LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article ; Online: The Therapeutic Potential in Cancer of Terpyridine-Based Metal Complexes Featuring Group 11 Elements.

Gil-Moles, María / Concepción Gimeno, M

2024 , Page(s) e202300645

Abstract: Terpyridine-based complexes with group 11 metals emerge as potent metallodrugs in cancer therapy. This comprehensive review focuses on the current landscape of anticancer examples, particularly highlighting the mechanisms of action. While Cu(II) ... ...

Abstract	Terpyridine-based complexes with group 11 metals emerge as potent metallodrugs in cancer therapy. This comprehensive review focuses on the current landscape of anticancer examples, particularly highlighting the mechanisms of action. While Cu(II) complexes, featuring diverse ancillary ligands, dominate the field, exploration of silver and gold species remains limited. These complexes exhibit significant cytotoxicity against various cancer cell lines with a commendable selectivity for non-tumorigenic cells. DNA interactions, employing intercalation and groove binding, are pivotal and finely tuned through terpyridine ligand functionalization. In addition, copper complexes showcase nuclease activity, triggering apoptosis through ROS generation. Despite silver's high affinity for nitrogen donor atoms, its exploration is relatively sparse, with indications of acting as intercalating agents causing DNA hydrolytic cleavage. Gold(III) compounds, overshadowing gold(I) due to stability concerns, not only intercalate but also induce apoptosis and disrupt the mitochondrial membrane. Further investigations are needed to fully understand the mechanism of action of these compounds, highlighting the necessity of exploring additional biological targets for these promising metallodrugs.
Language	English
Publishing date	2024-02-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202300645
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6280: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of substituents on the

Romo-Islas, Guillermo / Gil-Moles, María / Saxena, Arnav / Frontera, Antonio / Gimeno, M Concepción / Rodríguez, Laura

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 6, Page(s) 2475–2486

Abstract: Twelve (N^N^N)platinum pyridyl complexes, (N^N^N)Pt(pyF), were synthesised and investigated for their singlet oxygen generation and potential biological activities. They ... ...

Abstract	Twelve (N^N^N)platinum pyridyl complexes, (N^N^N)Pt(pyF), were synthesised and investigated for their singlet oxygen generation and potential biological activities. They exhibited
MeSH term(s)	DNA ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Platinum/chemistry ; Pyridines/pharmacology ; Pyridines/chemistry ; Singlet Oxygen ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/pharmacology
Chemical Substances	DNA (9007-49-2) ; Photosensitizing Agents ; Platinum (49DFR088MY) ; Pyridines ; Singlet Oxygen (17778-80-2) ; Organoplatinum Compounds
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt04050j
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2.

Gil-Moles, Maria / O'Beirne, Cillian / Esarev, Igor V / Lippmann, Petra / Tacke, Matthias / Cinatl, Jindrich / Bojkova, Denisa / Ott, Ingo

RSC medicinal chemistry

2023 Volume 14, Issue 7, Page(s) 1260–1271

Abstract: The ongoing SARS-CoV-2 pandemic has caused a high demand for novel innovative antiviral drug candidates. Despite promising results, metal complexes have been relatively unexplored as antiviral agents in general and in particular against SARS-CoV-2. Here ... ...

Abstract	The ongoing SARS-CoV-2 pandemic has caused a high demand for novel innovative antiviral drug candidates. Despite promising results, metal complexes have been relatively unexplored as antiviral agents in general and in particular against SARS-CoV-2. Here we report on silver NHC complexes with chloride or iodide counter ligands that are potent inhibitors of the SARS-CoV-2 papain-like protease (PL
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d3md00067b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Silver-Based Terpyridine Complexes as Antitumor Agents.

Gil-Moles, María / Olmos, M Elena / Monge, Miguel / Beltrán-Visiedo, Manuel / Marzo, Isabel / López-de-Luzuriaga, José M / Concepción Gimeno, M

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 37, Page(s) e202300116

Abstract: Silver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the ... ...

Abstract	Silver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the possibilities of combining the properties of the metal and the ability of the ligands for DNA binding. Here, the antiproliferative activity, stability, CT-DNA binding, and mechanism of cell death of these types of derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has been detected between tumour cells and healthy lymphocytes T for some of these compounds. The CT-DNA interaction study has shown that these derivatives are able to interact with CT-DNA by moderate intercalation. Furthermore, cell death studies indicate that these derivatives promote the apoptosis by a mitochondrial pathway.
MeSH term(s)	Humans ; Structure-Activity Relationship ; Silver ; Ligands ; Drug Screening Assays, Antitumor ; DNA/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Neoplasms ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Cell Line, Tumor
Chemical Substances	Silver (3M4G523W1G) ; Ligands ; DNA (9007-49-2) ; Antineoplastic Agents ; Coordination Complexes
Language	English
Publishing date	2023-05-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202300116
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Physicochemical properties of SARS-CoV-2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control.

