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  1. AU=Paulson J C
  2. AU="Saif, Tahir"
  3. AU=Alam Sabiha AU=Alam Sabiha
  4. AU="Braniff, Julia"
  5. AU="Kasim, Sazzli"
  6. AU=Brown Samuel M
  7. AU="Daubenberger, Claudia A."
  8. AU="Esteban, L"
  9. AU=Tyrka Audrey R.
  10. AU="Álvarez-Valenzuela, Francisco D"
  11. AU="Akrofi, M.M."
  12. AU="Torres, Daiana Rodrigues"
  13. AU="Bercovici, Nicholas"
  14. AU="Di Maio, Ginevra"
  15. AU="Indelicarto, Matthew"
  16. AU="Ma, Yan"
  17. AU="Ngan, CDR Kelly"
  18. AU="Arzamendi, Dabit"
  19. AU="Rezende, Carlos Eduardo Borges"
  20. AU="Brunvand, E."
  21. AU="Gateno, Jaime"

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  1. Artikel ; Online: Individual- and Community-Level Predictors of Hospital-at-Home Outcomes.

    Williams, Cynthia / Paulson, Nels / Sweat, Jeffrey / Rutledge, Rachel / Paulson, Margaret R / Maniaci, Michael / Burger, Charles D

    Population health management

    2024  

    Abstract: Advanced Care at Home is a Mayo Clinic hospital-at-home (HaH) program that provides hospital-level care for patients. The study examines patient- and community-level factors that influence health outcomes. The authors performed a retrospective study ... ...

    Abstract Advanced Care at Home is a Mayo Clinic hospital-at-home (HaH) program that provides hospital-level care for patients. The study examines patient- and community-level factors that influence health outcomes. The authors performed a retrospective study using patient data from July 2020 to December 2022. The study includes 3 Mayo Clinic centers and community-level data from the Agency for Healthcare Research and Quality. The authors conducted binary logistic regression analyses to examine the relationship among the independent variables (patient- and community-level characteristics) and dependent variables (30-day readmission, mortality, and escalation of care back to the brick-and-mortar hospital). The study examined 1433 patients; 53% were men, 90.58% were White, and 68.2% were married. The mortality rate was 2.8%, 30-day readmission was 11.4%, and escalation back to brick-and-mortar hospitals was 8.7%. At the patient level, older age and male gender were significant predictors of 30-day mortality (
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2454546-6
    ISSN 1942-7905 ; 1942-7891
    ISSN (online) 1942-7905
    ISSN 1942-7891
    DOI 10.1089/pop.2023.0297
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  2. Artikel ; Online: Adaptation of influenza viruses to human airway receptors.

    Thompson, Andrew J / Paulson, James C

    The Journal of biological chemistry

    2020  Band 296, Seite(n) 100017

    Abstract: Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction ... ...

    Abstract Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses. IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential. One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), which recognizes sialic-acid-containing glycans on host cells. HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal). In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors and thus require adaptive mutations to bind human-type receptors. Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic. This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources. In this review, we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.
    Mesh-Begriff(e) Adaptation, Physiological ; Animals ; Binding Sites ; Biological Coevolution ; Birds/virology ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Humans ; Influenza A virus/chemistry ; Influenza A virus/genetics ; Influenza A virus/metabolism ; Influenza in Birds/epidemiology ; Influenza in Birds/transmission ; Influenza in Birds/virology ; Influenza, Human/epidemiology ; Influenza, Human/transmission ; Influenza, Human/virology ; Models, Molecular ; Pandemics ; Polysaccharides/chemistry ; Polysaccharides/metabolism ; Protein Binding ; Receptors, Virus/chemistry ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; Respiratory System/virology ; Sialic Acids/chemistry ; Sialic Acids/metabolism ; Species Specificity
    Chemische Substanzen Hemagglutinin Glycoproteins, Influenza Virus ; Polysaccharides ; Receptors, Virus ; Sialic Acids
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.REV120.013309
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Robust quantification of the burst of OH radicals generated by ambient particles in nascent cloud droplets using a direct-to-reagent approach.

    Taghvaee, Sina / Shen, Jiaqi / Banach, Catherine / La, Chris / Campbell, Steven J / Paulson, Suzanne E

    The Science of the total environment

    2023  Band 900, Seite(n) 165736

    Abstract: Reactive oxygen species (ROS) play a central role in chemistry in cloud water, as well as in other aqueous phases such as lung fluid and in wastewater treatment. Recently, work simulating nascent cloud droplets showed that aerosol particles produce a ... ...

