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Article ; Online: Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy.

Petrina, Maria / Martin, Jacqueline / Basta, Sameh

2021 Volume 59, Page(s) 101–110

Abstract: GM-CSF acts as a pro-inflammatory cytokine and a key growth factor produced by several immune cells such as macrophages and activated T cells. In this review, we discuss recent studies that point to the crucial role of GM-CSF in the immune response ... ...

Abstract	GM-CSF acts as a pro-inflammatory cytokine and a key growth factor produced by several immune cells such as macrophages and activated T cells. In this review, we discuss recent studies that point to the crucial role of GM-CSF in the immune response against infections. Upon induction, GM-CSF activates four main signalling networks including the JAK/STAT, PI3K, MAPK, and NFκB pathways. Many of these transduction pathways such as JAK/STAT signal via proteins commonly activated with other antiviral signalling cascades, such as those induced by IFNs. GM-CSF also helps defend against respiratory infections by regulating alveolar macrophage differentiation and enhancing innate immunity in the lungs. Here, we also summarize the numerous clinical trials that have taken advantage of GM-CSF's mechanistic attributes in immunotherapy. Moreover, we discuss how GM-CSF is used as an adjuvant in vaccines and how its activity is interfered with to reduce inflammation such as in the case of COVID-19. This review brings forth the current knowledge on the antiviral actions of GM-CSF, the associated signalling cascades, and its application in immunotherapy.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Animals ; Antiviral Agents/immunology ; Antiviral Agents/therapeutic use ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/immunology ; Macrophages, Alveolar/immunology ; Recombinant Proteins/immunology ; Recombinant Proteins/therapeutic use ; SARS-CoV-2/immunology
Chemical Substances	Adjuvants, Immunologic ; Antiviral Agents ; COVID-19 Vaccines ; Recombinant Proteins ; sargramostim (5TAA004E22) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2021-01-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330534-7
ISSN	1879-0305 ; 1359-6101
ISSN (online)	1879-0305
ISSN	1359-6101
DOI	10.1016/j.cytogfr.2021.01.001
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Article ; Online: Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype.

Petrina, Maria / Alothaimeen, Torki / Bouzeineddine, Nasry Zane / Trus, Evan / Banete, Andra / Gee, Katrina / Basta, Sameh

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2023 Volume 73, Issue 2, Page(s) 253–262

Abstract: Background: Macrophages (Mφ) can exist along a spectrum of phenotypes that include pro-inflammatory (M1) or anti-inflammatory (M2) immune cells. Mφ colony stimulating factor (M-CSF) and granulocyte Mφ colony stimulating factor (GM-CSF) are cytokines ... ...

Abstract	Background: Macrophages (Mφ) can exist along a spectrum of phenotypes that include pro-inflammatory (M1) or anti-inflammatory (M2) immune cells. Mφ colony stimulating factor (M-CSF) and granulocyte Mφ colony stimulating factor (GM-CSF) are cytokines important in hematopoiesis, polarization and activation of Mφ. Methods and results: To gain a greater understanding of the relationship between GM-CSF and M-CSF, we investigated an in vitro model of differentiation to determine if GM-CSF and M-CSF can antagonize each other, in terms of Mφ phenotype and functions. We determined that Mφ cultured in mixed M-CSF: GM-CSF ratios exhibit M1-like GM-CSF-treated macrophage phenotype when the ratios of the two cytokines are 1:1 in culture. Moreover, GM-CSF is dominant over M-CSF in influencing Mφ production of proinflammatory cytokines such as IL-6, TNFα, and IL-12p40, and the anti-inflammatory cytokine IL-10. Conclusions: Our data established that GM-CSF is more dominant over M-CSF, triggering the Mφ to become pro-inflammatory cells. These findings provide insight into how GM-CSF can influence Mφ activation with implications in inflammatory diseases where the Mφ status can play a significant role in supporting the inflammatory conditions.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Cell Differentiation ; Cells, Cultured ; Cytokines/pharmacology ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Hematopoiesis ; Macrophage Colony-Stimulating Factor/pharmacology ; Macrophages ; Phenotype
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Macrophage Colony-Stimulating Factor (81627-83-0)
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-023-01834-9
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Article ; Online: The integrity of underlying phonological representations of Greek-speaking children with speech sound disorders.

