LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 470

Search options

  1. Book ; Conference proceedings: New insights into GnRH neuron development, programming and regulation in health and disease

    Millar, Robert P.

    (Neuroendocrinology ; 102, 15, 3)

    2015  

    Event/congress International Congress of Neuroendocrinology (8., 2014, Sydney)
    Author's details editor Robert P. Millar, Edinburgh
    Series title Neuroendocrinology ; 102, 15, 3
    Collection
    Keywords Endocrinology ; Neuroendocrinology ; Reproduction ; Gonadotropin-Releasinghormon ; Endokrinologie
    Subject CAS 33515-09-2 ; Folliberin ; Follikelstimulierendes Hormon Releasing-Hormon ; Follikelstimulierendes Hormon-Releasing-Hormon ; FSHRH ; FSH-RH ; GnRF ; GnRH ; GnRH1 ; Gonadoliberin ; Gonadorelin ; Gonadotropin releasing factor ; Gonadotropin releasing hormone ; Gonadotropin Releasing-Hormon 1 ; Gonadotropin-Releasing-Hormon ; GRF ; GRH ; LHRF ; LH-RH ; LHRH ; Luliberin ; Luteinisierendes Hormon Releasing-Hormon ; Luteinisierendes Hormon-Releasing Hormon
    Language English
    Size Seite 182-245, Illustrationen, 28 cm, 240 g
    Publisher Karger
    Publishing place Basel ; Freiburg Breisgau
    Publishing country Switzerland ; Germany
    Document type Book ; Conference proceedings
    Note "This special issue arises from Symposia on GnRH and reproduction presented at the International Congress of Neuroendocrinology in Sydney, August 2014" - Preface
    HBZ-ID HT019005399
    ISBN 978-3-318-05693-8 ; 3-318-05693-6 ; 9783318056945 ; 3318056944
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 531 -102,3- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Recollections on Jean E. Rivier: A Giant in Neuroendocrinology.

    Millar, Robert P

    Neuroendocrinology

    2020  Volume 110, Issue 6, Page(s) 443

    Language English
    Publishing date 2020-03-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000507085
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Cushing's syndrome update: 100 years after Minnie G.

    Millar, Robert P / Karavitaki, Niki / Kastelan, Darko

    Journal of neuroendocrinology

    2022  Volume 34, Issue 8, Page(s) e13167

    MeSH term(s) Cushing Syndrome ; Humans ; Hydrocortisone
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 1007517-3
    ISSN 1365-2826 ; 0953-8194
    ISSN (online) 1365-2826
    ISSN 0953-8194
    DOI 10.1111/jne.13167
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application.

    Anderson, Richard A / Millar, Robert P

    Journal of neuroendocrinology

    2021  Volume 34, Issue 5, Page(s) e13081

    Abstract: The delivery of gonadotropin-releasing hormone (GnRH) in a pulsatile mode to the gonadotropes has long been known to be essential for normal reproductive function. There have been numerous studies aimed at dissecting out the mechanisms underlying GnRH ... ...

    Abstract The delivery of gonadotropin-releasing hormone (GnRH) in a pulsatile mode to the gonadotropes has long been known to be essential for normal reproductive function. There have been numerous studies aimed at dissecting out the mechanisms underlying GnRH pulse generation. The discovery of kisspeptin as an upstream regulator of GnRH attracted the possibility that pulsatile kisspeptin governed the pulsatile secretion of GnRH. Subsequent studies have shown the importance of the neurokinin B (NKB) system in modulating kisspeptin secretion and this GnRH. A number of studies in laboratory rodents have supported this notion. By contrast, we present data from clinical studies in men and women, in a range of contexts, showing that continuous infusion of kisspeptin 10 at receptor-saturating levels gives rise to an increase in luteinizing hormone (LH) (GnRH) pulse frequency. This has been demonstrated in normal healthy and hypogonadal men, in normal women during the mid-cycle LH surge, in men and women with mutations in the genes encoding NKB or its receptor, neurokinin 3 receptor (NK3R), in women with polycystic ovary syndrome treated with NK3R antagonist, and in women treated with NK3R antagonist during the LH surge. These finds indicate that pulsatile secretion and action of kisspeptin on GnRH neurons is not required for the generation of LH (GnRH) pulses in humans. We also report that there is an absence of desensitization in humans exposed to continuous infusion of kisspeptin-10 at receptor-saturating concentrations over 22 h and briefly review GnRH, kisspeptin and NKB analogs and their clinical application.
    MeSH term(s) Female ; Gonadotropin-Releasing Hormone ; Humans ; Kisspeptins ; Luteinizing Hormone ; Neurokinin B ; Neurons ; Receptors, Neurokinin-3
    Chemical Substances Kisspeptins ; Receptors, Neurokinin-3 ; Gonadotropin-Releasing Hormone (33515-09-2) ; Neurokinin B (86933-75-7) ; Luteinizing Hormone (9002-67-9)
    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1007517-3
    ISSN 1365-2826 ; 0953-8194
    ISSN (online) 1365-2826
    ISSN 0953-8194
    DOI 10.1111/jne.13081
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Correction to: Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus.

    Singh, Ankur / Lal, Bechan / Kumar, Pankaj / Parhar, Ishwar S / Millar, Robert P

    Cell and tissue research

    2023  Volume 393, Issue 3, Page(s) 595–596

    Language English
    Publishing date 2023-07-14
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-023-03812-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Human reproduction

    Millar, Robert P.

    pharmaceutical and technical advances

    (British medical bulletin ; 56,3)

    2000  

    Author's details scientific ed. Robert P. Millar
    Series title British medical bulletin ; 56,3
    Collection
    Keywords Reproduktionsmedizin
    Subject Reproduktionstechnik ; Fortpflanzungstechnologie ; Reproduktionstechnologie ; Fortpflanzungsmedizin ; Fortpflanzung ; Humanbiotechnologie ; Gentechnologie
    Language English
    Size IV S., S. 577 - 842 : Ill., graph. Darst.
    Publisher Royal Soc. of Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012895916
    ISBN 1-85315-458-X ; 978-1-85315-458-4
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 277 -56,3- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: New Developments in Reproductive and Stress Neuroendocrinology.