Scheller, Christin / Krebs, Finja / Minkner, Robert / Astner, Isabel / Gil-Moles, Maria / Wätzig, Hermann

Electrophoresis

2020 Volume 41, Issue 13-14, Page(s) 1137–1151

Abstract: The material properties of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its proteins are discussed. We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, ... ...

Abstract	The material properties of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its proteins are discussed. We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, stability against pH, temperature, UV light, gamma radiation, and susceptibility to various chemical agents including solvents and detergents. Possible inactivation, downstream, and formulation conditions are given including suitable buffers and some first ideas for quality-control methods. This information supports vaccine development and discussion with competent authorities during vaccine approval and is certainly related to drug-targeting strategies and hygienics. Several instructive tables are given, including the pI and grand average of hydropathicity (GRAVY) of SARS-CoV-1 and -2 proteins in comparison. SARS-CoV-1 and SARS-CoV-2 are similar in many regards, so information can often be derived. Both are unusually stable, but sensitive at their lipophilic membranes. However, since seemingly small differences can have strong effects, for example, on immunologically relevant epitope settings, unevaluated knowledge transfer from SARS-CoV-1 to SARS-CoV-2 cannot be advised. Published knowledge regarding downstream processes, formulations and quality assuring methods is, as yet, limited. However, standard approaches employed for other viruses and vaccines seem to be feasible including virus inactivation, centrifugation conditions, and the use of adjuvants.
MeSH term(s)	Animals ; Betacoronavirus/chemistry ; Betacoronavirus/drug effects ; Betacoronavirus/radiation effects ; Disinfectants/pharmacology ; Electrophoresis ; Hot Temperature ; Humans ; Hydrogen-Ion Concentration ; Isoelectric Point ; SARS-CoV-2 ; Ultraviolet Rays ; Vaccines, Attenuated/immunology ; Vaccines, Attenuated/pharmacology ; Viral Proteins/chemistry ; Viral Vaccines/immunology ; Viral Vaccines/pharmacology ; Virus Inactivation/radiation effects
Chemical Substances	Disinfectants ; Vaccines, Attenuated ; Viral Proteins ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.202000121
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1868: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike-ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics*.

Gil-Moles, Maria / Basu, Uttara / Büssing, Rolf / Hoffmeister, Henrik / Türck, Sebastian / Varchmin, Agnieszka / Ott, Ingo

Chemistry (Weinheim an der Bergstrasse, Germany)

2020 Volume 26, Issue 66, Page(s) 15140–15144

Abstract: Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti-infective effects have been confirmed. Herein, we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two ... ...

Abstract	Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti-infective effects have been confirmed. Herein, we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two relevant drug targets of severe acute respiratory syndrome coronaviruses (SARS-CoV). The gold metallodrugs were effective inhibitors of the interaction of the SARS-CoV-2 spike protein with the angiotensin converting enzyme 2 (ACE2) host receptor and might thus interfere with the viral entry process. The gold metallodrugs were also efficient inhibitors of the papain-like protease (PLpro) of SARS-CoV-1 and SARS-CoV-2, which is a key enzyme in the viral replication. Regarding PLpro from SARS-CoV-2, the here reported inhibitors are among the very first experimentally confirmed examples with activity against this target enzyme. Importantly, the activity of the complexes against both PLpro enzymes correlated with the ability of the inhibitors to remove zinc ions from the labile zinc center of the enzyme. Taken together, the results of this pilot study suggest further evaluation of gold complexes as SARS-CoV antiviral drugs.
MeSH term(s)	Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; Auranofin/chemistry ; Auranofin/pharmacology ; COVID-19/virology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Gold/chemistry ; Gold/pharmacology ; Humans ; Molecular Targeted Therapy ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Organometallic Compounds ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Auranofin (3H04W2810V) ; Gold (7440-57-5) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; 3C-like protease, SARS coronavirus (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202004112
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

Scheller, Christin / Krebs, Finja / Minkner, Robert / Astner, Isabel / Gil‐Moles, Maria / Wätzig, Hermann

ELECTROPHORESIS

2020 Volume 41, Issue 13-14, Page(s) 1137–1151

Keywords	Clinical Biochemistry ; Biochemistry ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.202000121
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 1868: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Physicochemical properties of SARS-CoV-2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

Scheller, Christin / Krebs, Finja / Minkner, Robert / Astner, Isabel / Gil-Moles, Maria / Wätzig, Hermann

