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Article: Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps.

Gray, Robert D / Lucas, Christopher D / MacKellar, Annie / Li, Feng / Hiersemenzel, Katia / Haslett, Chris / Davidson, Donald J / Rossi, Adriano G

Journal of inflammation (London, England)

2013 Volume 10, Issue 1, Page(s) 12

Abstract: ... formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely ...

Abstract	Background: Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation. Methods: Pharmacological inhibitors were used to block PKC activity in neutrophils harvested from healthy donor blood. Results: Pan PKC inhibition with Ro-31-8220 (p<0.001), conventional PKC inhibition with Go 6976 (p<0.001) and specific PKCβ inhibition with LY333531 (p<0.01) blocked NET formation in response to PMA. Inhibition of novel and atypical PKC had no effect. LY333531 blocked NET induction by the diacylglycerol analogue OAG (conventional PKC activator) (p<0.001). Conclusions: Conventional PKCs have a prominent role in NET formation. Furthermore PKCβ is the major isoform implicated in NET formation.
Language	English
Publishing date	2013-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2164385-4
ISSN	1476-9255
ISSN	1476-9255
DOI	10.1186/1476-9255-10-12
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Article: Phospholipase C epsilon suppresses integrin activation.

Lad, Yatish / McHugh, Brian / Hodkinson, Philip S / Mackinnon, Alison C / Haslett, Christopher / Ginsberg, Mark H / Sethi, Tariq

The Journal of biological chemistry

2006 Volume 281, Issue 40, Page(s) 29501–29512

Abstract: Phospholipase Cepsilon (PLCepsilon) is a newly described effector of the small GTP-binding protein H-Ras. Utilizing H-Ras effector mutants, we show that mutants H-Ras(G12V/E37G) and H-Ras(G12V/D38N) suppressed integrin activation in an ERK-independent ... ...

Abstract	Phospholipase Cepsilon (PLCepsilon) is a newly described effector of the small GTP-binding protein H-Ras. Utilizing H-Ras effector mutants, we show that mutants H-Ras(G12V/E37G) and H-Ras(G12V/D38N) suppressed integrin activation in an ERK-independent manner. H-Ras(G12V/D38N) specifically activated the PLCepsilon effector pathway and suppressed integrin activation. Inhibition of PLCepsilon activation with a kinase-dead PLCepsilon mutant prevented H-Ras(G12V/D38N) from suppressing integrin activation, and low level expression of H-Ras(G12V/D38N) could synergize with wild-type PLCepsilon to suppress integrins. In addition, knockdown of endogenous PLCepsilon with small interfering RNA blocked H-Ras(G12V/D38N)-mediated integrin suppression. Suppressing integrin function with the H-Ras(G12V/D38N) mutant reduced cell adhesion to von Willebrand factor and fibronectin; this reduction in cell adhesion was blocked by coexpression of the kinase-dead PLCepsilon mutant. These results show that H-Ras suppresses integrin affinity via independent Raf and PLCepsilon signaling pathways and demonstrate a new physiological function for PLCepsilon in the regulation of integrin activation.
MeSH term(s)	Amino Acid Substitution/genetics ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Down-Regulation/genetics ; Glycine/genetics ; Integrins/metabolism ; Phosphoinositide Phospholipase C ; Rats ; Serine/genetics ; Signal Transduction/genetics ; Threonine/genetics ; Type C Phospholipases/genetics ; Type C Phospholipases/physiology ; Valine/genetics ; ras Proteins/physiology
Chemical Substances	Integrins ; Threonine (2ZD004190S) ; Serine (452VLY9402) ; Type C Phospholipases (EC 3.1.4.-) ; Phosphoinositide Phospholipase C (EC 3.1.4.11) ; phospholipase C epsilon (EC 3.1.4.11) ; ras Proteins (EC 3.6.5.2) ; Valine (HG18B9YRS7) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2006-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M513471200
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Article: Temperature-dependent arrest of neutrophil apoptosis. Failure of Bax insertion into mitochondria at 15 degrees C prevents the release of cytochrome c.

