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  1. Book ; Online: Nanomaterials for Surface-Enhanced Raman Spectroscopy and Application in Trace Detection

    Lu, Xiaonan / Hu, Yaxi / Hu, Yaxi

    2020  

    Keywords Technology: general issues ; SERS ; Ag NPs ; coffee ring ; pesticide detection ; Surface-enhanced Raman spectroscopy (SERS) ; wire mesh ; steel mesh ; SERS platform ; Escherichia coli ; Bacillus subtilis ; biomolecule ; surface enhanced Raman spectroscopy (SERS) ; nanomaterial ; analysis ; identification ; biology ; chemometrics ; resistance ; biosensing ; rapid detection ; Ag nanowires ; tartrazine ; large yellow croaker ; surface-enhanced Raman spectroscopy ; transformer aging ; concentration detection ; circulating tumor cells (CTC) ; prostate cancer (PC3) ; cervical carcinoma (HeLa) ; label-free detection
    Size 1 electronic resource (130 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046268
    ISBN 9783039362738 ; 3039362739
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients.

    Hu, Xiaonan / Yu, Jiawei / Chen, Mengshi / Pang, Rui

    Biomarkers in medicine

    2024  Volume 18, Issue 5, Page(s) 169–179

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Thyroid Cancer, Papillary ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Carcinoma/pathology ; Carcinoma/surgery ; Carcinoma, Papillary/diagnosis ; Carcinoma, Papillary/surgery ; Prognosis ; Protein Serine-Threonine Kinases/genetics
    Chemical Substances PLK4 protein, human (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2023-0565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6985: Show issues Location:
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  3. Article ; Online: Polyethersulfone-Based Microfluidic Device Integrated with DNA Extraction on Paper and Recombinase Polymerase Amplification for the Detection of

    Chen, Yunxuan / Hu, Yaxi / Lu, Xiaonan

    ACS sensors

    2023  Volume 8, Issue 6, Page(s) 2331–2339

    Abstract: Rising consumption, large-scale production, and widespread distribution have been accompanied by an increase in the number ... ...

    Abstract Rising consumption, large-scale production, and widespread distribution have been accompanied by an increase in the number of
    MeSH term(s) Salmonella enterica/genetics ; Recombinases ; Nucleic Acids/analysis ; DNA ; Lab-On-A-Chip Devices
    Chemical Substances Recombinases ; polyether sulfone (25667-42-9) ; Nucleic Acids ; DNA (9007-49-2)
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c00387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimicrobial Resistance and Molecular Characterization of

    Li, Lulu / Zhao, Xiaonan / Zhang, Qing / Luo, Yanbo / Guo, Genglin / Hu, Ming / Chen, Yibao / Liu, Yuqing

    Foodborne pathogens and disease

    2024  

    Abstract: Antimicrobial resistance (AMR) is a great threat to animal and public health. Here, we conducted a surveillance ... ...

    Abstract Antimicrobial resistance (AMR) is a great threat to animal and public health. Here, we conducted a surveillance of
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2148479-X
    ISSN 1556-7125 ; 1535-3141
    ISSN (online) 1556-7125
    ISSN 1535-3141
    DOI 10.1089/fpd.2023.0120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7517: Show issues

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  5. Article ; Online: Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty.

    Hu, Xiaonan / Meng, Zhen

    Annals of human genetics

    2022  Volume 86, Issue 5, Page(s) 257–267

    Abstract: One of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. ... ...

    Abstract One of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. However, the underlying genetic models of inheritance are rarely known in practice. Misspecifying a genetic model may result in power loss. By using some potential genetic variables to separate the genotype coding and genetic model parameter, we construct a model-embedded score test (MEST). Our test is free of assumption of gene-environment independence and allows for covariates in the model. An effective sequential optimization algorithm is developed. Extensive simulations show the proposed MEST is robust and powerful in most of scenarios. Finally, we apply the proposed method to rheumatoid arthritis data from the Genetic Analysis Workshop 16 to further investigate the potential interaction effects.
    MeSH term(s) Gene-Environment Interaction ; Genetic Association Studies ; Genotype ; Humans ; Models, Genetic ; Uncertainty
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 333-5
    ISSN 1469-1809 ; 0003-4800
    ISSN (online) 1469-1809
    ISSN 0003-4800
    DOI 10.1111/ahg.12470
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.193: Show issues Location:
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  6. Article ; Online: Long-term in vitro monitoring of AAV-transduction efficiencies in real-time with Hoechst 33342.

