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Article: Ultra-Morphology and Mechanical Function of the Trichoideum Sensillum in

Chakilam, Shashikanth / Brożek, Jolanta / Chajec, Łukasz / Poprawa, Izabela / Gaidys, Rimvydas

2022 Volume 13, Issue 9

Abstract: The present study aims to investigate the morphological features of the antennal sensilla by using SEM and TEM. The construction of a 3D model of trichoideum sensillum using Amira software is presented in this paper. Five sensillum types, namely ... ...

Abstract	The present study aims to investigate the morphological features of the antennal sensilla by using SEM and TEM. The construction of a 3D model of trichoideum sensillum using Amira software is presented in this paper. Five sensillum types, namely trichoideum, chaeticum, campaniformium, coeloconicum, and basiconicum, were recorded. This model exhibits the mechanosensillum components, including the embedded hair in a socket attached by the joint membrane and the dendrite connected to the hair base passing through the cuticle layers. TEM images present the dendrite way, micro-tubules inside the dendritic sheath, and terminal structure of the tubular dendrite body and so-called companion cells included in the receptor, e.g., tormogen and trichogen. The parameters noted for the external structure and ultrastructure of the mechano-receptor indicate that they are specific to a particular type of sensillum and would be useful in developing the model for a biosensor. Results show that bio-inspired sensors can be developed based on morphological and ultrastructural studies and to conduct mechanical studies on their components.
Language	English
Publishing date	2022-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects13090799
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Article ; Online: No Room for Error in Medicine-A Case of Déjà Vu.

Schünemann, Holger J / Brożek, Jan L

American journal of respiratory and critical care medicine

2018 Volume 197, Issue 11, Page(s) 1501–1502

MeSH term(s)	Critical Care ; Deja Vu
Language	English
Publishing date	2018-02-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201710-2076LE
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Article ; Online: Interactive Summary of Findings tables: the way to present and understand results of systematic reviews.

Schünemann, Holger J / Santesso, Nancy / Brozek, Jan L

JBI database of systematic reviews and implementation reports

2019 Volume 17, Issue 3, Page(s) 259–260

MeSH term(s)	Delivery of Health Care/organization & administration ; Delivery of Health Care/standards ; Evidence-Based Medicine/trends ; Guidelines as Topic ; Humans ; Information Dissemination/methods ; Statistics as Topic
Language	English
Publishing date	2019-03-09
Publishing country	Australia
Document type	Journal Article ; Systematic Review
ISSN	2202-4433
ISSN (online)	2202-4433
DOI	10.11124/JBISRIR-D-19-00059
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Article ; Online: Indirectness (transferability) is critical when considering existing economic evaluations for GRADE clinical practice guidelines: a systematic review.

Riva, John J / Bhatt, Meha / Martins, Carolina C / Brunarski, David J / Busse, Jason W / Xie, Feng / Schünemann, Holger J / Brozek, Jan L

Journal of clinical epidemiology

2022 Volume 148, Page(s) 81–92

Abstract: Objectives: Grading of Recommendations Assessment, Development and Evaluation (GRADE) practice guideline developers often perform systematic reviews of potential economic evaluations to inform recommendation decision-making. We aimed to identify ... ...

Abstract	Objectives: Grading of Recommendations Assessment, Development and Evaluation (GRADE) practice guideline developers often perform systematic reviews of potential economic evaluations to inform recommendation decision-making. We aimed to identify indirectness characteristics of economic evaluations, related to GRADE evidence-to-decision (EtD) theoretical frameworks, that influence selection of these articles. Study design and setting: MEDLINE, EMBASE, CINAHL, and EconLit were systematically searched to May 2020 to identify indirectness characteristics relevant for economic evaluation transferability to GRADE EtD theoretical frameworks. Four reviewers screened citations to identify articles of any type that explored study characteristics most important or relevant to economic evaluation transferability, restricted to English language we generated frequencies of article features, used thematic analysis to summarize study characteristics, and assessed certainty in the evidence using GRADE-CERQual. Results: We included 57 articles, with a dearth of empirical literature-some may have been missed. We identified eight general themes and 28 subthemes most important to transferability from 41% of articles. Moderate-to-high confidence evidence suggested that GRADE EtD domains of population, intervention and comparison research question elements, resource use estimation and methodology, and provider and decision maker acceptability are most important indirectness study characteristics that economists consider when choosing economic evaluation outcomes for use in recommendation decision-making. Conclusion: We have identified factors important for guideline developers to consider when selecting economic evaluations as research evidence. An economic competency on the development team facilitates these endeavors. This supports the GRADE Working Group's tenant of transparent reporting or availability of sufficient information elsewhere to assess indirectness.
MeSH term(s)	Humans ; Cost-Benefit Analysis ; GRADE Approach ; Delivery of Health Care
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2022.04.011
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Article ; Online: Case studies to explore the optimal use of randomized and nonrandomized studies in evidence syntheses that use GRADE.