    Abstract Reactive oxygen species (ROS) play a central role in chemistry in cloud water, as well as in other aqueous phases such as lung fluid and in wastewater treatment. Recently, work simulating nascent cloud droplets showed that aerosol particles produce a large burst of OH radicals when they first take up water. This activity stops abruptly, within two minutes. The source of the OH radicals is not well understood, but it likely includes the aqueous phase chemistry of ROS and/or organic hydroperoxides and redox active metals such as iron and copper. ROS and their precursors are in general highly reactive and labile, and thus may not survive during traditional sampling methods, which typically involve multi-hour collection on a filter or direct sampling into water or another collection liquid. Further, these species may further decay during storage. Here, we develop a technique to grow aerosol particles into small droplets and capture the droplets directly into a vial containing the terephthalate probe in water, which immediately scavenges OH radicals produced by aerosol particles. The method uses a Liquid Spot Sampler. Extensive characterization of the approach reveals that the collection liquid picks up substantial OH/OH precursors from the gas phase. This issue is effectively addressed by adding an activated carbon denuder. We then compared OH formation measured with the direct-to-reagent approach vs. filter collection. We find that after a modest correction for OH formed in the collection liquid, the samples collected into the reagent produce about six times those collected on filters, for both PM
    Sprache Englisch
    Erscheinungsdatum 2023-07-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165736
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  4. Artikel ; Online: If you build it, they may not come: Understanding factors influencing use of a community resource referral technology.

    Fichtenberg, Caroline / Cartier, Yuri / Burnett, Jessica / Ricks-Stephen, Coiel / Paulson, Gregory

    Health services research

    2023  Band 59 Suppl 1, Seite(n) e14234

    Abstract: Objective: Identify factors affecting the use of a community resource referral platform among local community-based organizations (CBOs) and test strategies to increase platform use.: Data sources and study setting: Data sources included platform ... ...

    Abstract Objective: Identify factors affecting the use of a community resource referral platform among local community-based organizations (CBOs) and test strategies to increase platform use.
    Data sources and study setting: Data sources included platform usage data and semi-structured interviews. The study took place in a small city in the Northeastern United States from 2020 to 2022.
    Study design: We analyzed platform data and conducted interviews with local organizations and organizations in other communities to understand barriers to CBOs' use of the referral platform and identify strategies that might increase use. We then tested 4 strategies and assessed impacts via time trend analysis of platform usage and qualitative interviews.
    Data collection/extraction methods: Platform usage data were obtained from the platform. Semi-structured interviews were conducted with staff and leaders of 36 local CBOs and 9 external organizations.
    Principal findings: Four years after launch, platform use remained relatively low. None of the tested strategies (data insight reports, a referral hub, tailored training, and a communication campaign) noticeably increased platform use. The main barrier to the use of the platform was the lack of perceived usefulness, mostly because existing processes for identifying resources and referring clients worked well enough and because many organizations were already required to use a client management or referral tool. Additional barriers included the lack of comfort with and, in some cases, active dislike of e-referrals, and lack of comfort with technology tools overall. Organizations that were most likely to find the platform useful and to use it were those that provided referrals for a wide range of needs and whose staff were not already familiar with local resources.
    Conclusions: Organizations seeking to implement referral platforms should not assume that local CBOs will automatically take up these platforms. For these platforms to succeed, much more attention needs to be paid to ensuring the platforms provide value to the CBOs they seek to engage.
    Mesh-Begriff(e) Humans ; Community Resources ; Referral and Consultation ; New England
    Sprache Englisch
    Erscheinungsdatum 2023-09-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 410435-3
    ISSN 1475-6773 ; 0017-9124
    ISSN (online) 1475-6773
    ISSN 0017-9124
    DOI 10.1111/1475-6773.14234
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  5. Artikel: Adaptation of Influenza Viruses to Human Airway Receptors

    Thompson, Andrew J / Paulson, James C

    J. biol. chem

    Abstract: Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction ... ...

    Abstract Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses. IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential. One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), that recognizes sialic acid-containing glycans on host cells. HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal). In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors, and thus require adaptive mutations to bind human-type receptors. Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic. This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources. In this review we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #910220
    Datenquelle COVID19

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  6. Artikel ; Online: Evaluating the economic burden of acute myeloid leukemia in Canada.