    Hu, Xiaonan / Meister, Roland / Tode, Jan / Framme, Carsten / Fuchs, Heiko

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0298173

    Abstract: Adeno-associated viral transduction allows the introduction of nucleic fragments into cells and is widely used to modulate gene expressions in vitro and in vivo. It enables the study of genetic functions and disease mechanisms and, more recently, serves ... ...

    Abstract Adeno-associated viral transduction allows the introduction of nucleic fragments into cells and is widely used to modulate gene expressions in vitro and in vivo. It enables the study of genetic functions and disease mechanisms and, more recently, serves as a tool for gene repair. To achieve optimal transduction performance for a given cell type, selecting an appropriate serotype and the number of virus particles per cell, also known as the multiplicity of infection, is critical. Fluorescent proteins are one of the common reporter genes to visualize successfully transduced cells and assess transduction efficiencies. Traditional methods of measuring fluorescence-positive cells are endpoint analysis by flow cytometry or manual counting with a fluorescence microscope. However, the flow cytometry analysis does not allow further measurement in a test run, and manual counting by microscopy is time-consuming. Here, we present a method that repeatedly evaluates transduction efficiencies by adding the DNA-stain Hoechst 33342 during the transduction process combined with a microscope or live-cell imager and microplate image analysis software. The method achieves fast, high-throughput, reproducible, and real-time post-transduction analysis and allows for optimizing transduction parameters and screening for a proper approach.
    MeSH term(s) Cell Nucleus ; Coloring Agents ; Dependovirus/genetics ; Microscopy, Fluorescence ; Benzimidazoles
    Chemical Substances bisbenzimide ethoxide trihydrochloride (P976261J69) ; Coloring Agents ; Benzimidazoles
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An Integrated Paper Microfluidic Device Based on Isothermal Amplification for Simple Sample-to-Answer Detection of

    Chen, Yunxuan / Hu, Yaxi / Lu, Xiaonan

    Applied and environmental microbiology

    2023  Volume 89, Issue 7, Page(s) e0069523

    Abstract: Campylobacter jejuni is recognized as the most common species in the genus Campylobacter that causes foodborne diseases. The main reservoirs harboring C. jejuni are poultry products, which are associated with most illnesses, creating a demand for ... ...

    Abstract Campylobacter jejuni is recognized as the most common species in the genus Campylobacter that causes foodborne diseases. The main reservoirs harboring C. jejuni are poultry products, which are associated with most illnesses, creating a demand for effective detection methods to achieve point-of-need diagnostics. We developed an easy-to-use, hybrid paper/polymer-based microfluidic device that integrates paper-based DNA extraction, isothermal nucleic acid amplification, and lateral flow detection. Overall, the recombinase polymerase amplification (RPA) reaction was completed in 20 min and demonstrated 100% specificity to C. jejuni, including 2 reference strains and 6 wild strains isolated from the agroecosystem, 9 other Campylobacter subspecies strains, and 11 non-Campylobacter strains. The limit of detection (LOD) was 46 CFU/mL with DNA extracted on the cellulose paper. The sensitivity was reduced to 460 CFU/mL on the integrated hybrid paper/polymer-based microfluidic device. This device could detect C. jejuni spiked at concentrations ranging from 10
    MeSH term(s) Animals ; Campylobacter jejuni/genetics ; Chickens/microbiology ; Campylobacter/genetics ; Nucleic Acid Amplification Techniques/methods ; Lab-On-A-Chip Devices ; Nucleic Acids ; Sensitivity and Specificity
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00695-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
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  8. Article ; Online: Synthesis of Heptamethine Cyanines from Furfural Derivatives.