Pryde, J G / Walker, A / Rossi, A G / Hannah, S / Haslett, C

The Journal of biological chemistry

2000 Volume 275, Issue 43, Page(s) 33574–33584

Abstract: ... neutrophils at 15 degrees C for 20 h arrested apoptosis and subsequent warming to 37 degrees C triggered ... a synchronous burst of apoptosis. Treatment of 15 degrees C cultured neutrophils with the pan-caspase inhibitor ... zVAD-fmk just before warming to 37 degrees C inhibited the morphological changes associated ...

Abstract	Apoptosis is essential for the resolution of neutrophilic inflammation. To define the mechanisms triggering the execution phase of apoptosis we developed and utilized a model in which culture of human neutrophils at 15 degrees C for 20 h arrested apoptosis and subsequent warming to 37 degrees C triggered a synchronous burst of apoptosis. Treatment of 15 degrees C cultured neutrophils with the pan-caspase inhibitor zVAD-fmk just before warming to 37 degrees C inhibited the morphological changes associated with apoptosis, but did not prevent the insertion of the proapoptotic protein Bax into mitochondria nor the inhibition of secretion and the externalization of phosphatidylserine, indices of neutrophil apoptosis. In both intact neutrophils and a cell-free extract, cytochrome c released from mitochondria induced proteolytic cleavage of procaspase-3. At 15 degrees C the binding of Bax to mitochondria was uncoupled from Bax insertion into the mitochondrial membrane required for the release of cytochrome c. Apoptosis was also inhibited by low pH during warming to 37 degrees C, suggesting that changes to the conformation of Bax, necessary for membrane insertion, were being inhibited. Bax insertion was only sensitive to zVAD-fmk when added at the start of the 15 degrees C culture period, suggesting that a cytoplasmic substrate of the effector caspases may mediate in the mechanism of Bax insertion into mitochondria.
MeSH term(s)	Amino Acid Chloromethyl Ketones/pharmacology ; Apoptosis ; Biological Transport ; Caspase 3 ; Caspases/physiology ; Cells, Cultured ; Cytochrome c Group/metabolism ; Enzyme Activation ; Humans ; Hydrogen-Ion Concentration ; Mitochondria/metabolism ; Neutrophils/physiology ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2 ; Temperature ; bcl-2-Associated X Protein
Chemical Substances	Amino Acid Chloromethyl Ketones ; BAX protein, human ; Cytochrome c Group ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein ; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2000-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M001008200
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Article ; Online: Access to oral COVID-19 antivirals in the community: are eligibility criteria and systems ensuring equity?

Allard, Nicole L / Canevari, Jose / Haslett, Nick / Cowie, Benjamin C

The Medical journal of Australia

2023 Volume 218, Issue 10, Page(s) 438–441

MeSH term(s)	Humans ; COVID-19 ; Antiviral Agents/therapeutic use ; Health Services Accessibility ; Health Equity
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-05-08
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.51949
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Article ; Online: Effect of antenatal micronutrient or antidepressant exposure on Brazelton neonatal behavioral assessment scale (NBAS) performance within one-month of birth.

Campbell, S A / Bradley, H A / Mulder, R T / Henderson, J M T / Dixon, L / Haslett, L C / Rucklidge, J J

Early human development

2024 Volume 190, Page(s) 105948

Abstract: Background: Antenatal depression is a risk factor for poor infant outcomes. Broad-spectrum-micronutrients (vitamins and minerals) have shown efficacy in treating psychiatric symptoms in non-pregnant populations and are associated with reduced incidence ... ...

