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  1. Article: Wem helfen Stammzellen aus Nabelschnurblut? Prof Dr. Hans-Jochem Kolb richtet den Blick auf die medizinischen Chancen und Grenzen

    Kolb, Hans-Jochem

    Deutsche Hebammenzeitschrift

    2002  Volume -, Issue 7, Page(s) 18

    Language German
    Document type Article
    ZDB-ID 80218-9
    ISSN 0012-026X
    Database Current Contents Medicine

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    Zs.A 457: Show issues Location:
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  2. Article ; Online: The FLAMSA concept-past and future.

    Kolb, Hans-Jochem / Schmid, Christoph

    Annals of hematology

    2020  Volume 99, Issue 9, Page(s) 1979–1988

    Abstract: The FLAMSA reduced intensity (RIC) concept, also known as "sequential therapy", is a conceptual platform for the treatment of leukemia separated in several parts: induction therapy, a sequence of antileukemic and immunosuppressive conditioning for ... ...

    Abstract The FLAMSA reduced intensity (RIC) concept, also known as "sequential therapy", is a conceptual platform for the treatment of leukemia separated in several parts: induction therapy, a sequence of antileukemic and immunosuppressive conditioning for allogeneic stem cell transplantation, and immune restitution supported by donor lymphocyte transfusions. The antileukemic part consists of fludarabine, cytosine arabinoside, and amsacrine (FLAMSA); non-cross reactive agents like fludarabine and amsacrine have been successfully used in cases of refractoriness and relapse. Immunosuppressive conditioning and transplantation follow after only 3 days of rest. This way, the toxicity of allogeneic transplantation could be reduced and the anti-leukemia effects by using allogeneic immune cells could be optimized. This review summarizes available data on efficacy and toxicity of this approach. Further, possible strategies for improvements are discussed in order to provide better chances for elderly and frail patients and patients with advanced and high-risk disease. Among others, several new agents are available that target molecular changes of leukemia for induction of remission and allow for bridging the time after transplantation until adoptive immunotherapy becomes safe and effective.
    MeSH term(s) Amsacrine/administration & dosage ; Antineoplastic Agents/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cytarabine/administration & dosage ; Forecasting ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/trends ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunotherapy, Adoptive/methods ; Immunotherapy, Adoptive/trends ; Leukemia/immunology ; Leukemia/therapy ; Transplantation Conditioning/methods ; Transplantation Conditioning/trends ; Transplantation, Homologous/methods ; Transplantation, Homologous/trends ; Vidarabine/administration & dosage ; Vidarabine/analogs & derivatives
    Chemical Substances Antineoplastic Agents ; Immunosuppressive Agents ; Amsacrine (00DPD30SOY) ; Cytarabine (04079A1RDZ) ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2020-06-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-020-04131-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: As time goes by...

    Kolb, Hans-Jochem

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2015  Volume 21, Issue 1, Page(s) 1–2

    MeSH term(s) Age Factors ; Aged ; Bone Marrow Transplantation ; Cells, Cultured ; Graft vs Host Disease/immunology ; Graft vs Host Disease/mortality ; Graft vs Host Disease/pathology ; Granulocyte Colony-Stimulating Factor/pharmacology ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/pathology ; Hematologic Neoplasms/therapy ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Myeloablative Agonists/therapeutic use ; Peripheral Blood Stem Cell Transplantation ; Stem Cells/cytology ; Stem Cells/drug effects ; Stem Cells/immunology ; Survival Analysis ; Transplantation Conditioning/methods ; Treatment Outcome
    Chemical Substances Myeloablative Agonists ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2014.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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  4. Article ; Online: Mast cells and GVHD: old cells with a new role.

    Kolb, Hans-Jochem

    Blood

    2013  Volume 122, Issue 22, Page(s) 3556–3557

    Abstract: In this issue of Blood, Leveson-Gower et al describe an immunomodulatory role of mast cells in graft-versus-host-disease (GVHD). ...

    Abstract In this issue of Blood, Leveson-Gower et al describe an immunomodulatory role of mast cells in graft-versus-host-disease (GVHD).
    MeSH term(s) Animals ; Female ; Graft vs Host Disease/immunology ; Graft vs Host Disease/prevention & control ; Male ; Mast Cells/immunology ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2013-11-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2013-09-527705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  5. Article ; Online: Late transplant-associated thrombotic microangiopathy verified in bone marrow biopsy specimens is associated with chronic GVHD and viral infections.

    Hill, Wolfgang / Sotlar, Karl / Hautmann, Anke / Kolb, Hans-Jochem / Ullmann, Johanna / Hausmann, Andreas / Schmidt, Michael / Tischer, Johanna / Pham, Thu-Trang / Rank, Andreas / Hoechstetter, Manuela A

    European journal of haematology

    2024  Volume 112, Issue 5, Page(s) 819–831

    Abstract: Objectives: To describe late transplant-associated thrombotic microangiopathy (TA-TMA) as chronic endothelial complication in bone marrow (BM) after allogeneic hematopoietic stem cell transplantation (HSCT).: Methods: BM specimens along with ... ...

