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  1. Book: Rheumatoid arthritis

    St. Clair, E. William

    2004  

    Author's details ed. by E. William St. Clair
    Keywords Arthritis, Rheumatoid
    Language English
    Size XIV, 555 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014023463
    ISBN 0-7817-4149-1 ; 978-0-7817-4149-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 2854 order for loan Magazin

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  2. Article ; Online: In ANCA-associated vasculitis in remission, tailored vs fixed-schedule rituximab did not differ for relapse at 28 months.

    St Clair, E William

    Annals of internal medicine

    2018  Volume 169, Issue 6, Page(s) JC33

    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Humans ; Recurrence ; Rituximab
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2018-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJC-2018-169-6-033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Gamma Knife Radiosurgery to Four Brainstem Lesions After Whole Brain Radiation Therapy.

    Bernard, Mark E / St Clair, William / Pokhrel, Damodar

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17226

    Abstract: Our patient was a 58-year-old female with a history of extensive stage small cell lung cancer initially diagnosed in November 2018. She received palliative radiation to the right hip and whole brain in December of 2018 and then received chemotherapy. ... ...

    Abstract Our patient was a 58-year-old female with a history of extensive stage small cell lung cancer initially diagnosed in November 2018. She received palliative radiation to the right hip and whole brain in December of 2018 and then received chemotherapy. Unfortunately, in October 2019, the repeat brain magnetic resonance imaging (MRI) showed recurrent lesions and she was referred for Gamma Knife Radiosurgery (GKRS). At the time of the treatment, she was found to have four brainstem lesions as well as a left frontal lobe and a right frontal lobe lesion. She completed GKRS to all six lesions without any neurological complications seen in her short-term follow-up. This case report adds to the growing body of literature showing safety of GKRS for multiple brainstem lesions.
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply.

    Fraenkel, Liana / Bathon, Joan M / England, Bryant R / St Clair, E William / Akl, Elie A

    Arthritis & rheumatology (Hoboken, N.J.)

    2021  Volume 74, Issue 1, Page(s) 175

    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 24: Show issues Location:
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  5. Book ; Online: Rheumatoid arthritis

    St. Clair, E. William / Pisetsky, David S. / Haynes, Barton F.

    2004  

    Author's details editors, E. William St. Clair, David S. Pisetsky, Barton F. Haynes ; with contributing authors
    Keywords Arthritis, rheumatoid
    Language English
    Size 1 Online-Ressource (xiv, 555 Seiten), Illustrationen
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-4149-1 ; 0-7817-4149-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  6. Article ; Online: ACR Presidential Address: RethinkingRheumatology: A Brave New World.

    St Clair, E William

    Arthritis & rheumatology (Hoboken, N.J.)

    2016  Volume 68, Issue 2, Page(s) 277–281

    MeSH term(s) Cost-Benefit Analysis ; Delivery of Health Care/history ; Delivery of Health Care/trends ; History, 20th Century ; History, 21st Century ; Humans ; Quality of Health Care ; Reimbursement Mechanisms ; Rheumatology/history ; Rheumatology/trends ; Societies, Medical ; United States
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Addresses ; Historical Article ; Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.39533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Introducing the New Editor of Arthritis & Rheumatology, Richard J. Bucala, MD, PhD.

    St Clair, E William

    Arthritis & rheumatology (Hoboken, N.J.)

    2015  Volume 67, Issue 7, Page(s) 1687–1688

    MeSH term(s) Arthritis/history ; History, 20th Century ; History, 21st Century ; Humans ; Periodicals as Topic/history ; Rheumatology/history ; United States
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.39171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical validation of novel lightning dose optimizer for gamma knife radiosurgery of irregular-shaped arteriovenous malformations and pituitary adenomas.

    Pokhrel, Damodar / Bernard, Mark E / Knight, James / St Clair, William / Fraser, Justin F

    Journal of applied clinical medical physics

    2022  Volume 23, Issue 8, Page(s) e13669

    Abstract: Purpose: To demonstrate the clinical feasibility of a novel treatment planning algorithm via lightning dose optimizer (LDO) on Leksell Gamma Knife (LGK) GammaPlan with significantly faster planning times for stereotactic radiosurgery (SRS) of the ... ...

    Abstract Purpose: To demonstrate the clinical feasibility of a novel treatment planning algorithm via lightning dose optimizer (LDO) on Leksell Gamma Knife (LGK) GammaPlan with significantly faster planning times for stereotactic radiosurgery (SRS) of the complex and difficult arteriovenous malformations (AVMs) and pituitary adenomas.
    Methods and materials: After completing the in-house end-to-end phantom testing and independent dose verification of the recently upgraded LDO algorithm on GammaPlan using the MD Anderson's IROC anthropomorphic SRS head phantom irradiation credentialing, 20 previously treated GK-SRS patients (10 AVM, average volume 3.61 cm
    Results: For both patient cohorts, LDO provided similar target coverage with better dose conformity, tighter radiosurgical dose distribution with a lower value of gradient indices (all p < 0.001), and lower dose to critical organs. For AVMs, there was a significant reduction of normal brain V
    Conclusion: GK-SRS treatment on Leksell Perfexion GammaPlan using the LDO provided highly conformal target coverage with a steep dose gradient, spared critical organs, and significantly reduced normal brain dose for complex targets at the cost of slightly higher treatment times. LDO generated high-quality treatment plans and could significantly reduce planning time. If available, the LDO algorithm is suggested for validation and clinical use for complex and difficult GK cases.
    MeSH term(s) Arteriovenous Malformations ; Humans ; Lightning ; Pituitary Neoplasms/surgery ; Radiosurgery/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Retrospective Studies
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.13669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Conebeam CT-guided 3D MLC-based spatially fractionated radiation therapy for bulky masses.

