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  1. Article ; Online: Graphene Field Effect Transistors for Biomedical Applications

    Rhiannan Forsyth / Anitha Devadoss / Owen J. Guy

    Diagnostics, Vol 7, Iss 3, p

    Current Status and Future Prospects

    2017  Volume 45

    Abstract: Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical ... ...

    Abstract Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractive as next generation bioelectronics due to their mass-scalability and low cost of the technology’s manufacture. Furthermore, G-FETs offer the potential to complete label-free, rapid, and highly sensitive analysis coupled with a high sample throughput. These properties, coupled with the potential for integration into portable instrumentation, contribute to G-FETs’ suitability for point-of-care diagnostics. This review focuses on elucidating the recent developments in the field of G-FET sensors that act on a bioaffinity basis, whereby a binding event between a bioreceptor and the target analyte is transduced into an electrical signal at the G-FET surface. Recognizing and quantifying these target analytes accurately and reliably is essential in diagnosing many diseases, therefore it is vital to design the G-FET with care. Taking into account some limitations of the sensor platform, such as Debye–Hükel screening and device surface area, is fundamental in developing improved bioelectronics for applications in the clinical setting. This review highlights some efforts undertaken in facing these limitations in order to bring G-FET development for biomedical applications forward.
    Keywords G-FET (graphene-based field effect transistors) ; DNA ; aptamer ; Debye length ; antigen binding fragment ; Dirac voltage ; point-of-care ; Medicine (General) ; R5-920
    Subject code 620
    Language English
    Publishing date 2017-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects.

    Forsyth, Rhiannan / Devadoss, Anitha / Guy, Owen J

    Diagnostics (Basel, Switzerland)

    2017  Volume 7, Issue 3

    Abstract: Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical ... ...

    Abstract Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractive as next generation bioelectronics due to their mass-scalability and low cost of the technology's manufacture. Furthermore, G-FETs offer the potential to complete label-free, rapid, and highly sensitive analysis coupled with a high sample throughput. These properties, coupled with the potential for integration into portable instrumentation, contribute to G-FETs' suitability for point-of-care diagnostics. This review focuses on elucidating the recent developments in the field of G-FET sensors that act on a bioaffinity basis, whereby a binding event between a bioreceptor and the target analyte is transduced into an electrical signal at the G-FET surface. Recognizing and quantifying these target analytes accurately and reliably is essential in diagnosing many diseases, therefore it is vital to design the G-FET with care. Taking into account some limitations of the sensor platform, such as Debye-Hükel screening and device surface area, is fundamental in developing improved bioelectronics for applications in the clinical setting. This review highlights some efforts undertaken in facing these limitations in order to bring G-FET development for biomedical applications forward.
    Language English
    Publishing date 2017-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics7030045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing.

    Devadoss, Anitha / Forsyth, Rhiannan / Bigham, Ryan / Abbasi, Hina / Ali, Muhammad / Tehrani, Zari / Liu, Yufei / Guy, Owen J

    Biosensors

    2019  Volume 9, Issue 1

    Abstract: Grafting thin polymer layers on graphene enables coupling target biomolecules to graphene surfaces, especially through amide and aldehyde linkages with carboxylic acid and primary amine derivatives, respectively. However, functionalizing monolayer ... ...

    Abstract Grafting thin polymer layers on graphene enables coupling target biomolecules to graphene surfaces, especially through amide and aldehyde linkages with carboxylic acid and primary amine derivatives, respectively. However, functionalizing monolayer graphene with thin polymer layers without affecting their exceptional electrical properties remains challenging. Herein, we demonstrate the controlled modification of chemical vapor deposition (CVD) grown single layer graphene with ultrathin polymer 1,5-diaminonaphthalene (DAN) layers using the electropolymerization technique. It is observed that the controlled electropolymerization of DAN monomer offers continuous polymer layers with thickness ranging between 5⁻25 nm. The surface characteristics of pure and polymer modified graphene was examined. As anticipated, the number of surface amine groups increases with increases in the layer thickness. The effects of polymer thickness on the electron transfer rates were studied in detail and a simple route for the estimation of surface coverage of amine groups was demonstrated using the electrochemical analysis. The implications of grafting ultrathin polymer layers on graphene towards horseradish peroxidase (HRP) enzyme immobilization and enzymatic electrochemical sensing of H₂O₂ were discussed elaborately.
    MeSH term(s) Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Electrochemical Techniques/instrumentation ; Electrochemical Techniques/methods ; Electrodes ; Enzymes, Immobilized/chemistry ; Enzymes, Immobilized/metabolism ; Glucose/metabolism ; Graphite/chemistry ; Horseradish Peroxidase/chemistry ; Horseradish Peroxidase/metabolism ; Hydrogen Peroxide/analysis ; Polymers/chemistry ; Surface Properties
    Chemical Substances Enzymes, Immobilized ; Polymers ; Graphite (7782-42-5) ; Hydrogen Peroxide (BBX060AN9V) ; Horseradish Peroxidase (EC 1.11.1.-) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios9010016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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