    Abstract Objectives: To describe late transplant-associated thrombotic microangiopathy (TA-TMA) as chronic endothelial complication in bone marrow (BM) after allogeneic hematopoietic stem cell transplantation (HSCT).
    Methods: BM specimens along with conventional diagnostic parameters were assessed in 14 single-institutional patients with late TA-TMA (more than 100 days after HCST), including 11 late with history of early TA-TMA, 10 with early TA-TMA (within 100 days), and 12 non TA-TMA patients. Three non-HSCT patients served as control. The time points of BM biopsy were +1086, +798, +396, and +363 days after HSCT, respectively.
    Results: Late TA-TMA patients showed an increase of CD34+ and von Willebrand Factor (VWF)+ microvascular endothelial cells with atypical VWF+ conglomerates forming thickened VWF+ plaque sinus in the BM compared to patients without late TA-TMA and non-HSCT. Severe chronic (p = .002), steroid-refractory GVHD (p = .007) and reactivation of HHV6 (p = .002), EBV (p = .003), and adenovirus (p = .005) were pronounced in late TA-TMA. Overall and relapse-free survival were shorter in late TA-TMA than in patients without late TA-TMA (5-year OS and RFS: 78.6% vs. 90.2%, 71.4% vs. 86.4%, respectively).
    Conclusion: Chronic allo-immune microangiopathy in BM associated with chronic, steroid-refractory GVHD and/or viral infections are key findings of late, high-risk TA-TMA, which deserves clinical attention.
    MeSH term(s) Humans ; Bone Marrow/pathology ; Endothelial Cells/pathology ; von Willebrand Factor ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/therapy ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Virus Diseases/complications ; Biopsy ; Steroids
    Chemical Substances von Willebrand Factor ; Steroids
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.14174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 323: Show issues Location:
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  6. Article ; Online: Obituary. In memoriam Stefan Thierfelder.

    Kolb, Hans-Jochem

    Annals of hematology

    2010  Volume 89, Issue 11, Page(s) 1071

    MeSH term(s) Allergy and Immunology/manpower ; Antibodies/immunology ; Antigens/immunology ; Humans ; Stem Cells/immunology
    Chemical Substances Antibodies ; Antigens
    Language English
    Publishing date 2010-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-010-0963-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mechanisms of graft-versus-leukemia effects after allogeneic stem cell transplantation (a video lecture)

    Hans-Jochem Kolb

    Cellular Therapy and Transplantation, Vol 2, Iss 6, p 2011;2:e.000088.

    2011  Volume 01

    Abstract: The lecture begins by describing the historical features of hematopoietic stem cell transplantation (HSCT), followed by the first clinical experiences with T cell-depleted allografts. A concept of adoptive immune therapy is proposed for chimeric ... ...

    Abstract The lecture begins by describing the historical features of hematopoietic stem cell transplantation (HSCT), followed by the first clinical experiences with T cell-depleted allografts. A concept of adoptive immune therapy is proposed for chimeric organisms after T-cell depleted grafting, aiming for an increased graft-versus-leukemia (GvL) effect.The efficiency of donor lymphocyte transfusions (DLT) was extensively tested, being more expressed in chronic myeloid leukemia (CML). The intensity of graft-versus-host disease (GvHD), generally correlates with GvL, and is thus associated with an anti-leukemic response. Hence, DLT is a useful means of achieving long-term molecular remission in CML, as confirmed by EMBT studies. The clinical efficiency of post-transplant adoptive immunotherapy was shown in EBMT trials. This effect is more pronounced in CML, since malignant myeloid precursors supposedly produce antigen-presenting dendritic cells (DCs). Within the general mechanism of GvHD, a “cytokine storm” may promote this type of immune response. DCs present MHC antigens to the CD8+ effector cells, thus providing them with a “license to kill”. A clinical protocol was introduced on this basis, using a combined therapeutic schedule including GM-CSF and carefully timed DLT procedures.A theory of evolving immune tolerance is also discussed, encompassing specific interactions between host DCs and donor CD25+ regulatory T cells. A concept of central (thymus-dependent) tolerance is developed, primarily for children undergoing therapy. Haploidentical transplants are therefore considered with respect to increased NK cell production, especially in acute lymphoblastic leukemia (ALL). A possible role of HLA mismatches and the association between chronic GvHD (cGvHD) and long-term GvL effects is discussed, such as the favorable role of cGvHD in CML, unlike ALL. Fractionation of mobilized peripheral blood cells with CD6+ cell depletion proved to be a useful immune modulation tool.The significance of HLA mismatches is discussed in connection with modulation of NK activity; this is presumably dependent upon specific interactions between homozygous and heterozygous immune cells, either of donor or recipient origin.Antiviral immunity is also discussed: in particular, generation of anti-EBV-specific cells and their in vitro and in vivo expansion, aiming for potential lymphoma prevention and control in clinical settings.Meanwhile, GvL is postulated to proceed either via naïve or memory T cell populations, as illustrated by cases of double cord blood transplantations. The possible mechanisms of graft-graft interactions are discussed.Hence, adoptive immune therapy in chimeric patients should be regarded as an effective accessory tool for eradication of leukemic cells — at least in some types of leukemia.
    Keywords chronic myeloid leukemia ; adoptive immune therapy ; dendritic cells ; T cells ; HLA mismatch ; immune tolerance ; antiviral immunity ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610 ; 570
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hamburg University Medical Center, St.Petersburg State Medical I.Pavlov University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online ; Thesis: Allogene Stammzelltransplantation bei der Behandlung des multiplen Myeloms

