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Article ; Online: Une obstruction atypique du canal lacrymonasal.

Simondet, N / Keilani, C / Fligny, I

2022 Volume 45, Issue 6, Page(s) e249–e251

Title translation	Atypical nasolacrimal duct obstruction.
MeSH term(s)	Dacryocystorhinostomy ; Humans ; Lacrimal Duct Obstruction/diagnosis ; Nasolacrimal Duct
Language	French
Publishing date	2022-03-08
Publishing country	France
Document type	Letter
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2021.10.017
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Article: Prescribing Exercise to Cancer Patients Suffering from Increased Bone Fracture Risk Due to Metastatic Bone Disease or Multiple Myeloma in Austria-An Inter- and Multidisciplinary Evaluation Measure.

Crevenna, Richard / Hasenoehrl, Timothy / Wiltschke, Christoph / Kainberger, Franz / Keilani, Mohammad

Cancers

2023 Volume 15, Issue 4

Abstract: Introduction: In the current absence of specific functional fracture risk assessment technology, the planning of physical exercise interventions for cancer patients suffering from increased bone fracture risk remains a serious clinical challenge. Until ... ...

Abstract	Introduction: In the current absence of specific functional fracture risk assessment technology, the planning of physical exercise interventions for cancer patients suffering from increased bone fracture risk remains a serious clinical challenge. Until a reliable, solely technical solution is available for the clinician, fracture risk assessment remains an inter- and multidisciplinary decision to be made by various medical experts. The aim of this short paper is depicting how this challenge should be approached in the clinical reality according to Austrian experts in cancer rehabilitation, presenting the best-practice model in Austria. Following referral from the specialist responsible for the primary cancer treatment (oncologist, surgeon, etc.), the physiatrist takes on the role of rehabilitation case manager for each individual patient. Fracture risk assessment is then undertaken by specialists in radiology, orthopedics, oncology, and radiation therapy, with the result that the affected bone regions are classified as being at highly/slightly/not increased fracture risk. Following internal clearance, exercise planning is undertaken by a specialist in exercise therapy together with the physiatrist based on the individual's fracture risk assessment. In the case in which the patient shows exercise limitations due to additional musculoskeletal impairments, adjuvant physical modalities such as physiotherapy should be prescribed to increase exercisability. Conclusion: Exercise prescription for cancer patients suffering from increased fracture risk is an inter- and multidisciplinary team decision for each individual patient.
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041245
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Article ; Online: A triple-layered closing technique using the recti muscles to augment implant coverage in eye enucleation after maxillofacial radiotherapy: A case report.

Keilani, C / Herdan, M-L

Journal of stomatology, oral and maxillofacial surgery

2019 Volume 121, Issue 4, Page(s) 450–453

Abstract: Eye enucleation (EE) of a previously irradiated orbit can lead to difficult wound closure due to the soft tissues fibrosis such as Tenon's capsule and conjunctiva. We, here, report a technique modiﬁcation for EE surgery after facial radiotherapy that may ...

