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Article: Exposure to oxyfluorfen-induced hematobiochemical alterations, oxidative stress, genotoxicity, and disruption of sex hormones in male African catfish and the potential to confront by Chlorella vulgaris.

Mansour, Abdallah Tageldein / Amen, Rehab M / Mahboub, Heba H / Shawky, Sherif M / Orabi, Sahar H / Ramah, Amany / Hamed, Heba S

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

2023 Volume 267, Page(s) 109583

Abstract: The present study evaluated the effect of chronic exposure to oxyfluorfen (OXY) on different physiological responses of male African catfish, Clarias gariepinus, and the ameliorative effect of Chlorella vulgaris. The fish (160 ± 5.10 g) were exposed to 1/ ...

Abstract	The present study evaluated the effect of chronic exposure to oxyfluorfen (OXY) on different physiological responses of male African catfish, Clarias gariepinus, and the ameliorative effect of Chlorella vulgaris. The fish (160 ± 5.10 g) were exposed to 1/20 LC
MeSH term(s)	Male ; Animals ; Antioxidants/metabolism ; Chlorella vulgaris/metabolism ; Catfishes/metabolism ; Oxidative Stress ; Gonadal Steroid Hormones
Chemical Substances	Antioxidants ; oxyfluorofen (46GY4Y6567) ; Gonadal Steroid Hormones
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	189285-x
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
DOI	10.1016/j.cbpc.2023.109583
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Article ; Online: Grape-Leaf Extract Attenuates Alcohol-Induced Liver Injury via Interference with NF-κB Signaling Pathway.

Amen, Yhiya / Sherif, Asmaa E / Shawky, Noha M / Abdelrahman, Rehab S / Wink, Michael / Sobeh, Mansour

Biomolecules

2020 Volume 10, Issue 4

Abstract: Grape (Vitis vinifera) leaf extracts (GLEs) are known to be rich in phenolic compounds that exert potent antioxidant effects. Given the vulnerability of the liver to oxidative damage, antioxidants have been proposed as therapeutic agents and coadjuvant ... ...

Abstract	Grape (Vitis vinifera) leaf extracts (GLEs) are known to be rich in phenolic compounds that exert potent antioxidant effects. Given the vulnerability of the liver to oxidative damage, antioxidants have been proposed as therapeutic agents and coadjuvant drugs to ameliorate liver pathologies. The current study was designed to characterize secondary metabolites and investigate the hepatoprotective effects of GLE and its underlying mechanisms. The secondary metabolites were profiled using HPLC-PDA-ESI-MS, and forty-five compounds were tentatively identified. In experimental in vivo design, liver injury was induced by oral administration of high doses of ethanol (EtOH) for 12 days to male Sprague Dawley rats that were split into five different groups. Blood samples and livers were then collected, and used for various biochemical, immunohistochemical, and histopathological analyses. Results showed that GLE-attenuated liver injury and promoted marked hepatic antioxidant effects, in addition to suppressing the increased heat-shock protein-70 expression. Moreover, GLE suppressed EtOH-induced expression of nuclear factor-κB (NF-B) p65 subunit and proinflammatory cytokine tumor necrosis factor-α. Caspase-3 and survivin were enhanced by EtOH intake and suppressed by GLE intake. Finally, EtOH-induced histopathological changes in liver sections were markedly normalized by GLE. In conclusion, our results suggested that GLE interferes with NF-B signaling and induces antioxidant effects, which both play a role in attenuating apoptosis and associated liver injury in a model of EtOH-induced liver damage in rats.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Chemical and Drug Induced Liver Injury, Chronic/drug therapy ; Chemical and Drug Induced Liver Injury, Chronic/metabolism ; Chemical and Drug Induced Liver Injury, Chronic/pathology ; Cytoprotection/drug effects ; Ethanol/adverse effects ; Gene Expression Regulation/drug effects ; HSP70 Heat-Shock Proteins/metabolism ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Vitis/chemistry
Chemical Substances	HSP70 Heat-Shock Proteins ; NF-kappa B ; Plant Extracts ; Ethanol (3K9958V90M)
Language	English
Publishing date	2020-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10040558
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Article ; Online: In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity.

Agwa, Sara H A / Elghazaly, Hesham / Meteini, Mahmoud Shawky El / Shawky, Sherif M / Ali, Marwa / Abd Elsamee, Aya M / Sayed, Safa Matbouly / Sherif, Nadine / Sharaf, Howida M / Alhadidy, Mohamed A / Matboli, Marwa

Cells

2021 Volume 10, Issue 11

Abstract: 1) Background: The coronavirus (COVID-19) pandemic is still a major global health problem, despite the development of several vaccines and diagnostic assays. Moreover, the broad symptoms, from none to severe pneumonia, and the various responses to ... ...