Geronikou, Eleftheria / Kimoglou, Maria / Roussou, Petrina

Clinical linguistics & phonetics

2021 Volume 36, Issue 2-3, Page(s) 260–275

Abstract: Underlying representations are important for the development of spoken and written language. English-speaking children with speech sound disorders (SSD) have been reported to show significant difficulty with tasks tapping phonological representations. ... ...

Abstract	Underlying representations are important for the development of spoken and written language. English-speaking children with speech sound disorders (SSD) have been reported to show significant difficulty with tasks tapping phonological representations. The present study describes the development of a task for the assessment of phonological representations in Greek-speaking children. The purpose of the study is twofold: to investigate the development of phonological representation in typically developing (TD) Greek-speaking children and to explore the possibility that children with SSD may have insufficiently defined phonological representations. Greek-speaking preschool aged children (4;0-5;5 years) with SSD receiving intervention (N = 20) were compared to their typically developing peers (N = 80) on their ability to complete a task of real-word auditory discrimination with picture choice. Performance differences were assessed across segmental properties and variation in word structure.TD children aged 4;0-4;5 scored lower than older TD children. A marginally significant difference in performance was found between children with SSD and TD controls. Quantitative analysis of mistakes indicated that children with SSD and TD children aged 4;0-4;5 opt for the phonological distractor. Stimuli tapping on the specification of underlying representations at a segmental level were more taxing compared to stimuli tapping on the integrity of stored word structures.Task materials and procedures used in the present study provide preliminary normative data and may be used for the assessment of Greek-speaking children with SSD. Children with SSD are at risk of developing underspecified phonological representations and therefore should receive assessment of underlying representations to guide intervention.
MeSH term(s)	Child ; Child, Preschool ; Greece ; Humans ; Language ; Language Development Disorders ; Phonetics ; Speech ; Speech Sound Disorder
Language	English
Publishing date	2021-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	639459-0
ISSN	1464-5076 ; 0269-9206
ISSN (online)	1464-5076
ISSN	0269-9206
DOI	10.1080/02699206.2021.1966100
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Article ; Online: Detection and analysis of Shiga toxin producing and enteropathogenic Escherichia coli in cattle from Tierra del Fuego, Argentina.

Bonino, Maria Paz / Crivelli, Ximena Blanco / Petrina, Juan Facundo / Galateo, Sebastian / Gomes, Tania Aparecida Tardelli / Navarro, Armando / Cundon, Cecilia / Broglio, Alicia / Sanin, Mariana / Bentancor, Adriana

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2023 Volume 54, Issue 2, Page(s) 1257–1266

Abstract: Shiga toxin producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are pathovars that affect mainly infants' health. Cattle are the main reservoir of STEC. Uremic hemolytic syndrome and diarrheas can be found at high rates in Tierra del ... ...