Cuello, Carlos A / Morgan, Rebecca L / Brozek, Jan / Verbeek, Jos / Thayer, Kris / Ansari, Mohammed T / Guyatt, Gordon / Schünemann, Holger J

Journal of clinical epidemiology

2022 Volume 152, Page(s) 56–69

Abstract: Objectives: Randomized controlled trials (RCTs) are the preferred source of evidence for the relative effect of healthcare interventions summarized in knowledge syntheses. Nonrandomized studies of interventions (NRSI) may provide replacement, sequential, ...

Abstract	Objectives: Randomized controlled trials (RCTs) are the preferred source of evidence for the relative effect of healthcare interventions summarized in knowledge syntheses. Nonrandomized studies of interventions (NRSI) may provide replacement, sequential, or complementary evidence to RCTs. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach can provide different options for properly using RCTs and NRSI integrated in health syntheses. In this article, we discuss different implications on the certainty of evidence when authors consider the use of NRSI and RCTs in systematic reviews using GRADE. Although this is a GRADE-related article, it is not an official GRADE guidance or concept article. Study design and setting: We present case studies used during GRADE working group meetings for discussion of the effects of using NRSI and RCTs on GRADE domains and on the certainty of evidence. Several concepts were discussed through iterative feedback with experts in GRADE methods and Cochrane authors. We compared suggested solutions for possible scenarios that can be met in evidence syntheses informing decisions and future guidance. Results: Different scenarios for the use of RCTs and NRSI in evidence syntheses are presented, focusing on how different GRADE ratings between RCTs and NRSI affect the overall assessment of the evidence and possible health recommendations. Conclusions: Considering differences and similarities grounded in the GRADE approach between NRSI and RCTs may help complement one another and maximize the value of knowledge syntheses and health recommendations.
MeSH term(s)	Humans ; Systematic Reviews as Topic ; Randomized Controlled Trials as Topic ; Non-Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2022.09.014
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Article: World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update - XIII - Oral immunotherapy for CMA - Systematic review.

Bognanni, Antonio / Chu, Derek K / Firmino, Ramon T / Arasi, Stefania / Waffenschmidt, Siw / Agarwal, Arnav / Dziechciarz, Piotr / Horvath, Andrea / Jebai, Rime / Mihara, Hanako / Roldan, Yetiani / Said, Maria / Shamir, Raanan / Bozzola, Martin / Bahna, Sami / Fiocchi, Alessandro / Waserman, Susan / Schünemann, Holger J / Brożek, Jan L

The World Allergy Organization journal

2022 Volume 15, Issue 9, Page(s) 100682

Abstract: Background: Allergy to cow's milk is the most common food allergy in infants and it is usually outgrown by 5 years of age. In some individuals it persists beyond early childhood. Oral immunotherapy (OIT, oral desensitization, specific oral tolerance ... ...

Abstract	Background: Allergy to cow's milk is the most common food allergy in infants and it is usually outgrown by 5 years of age. In some individuals it persists beyond early childhood. Oral immunotherapy (OIT, oral desensitization, specific oral tolerance induction) has been proposed as a promising therapeutic strategy for persistent IgE-mediated cow's milk allergy. We previously published the systematic review of OIT for cow's milk allergy (CMA) in 2010 as part of the World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. Objective: To systematically synthesize the currently available evidence about OIT for IgE-mediated CMA and to inform the updated 2022 WAO guidelines. Methods: We searched the electronic databases including PubMed, Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and the websites of selected allergy organizations. We included all studies irrespective of the language of the original publication. The last search was conducted in February 2021. We registered the protocol on Open Science Framework (10.17605/OSF.IO/AH2DT). Results: We identified 2147 unique records published between 2010 and 2021, including 13 randomized trials and 109 observational studies addressing cow's milk OIT. We found low-certainty evidence that OIT with unheated cow's milk, compared to elimination diet alone, increased the likelihood of being able to consume ≥150 ml of cow's milk in controlled settings (risk ratio (RR): 12.3, 95% CI: 5.9 to 26.0; risk difference (RD): 25 more per 100, 95% CI 11 to 56) as well as accidently ingest a small amount (≥5 ml) of cow's milk (RR: 8.7, 95% CI: 4.7 to 16.1; RD: 25 more per 100, 95% CI 12 to 50). However, 2-8 weeks after discontinuation of a successful OIT, tolerance of cow's milk persisted in only 36% (range: 20%-91%) of patients. OIT increased the frequency of anaphylaxis (rate ratio: 60.0, 95% CI 15 to 244; rate difference 5 more anaphylactic reactions per 1 person per year, 95% CI: 4 to 6; moderate evidence) and the frequency of epinephrine use (rate ratio: 35.2, 95% CI: 9 to 136.5; rate difference 268 more events per 100 person-years, 95% CI: 203 to 333; high certainty). OIT also increased the risk of gastrointestinal symptoms (RR 6.9, 95% CI 1.6-30.9; RD 28 more per 100, CI 3 to 100) and respiratory symptoms (RR 49.0, 95% CI 3.12-770.6; RD 77 more per 100, CI 62 to 92), compared with avoidance diet alone. Single-arm observational studies showed that on average 6.9% of OIT patients (95% CI: 3.8%-10%) developed eosinophilic esophagitis (very low certainty evidence). We found 1 trial and 2 small case series of OIT with baked milk. Conclusions: Moderate certainty evidence shows that OIT with unheated cow's milk in patients with IgE-mediated CMA is associated with an increased probability of being able to drink milk and, at the same time, an increased risk of serious adverse effects.
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2022.100682
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Article ; Online: Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety.