Abstract	Eye enucleation (EE) of a previously irradiated orbit can lead to difficult wound closure due to the soft tissues fibrosis such as Tenon's capsule and conjunctiva. We, here, report a technique modiﬁcation for EE surgery after facial radiotherapy that may decrease implant exposure by using recti muscles native tissue to reinforce the anterior implant coverage. A 71-year-old African male presented in 2003 a right orbital extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type. He was treated with chemotherapy followed by whole orbital radiotherapy. His right vision remained impaired due to phtisis bulbi secondary to facial radiotherapy. By 2017, he developed right painful phthisis bulbi. Radiological systemic staging did not reveal any recurrence or metastasis. Because of the history of neoplasia, the right eye had to be enucleated. Due to tissue fibrosis secondary to radiotherapy, we took care to preserve as much conjunctiva and Tenon as possible. EE was performed under general anesthesia. EE consisted of a standard procedure with a modified triple-layered closing technique. The four recti muscles were attached with 5-0 Vicryl to the anterior part of the implant by passing the needle through the tunnels and tying the suture. The horizontal muscles were spread with a forceps to cover the lateral and medial part of the implant. The vertical muscles were spread with a forceps to cover the superior and the inferior part of the implant. Finally the edges of the recti muscles were sutured to each other with 5-0 Vicryl to create a muscle layer. Tenon's capsule and conjunctiva were closed separately, using horizontal interrupted 6-0 Vicryl sutures. One year after surgery, wound closure was complete with no sign of extrusion. The triple-layered closing technique using the recti muscles in EE represents a potentially viable alternative to augment implant coverage in case of Tenon and conjunctival fibrosis secondary to facial radiotherapy.
MeSH term(s)	Aged ; Conjunctiva ; Eye Enucleation ; Humans ; Male ; Oculomotor Muscles/surgery ; Ophthalmologic Surgical Procedures ; Orbit
Language	English
Publishing date	2019-09-14
Publishing country	France
Document type	Case Reports
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2019.09.003
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Article ; Online: Incision of Hasner's valve under endoscopic intranasal surgery for the treatment of nasolacrimal duct obstruction in children.

Keilani, C / Keller, P / Piaton, J-M

The Journal of laryngology and otology

2020 Volume 134, Issue 1, Page(s) 56–62

Abstract: Objective: To evaluate the effectiveness and safety of a Hasner's valve incision performed under endoscopic intranasal surgery for the management of congenital nasolacrimal duct obstruction.: Methods: This retrospective study comprised 484 patients ... ...

Abstract	Objective: To evaluate the effectiveness and safety of a Hasner's valve incision performed under endoscopic intranasal surgery for the management of congenital nasolacrimal duct obstruction. Methods: This retrospective study comprised 484 patients with congenital nasolacrimal duct obstruction who underwent incision of Hasner's valve under endoscopic intranasal surgery between April 2000 and October 2016. The primary endpoint was the procedure's functional success rate. The secondary endpoints were Hasner's valve and inferior turbinate anatomical findings, demographic data, complication rate and surgical duration. Results: In patients with no medical history of nasolacrimal duct probing, 91 per cent had a successful result, 5 per cent had a partially successful result, 3.9 per cent showed no change and 0.1 per cent had a worse result following the procedure. Concerning the secondary endpoints, outcomes were more frequently successful in children younger than three years. Only one patient had a post-operative infection. All patients underwent general anaesthesia; no complications related to general anaesthesia were observed. Mean surgical duration was 13.1 ± 5.7 minutes. Conclusion: Incising Hasner's valve after medially displacing the inferior turbinate under nasal endoscopy seems to be an adequate primary surgical treatment for congenital nasolacrimal duct obstruction.
MeSH term(s)	Child, Preschool ; Dacryocystorhinostomy/methods ; Endoscopy ; Female ; Humans ; Infant ; Lacrimal Duct Obstruction/congenital ; Lacrimal Duct Obstruction/therapy ; Male ; Nasolacrimal Duct/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215119002597
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Article ; Online: An uncommon case of symptomatic multiple meningiomas with bilateral compressive optic neuropathy rapidly induced under cyproterone acetate treatment.

Keilani, Chafik / Abada, Samir

Current drug safety

2017

Abstract: Multiple meningiomas growth in patients under cyproterone acetate (CPA) is now well known. However, time between initial CPA intake and diagnosis remains unclear. The exposure time differs in each reported case: from 2 to 10 years. We present the case of ...

Abstract	Multiple meningiomas growth in patients under cyproterone acetate (CPA) is now well known. However, time between initial CPA intake and diagnosis remains unclear. The exposure time differs in each reported case: from 2 to 10 years. We present the case of an old man with acute visual impairment caused by an unusual bilateral optic nerve compression by three likely planum sphenoidale meningiomas rapidly induced by the admistration of CPA for prostatic adenocarinoma. This case is the first reported with a short exposure time (7 months) to CPA treatment before diagnosis of multiple meningiomas and stabilization on clinical follow-up after CPA treatment discontinuation.
Language	English
Publishing date	2017-05-23
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2250840-5
ISSN	2212-3911 ; 1574-8863
ISSN (online)	2212-3911
ISSN	1574-8863
DOI	10.2174/1574886312666170523154548
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Article ; Online: Correlation of PKM2 Expression With HER2/neu and Additional Breast Cancer Biomarkers and its Prognostic Significance.

