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  1. Article ; Online: Management of Recurrent Clostridioides Infection: A Difficile Problem in Inflammatory Bowel Disease Patients.

    Lam, Angela Y / Gutin, Liat S / Nguyen, Yume / Velayos, Fernando S

    Digestive diseases and sciences

    2020  Volume 65, Issue 11, Page(s) 3111–3115

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/surgery ; Clostridioides difficile ; Clostridium Infections/complications ; Clostridium Infections/drug therapy ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; Colonoscopy ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation ; Recurrence ; Vancomycin/therapeutic use ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; Immunosuppressive Agents ; Vancomycin (6Q205EH1VU)
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06521-x
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  2. Article ; Online: Going Viral: Management of IBD in the Era of the COVID-19 Pandemic.

    Gutin, Liat S / Lam, Angela Y / Velayos, Fernando S / Santos, Stephanie A

    Digestive diseases and sciences

    2020  Volume 65, Issue 6, Page(s) 1571–1575

    MeSH term(s) Betacoronavirus ; COVID-19 ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/therapy ; Colitis, Ulcerative/virology ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Humans ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/therapy ; Irritable Bowel Syndrome/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Respiratory Distress Syndrome ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06299-y
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  3. Article: Management of Recurrent Clostridioides Infection: A Difficile Problem in Inflammatory Bowel Disease Patients

    Lam, Angela Y / Gutin, Liat S / Nguyen, Yume / Velayos, Fernando S

    Dig. dis. sci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #710916
    Database COVID19

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  5. Article ; Online: Going Viral

    Gutin, Liat S. / Lam, Angela Y. / Velayos, Fernando S. / Santos, Stephanie A.

    Digestive Diseases and Sciences

    Management of IBD in the Era of the COVID-19 Pandemic

    2020  Volume 65, Issue 6, Page(s) 1571–1575

    Keywords Gastroenterology ; Physiology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06299-y
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  6. Article ; Online: Parity and aortic dimensions in healthy women.

    Gutin, Liat S / Merz, Alexa E / Bakalov, Vladimir K / Gharib, Ahmed M / Bondy, Carolyn A

    International journal of cardiology

    2012  Volume 165, Issue 2, Page(s) 383–384

    MeSH term(s) Adult ; Aorta/anatomy & histology ; Aorta/physiology ; Aorta, Thoracic/anatomy & histology ; Aorta, Thoracic/physiology ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Parity/physiology ; Pregnancy
    Language English
    Publishing date 2012-09-19
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2012.08.022
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  7. Article ; Online: N-terminal pro-brain natriuretic peptide levels and aortic diameters.

    Gutin, Liat S / Bakalov, Vladimir K / Rosing, Douglas R / Arai, Andrew E / Gharib, Ahmed M / Bondy, Carolyn A

    American heart journal

    2012  Volume 164, Issue 3, Page(s) 419–424

    Abstract: Background: Women with X-chromosome monosomy or Turner syndrome (TS) are at increased risk for aortic dilation and dissection. To better understand the pathology and develop tools to monitor the risk of aortic disease, we investigated N-terminal pro- ... ...

    Abstract Background: Women with X-chromosome monosomy or Turner syndrome (TS) are at increased risk for aortic dilation and dissection. To better understand the pathology and develop tools to monitor the risk of aortic disease, we investigated N-terminal pro-brain natriuretic peptide (BNP) (NT-proBNP) levels in women with TS and healthy female controls.
    Methods: We evaluated NT-proBNP levels in women with karyotype-proven TS and healthy female volunteers in relation to ascending aortic diameter and descending aortic diameter measured by cardiovascular magnetic resonance imaging.
    Results: The NT-proBNP levels were strongly and positively correlated with ascending aortic diameter and descending aortic diameter in both cohorts. The TS group (n = 114, age 37.4 ± 12 yr) had greater body surface area-indexed aortic diameters and higher NT-proBNP levels than the control group (n = 27, age 46.4 ± 11 years): 88.3 ± 62.7 versus 53.5 ± 35 pg/mL, P = .0003. Within the TS group, NT-proBNP levels were higher in those with dilated ascending aorta (n = 42, 112.4 ± 75.7 pg/mL) compared with those with normal aortic dimensions (n = 72, 74.2 ± 49 pg/mL, P = .0014). Abnormally high NT-pro BNP levels were seen in 3 of 4 TS women who presented with previously undetected aortic aneurysm and/or dissection.
    Conclusions: The NT-proBNP levels are positively associated with aortic diameters in women with and without TS, suggesting a role for BNP in arterial wall homeostasis. Further study is necessary to determine whether NT-proBNP measurement may be used to monitor aortic diameter and/or detect aortic pathology in individuals at risk for aortic disease.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aorta/pathology ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Turner Syndrome/blood ; Turner Syndrome/pathology ; Young Adult
    Chemical Substances Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2012-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2012.06.021
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  8. Article: Trends in GH use in a Turner syndrome natural history study.