Electrophoresis

Abstract	The material properties of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its proteins are discussed. We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, stability against pH, temperature, UV light, gamma radiation, and susceptibility to various chemical agents including solvents and detergents. Possible inactivation, downstream, and formulation conditions are given including suitable buffers and some first ideas for quality-control methods. This information supports vaccine development and discussion with competent authorities during vaccine approval and is certainly related to drug-targeting strategies and hygienics. Several instructive tables are given, including the pI and grand average of hydropathicity (GRAVY) of SARS-CoV-1 and -2 proteins in comparison. SARS-CoV-1 and SARS-CoV-2 are similar in many regards, so information can often be derived. Both are unusually stable, but sensitive at their lipophilic membranes. However, since seemingly small differences can have strong effects, for example, on immunologically relevant epitope settings, unevaluated knowledge transfer from SARS-CoV-1 to SARS-CoV-2 cannot be advised. Published knowledge regarding downstream processes, formulations and quality assuring methods is, as yet, limited. However, standard approaches employed for other viruses and vaccines seem to be feasible including virus inactivation, centrifugation conditions, and the use of adjuvants.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32469436
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Temperature-assisted formation of reversible metallophilic Au-Ag interaction arrays.

Gil-Moles, María / Gimeno, M Concepción / López-de-Luzuriaga, José M / Monge, Miguel / Olmos, M Elena

Dalton transactions (Cambridge, England : 2003)

2019 Volume 48, Issue 16, Page(s) 5149–5155

Abstract: A temperature-controlled self-assembly process in a solution of [Ag(terpy)]nn+ and [Au(C6F5)2]- units has been performed. For this, the crystallisation of the complex [{Au(C6F5)2}Ag(terpy)]n under the same experimental conditions, changing only the ... ...

Abstract	A temperature-controlled self-assembly process in a solution of [Ag(terpy)]nn+ and [Au(C6F5)2]- units has been performed. For this, the crystallisation of the complex [{Au(C6F5)2}Ag(terpy)]n under the same experimental conditions, changing only the temperature, allows the synthesis of polymorphs [{Au(C6F5)2}2Ag2(terpy)2]n (2a) at 298 K and [{Au(C6F5)2}Ag(terpy)]n (2b) at 280 K. The X-ray diffraction studies previously reported for 2a revealed a polymeric structure with an unusual + + - - + + - - charge sequence, whereas for polymorph 2b, a more classical + - + - disposition has been obtained. The conversion of one polymorph into the other can be achieved by simple dissolution of one of them and by recrystallisation at the corresponding temperature. The mechanism of the formation of each polymorph is proposed in view of their 1H NMR, 1H-PGSE NMR and molar conductivity measurements.
Language	English
Publishing date	2019-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c9dt00751b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

Scheller, Christin / Krebs, Finja / Minkner, Robert / Astner, Isabel / Gil‐Moles, Maria / Wätzig, Hermann

Electrophoresis. 2020 July, v. 41, no. 13-14

2020

Abstract: The material properties of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its proteins are discussed. We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, ... ...

Abstract	The material properties of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its proteins are discussed. We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, stability against pH, temperature, UV light, gamma radiation, and susceptibility to various chemical agents including solvents and detergents. Possible inactivation, downstream, and formulation conditions are given including suitable buffers and some first ideas for quality‐control methods. This information supports vaccine development and discussion with competent authorities during vaccine approval and is certainly related to drug‐targeting strategies and hygienics. Several instructive tables are given, including the pI and grand average of hydropathicity (GRAVY) of SARS‐CoV‐1 and ‐2 proteins in comparison. SARS‐CoV‐1 and SARS‐CoV‐2 are similar in many regards, so information can often be derived. Both are unusually stable, but sensitive at their lipophilic membranes. However, since seemingly small differences can have strong effects, for example, on immunologically relevant epitope settings, unevaluated knowledge transfer from SARS‐CoV‐1 to SARS‐CoV‐2 cannot be advised. Published knowledge regarding downstream processes, formulations and quality assuring methods is, as yet, limited. However, standard approaches employed for other viruses and vaccines seem to be feasible including virus inactivation, centrifugation conditions, and the use of adjuvants.
Keywords	Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; centrifugation ; electrophoresis ; epitopes ; gamma radiation ; isoelectric point ; lipophilicity ; pH ; quality control ; temperature ; ultraviolet radiation ; vaccine development ; vaccines ; viral morphology ; viruses
Language	English
Dates of publication	2020-07
Size	p. 1137-1151.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; REVIEW
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.202000121
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 84/705: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED