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  1. Article: Editorial: Does the golgi complex enable oncogenesis?

    Colanzi, Antonino / Parashuraman, Setharaman / Reis, Celso A / Ungar, Daniel

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 1000946

    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1000946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Glycans: Masters of immunity, from cancers to inflammatory disease.

    Beatson, Richard / Läubli, Heinz / Pearce, Oliver M T / Reis, Celso A

    Frontiers in immunology

    2022  Volume 13, Page(s) 1002679

    MeSH term(s) Humans ; Neoplasms ; Polysaccharides
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1002679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Insights on ErbB glycosylation - contributions to precision oncology.

    Duarte, Henrique O / Reis, Celso A / Gomes, Joana

    Trends in cancer

    2022  Volume 8, Issue 6, Page(s) 448–455

    Abstract: Although the ErbB receptors remain incontrovertible drivers of human neoplastic transformation, the clinical performance of ErbB-directed therapeutics is significantly undermined by the emergence of molecular resistance. The ErbB extracellular region ... ...

    Abstract Although the ErbB receptors remain incontrovertible drivers of human neoplastic transformation, the clinical performance of ErbB-directed therapeutics is significantly undermined by the emergence of molecular resistance. The ErbB extracellular region undergoes extensive post-translational glycosylation, which crucially impacts receptor structure, functionality, and therapeutic response, thereby hindering efforts towards the successful translation of such molecular insights into the clinical setting. The unraveling of the ErbB site-specific glycome will allow for the design of more efficient ErbB-directed therapeutic strategies capable of circumventing molecular resistance, the establishment of novel prognostic and predictive clinical biomarkers supporting improved patient stratification, and the rational guidance of therapeutic decisions.
    MeSH term(s) ErbB Receptors/metabolism ; Glycosylation ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Precision Medicine ; Prognosis
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-03-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial

    Antonino Colanzi / Setharaman Parashuraman / Celso A. Reis / Daniel Ungar

    Frontiers in Cell and Developmental Biology, Vol

    Does the golgi complex enable oncogenesis?

    2022  Volume 10

    Keywords golgi apparatus glycosylation ; golgi structure ; cancer ; mitosis ; signaling ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Adhesion of

    Matos, Rita / Amorim, Irina / Magalhães, Ana / Haesebrouck, Freddy / Gärtner, Fátima / Reis, Celso A

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 656439

    Abstract: ... ...

    Abstract Helicobacter
    Language English
    Publishing date 2021-05-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.656439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of O-glycosylation in human disease.

    Magalhães, Ana / Duarte, Henrique O / Reis, Celso A

    Molecular aspects of medicine

    2021  Volume 79, Page(s) 100964

    Abstract: O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular ... ...

    Abstract O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.
    MeSH term(s) Glycosylation ; Humans ; Neoplasms/genetics ; Polysaccharides ; Protein Processing, Post-Translational
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2021.100964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression.

    Marques, Catarina / Reis, Celso A / Vivès, Romain R / Magalhães, Ana

    Frontiers in oncology

    2021  Volume 11, Page(s) 778752

    Abstract: Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix (ECM) maestros involved in the orchestration of multiple cellular events in physiology and pathology. These glycoconjugates bind to various bioactive ... ...

    Abstract Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix (ECM) maestros involved in the orchestration of multiple cellular events in physiology and pathology. These glycoconjugates bind to various bioactive proteins
    Language English
    Publishing date 2021-11-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.778752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Phenylethyl Isothiocyanate: A Bioactive Agent for Gastrointestinal Health.

    Coscueta, Ezequiel R / Sousa, Ana Sofia / Reis, Celso A / Pintado, Maria Manuela

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 3

    Abstract: The incidence of gastrointestinal pathologies (cancer in particular) has increased progressively, with considerable morbidity and mortality, and a high economic impact on the healthcare system. The dietary intake of natural phytochemicals with certain ... ...

    Abstract The incidence of gastrointestinal pathologies (cancer in particular) has increased progressively, with considerable morbidity and mortality, and a high economic impact on the healthcare system. The dietary intake of natural phytochemicals with certain bioactive properties has shown therapeutic and preventive effects on these pathologies. This includes the cruciferous vegetable derivative phenylethyl isothiocyanate (PEITC), a bioactive compound present in some vegetables, such as watercress. Notably, PEITC has antioxidant, anti-inflammatory, bactericidal, and anticarcinogenic properties. This review summarized the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discussed the safe and recommended dose of PEITC. In addition, we established a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural molecule for industrial use. With PEITC, there is great potential to develop a viable strategy for preventing cancer and other associated diseases of the gastrointestinal tract. However, this topic still needs more scientific studies to help develop new PEITC products for the nutraceutical, pharmaceutical, or food industries.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Cell Line, Tumor ; Dietary Supplements ; Gastrointestinal Tract/drug effects ; Humans ; Isothiocyanates/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Isothiocyanates ; phenethyl isothiocyanate (6U7TFK75KV)
    Language English
    Publishing date 2022-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27030794
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: Crucial Role of Oncogenic

    Ferreira, Anabela / Pereira, Flávia / Reis, Celso / Oliveira, Maria José / Sousa, Maria João / Preto, Ana

    Cells

    2022  Volume 11, Issue 14

    Abstract: KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells, ...

    Abstract KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells,
    MeSH term(s) Apoptosis/genetics ; Autophagy/genetics ; Cell Line, Tumor ; Mutation/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; TNF-Related Apoptosis-Inducing Ligand/genetics ; TNF-Related Apoptosis-Inducing Ligand/pharmacology
    Chemical Substances TNF-Related Apoptosis-Inducing Ligand ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11142183
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  10. Article ; Online: Glycosylation is a key in SARS-CoV-2 infection.

    Reis, Celso A / Tauber, Rudolf / Blanchard, Véronique

    Journal of molecular medicine (Berlin, Germany)

    2021  Volume 99, Issue 8, Page(s) 1023–1031

    Abstract: SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how ... ...

    Abstract SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how glycosylation of both SARS-CoV-2 and target cells crucially impacts SARS-CoV-2 infection at different levels: (1) virus binding and entry to host cells, with glycosaminoglycans of host cells acting as a necessary co-factor for SARS-CoV-2 infection by interacting with the receptor-binding domain of the SARS-CoV-2 spike glycoprotein, (2) innate and adaptive immune response where glycosylation plays both a protective role and contributes to immune evasion by masking of viral polypeptide epitopes and may add to the cytokine cascade via non-fucosylated IgG, and (3) therapy and vaccination where a monoclonal antibody-neutralizing SARS-CoV-2 was shown to interact also with a distinct glycan epitope on the SARS-CoV-2 spike protein. These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing.
    MeSH term(s) Adaptive Immunity ; Animals ; Blood Group Antigens/immunology ; Blood Group Antigens/metabolism ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/therapy ; Exocytosis ; Glycosylation ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization ; Virus Replication
    Chemical Substances Blood Group Antigens ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-05-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-021-02092-0
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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