    Gutin, Liat / Collier, Suzanne / Bakalov, Vladimir K / Bondy, Carolyn

    Pediatric endocrinology reviews : PER

    2012  Volume 9 Suppl 2, Page(s) 725–727

    Abstract: The present observations are derived from 273 girls and women aged 7-40 years participating in the National Institutes of Health natural history study of Turner syndrome (TS) in the interval 2001-2011. There was a higher percentage of GH use among ... ...

    Abstract The present observations are derived from 273 girls and women aged 7-40 years participating in the National Institutes of Health natural history study of Turner syndrome (TS) in the interval 2001-2011. There was a higher percentage of GH use among individuals in the pediatric age group (7-17, n = 118, 83%) compared to young adult women with prior GH use (18-40, n = 155, 61%). The major factor in this divergence seems to be a trend toward earlier diagnosis of TS in the younger age group. We find a striking association between history of GH use and lower total body and abdominal fat mass in young adults with TS approximately one decade after discontinuation of GH treatment. The interpretation of this observation is limited by the fact that our study subjects were not randomly assigned to GH treatment. There may be a bias involving poor health care, childhood obesity, delayed diagnosis, absent GH treatment and persistent adult obesity. Further studies on the socioeconomic factors implicated in patterns of GH use and non-use for girls with TS are needed to illuminate this important issue.
    MeSH term(s) Abdominal Fat ; Adolescent ; Adult ; Body Height/drug effects ; Child ; Drug Therapy/trends ; Female ; Growth Hormone/therapeutic use ; Humans ; Retrospective Studies ; Turner Syndrome/drug therapy
    Chemical Substances Growth Hormone (9002-72-6)
    Language English
    Publishing date 2012-09-03
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2434390-0
    ISSN 1565-4753
    ISSN 1565-4753
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  9. Article: Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile.

    Gutin, Liat / Piceno, Yvette / Fadrosh, Douglas / Lynch, Kole / Zydek, Martin / Kassam, Zain / LaMere, Brandon / Terdiman, Jonathan / Ma, Averil / Somsouk, Ma / Lynch, Susan / El-Nachef, Najwa

    United European gastroenterology journal

    2019  Volume 7, Issue 6, Page(s) 807–814

    Abstract: Background: Emerging trials suggest fecal microbiota transplantation (FMT) is a promising treatment for ulcerative colitis; however, there is a paucity of data in Crohn disease (CD).: Objective: The objectives of this article are to determine whether ...

