Article ; Online: A tell tail sign: a conserved C-terminal tail-anchor domain targets a subset of pathogen effectors to the plant endoplasmic reticulum.
Journal of experimental botany
2023 Volume 74, Issue 10, Page(s) 3188–3202
Abstract: ... system including the ER. We identified and validated a conserved C-terminal tail-anchor motif in a set ...
| Abstract | The endoplasmic reticulum (ER) is the entry point to the secretory pathway and, as such, is critical for adaptive responses to biotic stress, when the demand for de novo synthesis of immunity-related proteins and signalling components increases significantly. Successful phytopathogens have evolved an arsenal of small effector proteins which collectively reconfigure multiple host components and signalling pathways to promote virulence; a small, but important, subset of which are targeted to the endomembrane system including the ER. We identified and validated a conserved C-terminal tail-anchor motif in a set of pathogen effectors known to localize to the ER from the oomycetes Hyaloperonospora arabidopsidis and Plasmopara halstedii (downy mildew of Arabidopsis and sunflower, respectively) and used this protein topology to develop a bioinformatic pipeline to identify putative ER-localized effectors within the effectorome of the related oomycete, Phytophthora infestans, the causal agent of potato late blight. Many of the identified P. infestans tail-anchor effectors converged on ER-localized NAC transcription factors, indicating that this family is a critical host target for multiple pathogens. |
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| MeSH term(s) | Plants/metabolism ; Oomycetes ; Transcription Factors/metabolism ; Phytophthora infestans ; Virulence ; Endoplasmic Reticulum/metabolism ; Plant Diseases |
| Chemical Substances | Transcription Factors |
| Language | English |
| Publishing date | 2023-03-15 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2976-2 |
| ISSN | 1460-2431 ; 0022-0957 |
| ISSN (online) | 1460-2431 |
| ISSN | 0022-0957 |
| DOI | 10.1093/jxb/erad075 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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