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Article: Response of serum biochemical profile, antioxidant enzymes, and gut microbiota to dietary Hong-bailanshen supplementation in horses.

Ding, Jinxue / Gu, Bolin / Meng, Jinwu / Hu, Mengxin / Wang, Wenjia / Liu, Jiaguo

2024 Volume 15, Page(s) 1327210

Abstract: ... conducted to investigate the effects of dietary Hong-bailanshen (HBLS) supplementation in horses on serum ...

Abstract	Background: Traditional Chinese medicine (TCM) is widely used in humans and animals, which is very important for health. TCM affects the body 's immunity and changes in intestinal flora. This study was conducted to investigate the effects of dietary Hong-bailanshen (HBLS) supplementation in horses on serum biochemical profile, antioxidant enzymes and gut microbiota. Methods: In this study, five horses were selected. On day 0, 14, 28, blood samples and feces were collected on days 0, 14, and 28 to analyse gut microbiota, serum biochemical and redox indexes. Results: The results showed that the addition of HBLS to horse diets significantly decreased the level of alanine aminotransferase, alkaline phosphatase, creatine kinase and malondialdehyde ( Conclusion: Adding HBLS to the diet could be a potentially effective strategy to improve horses' health.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1327210
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Article ; Online: Maintaining key ecosystem services under multiple development scenarios: A case study in Guangdong-Hong Kong-Macao Greater Bay Area, China

Wen, Ding / Wang, Xiuming / Liu, Jun / Xu, Naizhong / Zhou, Wen / Hong, Man

Ecological Indicators. 2023, p.110691-

2023 , Page(s) 110691–

Abstract: ... ESs) in highly urbanized areas remain poorly understood. Taking the Guangdong-Hong Kong-Macao Greater ...

Abstract	Effective land use management can better maintain ecosystem services, especially in urban agglomerations. However, rational urban scale systems and landscape patterns to maintain key ecosystem services (ESs) in highly urbanized areas remain poorly understood. Taking the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) as a study area, we quantified the spatio-temporal change of key ESs from 2000 to 2020 by the Integrated Valuation of Environmental Services and Tradeoffs (InVEST) model, and simulated land use change prior considering ES conservation priority areas under different multiple development scenarios in 2050 by adopting the future land use simulation (FLUS) model. The main findings were as follows: (1) From 2000 to 2020, natural habitat, water retention and carbon sequestration decreased by 5.5%, 7.9%, and 3.9%, respectively, while the soil conservation increased by 63.7%. (2) The proportion of different conservation priority areas ranged from 10.6% to 22.6%, which were mainly located in the mountainous region. (3) The urban land area would increase from 4286.00 km² to 4802.25 km² between 2020 and 2050 in the GBA, with a growth rate of 12.05%. Under the simulation scenarios, the new urban land was mainly distributed in megacities and supercities. (4) Under the integrative conservation scenario, the habitat quality index, water conservation, soil conservation and carbon sequestration would increase by 0.036, 7×10⁴ t, 5.11×10⁶ t and 0.93×10⁶ t, respectively. To maintain the key ESs, we recommend optimizing the urban scale system, making it compact at the city scale and scattered at the regional scale, and strictly restricting the conversion of forestland and farmland adjacent to megacities into urban land. These findings were beneficial to achieve regional high-quality development and sustainable development via rational urban system and landscape management.
Keywords	agricultural land ; carbon sequestration ; case studies ; ecosystems ; forest land ; habitats ; land use change ; land use planning ; landscape management ; landscapes ; models ; mountains ; soil conservation ; sustainable development ; urbanization ; water conservation ; China ; urban expansion ; ecosystem services ; ecological protection redlines ; FLUS model
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2023.110691
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Article ; Online: Comparison of multi-mode Hong-Ou-Mandel interference and multi-slit interference.

Guo, Yan / Yang, Zi-Xiang / Zeng, Zi-Qi / Ding, Chunling / Shimizu, Ryosuke / Jin, Rui-Bo

Optics express

2023 Volume 31, Issue 20, Page(s) 32849–32864

Abstract: Hong-Ou-Mandel (HOM) interference of multi-mode frequency entangled states plays a crucial role ...

Abstract	Hong-Ou-Mandel (HOM) interference of multi-mode frequency entangled states plays a crucial role in quantum metrology. However, as the number of modes increases, the HOM interference pattern becomes increasingly complex, making it challenging to comprehend intuitively. To overcome this problem, we present the theory and simulation of multi-mode-HOM interference (MM-HOMI) and compare it to multi-slit interference (MSI). We find that these two interferences have a strong mapping relationship and are determined by two factors: the envelope factor and the details factor. The envelope factor is contributed by the single-mode HOM interference (single-slit diffraction) for MM-HOMI (MSI). The details factor is given by sin (Nx)/sin (x) ([sin (Nv)/sin (v)]
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.501645
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Article: Scientific research on COVID-19 conducted in Hong Kong in 2020.