    Pokhrel, Damodar / Bernard, Mark E / Mallory, Richard / St Clair, William / Kudrimoti, Mahesh

    Journal of applied clinical medical physics

    2022  Volume 23, Issue 5, Page(s) e13608

    Abstract: For fast, safe, and effective management of large and bulky (≥8 cm) non-resectable tumors, we have developed a conebeam CT-guided three-dimensional (3D)-conformal MLC-based spatially fractionated radiation therapy (SFRT) treatment. Using an in-house MLC- ... ...

    Abstract For fast, safe, and effective management of large and bulky (≥8 cm) non-resectable tumors, we have developed a conebeam CT-guided three-dimensional (3D)-conformal MLC-based spatially fractionated radiation therapy (SFRT) treatment. Using an in-house MLC-fitting algorithm, Millennium 120 leaves were fitted to the gross tumor volume (GTV) generating 1-cm diameter holes at 2-cm center-to-center distance at isocenter. SFRT plans of 15 Gy were generated using four to six coplanar crossfire gantry angles 60° apart with a 90° collimator, differentially weighted with 6- or 10-MV beams. A dose was calculated using AcurosXB algorithm, generating sieve-like dose channels without post-processing the physician-drawn GTV contour within an hour of CT simulation allowing for the same day treatment. In total, 50 extracranial patients have been planned and treated using this method, comprising multiple treatment sites. This novel MLC-fitting algorithm provided excellent dose parameters with mean GTV (V7.5 Gy) and mean GTV doses of 53.2% and 7.9 Gy, respectively, for 15 Gy plans. Average peak-to-valley dose ratio was 3.2. Mean beam-on time was 3.32 min, and treatment time, including patient setup and CBCT to beam-off, was within 15 min. Average 3D couch correction from original skin-markers was <1.0 cm. 3D MLC-based SFRT plans enhanced target dose for bulky masses, including deep-seated large tumors while protecting skin and adjacent critical organs. Additionally, it provides the same day, safe, effective, and convenient treatment by eliminating the risk to therapists and patients from heavy gantry-mounted physical GRID-block-we recommend other centers to use this simple and clinically useful method. This rapid SFRT planning technique is easily adoptable in any radiation oncology clinic by eliminating the need for plan optimization and patient-specific quality assurance times while providing dosimetry information in the treatment planning system. This potentially allows for dose-escalation to deep-seated masses to debulk unresectable large tumors providing an option for neoadjuvant treatment. An outcome study of clinical trial is underway.
    MeSH term(s) Humans ; Neoplasms/radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.13608
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  10. Article ; Online: Feasibility Study of Stereotactic Radiosurgery Treatment of Glomus Jugulare Tumors via HyperArc VMAT.

    Pokhrel, Damodar / Mallory, Richard / Bush, Matthew / St Clair, William / Bernard, Mark E

    Medical dosimetry : official journal of the American Association of Medical Dosimetrists

    2022  Volume 47, Issue 4, Page(s) 307–311

    Abstract: This study aims to report on the clinical validation and feasibility of utilizing a novel fully automated treatment planning and delivery system, HyperArc VMAT stereotactic radiosurgery (SRS) for glomus jugulare tumors (GJT). Independent dose ... ...

    Abstract This study aims to report on the clinical validation and feasibility of utilizing a novel fully automated treatment planning and delivery system, HyperArc VMAT stereotactic radiosurgery (SRS) for glomus jugulare tumors (GJT). Independent dose verification of the HyperArc module via the MD Anderson's SRS head phantom irradiation and credentialing results showed compliance with the SRS treatment requirements per IROC MD Anderson's standard. Following the Alliance clinical trial, AAPM, RTOG protocols, and QUANTEC requirements, utilizing selected three-partial arc geometry of HyperArc module on TrueBeam Linac with 6MV-FFF beam, GJT SRS plans were generated for nine previously treated Gamma Knife (GK) radiosurgery patients using advanced Acuros-based algorithm to account for tissue inhomogeneity corrections and frameless immobilization with Q-fix mask and Encompass device insert. HyperArc VMAT produced highly conformal SRS dose distributions to GJT, a steep dose gradient around the GJT, and spared adjacent critical organs including the spinal cord (< 3.0 Gy). Due to faster patient setup and less MLC modulation through the target (average beam-on time, 6.2 minutes), the HyperArc VMAT plan can deliver a single high-dose of 18 Gy to the GJT in less than 15 minutes overall treatment time, significantly improving patient comfort and clinic workflow. Pretreatment portal dosimetry quality assurance results and independent dose verification via Monte Carlo-based physics second check met our clinical SRS protocol's requirements for treatment. Due to the highly conformal dose distribution, rapid dose fall-off, excellent sparing of adjacent critical organs, and highly precise and accurate treatment, clinical implementation of frameless HyperArc VMAT for GJT patients who may not have access to nor tolerate frame-based GK SRS treatment are underway.
    MeSH term(s) Humans ; Radiosurgery/methods ; Glomus Jugulare Tumor ; Feasibility Studies ; Radiotherapy Planning, Computer-Assisted/methods ; Radiometry ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy Dosage
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645065-9
    ISSN 1873-4022 ; 0958-3947 ; 0739-0211
    ISSN (online) 1873-4022
    ISSN 0958-3947 ; 0739-0211
    DOI 10.1016/j.meddos.2022.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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