Abstract	Shiga toxin producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are pathovars that affect mainly infants' health. Cattle are the main reservoir of STEC. Uremic hemolytic syndrome and diarrheas can be found at high rates in Tierra del Fuego (TDF). This study aimed to establish the prevalence of STEC and EPEC in cattle at slaughterhouses in TDF and to analyze the isolated strains. Out of 194 samples from two slaughterhouses, STEC prevalence was 15%, and EPEC prevalence was 5%. Twenty-seven STEC strains and one EPEC were isolated. The most prevalent STEC serotypes were O185:H19 (7), O185:H7 (6), and O178:H19 (5). There were no STEC eae + strains (AE-STEC) or serogroup O157 detected in this study. The prevalent genotype was stx2c (10/27) followed by stx1a/stx2hb (4/27). Fourteen percent of the strains presented at least one stx non-typeable subtype (4/27). Shiga toxin production was detected in 25/27 STEC strains. The prevalent module for the Locus of Adhesion and Autoaggregation (LAA) island was module III (7/27). EPEC strain was categorized as atypical and with the ability to cause A/E lesion. The ehxA gene was present in 16/28 strains, 12 of which were capable of producing hemolysis. No hybrid strains were detected in this work. Antimicrobial susceptibility tests showed that all strains were resistant to ampicillin and 20/28 were resistant to aminoglycosides. No statistical differences could be seen in the detection of STEC or EPEC either by slaughterhouse location or by production system (extensive grass or feedlot). The rate of STEC detection was lower than the one reported for the rest of Argentina. STEC/EPEC relation was 3 to 1. This is the first study on cattle from TDF as reservoir for strains that are potentially pathogenic to humans.
MeSH term(s)	Animals ; Cattle ; Humans ; Enteropathogenic Escherichia coli ; Shiga Toxin ; Escherichia coli Proteins/genetics ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/veterinary ; Escherichia coli Infections/microbiology ; Argentina/epidemiology ; Shiga-Toxigenic Escherichia coli
Chemical Substances	Shiga Toxin (75757-64-1) ; Escherichia coli Proteins
Language	English
Publishing date	2023-04-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-023-00958-8
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Article ; Online: Greek Adaptation of the Positive Aspects of Caregiving (PAC) Scale in Dementia Caregivers.

Tsatali, Marianna / Egkiazarova, Maria / Toumpalidou, Maria / Karagiozi, Konstantina / Margaritidou, Petrina / Tsolaki, Magda

Clinical gerontologist

2019 Volume 45, Issue 3, Page(s) 538–547

Abstract: ... ...

Abstract	Objectives
MeSH term(s)	Caregivers/psychology ; Dementia/psychology ; Humans ; Psychometrics ; Quality of Life ; Reproducibility of Results
Language	English
Publishing date	2019-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	226146-7
ISSN	1545-2301 ; 0731-7115
ISSN (online)	1545-2301
ISSN	0731-7115
DOI	10.1080/07317115.2019.1685047
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Article: Development and evaluation of liposomal nanoparticles incorporating dimethoxycurcumin. In vitro toxicity and permeability studies

Zouliati, Konstantina / Stavropoulou, Petrina / Chountoulesi, Maria / Naziris, Nikolaos / Demisli, Sotiria / Mitsou, Evgenia / Papadimitriou, Vassiliki / Chatzidaki, Maria / Xenakis, Aristotelis / Demetzos, Costas

Colloids and surfaces. 2022 Sept. 05, v. 648

2022

Abstract: Liposomes belong to the class of drug delivery nanosystems and are widely used for the incorporation and delivery of lipophilic drug molecules. The present work deals with the physicochemical characterization of different liposomal nanocarriers, loaded ... ...

Abstract	Liposomes belong to the class of drug delivery nanosystems and are widely used for the incorporation and delivery of lipophilic drug molecules. The present work deals with the physicochemical characterization of different liposomal nanocarriers, loaded with dimethoxycurcumin (DMC), an analog of curcumin with antioxidant and anticancer activity. The in vitro toxicity and intestinal permeability of drug-free liposomes were evaluated using a Caco-2/TC7 and HT29-MTX co-culture. The results revealed that all liposomal nanosystems were of size lower than 180 nm upon preparation, while their ζ-potential depended on the type of utilized biomaterials. The incorporation efficiency of DMC inside the nanocarriers was dependent on their composition and affected their properties. In addition, the systems did not induce cytotoxic effects on epithelial cells, as MTT assay indicated. Permeability studies of rhodamine-loaded nanoparticles demonstrated 2–2.5-fold intestinal permeability enhancement of the chromophore when using liposomes compared to the free molecule. Among these systems, the liposomes containing cationic lipids exhibited the highest percentage of transport across the epithelial monolayer. Conclusively, the composition and resultant properties of the liposomes are determinant for DMC incorporation and their in vitro toxicity and permeability. The herein developed nanosystems are promising for further application, due to their biocompatibility and permeability.
Keywords	antineoplastic activity ; antioxidants ; biocompatibility ; biocompatible materials ; coculture ; curcumin ; cytotoxicity ; drugs ; epithelium ; intestines ; lipophilicity ; nanocarriers ; permeability ; toxicity testing
Language	English
Dates of publication	2022-0905
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.129223
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: THE IMPORTANCE OF THE ACCOUNTING INFORMATION IN HIGHER EDUCATION INSTITUTIONS MANAGEMENT

DRĂGUŞIN CRISTINA-PETRINA / CRIVEANU MARIA

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, Vol 1, Iss 5, Pp 63-

2014 Volume 66

Abstract: In the context of globalization, accounting, as main provider of credible and highly valuable economic information in the decision making process, must keep pace and be constantly adapted to the reality and evolution of the modern society. The knowledge ... ...

