water (059QF0KO0R) ; Soil
    Language English
    Publishing date 2023-04-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-023-01579-8
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  5. Article: Mutated COVID-19, May Foretells Mankind in a Great Risk in the Future

    Dawood, Ali A

    New Microbes New Infect

    Abstract: Corona virus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe of respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The highly prevalence of COVID-19 is due to the lack onset of symptoms. ... ...

    Abstract Corona virus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe of respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The highly prevalence of COVID-19 is due to the lack onset of symptoms. Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. Conduct the differences of whole genome sequence and some viral proteins to determine the gap and the change alternation of nucleotides and amino acids sequences. We evaluate 11 complete genome sequence of different coronavirus using BAST and MAFFT software. We also selected 7 types of structural proteins. We were conclude that COVID-19 might be created new mutations specifically in glycoproteins hence requires caution and complete preparation by health authorities.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #87552
    Database COVID19

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  6. Article ; Online: Transmission of SARS CoV-2 virus through the ocular mucosa worth taking precautions

    Dawood, Ali A

    Vacunas ; ISSN 1576-9887

    2020  

    Keywords Immunology ; Infectious Diseases ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.vacun.2020.09.003
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Expression profile of serum LncRNAs

    Ali, Marwa A / Shaker, Olfat G / Gomaa Ali, El Shimaa / Ezzat, Eman M / Khalifa, Abeer A / Hassan, Essam A / Habib, Marwa A / Ahmed, Heba Mostafa / Dawood, Asmaa F A / Mohamed, Esam Ali

    Non-coding RNA research

    2024  Volume 9, Issue 2, Page(s) 318–329

    Abstract: Background: Ulcerative colitis (UC) has emerged as an accelerated-incidence chronic condition. UC has been identified as a precancerous lesion for colorectal cancer. Up-to-date genomic research revealed the value of many noncoding RNAs (ncRNAs) in UC ... ...

    Abstract Background: Ulcerative colitis (UC) has emerged as an accelerated-incidence chronic condition. UC has been identified as a precancerous lesion for colorectal cancer. Up-to-date genomic research revealed the value of many noncoding RNAs (ncRNAs) in UC pathogenesis, diagnosis, and prognosis.
    Aim: The present study was aimed at measuring both
    Patients and methods: Sixty-six UC patients and 80 healthy individuals participated in this study, the serum fold changes of
    Results: The current study findings include overexpressed lncRNAs
    Conclusion: MALAT-1
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2024.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pneumococcal Disease: Global Disease Prevention Strategies with a Focus on the Challenges in Iraq.

    Al-Jumaili, Ali / Dawood, Haider N / Ikram, Delan / Al-Jabban, Ali

    International journal of general medicine

    2023  Volume 16, Page(s) 2095–2110

    Abstract: Pneumococcal disease is a global public health concern that significantly contributes to clinical disease burden and economic burden. Patients frequently afflicted are young children and older adults, as well as the immunocompromised population. ... ...

    Abstract Pneumococcal disease is a global public health concern that significantly contributes to clinical disease burden and economic burden. Patients frequently afflicted are young children and older adults, as well as the immunocompromised population. Immunization is the most effective public health strategy to combat pneumococcal disease and several vaccine formulations have been developed in this regard. Although vaccines have had a significant global impact in reducing pneumococcal disease, there are several barriers to its success in Iraq. The war and conflict situation, increasing economic crises and poverty, poor vaccine accessibility in the public sector, and high vaccine costs are a few of the major obstacles that impede a successful immunization program. The last reported third dose pneumococcal conjugate vaccine coverage for Iraq was 37% in 2019, which is expected to reduce even further owing to the COVID-19 pandemic. Thus, strategies and policies to improve pneumococcal vaccine availability and coverage need to be strengthened to achieve maximum benefits of immunization. In the current review, we provide an overview of the existing knowledge on pneumococcal disease-prevention strategies across the globe. The main aim of this manuscript is to discuss the current status and challenges of pneumococcal vaccination in Iraq as well as the strategies to prevent pneumococcal infections.
    Language English
    Publishing date 2023-05-29
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S409476
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  9. Article: A rare case report of orchiopexy and hysterectomy in an Afghan boy with persistent Müllerian duct syndrome.

    Hossaini, Dawood / Wahdat, Mohammad Mahdi / Aklaqi, Ali / Haidary, Murtaza

    International journal of surgery case reports

    2024  Volume 115, Page(s) 109235

    Abstract: Introduction: Persistent Müllerian duct syndrome (PMDS), a rare genetic aberration, is characterized by the presence of Müllerian duct (MD) features in males. PMDS is usually caused by a defect in the Müllerian inhibitory system and is discovered during ...

    Abstract Introduction: Persistent Müllerian duct syndrome (PMDS), a rare genetic aberration, is characterized by the presence of Müllerian duct (MD) features in males. PMDS is usually caused by a defect in the Müllerian inhibitory system and is discovered during surgical interventions.
    Case report: We present the case of a 14-year-old Afghan boy with severe abdominal pain who was initially diagnosed with bilateral undescended testicles and abdominal complex cysts. He was supposed to undergo a cystectomy and orchiopexy surgery. During the surgical intervention, an unexpected finding was made whereby fibrotic-like ovaries, fallopian tubes, and a segment of the uterus were identified, ultimately leading to the diagnosis of PMDS. The MD was carefully removed, and the testicles were delicately repositioned during an orchiopexy procedure.
    Discussion: In our case, the patient exhibited bilateral undescended testicles along with fibrotic-like ovaries, fallopian tubes, and a portion of the uterus, representing the presence of the female type of PMDS. To safeguard fertility, orchidopexy is recommended for pediatric patients. Conversely, in the older age group, orchidectomy is advised as a precautionary measure against the heightened susceptibility to testicular carcinoma.
    Conclusion: PMDS can be associated with an undescended testicle and abdominal pain. Hence, it is crucial to thoroughly evaluate patients who have undescended testes for the presence of PMDS, and surgeons must maintain a heightened sense of awareness for PMDS while exploring individuals who present with bilateral undescended testes, as exemplified in our case.
    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Emerging pneumococcal serotypes in Iraq: scope for improved vaccine development.

    Dawood, Haider N / Al-Jumaili, Ali H / Radhi, Ahmed H / Ikram, Delan / Al-Jabban, Ali

    F1000Research

    2023  Volume 12, Page(s) 435

    Abstract: Pneumococcal disease is a global public health concern as it affects the young, aged and the immunocompromised. The development of pneumococcal vaccines and their incorporation in the immunization programs has helped to reduce the global burden of ... ...

    Abstract Pneumococcal disease is a global public health concern as it affects the young, aged and the immunocompromised. The development of pneumococcal vaccines and their incorporation in the immunization programs has helped to reduce the global burden of disease. However, serotype replacement and the emergence of non-vaccine serotypes as well as the persistence of a few vaccine serotypes underscores the need for development of new and effective vaccines against such pneumococcal serotypes. In the Middle East, places of religious mass gatherings are a hotspot for disease transmission in addition to the global risk factors. Therefore, the periodic surveillance of pneumococcal serotypes circulating in the region to determine the effectiveness of existing prevention strategies and develop improved vaccines is warranted. Currently, there is a lack of serotype prevalence data for Iraq due to inadequate surveillance in the region. Thus, this review aims to determine the pneumococcal serotypes circulating in Iraq which may help in the development and introduction of improved pneumococcal vaccines in the country.
    MeSH term(s) Humans ; Aged ; Serogroup ; Streptococcus pneumoniae ; Iraq/epidemiology ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/therapeutic use
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.132781.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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