Abstract	(1) Background: The coronavirus (COVID-19) pandemic is still a major global health problem, despite the development of several vaccines and diagnostic assays. Moreover, the broad symptoms, from none to severe pneumonia, and the various responses to vaccines and the assays, make infection control challenging. Therefore, there is an urgent need to develop non-invasive biomarkers to quickly determine the infection severity. Circulating RNAs have been proven to be potential biomarkers for a variety of diseases, including infectious ones. This study aimed to develop a genetic network related to cytokines, with clinical validation for early infection severity prediction. (2) Methods: Extensive analyses of in silico data have established a novel IL11RA molecular network (IL11RNA mRNA, LncRNAs RP11-773H22.4 and hsa-miR-4257). We used different databases to confirm its validity. The differential expression within the retrieved network was clinically validated using quantitative RT-PCR, along with routine assessment diagnostic markers (CRP, LDH, D-dimmer, procalcitonin, Ferritin), in100 infected subjects (mild and severe cases) and 100 healthy volunteers. (3) Results: IL11RNA mRNA and LncRNA RP11-773H22.4, and the IL11RA protein, were significantly upregulated, and there was concomitant downregulation of hsa-miR-4257, in infected patients, compared to the healthy controls, in concordance with the infection severity. (4) Conclusion: The in-silico data and clinical validation led to the identification of a potential RNA/protein signature network for novel predictive biomarkers, which is in agreement with ferritin and procalcitonin for determination of COVID-19 severity.
MeSH term(s)	Adult ; Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/metabolism ; Computational Biology ; Female ; Gene Regulatory Networks ; Humans ; Interleukin-11 Receptor alpha Subunit/blood ; Interleukin-11 Receptor alpha Subunit/genetics ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; RNA, Long Noncoding/blood ; RNA, Long Noncoding/genetics ; RNA, Messenger/blood ; RNA, Messenger/genetics ; ROC Curve ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Chemical Substances	Biomarkers ; IL11RA protein, human ; Interleukin-11 Receptor alpha Subunit ; MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger
Language	English
Publishing date	2021-11-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10113098
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Article ; Online: Effect of Short-Term High Fat Diet Inducing Obesity on Hematological, Some Biochemical Parameters and Testicular Oxidative Stress in Male Rats

Sherif M. Shawky

Journal of Advanced Veterinary Research, Vol 5, Iss 4, Pp 151-

2015 Volume 156

Abstract: Obesity constitutes a health problem due to its increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. Some studies have shown a relationship between obesity and infertility, but until now it remains ... ...

Abstract	Obesity constitutes a health problem due to its increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. Some studies have shown a relationship between obesity and infertility, but until now it remains controversial. The objective of the current work was to examine the effect of diet-induced obesity on blood parameters, liver and kidney function tests, lipid profile and testicular oxidative stress. For that purpose, Male rats were fed ad libitum with a standard diet (control group; n.= 15) and high fat diet (HFD group; n.= 15) for 6 weeks. Hematological parameters, urea, creatinine, albumin were similar between the two groups. Intergroup testosterone levels were also comparable. The high fat diet induced significant increase in serum triglycerides, cholesterol, low density lipoprotein and very low density lipoprotein cholesterol concentrations. This diet also increases significantly alanine aminotransferase and aspartate aminotransferase activities and decreased total protein level and high-density lipoprotein cholesterol concentration. Furthermore, HFD showed a significant increasing in malondialdehyde contents in testes and decreasing in superoxide dismutase activity, the results of this study concluded that short-term high fat diet affect on liver enzymes and causing oxidative stress in testes.
Keywords	Veterinary medicine ; SF600-1100
Subject code	630 ; 796
Language	English
Publishing date	2015-10-01T00:00:00Z
Publisher	Assiut University
Document type	Article ; Online
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Article: Integration of transcriptomes analysis with spectral signature of total RNA for generation of affordable remote sensing of Hepatocellular carcinoma in serum clinical specimens.

Aboughaleb, Ibrahim H / Matboli, Marwa / Shawky, Sherif M / El-Sharkawy, Yasser H

Heliyon

2021 Volume 7, Issue 3, Page(s) e06388

Abstract: Hepatocellular carcinoma (HCC) is a major global health problem with about 841,000 new cases and 782,000 deaths annually, due to lacking early biomarker/s, and centralized diagnosis. Transcriptomes research despite its infancy has proved excellence in ... ...