Abstract	In the context of globalization, accounting, as main provider of credible and highly valuable economic information in the decision making process, must keep pace and be constantly adapted to the reality and evolution of the modern society. The knowledge based society awards academic education with an essential role fully recognized at the EU and global level. Accounting of public institutions of higher education has evolved in parallel with the development of the Romanian public accounting system, but we still notice a significant potential of improvement and development in conditions under what a more stringent convergence towards globalization is felt.
Keywords	HEIs accounting ; accounting information ; informational users ; university management ; Commercial geography. Economic geography ; HF1021-1027 ; Economics as a science ; HB71-74
Language	English
Publishing date	2014-10-01T00:00:00Z
Publisher	Academica Brâncuşi
Document type	Article ; Online
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Article ; Online: Phytobezoar-Induced Mechanical Ileus and Incipient Intussusception: A Case Report.

Kosmidis, Christoforos S / Mystakidou, Chrysi Maria / Varsamis, Nikolaos / Koulouris, Charilaos / Sevva, Christina / Papadopoulou, Konstantina / Michael, Christina / Katsios, Nikolaos Iason / Theodorou, Vasiliki / Miltiadous, Petrina / Papadopoulos, Konstantinos / Vlassopoulos, Konstantinos / Zarampouka, Katerina / Mantalovas, Stylianos

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 7

Abstract: Phytobezoars constitute conglomerates of indigested plant fibers and are a rare cause of acute mechanical ileus. They exhibit an increased prevalence in the elderly population and people with specific predisposing conditions. Radiological imaging can ... ...

Abstract	Phytobezoars constitute conglomerates of indigested plant fibers and are a rare cause of acute mechanical ileus. They exhibit an increased prevalence in the elderly population and people with specific predisposing conditions. Radiological imaging can often set a definitive diagnosis and dictate the optimal therapeutic approach, combined with the patient's clinical status. An 81-year-old male presented with deteriorating clinical symptoms of intestinal obstruction, and an exploratory laparotomy was performed following inconclusive radiological findings; multiple phytobezoars and incipient intussusception were revealed intraoperatively. A patient's medical history can often raise clinical suspicion of phytobezoars. However, a careful etiological investigation is imperative in all cases of mechanical ileus in advanced ages; early detection and dissolution of phytobezoars, when applicable, can reduce the need for surgical interventions.
MeSH term(s)	Aged ; Humans ; Aged, 80 and over ; Intussusception/surgery ; Intussusception/complications ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Bezoars/complications ; Bezoars/surgery ; Bezoars/diagnosis ; Dyspepsia ; Ileus/etiology
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59071227
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Article ; Online: "Community members have more impact on their neighbors than celebrities": leveraging community partnerships to build COVID-19 vaccine confidence.

Tjilos, Maria / Tamlyn, Autumn L / Ragan, Elizabeth J / Assoumou, Sabrina A / Barnett, Katherine Gergen / Martin, Petrina / Perkins, Rebecca B / Linas, Benjamin P / Drainoni, Mari-Lynn

BMC public health

2023 Volume 23, Issue 1, Page(s) 350

Abstract: Background: Vaccines are a strong public health tool to protect against severe disease, hospitalization, and death from COVID-19. Still, inequities in COVID-19 vaccination rates and health outcomes continue to exist among Black and Latino populations. ... ...