    Prevot, Vincent / Millar, Robert P

    Neuroendocrinology

    2019  Volume 109, Issue 3, Page(s) 191–192

    MeSH term(s) Animals ; Congresses as Topic ; Humans ; Neurons/physiology ; Neurosecretory Systems/growth & development ; Neurosecretory Systems/physiology ; Neurosecretory Systems/physiopathology ; Reproduction/physiology ; Stress, Physiological/physiology ; Stress, Psychological/physiopathology
    Language English
    Publishing date 2019-07-31
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000502420
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus.

    Singh, Ankur / Lal, Bechan / Kumar, Pankaj / Parhar, Ishwar S / Millar, Robert P

    Cell and tissue research

    2023  Volume 393, Issue 2, Page(s) 377–391

    Abstract: Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss-GnRH neurons in vertebrate's brain. NKB is also characterized in gonadal tissues; however, its role in gonads is poorly understood. Therefore, in the ... ...

    Abstract Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss-GnRH neurons in vertebrate's brain. NKB is also characterized in gonadal tissues; however, its role in gonads is poorly understood. Therefore, in the present study, the effects of NKB on gonadal steroidogenesis and gametogenesis through in vivo and in vitro approaches using NKB antagonist MRK-08 were evaluated. The results suggest that the NKB antagonist decreases the development of advanced ovarian follicles and germ cells in the testis. In addition, MRK-08 further reduces the production of 17β-estradiol in the ovary and testosterone in the testis under both in vivo and in vitro conditions in a dose-dependent manner. Furthermore, the in vitro MRK-08 treatment of gonadal explants attenuated the expression of steroidogenic marker proteins, i.e., StAR, 3β-HSD, and 17β-HSD dose-dependently. Moreover, the MAP kinase proteins, pERK1/2 & ERK1/2 and pAkt & Akt were also downregulated by MRK-08. Thus, the study suggests that NKB downregulates steroidogenesis by modulating the expressions of steroidogenic marker proteins involving ERK1/2 & pERK1/2 and Akt/pAkt signalling pathways. NKB also appears to regulate gametogenesis by regulating gonadal steroidogenesis in the catfish.
    MeSH term(s) Male ; Animals ; Female ; Neurokinin B/metabolism ; Catfishes/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Testis/metabolism ; Gametogenesis
    Chemical Substances Neurokinin B (86933-75-7) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-06-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-023-03788-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: New Insights into GnRH Neuron Development, Programming and Regulation in Health and Disease. Preface.

    Millar, Robert P

    Neuroendocrinology

    2015  Volume 102, Issue 3, Page(s) 181–183

    MeSH term(s) Animals ; Brain/growth & development ; Brain/physiology ; Gonadotropin-Releasing Hormone/physiology ; Humans ; Kisspeptins/metabolism ; Neurons/physiology
    Chemical Substances Kisspeptins ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Introductory Journal Article
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000441115
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: A dual kisspeptin-GnRH immunogen for reproductive immunosterilization.

    Junco, Jesus A / Fuentes, Franklin / Millar, Robert P

    Vaccine

    2021  Volume 39, Issue 43, Page(s) 6437–6448

    Abstract: GnRH immunogens have been extensively employed in immunocontraception of animals. While they are effective, they are not 100% efficacious and of limited duration. GnRH secretion is dependent on upstream stimulation by kisspeptin. We therefore ... ...

    Abstract GnRH immunogens have been extensively employed in immunocontraception of animals. While they are effective, they are not 100% efficacious and of limited duration. GnRH secretion is dependent on upstream stimulation by kisspeptin. We therefore hypothesised that a dual immunogen combining GnRH and kisspeptin may be more efficacious through targeting two levels of the axis. We have previously shown GnRH immunogen elicits permanent sterilisation when sheep are vaccinated neonatally suggesting that the efficacy of GnRH immunisation may be dependent on the stage of reproductive development. We have now studied over 300 days the efficacy of immunisation with a dual immunogen comprising GnRH linked to kisspeptin via a hepatitis B T helper peptide sequence (GKT) administered to male and female rats prepubertally, pubertally and as adults. At all stages of development all immunised animals produced antibodies to GnRH, kisspeptin and GKT but differentially in titre with respect to sex and stage of development. In immunised adult, prepubertal and pubertal males testosterone and testes length was markedly reduced by 60 days and remained at low levels until day 150. Thereafter, testosterone recovered to pre immunisation levels and testes length increased to a maximum of about 40% of controls. 80% of males were infertile in three matings over 250 days. In prepubertal and pubertal female rats a single immunisation at day 0 reduced estradiol to low levels by day 60 which remained low until termination of the experiment on day 300. In matings of these females with fertile males on days 90, 120 and 250, 74% of prepubertal females were infertile and impressively, 100% (10/10) of pubertal females were infertile after a single immunisation on day 0. These findings set the scene for exploration of immunosterilisation of wild and domestic animals after a single immunisation.
    MeSH term(s) Animals ; Female ; Gonadotropin-Releasing Hormone ; Kisspeptins ; Male ; Rats ; Reproduction ; Sheep ; Testosterone
    Chemical Substances Kisspeptins ; Gonadotropin-Releasing Hormone (33515-09-2) ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2021-09-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.07.080
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top