Wang, H H X / Chen, L / Ding, H / Huang, J / Wong, M C S

Hong Kong medical journal = Xianggang yi xue za zhi

2021 Volume 27, Issue 4, Page(s) 244–246

MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Hong Kong ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-08-16
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj215121
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Zs.A 4347: Show issues

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Article ; Online: Evaluation of the industrial cooperation of the Guangdong Hong Kong Macao Greater Bay Area: Based on the Origin-Destination pairs of industrial parks and coupling model efficiency.

Ma, Sa / Ding, Jinge / Huang, Zhengdong / Guo, Renzhong

PloS one

2023 Volume 18, Issue 8, Page(s) e0290572

Abstract: The industrial cooperation of Guangdong Hong Kong Macao Greater Bay Area (GBA) is one ...

Abstract	The industrial cooperation of Guangdong Hong Kong Macao Greater Bay Area (GBA) is one of the leading regional development strategies of this world-class urban agglomeration. This study constructed the industrial cooperation network based on the travel Origin-Destination (OD) connections among industrial parks. A multi-dimensional industrial cooperation and industrial development calculation index system were also set up to measure the nonlinear interaction relationship between them. The research found that an industrial collaboration network has been basically formed in the GBA, particularly presented by major cities. Some undeveloped cities may receive more benefits in the industrial collaboration network. The Covid-19 pandemic has had an impact in terms of within city connection instead of cross-city industrial cooperation. In addition, the degree of coupling between urban industrial coordination and urban industrial development has improved significantly over one decade and taking industrial collaboration as the input variables, industrial collaboration efficiently leads to industrial development outputs in almost every city in the GBA. Practically, decision makers should encourage and support intercity industrial collaboration, particularly between cities with closer geographic proximity, as it has been found to result in stronger cooperation and better economic enhancement. In addition, although industrial collaboration does not guarantee industrial development, when the collaboration systems and policies are enhanced, the synergy and coordination between them gradually improve. This highlights the potential benefits of continued investment in industrial collaboration for economic development.
MeSH term(s)	Humans ; Hong Kong ; Macau ; Pandemics ; COVID-19/epidemiology ; Industry
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290572
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Article ; Online: Association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus: A prospective study of the Hong Kong Diabetes Register.

O, Chun-Kwan / Siu, Brian Wai-Hei / Leung, Vanessa Wai-Shan / Lin, Yuan-Yuan / Ding, Chen-Zhao / Lau, Eric Siu-Him / Luk, Andrea On-Yan / Chow, Elaine Yee-Kwan / Ma, Ronald Ching-Wan / Chan, Juliana Chung-Ngor / Chan, Rachel Ngan-Yin / Wing, Yun Kwok / Kong, Alice Pik-Shan

Journal of diabetes and its complications

2023 Volume 37, Issue 10, Page(s) 108598

Abstract: ... with T2D aged ≥60 years enrolled in the Hong Kong Diabetes Register completed the Insomnia Severity Index ...

Abstract	Aims: To examine the risk association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus (T2D). Methods: Between July 2010 and June 2015, patients with T2D aged ≥60 years enrolled in the Hong Kong Diabetes Register completed the Insomnia Severity Index (ISI) questionnaire. Patients were considered having insomnia if they had ISI score > 14. We prospectively followed up the cohort and censored outcome through reviewing diagnoses and clinical notes entered by attending physicians in electronic medical record to identify incident cases of mild cognitive impairment and dementia. Results: After excluding shift workers and those with established chronic cognitive impairment at baseline, we included 986 patients with T2D in this study (58.3 % men, mean age ± standard deviation: 62.5 ± 2.6 years, disease duration of diabetes: 10.7 ± 8.2 years, HbA1c: 7.4 ± 1.3 %, insulin users: 28.7 %, insomnia: 9.1 %). After a median follow-up of 7.6 (interquartile range = 2.0) years, 41 (4.2 %) developed chronic cognitive impairment. Using Cox regression analysis, insomnia (hazard ratio, HR 2.909, p = 0.012) and HbA1c ≥ 7 % (HR 2.300, p = 0.038) were positively associated with incident chronic cognitive impairment while insulin use (HR 0.309, p = 0.028) showed negative association. Conclusions: Insomnia, suboptimal glycemic control and non-insulin use are independent risk factors for incident chronic cognitive impairment in older adults with T2D.
MeSH term(s)	Male ; Humans ; Aged ; Female ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Prospective Studies ; Glycated Hemoglobin ; Hong Kong/epidemiology ; Sleep Initiation and Maintenance Disorders/complications ; Sleep Initiation and Maintenance Disorders/epidemiology ; Risk Factors ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/epidemiology ; Insulin
Chemical Substances	Glycated Hemoglobin ; Insulin
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2023.108598
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Zs.A 2225: Show issues

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Article ; Online: Use of sewage surveillance for COVID-19 to guide public health response: A case study in Hong Kong.

Deng, Yu / Xu, Xiaoqing / Zheng, Xiawan / Ding, Jiahui / Li, Shuxian / Chui, Ho-Kwong / Wong, Tsz-Kin / Poon, Leo L M / Zhang, Tong

The Science of the total environment

2022 Volume 821, Page(s) 153250

Abstract: ... variant outbreak in Hong Kong. On 21 June 2021, albeit under basically contained COVID-19 situation ... in Hong Kong, routine sewage surveillance identified a high viral load of severe acute respiratory syndrome ...

Abstract	Sewage surveillance could help develop proactive response to the Coronavirus Disease 2019 (COVID-19) pandemic, but currently there are limited reports about examples in practical exercises. Here, we report a use case of intensified sewage surveillance to initiate public health action to thwart a looming Delta variant outbreak in Hong Kong. On 21 June 2021, albeit under basically contained COVID-19 situation in Hong Kong, routine sewage surveillance identified a high viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a sewage sample from one site covering over 33,000 population, suggesting infected cases living in the respective sewershed. The use of a newly developed method based on allele-specific real-time quantitative polymerase chain reaction (AS RT-qPCR) served to alert the first documentation of the Delta variant in local community sewage three days before the case was confirmed to be a Delta variant carrier. Intensified sewage surveillance was triggered. Targeted upstream sampling at sub-sewershed areas pinpointed the source of positive viral signal across spatial scales from sewershed to building level, and assisted in determining the specific area for issuing a compulsory testing order for individuals on 23 June 2021. A person who lived in a building with the positive result of sewage testing was confirmed to be infected with COVID-19 on 24 June 2021. Viral genome sequences determined from the sewage sample were compared to those from the clinic specimens of the matched patient, and confirmed that the person was the source of the positive SARS-CoV-2 signal in the sewage sample. This study could help build confidences for public health agencies in using the sewage surveillance in their own communities.
MeSH term(s)	COVID-19/epidemiology ; Hong Kong/epidemiology ; Humans ; Public Health ; SARS-CoV-2/genetics ; Sewage
Chemical Substances	Sewage
Language	English
Publishing date	2022-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153250
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Article ; Online: Quantification of SARS-CoV-2 RNA in wastewater treatment plants mirrors the pandemic trend in Hong Kong.

Zheng, Xiawan / Li, Shuxian / Deng, Yu / Xu, Xiaoqing / Ding, Jiahui / Lau, Frankie T K / In Yau, Chung / Poon, Leo L M / Tun, Hein M / Zhang, Tong

The Science of the total environment

2022 Volume 844, Page(s) 157121

Abstract: ... flow rates and catchment area characteristics, which serve 28 % (2.1 million people) of Hong Kong residents ... to monitor overall SARS-CoV-2 pandemic dynamics in a densely populated city like Hong Kong, and provides ...

Abstract	Wastewater-based epidemiology (WBE) for the SARS-CoV-2 virus in wastewater treatment plants (WWTPs) has emerged as a cost-effective and unbiased tool for population-level testing in the community. In the present study, we conducted a 6-month wastewater monitoring campaign from three WWTPs of different flow rates and catchment area characteristics, which serve 28 % (2.1 million people) of Hong Kong residents in total. Wastewater samples collected daily or every other day were concentrated using ultracentrifugation and the SARS-CoV-2 virus RNA in the supernatant was detected using the N1 and E primer sets. The results showed significant correlations between the virus concentration and the number of daily new cases in corresponding catchment areas of the three WWTPs when using 7-day moving average values (Kendall's tau-b value: 0.227-0.608, p < 0.001). SARS-CoV-2 virus concentration was normalized to a fecal indicator using PMMoV concentration and daily flow rates, but the normalization did not enhance the correlation. The key factors contributing to the correlation were also evaluated, including the sampling frequency, testing methods, and smoothing days. This study demonstrates the applicability of wastewater surveillance to monitor overall SARS-CoV-2 pandemic dynamics in a densely populated city like Hong Kong, and provides a large-scale longitudinal reference for the establishment of the long-term sentinel surveillance in WWTPs for WBE of pathogens which could be combined into a city-wide public health observatory.
MeSH term(s)	COVID-19/epidemiology ; Hong Kong/epidemiology ; Humans ; Pandemics ; RNA, Viral ; SARS-CoV-2/genetics ; Wastewater ; Wastewater-Based Epidemiological Monitoring ; Water Purification
Chemical Substances	RNA, Viral ; Waste Water
Language	English
Publishing date	2022-07-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.157121
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Article ; Online: Use of Sewage Surveillance for COVID-19: A Large-Scale Evidence-Based Program in Hong Kong.