    Abstract Background: Emerging trials suggest fecal microbiota transplantation (FMT) is a promising treatment for ulcerative colitis; however, there is a paucity of data in Crohn disease (CD).
    Objective: The objectives of this article are to determine whether single-dose FMT improves clinical and endoscopic outcomes in CD patients and to identify meaningful changes in the microbiome in response to FMT.
    Methods: We performed a prospective, open-label, single-center study. Ten CD patients underwent FMT and were evaluated for clinical response (defined as decrease in Harvey-Bradshaw Index score ≥3 at one month post-FMT) and microbiome profile (16S ribosomal RNA sequencing) at one month post-FMT.
    Results: Three of 10 patients responded to FMT. Two of 10 patients had significant adverse events requiring escalation of therapy. On microbiome analysis, bacterial communities of responders had increased relative abundance of bacteria commonly found in donor gut microbiota.
    Conclusions: Single-dose FMT in this cohort of CD patients showed modest effect and potential for harm. Responders tended to have lower baseline alpha diversity, suggesting baseline perturbation of microbiota may be an indicator of potential responders to FMT in this patient population. Controlled trials are needed to further assess the efficacy and safety of FMT in CD and determine whether FMT is a viable option in this patient population.
    MeSH term(s) Adolescent ; Adult ; Aged ; Crohn Disease/etiology ; Crohn Disease/therapy ; Fecal Microbiota Transplantation/adverse effects ; Fecal Microbiota Transplantation/methods ; Female ; Gastrointestinal Microbiome ; Humans ; Male ; Metagenomics/methods ; Middle Aged ; RNA, Ribosomal, 16S/genetics ; Treatment Outcome ; Young Adult
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-04-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1177/2050640619845986
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  10. Article ; Online: Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency.

    Bakalov, Vladimir K / Gutin, Liat / Cheng, Clara M / Zhou, Jian / Sheth, Puja / Shah, Kavita / Arepalli, Sruthi / Vanderhoof, Vien / Nelson, Lawrence M / Bondy, Carolyn A

    Journal of autoimmunity

    2012  Volume 38, Issue 4, Page(s) 315–321

    Abstract: ... at the National Institutes of Health. We compared the study group prevalence to normative data for the U.S ... that in U.S. population of women (5.8%). Inflammatory bowel (IBD, 4%) and celiac disease (CD, 2.7%) were ...

    Abstract The higher prevalence of autoimmune diseases in women compared to men could be due to effects of ovarian hormones, pregnancy and/or the presence of a second X chromosome. To elucidate the role of these factors, we investigated the prevalence and spectrum of autoimmune diagnoses in women with primary ovarian insufficiency associated with X chromosome monosomy (Turner syndrome, TS, n = 244) and women with karyotypically normal (46,XX) primary ovarian insufficiency (POI, n = 457) in a prospective study, conducted at the National Institutes of Health. We compared the study group prevalence to normative data for the U.S. population of women. Chronic lymphocytic (Hashimoto's) thyroiditis (HT) occurred in 37% of women with TS vs. 15% with POI (P < 0.0001); HT prevalence in both ovarian insufficiency groups significantly exceeded that in U.S. population of women (5.8%). Inflammatory bowel (IBD, 4%) and celiac disease (CD, 2.7%) were significantly increased in TS, but not in POI. No other autoimmune diagnosis, including Graves' disease or Type 1 diabetes appears to be significantly increased in either group. Women with TS had higher pro-inflammatory IL6 and TGF β1 levels (p < 0.0001 for both), and lower anti-inflammatory IL10 and TGF β2 levels (p < 0.005 for both) compared to POI and to normal volunteers. Lifetime estrogen exposure and parity were significantly lower in TS compared to POI, which were in turn lower than the general population of women. The finding that lymphocytic thyroiditis is greatly increased in both women with TS and POI suggests that factors associated with ovarian insufficiency per se promote this form of autoimmunity. The absence of a normal second X-chromosome further contributes to increased autoimmunity in TS.
    MeSH term(s) Adolescent ; Adult ; Aged ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/etiology ; Cytokines/immunology ; Cytokines/metabolism ; Estrogens/immunology ; Estrogens/metabolism ; Female ; Hashimoto Disease/epidemiology ; Hashimoto Disease/etiology ; Humans ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/etiology ; Middle Aged ; Pregnancy ; Prevalence ; Primary Ovarian Insufficiency/complications ; Primary Ovarian Insufficiency/genetics ; Primary Ovarian Insufficiency/immunology ; Risk Factors ; Smoking ; Turner Syndrome/complications ; Turner Syndrome/genetics ; Turner Syndrome/immunology ; Young Adult
    Chemical Substances Cytokines ; Estrogens
    Language English
    Publishing date 2012-02-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2012.01.015
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