    Weipert, Anne / Kolb, Hans-Jochem

    Langzeitergebnisse

    2014  

    Author's details Anne Weipert. Betreuer: Hans-Jochem Kolb
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis München, Ludwig-Maximilians-Universität, Diss., 2014
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Graft-versus-leukemia effects of transplantation and donor lymphocytes.

    Kolb, Hans-Jochem

    Blood

    2008  Volume 112, Issue 12, Page(s) 4371–4383

    Abstract: Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) effect, but the beneficial effect is limited by graft-versus-host ... ...

    Abstract Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) effect, but the beneficial effect is limited by graft-versus-host disease (GVHD). Depletion of T cells abrogates GVHD and GVL effects. Delayed transfusion of donor lymphocytes into chimeras after T cell-depleted stem cell transplantation produces a GVL effect without necessarily producing GVHD. Chimerism and tolerance provide a platform for immunotherapy using donor lymphocytes. The allogeneic GVL effects vary from one disease to another, the stage of the disease, donor histocompatibility, the degree of chimerism, and additional treatment. Immunosuppressive therapy before donor lymphocyte transfusions may augment the effect as well as concomitant cytokine treatment. Possible target antigens are histocompatibility antigens and tumor-associated antigens. Immune escape of tumor cells and changes in the reactivity of T cells are to be considered. Durable responses may be the result of the elimination of leukemia stem cells or the establishment of a durable immune control on their progeny. Recently, we have learned from adoptive immunotherapy of viral diseases and HLA-haploidentical stem cell transplantation that T-cell memory may be essential for the effective treatment of leukemia and other malignancies.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Benzamides ; Blood Donors ; Graft vs Host Disease/etiology ; Graft vs Host Disease/immunology ; Graft vs Host Disease/mortality ; Graft vs Host Reaction ; Graft vs Leukemia Effect/immunology ; Graft vs Leukemia Effect/physiology ; Humans ; Imatinib Mesylate ; Immune Tolerance/immunology ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Leukemia/immunology ; Leukemia/mortality ; Leukemia/prevention & control ; Leukemia/therapy ; Lymphocyte Transfusion/adverse effects ; Lymphocyte Transfusion/methods ; Lymphocyte Transfusion/mortality ; Lymphocytes/immunology ; Lymphocytes/physiology ; Piperazines/therapeutic use ; Pyrimidines/therapeutic use ; Transplantation Immunology/physiology ; Tumor Escape/immunology
    Chemical Substances Antineoplastic Agents ; Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2008-11-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2008-03-077974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The vigor of defense against non-self: potential superiority of allorestricted T cells in immunotherapy of cancer?

    Burdach, Stefan / Kolb, Hans-Jochem

    Frontiers in oncology

    2013  Volume 3, Page(s) 100

    Abstract: Men and sharks are both jawed vertebrates at the top of the food chain. Sharks are the first extant to develop adaptive immunity preserved to man throughout jawed vertebrates. We hypothesize here, that T cell receptor/major histocompatibility complex ( ... ...

    Abstract Men and sharks are both jawed vertebrates at the top of the food chain. Sharks are the first extant to develop adaptive immunity preserved to man throughout jawed vertebrates. We hypothesize here, that T cell receptor/major histocompatibility complex (TCR/MHC) interactions developed as the defense mechanism of carnivors against takeover by their victims' cells derived pathogens. Germline encoded TCR segments have been conserved in evolution, providing the MHC bias of TCR. Ancestor genes of MHC polymorphisms may have first developed as a mating preference system, that later in evolution provided host immune responses destroying infectious non-self, yet maintaining tolerance to self. Pathogens may thus have simultaneously selected for alloimmunity. Allorejection has been observed in sharks and men. Cannibalism is a common ecological interaction in the animal kingdom, especially prevalent in aquatic communities; it favors selection of intraspecies allo responses for defense of self integrity. Alloreactive T cells do not undergo negative selection of strong TCR/MHC interactions; thus, they react stronger than self-MHC recognizing T cells. High levels of genetic diversity at MHC genes play a critical role in protecting populations of vertebrate species from contagious cells displaying stemness and homing features, including cancer cells. Recognition of self-MHC fails especially in diseases, which predominantly arise with age and after the peak of reproduction, e.g., cancer. So far, the treatment of malignant disease with autologous T cells has widely failed. Allorecognition constitutes an extremely powerful mechanism in evolution, which may be employed in immunotherapy of cancer by MHC-disparate, e.g., haploidentical transplantation and consecutive treatment with T cells from the donor parents recognizing tumor selective peptides presented by the non-inherited haplotype on the tumor.
    Language English
    Publishing date 2013-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2013.00100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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