Abstract	Background: Antenatal depression is a risk factor for poor infant outcomes. Broad-spectrum-micronutrients (vitamins and minerals) have shown efficacy in treating psychiatric symptoms in non-pregnant populations and are associated with reduced incidence of adverse birth outcomes, and improvements in neonatal development. We investigated the effects of treatment of antenatal depression with micronutrients above the Recommended Dietary Allowance on infant development compared to treatment with antidepressant medications and controls. Method: One-hundred-and-three infants were assessed using the Brazelton Neonatal Behavioral Assessment Scale (NBAS) within 28 days of birth: 37 exposed to micronutrients in-utero (50-182 days exposure), 18 to antidepressants in-utero (exposure for full gestation), and 48 controls whose mothers received neither treatment nor experienced depressive symptoms. Results: Controlling for gestational age and parity, there were significant group differences on habituation, orientation, motor, state regulation, autonomic stability and reflexes (p < .05). Micronutrient-exposed performed better than antidepressant-exposed and controls on habituation, motor and autonomic stability (p < .05), effect sizes ranged 1.0-1.7 and 0.5-1.0, respectively. Antidepressant-exposed performed significantly worse on orientation and reflexes compared to micronutrient-exposed and controls. Micronutrient-exposed had significantly better state regulation compared to antidepressant-exposed. There was an association between micronutrient exposure length and better habituation (r = 0.41, p = .028). Micronutrient exposure was generally identified as a stronger predictor of neonatal performance over maternal depression, social adversity, gestational age and infant sex. Conclusion: In-utero micronutrient exposure appears to mitigate risks of depression on infant outcomes showing positive effects on infant behavior, on par with or better than typical pregnancies and superior to antidepressants. Limitations include differential exposure to micronutrients/antidepressants and lack of group blinding.
MeSH term(s)	Infant, Newborn ; Infant ; Child ; Pregnancy ; Humans ; Female ; Micronutrients ; Vitamins ; Antidepressive Agents/adverse effects ; Trace Elements ; Mothers
Chemical Substances	Micronutrients ; Vitamins ; Antidepressive Agents ; Trace Elements
Language	English
Publishing date	2024-01-26
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2024.105948
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Zs.A 1373: Show issues

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Article ; Online: Hematopoiesis post anti-CD117 monoclonal antibody treatment in wild-type and Fanconi anemia settings.

Denis, Morgane / Swartzrock, Leah / Willner, Hana / Bubb, Quenton R / Haslett, Ethan / Chan, Yan Yi / Chen, Anzhi / Krampf, Mark R / Czechowicz, Agnieszka D

Haematologica

2024

Abstract: ... sequencing between untreated and treated mice, it was revealed that the ACK2 mAb, via c-Kit downregulation ...

Abstract	Anti-CD117 monoclonal antibody (mAb) agents have emerged as exciting alternative conditioning strategies to traditional genotoxic irradiation or chemotherapy conditioning for both allogeneic and autologous gene-modified hematopoietic stem cell transplantation. Further, these agents are concurrently being explored in the treatment of mast cell disorders. Despite promising results in animal models and more recently in patients, the short-term and long-term effects of these treatments have not been fully explored. We conducted rigorous assessments to evaluate the effects of antagonistic anti-mCD117 mAb, ACK2, on hematopoiesis in wild-type (WT) and Fanconi Anemia (FA) mice. Importantly, we found no evidence of short-term DNA damage in either setting following this treatment suggesting that ACK2 does not induce immediate genotoxicity, providing crucial insights into its safety profile. Surprisingly, FA mice exhibited an increase in colony formation post-ACK2 treatment without accompanying DNA damage, indicating a potential targeting of hematopoietic stem cells (HSCs) and expansion of hematopoietic progenitor cells. Moreover, the long-term phenotypic and functional changes in hematopoietic stem and progenitor cells did not significantly differ between the ACK2-treated and control groups, in either setting, supporting that ACK2 does not adversely affect hematopoietic capacity. These finding underscore the safety of these agents when utilized as a short-course treatment in the conditioning context, as they did not induce significant changes in DNA damage amongst hematopoietic stem or progenitor cells. However, through a comparison of gene expression via single-cell RNA sequencing between untreated and treated mice, it was revealed that the ACK2 mAb, via c-Kit downregulation, effectively modulated the MAPK pathway with Fos down-regulation in WT and FA mice. Importantly, this modulation was achieved without causing prolonged disruptions. These findings validate the safety of the treatment and also enhance our understanding of its intricate mode of action at the molecular level.
Language	English
Publishing date	2024-04-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.284275
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Article ; Online: Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial.

Stamp, Lisa / Horne, Anne / Mihov, Borislav / Drake, Jill / Haslett, Janine / Chapman, Peter T / Frampton, Christopher / Dalbeth, Nicola

Annals of the rheumatic diseases

2023 Volume 82, Issue 12, Page(s) 1626–1634

Abstract: Objectives: To determine whether placebo is non-inferior to low-dose colchicine for reducing gout flares during the first 6 months of allopurinol using the 'start-low go-slow' dose approach.: Methods: A 12-month double-blind, placebo-controlled non- ... ...