Abstract	Hepatocellular carcinoma (HCC) is a major global health problem with about 841,000 new cases and 782,000 deaths annually, due to lacking early biomarker/s, and centralized diagnosis. Transcriptomes research despite its infancy has proved excellence in its implementation in identifying a coherent specific cancer RNAs differential expression. However, results are sometimes overlapped by other cancer types which negatively affecting specificity, plus the high cost of the equipment used. Hyperspectral imaging (HSI) is an advanced tool with unique, spectroscopic features, is an emerging tool that has widely been used in cancer detection. Herein, a pilot study has been performed for HCC diagnosis, by exploiting HIS properties and the analysis of the transcriptome for the development of non-invasive remote HCC sensing. HSI data cube images of the sera extracted total RNA have been analyzed in HCC, normal subject, liver benign tumor, and chronic HCV with cirrhotic/non-cirrhotic liver groups. Data analyses have revealed a specific spectral signature for all groups and can be easily discriminated; at the computed optimum wavelength. Moreover, we have developed a simple setup based on a commercial laser pointer for sample illumination and a Smartphone CCD camera, with HSI consistent data output. We hypothesized that RNA differential expression and its spatial organization/folding are the key players in the obtained spectral signatures. To the best of our knowledge, we are the first to use HSI for sensing cancer based on total RNA in serum, using a Smartphone CCD camera/laser pointer. The proposed biosensor is simple, rapid (2 min), and affordable with specificity and sensitivity of more than 98% and high accuracy.
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e06388
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Article ; Online: Age-related changes in testicular morphometry and function in Egyptian donkeys.

Masoud, Shimaa R / Kishta, Afaf A / Canisso, Igor F / Abdel-Megeid, Nazema S / Fathalla, Said I / Shawky, Sherif M / Abdoon, Ahmed Sabry S

Reproduction in domestic animals = Zuchthygiene

2022 Volume 57, Issue 11, Page(s) 1319–1326

Abstract: This study aimed to assess the effects of age on testicular morphometry and function in donkeys. Testes and epididymides of 57 donkeys were harvested immediately after slaughtering. The donkeys were grouped: young (1-4 years old, n = 13); adult (5-15 ... ...

Abstract	This study aimed to assess the effects of age on testicular morphometry and function in donkeys. Testes and epididymides of 57 donkeys were harvested immediately after slaughtering. The donkeys were grouped: young (1-4 years old, n = 13); adult (5-15 years old, n = 25) and aged (>15 years old, n = 19). Each testis and epididymis were weighed separately. Testicular volume was calculated. Epididymal sperm was harvested by retrograde flushing method, and sperm parameters were evaluated. The testicular parenchyma was immunolabelled for BAX and COX2. Adult and aged donkeys had greater testicular weight and volume than young (p < .05). Epididymal sperm concentration, motility and viability were greater (p < .05) in adults and aged (931.8 ± 39.3 and 858.2 ± 33.2 × 10
MeSH term(s)	Male ; Animals ; Testis/anatomy & histology ; Equidae ; Egypt ; Cyclooxygenase 2 ; Semen ; Epididymis ; Spermatozoa ; Sperm Motility
Chemical Substances	Cyclooxygenase 2 (EC 1.14.99.1)
Language	English
Publishing date	2022-07-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14207
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Article ; Online: σ-Hole and LP-Hole Interactions of Pnicogen···Pnicogen Homodimers under the External Electric Field Effect: A Quantum Mechanical Study.

Ibrahim, Mahmoud A A / Moussa, Nayra A M / Saad, Sherif M A / Ahmed, Muhammad Naeem / Shawky, Ahmed M / Soliman, Mahmoud E S / Mekhemer, Gamal A H / Rady, Al-Shimaa S M

ACS omega

2022 Volume 7, Issue 13, Page(s) 11264–11275

Abstract: σ-Hole and lone-pair (lp)-hole interactions within σ-hole···σ-hole, σ-hole···lp-hole, and lp-hole···lp-hole configurations were comparatively investigated on the pnicogen···pnicogen homodimers ( ... ...

Abstract	σ-Hole and lone-pair (lp)-hole interactions within σ-hole···σ-hole, σ-hole···lp-hole, and lp-hole···lp-hole configurations were comparatively investigated on the pnicogen···pnicogen homodimers (PCl
Language	English
Publishing date	2022-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c00176
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Article: Antiulcer Potential of

Shady, Nourhan Hisham / Abdullah, Hend Samy / Maher, Sherif A / Albohy, Amgad / Elrehany, Mahmoud A / Mokhtar, Fatma Alzahraa / Oraby, Hesham Farouk / Shawky, Ahmed M / Abdelmohsen, Usama Ramadan

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 7

Abstract: One of the most severe human health problems is gastric ulceration. The main aim of our study is to explore the gastroprotective effect of ... ...

