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  1. Article ; Online: Limonoids isolated from Chisocheton ceramicus  Miq. and the antiadipogenic mechanism of action of ceramicine B.

    Bailly, Christian

    Archiv der Pharmazie

    2024  , Page(s) e2400160

    Abstract: Different types of limonoids have been isolated from plants of the Chisocheton genus, notably from the species Chisocheton ceramicus  Miq. which is largely distributed in the Indonesian archipelago and Malaysia region. A variety of natural products have ... ...

    Abstract Different types of limonoids have been isolated from plants of the Chisocheton genus, notably from the species Chisocheton ceramicus  Miq. which is largely distributed in the Indonesian archipelago and Malaysia region. A variety of natural products have been found in the bark of the tree and characterized as antimicrobial and/or antiproliferative agents. The isolated limonoids include chisomicines A-E, proceranolide, and a few other compounds. A focus is made on a large series of limonoids designated ceramicines A to Z including derivatives with antiparasitic activities, antioxidant, antimelanogenic, and antiproliferative effects and/or acting as regulators of lipogenesis. The lead compound in the series is ceramicine B functioning as a potent inhibitor of lipid droplet accumulation (LDA). Extracts from Chisocheton ceramicus and ceramicines have shown anti-LDA effects, with little or no cytotoxic effects. Ceramicine B is the most active compound functioning as a regulator of lipid storage in cells and tissues. Ceramicine B is a transcriptional repressor of peroxisome proliferator-activated receptor γ (PPARγ) and an inhibitor of phosphorylation of the transcription factor FoxO1, acting via an upstream molecular target. Targeting of glycogen synthase kinase-3β is proposed, based on the analogy with structurally related limonoids known to target this enzyme, and supported by a molecular docking analysis. The target and pathway implicated in ceramicine B activity are discussed. The analysis shed light on ceramicine B as a natural product precursor for the design of novel compounds capable of reducing LDA in cells and of potential interest for the treatment of obesity, liver diseases, and other pathologies.
    Language English
    Publishing date 2024-04-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202400160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ruta angustifolia

    Bailly, Christian

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: ... The ... ...

    Abstract The genus
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12040827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fissistigma oldhamii

    Bailly, Christian

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 24

    Abstract: ... The ... ...

    Abstract The species
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12244094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anticancer properties and mechanism of action of the fungal nucleoside clitocine and its derivatives

    Christian Bailly

    European Journal of Medicinal Chemistry Reports, Vol 10, Iss , Pp 100123- (2024)

    1481  

    Abstract: Clitocine (CLT) is an atypical nitro-containing pyrimidine nucleoside bearing a ribofuranosyl moiety attached to the exocyclic 4-amino position. It has been isolated first from the fungus Clitocybe inversa and then from fruiting bodies of Leucopaxillus ... ...

    Abstract Clitocine (CLT) is an atypical nitro-containing pyrimidine nucleoside bearing a ribofuranosyl moiety attached to the exocyclic 4-amino position. It has been isolated first from the fungus Clitocybe inversa and then from fruiting bodies of Leucopaxillus giganteus. Two intramolecular hydrogen-bonds between adjacent amino and nitro groups on the pyrimidine unit confer a planar structure to the pseudo-tricyclic core of the molecule, thus facilitating stacking interactions with aromatic amino acid or the nucleobases. Over the past thirty years, a variety of CLT analogues have been synthesized, including amino derivatives acting as potent inhibitors of adenosine kinase, and a variety of other molecules all described here. The antitumor action of the mushroom extracts and purified CLT has been evidenced in murine models. The capacity of CLT to reduce tumor cell proliferation, to trigger apoptosis and to inhibit tumor growth in mice have been associated with a drug-induced modulation of the NF-κB and Akt pathways, notably with a down-regulation and proteasome-dependent degradation of anti-apoptotic protein Mcl-1. The potential targeting of an upstream protein effector, possibly the kinase Akt, is discussed. Moreover, CLT can promote translational readthrough of stop codons. This emerging mechanism reinforces further the interest of the natural product to address different types of cancers and nonsense mutation-related genetic disorders. Altogether, the review provides an overview of the history of CLT, from its chemical discovery in fungi to the identification of its anticancer activities and different mechanisms of action. Research prospects are proposed to better delineate the mode of action of this original natural product and to promote mycomedicine.
    Keywords Amino-nucleoside ; Cancer ; Clitocine ; Fungi ; Kinase inhibition ; Anticancer mechanism ; Pharmacy and materia medica ; RS1-441 ; Other systems of medicine ; RZ201-999
    Subject code 540
    Language English
    Publishing date 2024-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus

    Bailly, Christian

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: The present analysis retraces the discovery of plagiochilins A-to-W, a series of seco-aromadendrane-type sesquiterpenes isolated from diverse leafy liverworts of the ... ...

    Abstract The present analysis retraces the discovery of plagiochilins A-to-W, a series of seco-aromadendrane-type sesquiterpenes isolated from diverse leafy liverworts of the genus
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13030758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Yuexiandajisu diterpenoids from Euphorbia ebracteolata Hayata (Langdu roots): An overview.

    Bailly, Christian

    Phytochemistry

    2023  Volume 213, Page(s) 113784

    Abstract: The roots of the plant Euphorbia ebracteolata Hayata (Yue Xian Da Ji) are commonly used in traditional Chinese medicine to treat multiple diseases such as chronic liver diseases, oedema, pulmonary diseases and cancer. It is the main ingredient of the TCM ...

    Abstract The roots of the plant Euphorbia ebracteolata Hayata (Yue Xian Da Ji) are commonly used in traditional Chinese medicine to treat multiple diseases such as chronic liver diseases, oedema, pulmonary diseases and cancer. It is the main ingredient of the TCM called Langdu which can be prepared also from roots of E. fischeriana Steud. and occasionally from Stellera chamaejasme species. Numerous bioactive natural products have been isolated from E. ebracteolata including a large diversity of diterpenoids with anti-inflammatory and anticancer properties. One little series of compounds has been named yuexiandajisu (A, B, C, D, D
    MeSH term(s) Euphorbia/chemistry ; Diterpenes/chemistry ; Plant Roots/chemistry ; Cell Line ; Neoplasms ; Molecular Structure
    Chemical Substances Yuexiandajisu D ; Diterpenes
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

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  7. Article ; Online: Etoposide: A rider on the cytokine storm.

    Bailly, Christian

    Cytokine

    2023  Volume 168, Page(s) 156234

    Abstract: For more than 40 years, the epipodophyllotoxin drug etoposide is prescribed to treat cancer. This semi-synthetic compound remains extensively used to treat advanced small-cell lung cancer and in various chemotherapy regimen for autologous stem cell ... ...

    Abstract For more than 40 years, the epipodophyllotoxin drug etoposide is prescribed to treat cancer. This semi-synthetic compound remains extensively used to treat advanced small-cell lung cancer and in various chemotherapy regimen for autologous stem cell transplantation, and other anticancer protocols. Etoposide is a potent topoisomerase II poison, causing double-stranded DNA breaks which lead to cell death if they are not repaired. It is also a genotoxic compound, responsible for severe side effects and secondary leukemia occasionally. Beyond its well-recognized function as an inducer of cancer cell death (a "killer on the road"), etoposide is also useful to treat immune-mediated inflammatory diseases associated with a cytokine storm syndrome. The drug is essential to the treatment of hemophagocytic lymphohistiocytosis (HLH) and the macrophage activation syndrome (MAS), in combination with a corticosteroid and other drugs. The use of etoposide to treat HLH, either familial or secondary to a viral or parasitic infection, or treatment-induced HLH and MAS is reviewed here. Etoposide dampens inflammation in HLH patients via an inhibition of the production of pro-inflammatory mediators, such as IL-6, IL-10, IL-18, IFN-γ and TNF-α, and reduction of the secretion of the alarmin HMGB1. The modulation of cytokines production by etoposide contributes to deactivate T cells and to dampen the immune stimulation associated to the cytokine storm. This review discussed the clinical benefits and mechanism of action of etoposide (a "rider on the storm") in the context of immune-mediated inflammatory diseases, notably life-threatening HLH and MAS. The question arises as to whether the two faces of etoposide action can apply to other topoisomerase II inhibitors.
    MeSH term(s) Humans ; Etoposide/pharmacology ; Etoposide/therapeutic use ; Cytokine Release Syndrome/drug therapy ; Hematopoietic Stem Cell Transplantation ; Transplantation, Autologous/adverse effects ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Lymphohistiocytosis, Hemophagocytic/genetics ; Macrophage Activation Syndrome/drug therapy
    Chemical Substances Etoposide (6PLQ3CP4P3)
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156234
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2840: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan).

    Bailly, Christian

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117127

    Abstract: Ethnopharmacological relevance: The herbal medicine designated Chai-Ling-Tang in China, Siryung-tang in South Korea, and Sairei-To (or Tsumura Saireito extract granules, TJ-114) in Japan is a complex polyherbal formulations with 12 plant components. It ... ...

    Abstract Ethnopharmacological relevance: The herbal medicine designated Chai-Ling-Tang in China, Siryung-tang in South Korea, and Sairei-To (or Tsumura Saireito extract granules, TJ-114) in Japan is a complex polyherbal formulations with 12 plant components. It is used historically to treat Shaoyang syndrome, recorded in an ancient Chinese medical text "Treatise on Cold Damage Disorder" (Shanghan Lun). Chai-Ling-Tang formula combines two traditional Chinese herbal medicine prescriptions: Xiao-Chai-Hu-Tang and Wu-Ling-San (known as Sho-Saiko-To and Goreisan in Japan, and So Shi Ho Tang and Oreonsang in Korea, respectively). These traditional Chinese/Korean medicines and Kampo medicine have been used for more than 2000 years in East Asia, notably as regulators of body fluid homeostasis.
    Aim of the study: This study aims to evaluate clinical uses, pharmacological effects and unwanted effects of Sairei-To through a narrative literature survey. The main active phytoconstituents and their mechanism of actions are also collated based on the literature.
    Methods: Several databases including SciFinder and PubMed were searched in sourcing information using keywords corresponding to the medicinal treatment names and the corresponding plants and phytochemicals. Relevant textbooks, reviews, and digital documents (mostly in English) were consulted to collate all available scientific literature and to provide a complete science-based survey of the topic.
    Results: Sairei-To derives from ten plants and two fungi. The three major components are Bupleuri radix (Saiko), Pinelliae rhizoma (Hange), and Alismatis rhizoma (Takusha). The rest includes the species Scutellariae radix, Zizyphi fructus, Ginseng radix, Glycyrrhizae radix, Zingiberis rhizoma, Cinnamomi cortex, Atractylodis lanceae rhizoma, Poria sclerotium, and Polyporus sclerotium. The therapeutic uses of Sairei-To are very diversified, ranging from the treatment of autoimmune diseases, intestinal inflammatory disorders, edema, intestinal and kidney diseases, cancers, inflammatory skin pathologies, and other conditions such as reproductive failure. Sairei-To is considered as a safe and efficient medication, with potential rare unwanted side effects, notably lung injuries (pneumonitis essentially). Marked anti-inflammatory and immune-modulatory effects of Sairei-To have been reported, generally associated to the action of saponins (saikosaponins, glycyrrhizin), terpenoids (alisols) and flavonoids (baicalin, oroxylin A).
    Conclusion: Sairei-To is commonly used to treat inflammatory diseases and appears efficient to decrease the side effects of corticosteroids. Its immune-regulatory action is well recognized and exploited to treat certain skin lesions and chemotherapy-related toxic effects. The activity of the Sairei-To product relies on the synergistic action of its individual ingredients. Further studies are warranted to quantify the synergy of action inherent to this interesting botanical medication.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/adverse effects ; Japan ; Medicine, Chinese Traditional ; Autoimmune Diseases/drug therapy
    Chemical Substances sairei-to ; Drugs, Chinese Herbal ; jujube extract ; ginger extract (C5529G5JPQ)
    Language English
    Publishing date 2023-09-07
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117127
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Identification of Taenia sp. in a mummy from a Christian Necropolis in El-Deir, Oasis of Kharga, ancient Egypt.

    Le Bailly, Matthieu / Mouze, Sidonie / da Rocha, Gino Chaves / Heim, Jean-Louis / Lichtenberg, Roger / Dunand, Françoise / Bouchet, Françoise

    The Journal of parasitology

    2010  Volume 96, Issue 1, Page(s) 213–215

    Abstract: For the first time, a palaeoparasitological study was performed on 12 mummies from a Christian ...

    Abstract For the first time, a palaeoparasitological study was performed on 12 mummies from a Christian cemetery excavated in El-Deir, Oasis of Kharga, Egypt. The analysis revealed the presence of a tapeworm, probably Taenia sp., in a single individual. The presence of just the presumed taeniid egg is surprising and raises the question of the relationship between residents of Egyptian oases and those residing in the Nile Valley. The result suggests information on the health status of the ancient oasis population and re-enforces a hypothesis regarding possible social stratification of the inhabitants. The work must be continued if we are to acquire additional knowledge dealing with life in ancient Egyptian oases.
    MeSH term(s) Animals ; Egypt, Ancient ; History, Ancient ; Humans ; Mummies/history ; Mummies/parasitology ; Taenia/classification ; Taenia/isolation & purification ; Taeniasis/history ; Taeniasis/parasitology
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 300870-8
    ISSN 1937-2345 ; 0022-3395
    ISSN (online) 1937-2345
    ISSN 0022-3395
    DOI 10.1645/GE-2076.1
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    Uh II Zs.76: Show issues Location:
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  10. Article: Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from

    Bailly, Christian

    Biomedicines

    2022  Volume 10, Issue 8

    Abstract: More than 100 protostane triterpenoids have been isolated from the dried rhizomes ... ...

    Abstract More than 100 protostane triterpenoids have been isolated from the dried rhizomes of
    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10081945
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