Abstract	Objectives: To determine whether placebo is non-inferior to low-dose colchicine for reducing gout flares during the first 6 months of allopurinol using the 'start-low go-slow' dose approach. Methods: A 12-month double-blind, placebo-controlled non-inferiority trial was undertaken. Adults with at least one gout flare in the preceding 6 months, fulfilling the American College of Rheumatology (ACR) recommendations for starting urate-lowering therapy and serum urate ≥0.36 mmol/L were recruited. Participants were randomised 1:1 to colchicine 0.5 mg daily or placebo for the first 6 months. All participants commenced allopurinol, increasing monthly to achieve target urate <0.36 mmol/L. The primary efficacy outcome was the mean number of gout flares/month between 0 and 6 months, with a prespecified non-inferiority margin of 0.12 gout flares/month. The primary safety outcome was adverse events over the first 6 months. Results: Two hundred participants were randomised. The mean (95% CI) number of gout flares/month between baseline and month 6 was 0.61 (0.47 to 0.74) in the placebo group compared with 0.35 (0.22 to 0.49) in the colchicine group, mean difference 0.25 (0.07 to 0.44), non-inferiority p=0.92. There was no difference in the mean number of gout flares/month between randomised groups over the 12-month period (p=0.68). There were 11 serious adverse events in 7 participants receiving colchicine and 3 in 2 receiving placebo. Conclusions: Placebo is not non-inferior to colchicine in prevention of gout flares in the first 6 months of starting allopurinol using the 'start-low go-slow' strategy. After stopping colchicine, gout flares rise with no difference in the mean number of gout flares/month between groups over a 12-month period. Trial registration number: ACTRN 12618001179224.
MeSH term(s)	Adult ; Humans ; Gout/drug therapy ; Allopurinol/therapeutic use ; Colchicine/therapeutic use ; Gout Suppressants/therapeutic use ; Uric Acid ; Symptom Flare Up ; Treatment Outcome
Chemical Substances	Allopurinol (63CZ7GJN5I) ; Colchicine (SML2Y3J35T) ; Gout Suppressants ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2023-224731
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Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 167: Show issues

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Article ; Online: A multi-sensory code for emotional arousal.

Sievers, Beau / Lee, Caitlyn / Haslett, William / Wheatley, Thalia

Proceedings. Biological sciences

2019 Volume 286, Issue 1906, Page(s) 20190513

Abstract: People express emotion using their voice, face and movement, as well as through abstract forms as in art, architecture and music. The structure of these expressions often seems intuitively linked to its meaning: romantic poetry is written in flowery ... ...

Abstract	People express emotion using their voice, face and movement, as well as through abstract forms as in art, architecture and music. The structure of these expressions often seems intuitively linked to its meaning: romantic poetry is written in flowery curlicues, while the logos of death metal bands use spiky script. Here, we show that these associations are universally understood because they are signalled using a multi-sensory code for emotional arousal. Specifically, variation in the central tendency of the frequency spectrum of a stimulus-its spectral centroid-is used by signal senders to express emotional arousal, and by signal receivers to make emotional arousal judgements. We show that this code is used across sounds, shapes, speech and human body movements, providing a strong multi-sensory signal that can be used to efficiently estimate an agent's level of emotional arousal.
MeSH term(s)	Arousal ; Communication ; Emotions ; Faculty ; Female ; Humans ; Kinesics ; Male ; Photic Stimulation ; Sound ; Speech ; Students
Language	English
Publishing date	2019-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2019.0513
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Zs.A 1364: Show issues

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Article: Long-Term Follow-up of a Randomized Controlled Trial of Allopurinol Dose Escalation to Achieve Target Serum Urate in People With Gout.

Coleman, George B / Dalbeth, Nicola / Frampton, Chris / Haslett, Janine / Drake, Jill / Su, Isabel / Horne, Anne M / Stamp, Lisa K

The Journal of rheumatology

2022 Volume 49, Issue 12, Page(s) 1372–1378

Abstract: Objective: To determine the long-term use of and adherence to urate-lowering therapy (ULT), serum urate (SU) control, and self-reported flares in participants from a randomized controlled trial of allopurinol dose escalation, in order to achieve target ... ...