Abstract	Background: Vaccines are a strong public health tool to protect against severe disease, hospitalization, and death from COVID-19. Still, inequities in COVID-19 vaccination rates and health outcomes continue to exist among Black and Latino populations. Boston Medical Center (BMC) has played a significant role in vaccinating medically underserved populations, and organized a series of community-engaged conversations to better understand community concerns regarding the COVID-19 vaccine. This paper describes the themes which resulted from these community-engaged conversations and proposes next steps for healthcare leaders. Methods: We accessed nine publicly available recordings of the community-engaged conversations which were held between March 2021 and September 2021 and ranged from 8 to 122 attendees. Six conversations prioritized specific groups: the Haitian-Creole community, the Cape Verdean community, the Latino community, the Black Christian Faith community, guardians who care for children living with disabilities, and individuals affected by systemic lupus erythematosus. Remaining conversations targeted the general public of the Greater Boston Area. We employed a Consolidated Framework for Implementation Research-driven codebook to code our data. Our analysis utilized a modified version of qualitative rapid analysis methods. Results: Five main themes emerged from these community-engaged conversations: (1) Structural factors are important barriers to COVID-19 vaccination; (2) Mistrust exists due to the negative impact of systemic oppression and perceived motivation of the government; (3) There is a desire to learn more about biological and clinical characteristics of the COVID-19 vaccine as well as the practical implications of being vaccinated; (4) Community leaders emphasize community engagement for delivering COVID-19 information and education and; (5) Community leaders believe that the COVID-19 vaccine is a solution to address the pandemic. Conclusion: This study illustrates a need for community-engaged COVID-19 vaccine messaging which reflects the nuances of the COVID-19 vaccine and pandemic without oversimplifying information. In highlighting common concerns of the Greater Boston Area which contribute to a lack of confidence in the COVID-19 vaccine, we underscore important considerations for public health and healthcare leadership in the development of initiatives which work to advance health equity.
MeSH term(s)	Child ; Humans ; COVID-19 Vaccines ; COVID-19/epidemiology ; COVID-19/prevention & control ; Haiti ; Learning ; Motivation ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15198-6
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Article ; Online: Melanoma: BRAFi Rechallenge.

Kosmidis, Christoforos S / Papadopoulou, Konstantina / Mystakidou, Chrysi Maria / Papadopoulou, Evanthia / Mantalovas, Stylianos / Varsamis, Nikolaos / Koulouris, Charilaos / Theodorou, Vasiliki / Papadopoulos, Konstantinos / Sevva, Christina / Miltiadous, Petrina / Petanidis, Savvas / Georgakoudi, Eleni / Papadopoulou, Eleni / Baka, Sofia

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: Melanoma is the most aggressive type of skin cancer. Half of melanoma cases are characterized by the mutation BRAF V600. The case presented concerns a 41-year-old patient with locally advanced melanoma, being positive in mutation BRAF V600. The patient ... ...

Abstract	Melanoma is the most aggressive type of skin cancer. Half of melanoma cases are characterized by the mutation BRAF V600. The case presented concerns a 41-year-old patient with locally advanced melanoma, being positive in mutation BRAF V600. The patient underwent surgery and received additional targeted therapy as part of a clinical study. In subsequent disease progression, immunotherapy was used. When the disease progressed again while the patient was in a good performance status, targeted therapy was administered again, and a good response was noted, making the patient reach a statistically significant overall survival, exceeding four years. Targeted therapy has proven to be an important tool in the treatment of melanoma. The use of BRAFi targeted therapy does not exclude the option of readministration at subsequent disease progression (BRAFi rechallenge). Preclinical models suggest that the resistance mechanism of cancer cells to BRAFi therapy bends, as these cell clones lose their evolutionary advantage after stopping BRAFi. Cell clones sensitive to BRAFi may then outcompete, making the treatment effective again. Therapeutical dilemmas in the management of patients with locally advanced melanoma that progresses to metastatic cancer are discussed.
MeSH term(s)	Humans ; Adult ; Proto-Oncogene Proteins B-raf/genetics ; Protein Kinase Inhibitors/therapeutic use ; Melanoma/genetics ; Skin Neoplasms/pathology ; Disease Progression ; Mutation
Chemical Substances	Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59050975
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