Chu, Derek K / Wood, Robert A / French, Shannon / Fiocchi, Alessandro / Jordana, Manel / Waserman, Susan / Brożek, Jan L / Schünemann, Holger J

Lancet (London, England)

2019 Volume 393, Issue 10187, Page(s) 2222–2232

Abstract: Background: Oral immunotherapy is an emerging experimental treatment for peanut allergy, but its benefits and harms are unclear. We systematically reviewed the efficacy and safety of oral immunotherapy versus allergen avoidance or placebo (no oral ... ...

Abstract	Background: Oral immunotherapy is an emerging experimental treatment for peanut allergy, but its benefits and harms are unclear. We systematically reviewed the efficacy and safety of oral immunotherapy versus allergen avoidance or placebo (no oral immunotherapy) for peanut allergy. Methods: In the Peanut Allergen immunotherapy, Clarifying the Evidence (PACE) systematic review and meta-analysis, we searched MEDLINE, EMBASE, Cochrane Controlled Register of Trials, Latin American & Caribbean Health Sciences Literature, China National Knowledge Infrastructure, WHO's Clinical Trials Registry Platform, US Food and Drug Administration, and European Medicines Agency databases from inception to Dec 6, 2018, for randomised controlled trials comparing oral immunotherapy versus no oral immunotherapy for peanut allergy, without language restrictions. We screened studies, extracted data, and assessed risk of bias independently in duplicate. Main outcomes included anaphylaxis, allergic or adverse reactions, epinephrine use, and quality of life, meta-analysed by random effects. We assessed certainty (quality) of evidence by the GRADE approach. This study is registered with PROSPERO, number CRD42019117930. Results: 12 trials (n=1041; median age across trials 8·7 years [IQR 5·9-11·2]) showed that oral immunotherapy versus no oral immunotherapy increased anaphylaxis risk (risk ratio [RR] 3·12 [95% CI 1·76-5·55], I Interpretation: In patients with peanut allergy, high-certainty evidence shows that available peanut oral immunotherapy regimens considerably increase allergic and anaphylactic reactions over avoidance or placebo, despite effectively inducing desensitisation. Safer peanut allergy treatment approaches and rigorous randomised controlled trials that evaluate patient-important outcomes are needed. Funding: None.
MeSH term(s)	Administration, Oral ; Child ; Child, Preschool ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Female ; Humans ; Male ; Peanut Hypersensitivity/therapy ; Quality of Life ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2019-04-25
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(19)30420-9
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Article ; Online: Guidelines that use the GRADE approach often fail to provide complete economic information for recommendations: A systematic survey.

Riva, John J / Bhatt, Meha / Brunarski, David J / Busse, Jason W / Martins, Carolina C / Xie, Feng / Schünemann, Holger J / Brozek, Jan L

Journal of clinical epidemiology

2021 Volume 136, Page(s) 203–215

Abstract: Objective: Little is known about how developers and panel members report cost and cost effectiveness considerations in GRADE guideline Evidence-to-Decision (EtD) frameworks. A systematic survey was conducted to explore approaches and factors ... ...