Abstract	Objective: To determine the long-term use of and adherence to urate-lowering therapy (ULT), serum urate (SU) control, and self-reported flares in participants from a randomized controlled trial of allopurinol dose escalation, in order to achieve target SU concentration (< 0.36 mmol/L) in people with gout. Methods: For surviving study participants, ULT dispensing and SU testing within the preceding 12 months was obtained by medical record review. A phone interview was conducted to determine self-reported flares and adherence. Results: Over a mean follow-up of 6.5 (SD 2.5) years since enrollment, 60 out of 183 (33%) participants had died. Review of the 119 surviving participants showed that 98 (82%) were receiving allopurinol, 5 (4%) were receiving febuxostat, and 10 (8%) were not receiving ULT; for the remaining 6 (5.0%), ULT use could not be determined. In those receiving allopurinol, the mean dose was 28.1 (range -600 to 500) mg/day lower than at the last study visit; 49% were receiving the same dose, 18% were on a higher dose, and 33% were on a lower dose than at the last study visit. SU values were available for 86 of the 119 (72%) participants; 50 out of 86 (58%) participants had an SU concentration of < 0.36 mmol/L. Of the 89 participants who participated in the phone interview, 19 (21%) reported a gout flare in the preceding 12 months and 79 (89%) were receiving allopurinol; 71 (90%) of those receiving allopurinol reported 90% or greater adherence. Conclusion: Most of the surviving participants in the allopurinol dose escalation study had good real-world persistence with allopurinol, remained at target SU, and had a low number of self-reported flares.
MeSH term(s)	Humans ; Allopurinol/therapeutic use ; Gout/drug therapy ; Uric Acid ; Gout Suppressants/therapeutic use ; Follow-Up Studies ; Treatment Outcome ; Symptom Flare Up
Chemical Substances	Allopurinol (63CZ7GJN5I) ; Uric Acid (268B43MJ25) ; Gout Suppressants
Language	English
Publishing date	2022-07-01
Publishing country	Canada
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.220270
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Arctic observations of hydroperoxymethyl thioformate (HPMTF) – seasonal behavior and relationship to other oxidation products of dimethyl sulfide at the Zeppelin Observatory, Svalbard

K. Siegel / Y. Gramlich / S. L. Haslett / G. Freitas / R. Krejci / P. Zieger / C. Mohr

Atmospheric Chemistry and Physics, Vol 23, Pp 7569-

2023 Volume 7587

Abstract: Dimethyl sulfide (DMS), a gas produced by phytoplankton, is the largest source of atmospheric sulfur over marine areas. DMS undergoes oxidation in the atmosphere to form a range of oxidation products, out of which sulfuric acid (SA) is well known for ... ...

Abstract	Dimethyl sulfide (DMS), a gas produced by phytoplankton, is the largest source of atmospheric sulfur over marine areas. DMS undergoes oxidation in the atmosphere to form a range of oxidation products, out of which sulfuric acid (SA) is well known for participating in the formation and growth of atmospheric aerosol particles, and the same is also presumed for methanesulfonic acid (MSA). Recently, a new oxidation product of DMS, hydroperoxymethyl thioformate (HPMTF), was discovered and later also measured in the atmosphere. Little is still known about the fate of this compound and its potential to partition into the particle phase. In this study, we present a full year (2020) of concurrent gas- and particle-phase observations of HPMTF, MSA, SA and other DMS oxidation products at the Zeppelin Observatory (Ny-Ålesund, Svalbard) located in the Arctic. This is the first time HPMTF has been measured in Svalbard and attempted to be observed in atmospheric particles. The results show that gas-phase HPMTF concentrations largely follow the same pattern as MSA during the sunlit months (April–September), indicating production of HPMTF around Svalbard. However, HPMTF was not observed in significant amounts in the particle phase, despite high gas-phase levels. Particulate MSA and SA were observed during the sunlit months, although the highest median levels of particulate SA were measured in February, coinciding with the highest gaseous SA levels with assumed anthropogenic origin. We further show that gas- and particle-phase MSA and SA are coupled in May–July, whereas HPMTF lies outside of this correlation due to the low particulate concentrations. These results provide more information about the relationship between HPMTF and other DMS oxidation products, in a part of the world where these have not been explored yet, and about HPMTF's ability to contribute to particle growth and cloud formation.
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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