Abstract	One of the most severe human health problems is gastric ulceration. The main aim of our study is to explore the gastroprotective effect of the
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11071230
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Article ; Online: Integration of transcriptomes analysis with spectral signature of total RNA for generation of affordable remote sensing of Hepatocellular carcinoma in serum clinical specimens

Ibrahim H. Aboughaleb / Marwa Matboli / Sherif M. Shawky / Yasser H. El-Sharkawy

Heliyon, Vol 7, Iss 3, Pp e06388- (2021)

2021

Abstract	Hepatocellular carcinoma (HCC) is a major global health problem with about 841,000 new cases and 782,000 deaths annually, due to lacking early biomarker/s, and centralized diagnosis. Transcriptomes research despite its infancy has proved excellence in its implementation in identifying a coherent specific cancer RNAs differential expression. However, results are sometimes overlapped by other cancer types which negatively affecting specificity, plus the high cost of the equipment used.Hyperspectral imaging (HSI) is an advanced tool with unique, spectroscopic features, is an emerging tool that has widely been used in cancer detection.Herein, a pilot study has been performed for HCC diagnosis, by exploiting HIS properties and the analysis of the transcriptome for the development of non-invasive remote HCC sensing.HSI data cube images of the sera extracted total RNA have been analyzed in HCC, normal subject, liver benign tumor, and chronic HCV with cirrhotic/non-cirrhotic liver groups. Data analyses have revealed a specific spectral signature for all groups and can be easily discriminated; at the computed optimum wavelength. Moreover, we have developed a simple setup based on a commercial laser pointer for sample illumination and a Smartphone CCD camera, with HSI consistent data output. We hypothesized that RNA differential expression and its spatial organization/folding are the key players in the obtained spectral signatures. To the best of our knowledge, we are the first to use HSI for sensing cancer based on total RNA in serum, using a Smartphone CCD camera/laser pointer. The proposed biosensor is simple, rapid (2 min), and affordable with specificity and sensitivity of more than 98% and high accuracy.
Keywords	Hepatocellular carcinoma ; Alpha-fetoprotein ; Transcriptomes ; Hyperspectral imaging ; Spectral signature ; Remote sensing ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity

Sara H. A. Agwa / Hesham Elghazaly / Mahmoud Shawky El Meteini / Sherif M. Shawky / Marwa Ali / Aya M. Abd Elsamee / Safa Matbouly Sayed / Nadine Sherif / Howida M. Sharaf / Mohamed A. Alhadidy / Marwa Matboli

Cells, Vol 10, Iss 3098, p

2021 Volume 3098

Abstract	(1) Background: The coronavirus (COVID-19) pandemic is still a major global health problem, despite the development of several vaccines and diagnostic assays. Moreover, the broad symptoms, from none to severe pneumonia, and the various responses to vaccines and the assays, make infection control challenging. Therefore, there is an urgent need to develop non-invasive biomarkers to quickly determine the infection severity. Circulating RNAs have been proven to be potential biomarkers for a variety of diseases, including infectious ones. This study aimed to develop a genetic network related to cytokines, with clinical validation for early infection severity prediction. (2) Methods: Extensive analyses of in silico data have established a novel IL11RA molecular network (IL11RNA mRNA, LncRNAs RP11-773H22.4 and hsa-miR-4257). We used different databases to confirm its validity. The differential expression within the retrieved network was clinically validated using quantitative RT-PCR, along with routine assessment diagnostic markers (CRP, LDH, D-dimmer, procalcitonin, Ferritin), in100 infected subjects (mild and severe cases) and 100 healthy volunteers. (3) Results: IL11RNA mRNA and LncRNA RP11-773H22.4, and the IL11RA protein, were significantly upregulated, and there was concomitant downregulation of hsa-miR-4257, in infected patients, compared to the healthy controls, in concordance with the infection severity. (4) Conclusion: The in-silico data and clinical validation led to the identification of a potential RNA/protein signature network for novel predictive biomarkers, which is in agreement with ferritin and procalcitonin for determination of COVID-19 severity.
Keywords	circulating RNAs ; bioinformatics ; SARS-COV-2 infection severity prediction ; interleukins genetic network ; coding and non-coding RNAs ; COVID-19 infection potential biomarker ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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