Al-Qudah, Mohammad A / Al-Keilani, Maha S / Obeidat, Marya / Haddad, Husam K / Bdeir, Roba / Samman, Lina M

Applied immunohistochemistry & molecular morphology : AIMM

2023 Volume 31, Issue 6, Page(s) 363–370

Abstract: Background: Pyruvate kinase M2 (PKM2) has a central role in both tumor development and metastasis, and it has increasingly become a valuable subject for many cancer studies due to its important prognostic value in various tumor types. In this study, we ... ...

Abstract	Background: Pyruvate kinase M2 (PKM2) has a central role in both tumor development and metastasis, and it has increasingly become a valuable subject for many cancer studies due to its important prognostic value in various tumor types. In this study, we aimed to elucidate the impact of PKM2 expression level on breast cancer prognosis and survival rates and its association with various clinicopathologic characteristics and tumor markers in breast cancer patients. Materials and methods: This retrospective study included sample tissues from patients with breast cancer who did not receive chemotherapy or radiotherapy before surgery. Expression levels of PKM2, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67 were analyzed using tissue microarray and immunohistochemistry. Results: A total of 164 patients were included with an age range from 28 to 82 years. High PKM2 was observed in 48.8% of cases (80/164). A significant association was found between PKM2 expression and breast cancer molecular subtype and HER2 status ( P <0.001). In HER2-negative tumors, there was a significant association between PKM2 expression and tumor grade, TNM stage, pN stage, lymphovascular invasion, and estrogen receptor/progesterone receptor status. Survival analysis revealed that high PKM2 expression levels were associated with decreased overall survival rate in HER2-positive cases with high Ki-67 index. Moreover, in the HER2-positive group, low PKM2 expression level impacted the survival outcome of metastasis ( P =0.002). Conclusions: PKM2 is a valuable prognostic and a potential diagnostic and predictive marker in breast cancer. Moreover, the combination of PKM2 with Ki-67 provides excellent prognostic accuracy in HER2-positive tumors.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Middle Aged ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Ki-67 Antigen/metabolism ; Prognosis ; Receptor, ErbB-2/metabolism ; Receptors, Progesterone/metabolism ; Retrospective Studies ; Thyroid Hormone-Binding Proteins
Chemical Substances	Biomarkers, Tumor ; Ki-67 Antigen ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptors, Progesterone
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0000000000001131
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Article ; Online: SURGICAL TREATMENT OF VITREORETINAL COMPLICATIONS DURING DISSEMINATED INTRAVASCULAR COAGULATION SECONDARY TO MENINGOCOCCEMIA.

Keilani, Chafik / Delbarre, Maxime / Rambaud, Camille / Marechal, Marie / Froussart, Françoise

Retinal cases & brief reports

2020 Volume 16, Issue 4, Page(s) 500–506

Abstract: Purpose: To report a case of the surgical management of vitreoretinal complications during disseminated intravascular coagulation secondary to meningococcemia.: Methods: A case report.: Results: A 25-year-old man presented with loss of vision due ... ...