Abstract	Objective: Little is known about how developers and panel members report cost and cost effectiveness considerations in GRADE guideline Evidence-to-Decision (EtD) frameworks. A systematic survey was conducted to explore approaches and factors contributing to variability in economic information reporting. Study design and setting: Guideline organization websites were systematically searched to create a convenience sample of guidelines. Reviewers screened published EtD frameworks and generated frequencies of reporting approaches. We used thematic analysis to summarize factors related to variability of economic information reporting. Results: We included 142 guidelines. The overall rate of reporting economic information was high (91%); however, there was variability across completion of predefined EtD Likert-type judgments (70%), noting information as not identified across EtD framework domains (57%), and providing remarks to justify recommendations (38%). Six themes contributing to variability emerged, related to: intervention, population, payor, provider, healthcare resource use, and economic model building factors. Only 2 guidelines performed a GRADE certainty appraisal of economic outcomes. Conclusion: Completing predefined EtD Likert-type judgments, specifically reporting a literature review approach, study selection criteria and economic model building limitations, as well as linking these to recommendation justification remarks are potential areas for improved use, adoption and adaptation of recommendation, and transparency of GRADE EtD frameworks.
MeSH term(s)	Biomedical Research/economics ; Biomedical Research/standards ; Biomedical Research/statistics & numerical data ; Cost-Benefit Analysis/statistics & numerical data ; Epidemiologic Research Design ; Evidence-Based Medicine/economics ; Evidence-Based Medicine/statistics & numerical data ; GRADE Approach/standards ; GRADE Approach/statistics & numerical data ; Guidelines as Topic ; Humans ; Research Design/standards ; Research Design/statistics & numerical data
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2021.04.018
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Article ; Online: Intranasal antihistamines and corticosteroids in allergic rhinitis: A systematic review and meta-analysis.

Sousa-Pinto, Bernardo / Vieira, Rafael José / Brozek, Jan / Cardoso-Fernandes, António / Lourenço-Silva, Nuno / Ferreira-da-Silva, Renato / Ferreira, André / Gil-Mata, Sara / Bedbrook, Anna / Klimek, Ludger / Fonseca, João A / Zuberbier, Torsten / Schünemann, Holger J / Bousquet, Jean

The Journal of allergy and clinical immunology

2024

Abstract: Background: There is insufficient systematised evidence on the effectiveness of individual intranasal medications in allergic rhinitis (AR).: Objective: To perform a systematic review to compare the efficacy of individual intranasal corticosteroids ... ...

Abstract	Background: There is insufficient systematised evidence on the effectiveness of individual intranasal medications in allergic rhinitis (AR). Objective: To perform a systematic review to compare the efficacy of individual intranasal corticosteroids and antihistamines against placebo in improving the nasal and ocular symptoms and the rhinoconjunctivitis-related quality-of-life of patients with perennial or seasonal AR. Methods: We searched four electronic bibliographic databases and three clinical trials databases for randomised controlled trials (i) assessing adult patients with seasonal or perennial AR and (ii) comparing the use of intranasal corticosteroids or antihistamines versus placebo. Assessed outcomes included the Total Nasal Symptom Score (TNSS), the Total Ocular Symptom Score (TOSS) and the Rhinoconjunctivitis Quality-of-Life Questionnaire (RQLQ). We performed random-effects meta-analyses of mean differences for each medication and outcome. We assessed evidence certainty using the GRADE approach. Results: We included 151 primary studies, most of which assessed patients with seasonal AR and displayed unclear or high risk of bias. Both in perennial and seasonal AR, most assessed treatments were more effective than placebo. In seasonal AR, azelastine-fluticasone, fluticasone furoate and fluticasone propionate were the medications with the highest probability of resulting in moderate or large improvements in the TNSS and RQLQ. Azelastine-fluticasone displayed the highest probability of resulting in moderate or large improvements of TOSS. Overall, evidence certainty was considered "high" in 6/46 analyses, "moderate" in 23/46 analyses, and "low"/"very low" in 17/46 analyses. Conclusion: Most intranasal medications are effective in improving rhinitis symptoms and quality-of-life. However, there are relevant differences in the associated evidence certainty.
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2024.04.016
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Article: The structure of extremely long mouthparts in the aphid genus

Brożek, Jolanta / Mróz, Ewa / Wylężek, Dominika / Depa, Łukasz / Węgierek, Piotr

Zoomorphology

2015 Volume 134, Issue 3, Page(s) 431–445

Abstract: Scanning electron microscopy and light microscopy were used to elucidate the morphology of labium and mandibular and maxillary stylets of the ... ...

Abstract	Scanning electron microscopy and light microscopy were used to elucidate the morphology of labium and mandibular and maxillary stylets of the aphids
Language	English
Publishing date	2015-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1462021-2
ISSN	1432-234X ; 2365-0109 ; 2365-0095 ; 0720-213X
ISSN (online)	1432-234X ; 2365-0109 ; 2365-0095
ISSN	0720-213X
DOI	10.1007/s00435-015-0266-7
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