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  1. Article ; Online: Controversies in the management of adjuvant breast cancer with taxanes: review of the current literature.

    Araque Arroyo, Patricia / Ubago Pérez, Ruth / Cancela Díez, Bárbara / Fernández Feijóo, Maria Amalia / Hernández Magdalena, Jorge / Calleja Hernández, Miguel Angel

    Cancer treatment reviews

    2011  Volume 37, Issue 2, Page(s) 105–110

    Abstract: Taxanes offer clear benefits in adjuvant chemotherapy for early breast cancer. This review examines evidence to date on the clinical effectiveness and cost-effectiveness of their use in the adjuvant treatment of women with early breast cancer, based on ... ...

    Abstract Taxanes offer clear benefits in adjuvant chemotherapy for early breast cancer. This review examines evidence to date on the clinical effectiveness and cost-effectiveness of their use in the adjuvant treatment of women with early breast cancer, based on three meta-analyses, one systematic review, five clinical practice guidelines and 16 randomized clinical trials. Against the background of a major increase in the use of docetaxel rather than paclitaxel in our setting over the past few years, implying a major increase in costs, we examined whether this higher use of docetaxel is supported by the available evidence. In this wide study, we found no evidence that regimens containing docetaxel yield greater benefits than those including paclitaxel. From an effectiveness standpoint, the change from paclitaxel to docetaxel in our setting is not justified.
    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Chemotherapy, Adjuvant ; Cost-Benefit Analysis ; Disease-Free Survival ; Female ; Humans ; Paclitaxel/therapeutic use ; Practice Guidelines as Topic ; Taxoids/therapeutic use
    Chemical Substances Taxoids ; docetaxel (15H5577CQD) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2011-04
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2010.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Good clinical and cost outcomes using dexrazoxane to treat accidental epirubicin extravasation.

    Arroyo, Patricia Araque / Perez, Ruth Ubago / Feijoo, Maria Amalia Fernandez / Hernandez, Miguel Angel Calleja

    Journal of cancer research and therapeutics

    2010  Volume 6, Issue 4, Page(s) 573–574

    Abstract: A 75-year-old man diagnosed with lower esophageal adenocarcinoma suffered from epirubicin extravasation during the second cycle of neoadjuvant chemotherapy with epirubicin and oxaliplatin. A full recovery was achieved after treatment with dexrazoxane ( ... ...

    Abstract A 75-year-old man diagnosed with lower esophageal adenocarcinoma suffered from epirubicin extravasation during the second cycle of neoadjuvant chemotherapy with epirubicin and oxaliplatin. A full recovery was achieved after treatment with dexrazoxane (Cardioxane® ). This is the first time in our hospital that extravasation of an anthracycline has been treated with dexrazoxane. We used Cardioxane® , approved for the prevention of anthracycline-induced cardiotoxicity, while Savene® is indicated for the treatment of anthracycline extravasation. The treatment was effective, and the selection of Cardioxane® (seven-fold cheaper than Savene® ) yielded a cost saving. Consequently, Cardioxane® has been included in our guidelines for anthracycline extravasation.
    MeSH term(s) Aged ; Antineoplastic Agents/adverse effects ; Cost-Benefit Analysis ; Epirubicin/adverse effects ; Extravasation of Diagnostic and Therapeutic Materials ; Humans ; Male ; Razoxane/economics ; Razoxane/therapeutic use ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Epirubicin (3Z8479ZZ5X) ; Razoxane (5AR83PR647)
    Language English
    Publishing date 2010-10
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.77081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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