Abstract	Purpose: To report a case of the surgical management of vitreoretinal complications during disseminated intravascular coagulation secondary to meningococcemia. Methods: A case report. Results: A 25-year-old man presented with loss of vision due to retinal and vitreous hemorrhages during disseminated intravascular coagulation secondary to meningococcemia. Examination revealed the visual acuity to be counting fingers in the right eye and light perception in the left eye. Bilateral vitreous hemorrhages were found on fundus examination. A dome-shaped lesion overlying the macula consistent with a subinternal limiting membrane hemorrhage was seen on optical coherence tomography. Bilateral vitrectomy was performed. Multiple subinternal limiting membrane hemorrhages were evident in the posterior pole. A membrane forceps was used to peel the internal limiting membrane and remove the fibrin under it. The internal limiting membrane and vitreous samples were sent for anatomopathological examination confirming our hypothesis. The peripheral retina revealed bilateral multiple ischemic areas, and argon laser photocoagulation was performed on it. Both eyes were filled with silicone oil. Eight months after surgery, his vision improved to 70 and 65 on the early diabetic retinopathy study scale in the right and left eyes, respectively. Conclusion: Published cases of retinal and vitreous hemorrhages during disseminated intravascular coagulation secondary to meningococcemia are few. There is no specific and codified management of these ocular complications. This case is the first reporting positive visual recovery after surgical treatment. Surgical procedure seems to be effective to treat multiple vitreoretinal hemorrhages secondary to meningococcemia.
MeSH term(s)	Adult ; Diabetic Retinopathy/surgery ; Disseminated Intravascular Coagulation/complications ; Disseminated Intravascular Coagulation/pathology ; Humans ; Male ; Meningococcal Infections/complications ; Retina/pathology ; Vitrectomy/adverse effects ; Vitreous Hemorrhage/etiology ; Vitreous Hemorrhage/pathology ; Vitreous Hemorrhage/surgery
Language	English
Publishing date	2020-06-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000001017
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Article: Eyelid Chemical Burns: A Multidisciplinary And Challenging Approach.

Keilani, C / De Faria, A / Baus, A / Delbarre, M / Schaal, J V / Froussart-Maille, F / Bey, E / Duhamel, P

Annals of burns and fire disasters

2022 Volume 34, Issue 4, Page(s) 312–318

Abstract: During second- and third-degree eyelid sulfuric acid burns, many surgeons prefer to wait until primary wound separation occurs before grafting. However, this approach may miss the chance to recover the eyelids and can cause ectropion, resulting in ... ...

Abstract	During second- and third-degree eyelid sulfuric acid burns, many surgeons prefer to wait until primary wound separation occurs before grafting. However, this approach may miss the chance to recover the eyelids and can cause ectropion, resulting in delayed eyeball healing with exposure keratitis. We propose that early eyelid release and grafting makes a significant difference in long-term outcomes and improves eyeball healing. Here, we present the case of a woman who presented second- and third-degree burns of the eyelids secondary to physical domestic assault with acid, who had an early surgical management with a full-thickness skin graft. Ten days after surgery, we found that the graft had survived totally, and the donor site of the right arm had already healed. Eyelids were successfully grafted and the functions of both eyelids were well recovered, allowing complete cover of the eyeball. Two months after surgery, functional and cosmetic results were satisfying, with no postoperative lagophthalmos or difficulties with exposure-related problems. Case reports of eyelid chemical burns are very few. No specific and codified management of eyelid chemical burns was found in the literature search. This case report demonstrated that a multidisciplinary approach led by both ophthalmologists and plastic surgeons must be decided early (<6h) in order to achieve synergistic and coordinated management between the eye and the eyelid. There is a significant improvement in ocular healing with early excision and grafting of eyelids after sulfuric acid burn.
Language	English
Publishing date	2022-01-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2106850-1
ISSN	1592-9566 ; 1592-9558
ISSN (online)	1592-9566
ISSN	1592-9558
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Article ; Online: PreserFlo MicroShunt® exposure: a case series.

Bunod, Roxane / Robin, Mathieu / Buffault, Juliette / Keilani, Chafik / Labbé, Antoine / Baudouin, Christophe

BMC ophthalmology

2021 Volume 21, Issue 1, Page(s) 273

Abstract: Background: PreserFlo® MicroShunt (PM) (also known as InnFocus® MicroShunt) is a subconjunctival stent implanted ab externo via a minimally invasive surgical procedure. The current indication is progressive, mild to moderate, open angle glaucoma ... ...