    Hao, Zhenming / Hu, Liming / Wang, Xiaonan / Liu, Youjun / Mo, Shanyan

    Organic letters

    2023  Volume 25, Issue 7, Page(s) 1078–1082

    Abstract: Despite the widespread theranostic utilization of cyanine dyes (Cy7), their synthetic method is still limited with pyridine or cyclohexanone derivatives as starting materials. Herein, we report the synthesis of Cy7 from furfural derivatives. First, a one- ...

    Abstract Despite the widespread theranostic utilization of cyanine dyes (Cy7), their synthetic method is still limited with pyridine or cyclohexanone derivatives as starting materials. Herein, we report the synthesis of Cy7 from furfural derivatives. First, a one-pot reaction strategy is developed to solve the unstable problem of the Stenhouse salts. Second, a stepwise condensation strategy is exploited to regioselectively synthesize asymmetrical Cy7. The methodology possesses advantages, such as easy handling, high yield, wide substrate scopes, and good functional group tolerance.
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c04289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Artemis as Predictive Biomarker of Responsiveness to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer.

    Liu, Hai / Huang, Runying / Shan, Jingjing / Xie, Xuyun / Wang, Chongwei / Hu, Peng / Sun, Xiaonan

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 1, Page(s) 535–546

    Abstract: The aim of this study was to identify Artemis as a predictive biomarker for guiding preoperative chemoradiotherapy in locally advanced rectal cancer. The resection specimens were collected from 50 patients with rectal cancer who underwent preoperative ... ...

    Abstract The aim of this study was to identify Artemis as a predictive biomarker for guiding preoperative chemoradiotherapy in locally advanced rectal cancer. The resection specimens were collected from 50 patients with rectal cancer who underwent preoperative chemoradiotherapy. Artemis expression in biopsy tissues was evaluated using immunohistochemical staining according to the percentage of positively stained cells combined with staining intensity. Among the 50 patients, 36 (72%) had a weakly positive Artemis protein expression, 10 (20%) had a moderately positive expression, and 4 (8%) showed a strongly positive expression. The criteria of magnetic resonance imaging tumor regression grade (mrTRG) and pathological rectal cancer regression grade (RCRG) were used to assess the tumor response to chemoradiotherapy. Correlation analysis shows that there is a significant negative correlation between high Artemis immunoscore and treatment response (
    MeSH term(s) Humans ; Neoplasms, Second Primary ; Rectal Neoplasms/therapy ; Biopsy ; Biomarkers ; Chemoradiotherapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31010037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Tuning microscopic structure of La-MOFs via ligand engineering effect towards enhancing phosphate adsorption.

    He, Qinqin / Zhao, Hongjun / Teng, Zedong / Guo, Yali / Ji, Xiaonan / Hu, Wei / Li, Min

    Journal of environmental management

    2024  Volume 353, Page(s) 120149

    Abstract: The selection of different organic ligands when synthesizing metal organic framework (MOFs) can change their effects on the adsorption performance. Here, four La-MOFs adsorbents (La-SA, La-FA, La-TA and La-OA) with different organic ligands and ... ...

    Abstract The selection of different organic ligands when synthesizing metal organic framework (MOFs) can change their effects on the adsorption performance. Here, four La-MOFs adsorbents (La-SA, La-FA, La-TA and La-OA) with different organic ligands and structures were synthesized by solvothermal method for phosphate adsorption, and the relationship between their adsorption properties and structures was established. Among four La-MOFs, their phosphate adsorption capacities and adsorption rates followed La-SA > La-FA > La-TA > La-OA. The results indicated that average pore diameter played a key role in phosphate adsorption and there was a positive correlation between average pore diameter and adsorption capacity (R
    MeSH term(s) Phosphates/chemistry ; Adsorption ; Metal-Organic Frameworks ; Spectroscopy, Fourier Transform Infrared ; Ligands ; Lanthanum/chemistry ; Kinetics ; Water Pollutants, Chemical
    Chemical Substances Phosphates ; Metal-Organic Frameworks ; Ligands ; Lanthanum (6I3K30563S) ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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