    Lachaine, Jean / Beauchemin, Catherine / Dodat, Fatéma / Au, Yunghan / Evans, William K / Leber, Brian / Paulson, Kristjan / Schuh, Andre / Storring, John

    Acta haematologica

    2024  

    Abstract: Background Acute myeloid leukemia (AML) represents a significant burden for patients and their families, and to the healthcare system. This study estimated the total cost of illness associated with newly diagnosed AML patients in Canada. Methods The ... ...

    Abstract Background Acute myeloid leukemia (AML) represents a significant burden for patients and their families, and to the healthcare system. This study estimated the total cost of illness associated with newly diagnosed AML patients in Canada. Methods The economic burden of AML was estimated using an incidence-based model, analyzing different types of AML cases in Canada. Direct and indirect costs were calculated using scientific literature and Canadian clinical experts' inputs. Patients were categorized depending on their eligibility for intensive chemotherapy (fit and unfit patients) as well as according to age and cytogenetic markers. Results The total average cost of AML per patient is estimated to be $178,073 with a cost of $210,983 and $145,163 for fit and unfit patients, respectively. The costs related to treatment represent half of the total average cost (52%), followed by hematopoietic stem cell transplant (23%), best supportive care (16%), productivity loss (6%) and wastage (4%) Conclusions For patients with AML, the costs associated with fit patients are higher than unfit patients. Hospitalization and best supportive care costs are key cost drivers for the total costs of fit and unfit patients, respectively. This study highlights that AML is associated with a significant economic burden in Canada.
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000537725
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  7. Artikel ; Konferenzbeitrag ; Online: REGULATION OF TERMINAL GLYCOSYLATION

    Svensson, Eric C. / Lee, Eryn Ujita / Livingston, Brian / Wen, Xiao-Hong / Weinstein, Jasminder / Paulson, James C.

    2024  

    Abstract: Mammalian cell lines used for production of recombinant glycoproteins elaborate terminal glycosylation structures on N-linked and O-linked carbohydrate groupsthat are determined by the glycosyltransferases expressed by these cells. As many as twelve ... ...

    Abstract Mammalian cell lines used for production of recombinant glycoproteins elaborate terminal glycosylation structures on N-linked and O-linked carbohydrate groupsthat are determined by the glycosyltransferases expressed by these cells. As many as twelve glycosyltransferase cDNAs have now been cloned by a variety of strategies (1). By expressing these glycosyltransferase cDNAs incells not normally expressing them, it is now possible to alter the cellular glycosylation machinery to produce new terminal glycosylation sequences (2,3). This principle was demonstrated by expressing the rat B-galactoside 02,6 sialyltransferase (a2,6ST) cDNA in CHOcells, which are known notto express the product of this sialyltransferase. After selection for stable expression, these cells were shown to produce Nlinked carbohydrate groups with terminal 02,6 linked sialic acid, demonstrating an altered glycosylation machinery (2).
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Verlag GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
    Erscheinungsland de
    Dokumenttyp Artikel ; Konferenzbeitrag ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Rapid auditory processing of puretones is associated with basic components of language in individuals with autism spectrum disorders.

    Demopoulos, Carly / Kopald, Brandon E / Bangera, Nitin / Paulson, Kim / David Lewine, Jeffrey

    Brain and language

    2023  Band 238, Seite(n) 105229

    Abstract: The goal of this study was to identify the specific domains of language that may be affected by deficits in rapid auditory processing in individuals with ASD. Auditory evoked fields were collected from 63 children diagnosed with ASD in order to evaluate ... ...

    Abstract The goal of this study was to identify the specific domains of language that may be affected by deficits in rapid auditory processing in individuals with ASD. Auditory evoked fields were collected from 63 children diagnosed with ASD in order to evaluate processing of puretone sounds presented in rapid succession. Measures of language and its components were assessed via standardized clinical tools to quantify expressive and receptive language, vocabulary, articulation, and phonological processing abilities. Rapid processing was significantly and bilaterally associated with phonological awareness, vocabulary, and articulation. Phonological processing was found to mediate the relationship between rapid processing and language. M100 response latency was not significantly associated with any language measures. Results suggest that rapid processing deficits may impact the basic components of language such as phonological processing, and the downstream effect of this impact may in turn impact overall language development.
    Mesh-Begriff(e) Child ; Humans ; Autism Spectrum Disorder ; Acoustic Stimulation/methods ; Auditory Perception/physiology ; Vocabulary ; Sound
    Sprache Englisch
    Erscheinungsdatum 2023-02-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 7448-2
    ISSN 1090-2155 ; 0093-934X
    ISSN (online) 1090-2155
    ISSN 0093-934X
    DOI 10.1016/j.bandl.2023.105229
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  9. Artikel ; Online: Consistency of endometrial receptivity array and histologic dating of spatially distinct endometrial samplings: a prospective, blinded study.