Abstract	Background: PreserFlo® MicroShunt (PM) (also known as InnFocus® MicroShunt) is a subconjunctival stent implanted ab externo via a minimally invasive surgical procedure. The current indication is progressive, mild to moderate, open angle glaucoma uncontrolled on topical medications. According to the literature, adverse events are rare, mild and transient. Case presentation: Two cases of stand-alone PreserFlo MicroShunt® implantation in patients with uncontrolled open-angle glaucoma are reported. Exposure occurred 7 days and 3 months respectively after implantation. These cases shared common features including preexisting blepharitis and the lack of a Tenon's flap. In both cases, removal of the device was required after several attempts at repair. Conclusions: PreserFlo MicroShunt® exposure is a potentially vision-threatening complication because of the risk of endophthalmitis. Potential risk factors include the absence of a Tenon's flap and pre-existing ocular surface inflammation. Ocular surface inflammation should be detected and treated prior to PM implantation. If a deficiency in Tenon's capsule is noted intraoperatively, close monitoring should be performed because of the higher risk of PM exposure.
MeSH term(s)	Glaucoma Drainage Implants/adverse effects ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure ; Tenon Capsule ; Tonometry, Ocular
Language	English
Publishing date	2021-07-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-021-02032-z
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Article ; Online: Follow-Up of Nonarteritic Anterior Ischemic Optic Neuropathy With Optical Coherence Tomography Angiography.

Augstburger, Edouard / Ballino, Arnaud / Keilani, Chafik / Robin, Mathieu / Baudouin, Christophe / Labbé, Antoine

Investigative ophthalmology & visual science

2021 Volume 62, Issue 2, Page(s) 42

Abstract: Purpose: The purpose of this study was to describe capillary changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography-angiography (OCT-A) and correlate the results with best corrected visual ... ...

Abstract	Purpose: The purpose of this study was to describe capillary changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography-angiography (OCT-A) and correlate the results with best corrected visual acuity (BCVA), visual field, OCT retinal nerve fiber layer (RNFL), and combined thickness of ganglion cell and inner plexiform layers (GCIPL) thicknesses. Methods: We enrolled 22 eyes with acute NAION and 30 normal control (NC) subjects in this study. Whole en face image vessel density (WiVD) was measured in the radial peripapillary capillary plexus (RPC), superficial capillary plexus (SCP), and deep vascular complex (DVC) using OCT-A. The examination was repeated at 1 (M1), 3 (M3), 6 (M6), and 9 (M9) months after presentation for NAION. Results: The initial RPC WiVD was significantly reduced in the acute NAION group compared to the NC group (P < 0.0001). Over the course of NAION follow-up, RPC WiVD was significantly reduced at M1 (P < 0.001 compared to M0) and M3 (P < 0.0001 compared to M1). However, there was no significant further decrease at M6 and M9. The initial SCP WiVD was significantly reduced in the NAION group compared to the NC group (P < 0.0001 for both). Over the course of NAION follow-up, a significant decrease was observed for SCP WiVD at M1 (P < 0.001 compared to M0), but no significant change was seen at M3, M6, or M9. DVC was normal in the NAION group. Correlations were found between GCIPL and SCP WiVD in the NAION acute phase (R = 0.604, P = 0.003) and in the M9 atrophic stage (R = 0.551, P = 0.009). At M9, RPC WiVD was correlated with BCVA (R = -0.562, P = 0.007), mean deviation (R = 0.518, P = 0.01), and RNFL (R = 0.655, P = 0.001). Conclusions: Over the course of NAION, OCT-A provided detailed visualization of retinal capillary plexus involvement.
MeSH term(s)	Adult ; Aged ; Case-Control Studies ; Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology ; Optic Disk/pathology ; Optic Neuropathy, Ischemic/diagnosis ; Optic Neuropathy, Ischemic/physiopathology ; Prospective Studies ; Retinal Ganglion Cells/pathology ; Retinal Vessels/pathology ; Tomography, Optical Coherence/methods ; Visual Acuity ; Visual Fields/physiology
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.62.4.42
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