Deng, Yu / Zheng, Xiawan / Xu, Xiaoqing / Chui, Ho-Kwong / Lai, Wai-Kwan / Li, Shuxian / Tun, Hein Min / Poon, Leo L M / Ding, Jiahui / Peiris, Malik / Leung, Gabriel M / Zhang, Tong

Environmental health perspectives

2022 Volume 130, Issue 5, Page(s) 57008

Abstract: ... unsuspected patient within a sewershed. Sewage surveillance in Hong Kong provided a basis for the statutory ...

Abstract	Background: Sewage surveillance, by detecting SARS-CoV-2 virus circulation at the community level, has the potential to supplement individual surveillance for COVID-19. However, to date, there have been no reports about the large-scale implementation and validation of sewage surveillance for public health action. Objective: Here, we developed a standardized approach for SARS-CoV-2 detection in sewage and applied it prospectively to supplement public health interventions. Methods: We analyzed 1,169 sewage samples collected at 492 sites from December 2020 to March 2021. Forty-seven of 492 sites tested positive, 44 (94%) of them had traceable sources of viral signals in the corresponding sewershed, either from previously unsuspected but subsequently confirmed patients or recently convalescent patients or from both patient groups. Results: Sewage surveillance had a sensitivity of 54%, a specificity of 95%, a positive predictive value of 53%, and a negative predictive value of 95% for identifying a previously unsuspected patient within a sewershed. Sewage surveillance in Hong Kong provided a basis for the statutory public health action to detect silent COVID-19 transmission. Discussion: Considering the epidemiological data together with the sewage testing results, compulsory testing was conducted for individual residents at 27 positive sewage sites and uncovered total of 62 previously unsuspected patients, demonstrating the value of sewage surveillance in uncovering previously unsuspected patients in the community. Our study suggests that sewage surveillance could be a powerful management tool for the control of COVID-19. https://doi.org/10.1289/EHP9966.
MeSH term(s)	COVID-19/epidemiology ; Hong Kong/epidemiology ; Humans ; Public Health ; SARS-CoV-2 ; Sewage
Chemical Substances	Sewage
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP9966
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Article ; Online: Time-series nighttime imagery for measuring the growth of Urban agglomeration in the Guangdong-Hong Kong-Macao Greater Bay Area

Guo, Chen / Yang, Fan / Ding, Yi / Liu, Hao / Feng, Jiajia

Applied Geography. 2023, p.103004-

2023 , Page(s) 103004–

Abstract: ... of most developed regions in China - the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) - based ...

Abstract	This paper studies the structure and dynamics of urban agglomeration between 1992 and 2018 in one of most developed regions in China - the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) - based on the harmonized night-time light (NTL) data from the Defense Meteorological Satellite Program (DMSP) and Visible Infrared Imaging Radiometer Suite (VIIRS) imagery. We adopted Zipf's law as the rule to control the spatial clustering of adjacent lit pixels. The clustered pixels as patches are concentration of human activities and can then be used for regional urbanization analysis. Unlike conventional spatial units that are rarely changed, such as administrative boundaries, these patches change subtly each year and, more importantly, can help us to examine precisely the urbanization pattern in both development mode and intensity. We investigated the urban growth pattern during the 27-year timespan and conducted the analysis at both region and city levels. Interestingly, the results suggest that Zipf's law of derived patch sizes can hold nearly every year, showcasing the consistent spatial coherency of the urban agglomeration process in the entire region. The correlation between urbanization metrics for each city at three stages (1992-2000, 2000-2010, and 2010-2018) can further lead to deep insights towards the synergetic course of the coordinated and multi-center development.
Keywords	geography ; humans ; satellites ; time series analysis ; urbanization ; China ; Megacity region ; Expansion dynamics ; Zipf's law ; Spatial structure ; NTL imagery
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	0143-6228
DOI	10.1016/j.apgeog.2023.103004
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