    Place, Trenton L / Agarwal, Ravi / Najafzadeh, Parisa / Walia, Saloni / McGinnis, Lynda K / Kohli, Priya / Felix, Juan C / Paulson, Richard J

    F&S reports

    2023  Band 4, Heft 4, Seite(n) 375–379

    Abstract: Objective: To compare the consistency of endometrial receptivity array (ERA) and histologic dating among 3 spatially distinct endometrial samples obtained during a cycle of exogenous estrogen and progesterone.: Design: Prospective blinded study.: ... ...

    Abstract Objective: To compare the consistency of endometrial receptivity array (ERA) and histologic dating among 3 spatially distinct endometrial samples obtained during a cycle of exogenous estrogen and progesterone.
    Design: Prospective blinded study.
    Setting: University practice.
    Patients: Twelve patients undergoing a mock frozen embryo transfer cycle.
    Intervention: Endometrial biopsy was performed in a manner that provided a spatially organized endometrial specimen, corresponding to the fundus, middle, and lower segment. Each of these 3 sections was further divided into immediately adjacent specimens for ERA and histology.
    Main outcome measure: Consistency of the ERA and histology results among fundal, mid, and lower endometrial biopsy specimens.
    Results: The ERA showed variability in outcome among different patients but dated all specimens originating from the same patient identically. Histologic dating showed variability between patients as well as between different locations within the uterus. When comparing average dating results for each patient, we saw a positive correlation between histologic and ERA dating (Spearman Rho = 0.45); however, this did not reach statistical significance. The ERA results from upper, mid, and lower uterine biopsy specimens were identical for each autologous biopsy, whereas histologic dating showed variability with an average standard deviation of 0.71 days.
    Conclusions: The increased heterogeneity of histologic dating is likely to be attributed to the subjectivity of the test. Furthermore, we did not observe a consistent lag or advancement in histologic or ERA dating between the fundal or lower uterine biopsies. Overall, clinicians should be reassured that endometrial tissue will return consistent ERA results independent of the location within the uterus in which it was obtained.
    Sprache Englisch
    Erscheinungsdatum 2023-08-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2666-3341
    ISSN (online) 2666-3341
    DOI 10.1016/j.xfre.2023.08.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site.

    Thompson, Andrew J / Wu, Nicholas C / Canales, Angeles / Kikuchi, Chika / Zhu, Xueyong / de Toro, Beatriz Fernández / Cañada, Francisco J / Worth, Charli / Wang, Shengyang / McBride, Ryan / Peng, Wenjie / Nycholat, Corwin M / Jiménez-Barbero, Jesús / Wilson, Ian A / Paulson, James C

    Cell host & microbe

    2024  Band 32, Heft 2, Seite(n) 261–275.e4

    Abstract: Hemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind α2-3-linked sialosides and must adapt to glycans with α2-6-linked sialic acids on human airway cells to transmit within the human population. Since their ... ...

    Abstract Hemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind α2-3-linked sialosides and must adapt to glycans with α2-6-linked sialic acids on human airway cells to transmit within the human population. Since their introduction during the 1968 pandemic, H3N2 viruses have evolved over the past five decades to preferentially recognize human α2-6-sialoside receptors that are elongated through addition of poly-LacNAc. We show that more recent H3N2 viruses now make increasingly complex interactions with elongated receptors while continuously selecting for strains maintaining this phenotype. This change in receptor engagement is accompanied by an extension of the traditional receptor-binding site to include residues in key antigenic sites on the surface of HA trimers. These results help explain the propensity for selection of antigenic variants, leading to vaccine mismatching, when H3N2 viruses are propagated in chicken eggs or cells that do not contain such receptors.
    Mesh-Begriff(e) Animals ; Humans ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/metabolism ; Receptors, Virus/chemistry ; Sialic Acids/metabolism ; Polysaccharides/metabolism ; Chickens ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza, Human
    Chemische Substanzen Receptors, Virus ; Sialic Acids ; Polysaccharides ; Hemagglutinin Glycoproteins, Influenza Virus
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2024.01.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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