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Article ; Online: Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallée du Kou, Burkina Faso.

Kwiatkowska, Rachel M / Platt, Naomi / Poupardin, Rodolphe / Irving, Helen / Dabire, Roch K / Mitchell, Sara / Jones, Christopher M / Diabaté, Abdoulaye / Ranson, Hilary / Wondji, Charles S

Gene

2013 Volume 519, Issue 1, Page(s) 98–106

Abstract: With the exception of target site mutations, insecticide resistance mechanisms in the principle malaria vector Anopheles gambiae, remains largely uncharacterized in Burkina Faso. Here we detected high prevalence of resistance in Vallée du Kou (VK) to ... ...

Abstract	With the exception of target site mutations, insecticide resistance mechanisms in the principle malaria vector Anopheles gambiae, remains largely uncharacterized in Burkina Faso. Here we detected high prevalence of resistance in Vallée du Kou (VK) to pyrethroids, DDT and dieldrin, moderate level for carbamates and full susceptibility to organophosphates. High frequencies of L1014F kdr (75%) and Rdl (87%) mutations were observed showing strong correlation with pyrethroids/DDT and dieldrin resistance. The frequency of ace1R mutation was low even in carbamate resistant mosquitoes. Microarray analysis identified genes significantly over-transcribed in VK. These include the cytochrome P450 genes, CYP6P3 and CYP6Z2, previously associated with pyrethroid resistance. Gene Ontology (GO) enrichment analysis suggested that elevated neurotransmitter activity is associated with resistance, with the over-transcription of target site resistance genes such as acetylcholinesterase and the GABA receptor. A rhodopsin receptor gene previously associated with pyrethroid resistance in Culex pipiens pallens was also over-transcribed in VK. This study highlights the complex network of mechanisms conferring multiple resistance in malaria vectors and such information should be taken into account when designing and implementing resistance control strategies.
MeSH term(s)	Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Animals ; Anopheles/drug effects ; Anopheles/genetics ; Burkina Faso ; Carbamates/pharmacology ; Culex/drug effects ; Culex/genetics ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; DDT/pharmacology ; Dieldrin/pharmacology ; Gene Frequency ; Genes, Insect ; Genotype ; Insect Vectors/drug effects ; Insect Vectors/genetics ; Insecticide Resistance/genetics ; Insecticides/pharmacology ; Microarray Analysis ; Mutation ; Phenotype ; Pyrethrins/pharmacology ; Receptors, GABA/genetics ; Receptors, GABA/metabolism ; Rhodopsin/genetics ; Rhodopsin/metabolism ; Up-Regulation
Chemical Substances	Carbamates ; Insecticides ; Pyrethrins ; Receptors, GABA ; Rhodopsin (9009-81-8) ; Cytochrome P-450 Enzyme System (9035-51-2) ; DDT (CIW5S16655) ; Acetylcholinesterase (EC 3.1.1.7) ; Dieldrin (I0246D2ZS0)
Language	English
Publishing date	2013-02-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2013.01.036
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Article: Assessment of VIIRS 375 m active fire using tropical peatland combustion algorithm applied to Landsat-8 over Indonesia’s peatlands

Sofan, Parwati / Bruce, David / Schroeder, Wilfrid / Jones, Eriita / Marsden, Jackie

International journal of digital earth. 2020 Dec. 1, v. 13, no. 12

2020

Abstract: ... Kalimantan’s peatlands were utilised. Most peatland fires were still within 750 m from their source over 15 h ... VIIRS 375 m active fire data (VNP14IMG), the highest spatial resolution available cost-free fire ... than 14 ha, a dissolved 375 m buffer (cluster buffer) of VNP14IMG active fires with an integration ...

Abstract	VIIRS 375 m active fire data (VNP14IMG), the highest spatial resolution available cost-free fire product, were assessed for representing fire in typical degraded tropical peatlands in Indonesia. The results of applying the Tropical Peatland Combustion Algorithm to Landsat-8 (ToPeCAl-L8) daytime imagery were utilised as the fire references. To permit the comparison of non-simultaneous VNP14IMG and ToPeCAl-L8, peatland fire propagation speeds resulting from previous study using TET-1 data in Central Kalimantan’s peatlands were utilised. Most peatland fires were still within 750 m from their source over 15 h under uniform conditions, except for very large fires. The detection rates of nighttime VNP14IMG compared with ToPeCAl-L8 showed about 80% agreement for small fire areas (< 14 ha). For fires larger than 14 ha, a dissolved 375 m buffer (cluster buffer) of VNP14IMG active fires with an integration of nighttime and daytime acquisitions, produced a probability of detection up to 90%. These results generated a recommendation for implementing cluster buffer analysis and integration of nighttime and daytime analysis of VNP14IMG data for better accuracy in fire detection for ground fire management. They also demonstrate the utility of the ToPeCAl-L8 algorithm with VIIRS 375 m active fire data.
Keywords	Borneo ; Landsat ; algorithms ; combustion ; fire detection ; peatlands ; probability ; Indonesia
Language	English
Dates of publication	2020-1201
Size	p. 1695-1716.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2410527-2
ISSN	1753-8955 ; 1753-8947
ISSN (online)	1753-8955
ISSN	1753-8947
DOI	10.1080/17538947.2020.1791268
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Article: Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallée du Kou, Burkina Faso

Kwiatkowska, Rachel M / Platt, Naomi / Poupardin, Rodolphe / Irving, Helen / Dabire, Roch K / Mitchell, Sara / Jones, Christopher M / Diabaté, Abdoulaye / Ranson, Hilary / Wondji, Charles S

Gene. 2013 Apr. 25, v. 519, no. 1

2013

Abstract	With the exception of target site mutations, insecticide resistance mechanisms in the principle malaria vector Anopheles gambiae, remains largely uncharacterized in Burkina Faso. Here we detected high prevalence of resistance in Vallée du Kou (VK) to pyrethroids, DDT and dieldrin, moderate level for carbamates and full susceptibility to organophosphates. High frequencies of L1014F kdr (75%) and Rdl (87%) mutations were observed showing strong correlation with pyrethroids/DDT and dieldrin resistance. The frequency of ace1ᴿ mutation was low even in carbamate resistant mosquitoes. Microarray analysis identified genes significantly over-transcribed in VK. These include the cytochrome P450 genes, CYP6P3 and CYP6Z2, previously associated with pyrethroid resistance. Gene Ontology (GO) enrichment analysis suggested that elevated neurotransmitter activity is associated with resistance, with the over-transcription of target site resistance genes such as acetylcholinesterase and the GABA receptor. A rhodopsin receptor gene previously associated with pyrethroid resistance in Culex pipiens pallens was also over-transcribed in VK. This study highlights the complex network of mechanisms conferring multiple resistance in malaria vectors and such information should be taken into account when designing and implementing resistance control strategies.
Keywords	Anopheles gambiae ; Culex pipiens pallens ; DDT (pesticide) ; acetylcholinesterase ; carbamates ; cytochrome P-450 ; dieldrin ; gamma-aminobutyric acid ; genes ; insecticide resistance ; microarray technology ; organophosphorus compounds ; phenotype ; pyrethrins ; resistance mechanisms ; rhodopsin ; site-directed mutagenesis ; Burkina Faso
Language	English
Dates of publication	2013-0425
Size	p. 98-106.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2013.01.036
Database	NAL-Catalogue (AGRICOLA)

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Article: Innovation in rangeland monitoring: annual, 30 m, plant functional type percent cover maps for U.S. rangelands, 1984–2017

Jones, Matthew O / Allred, Brady W / Bestelmeyer, Brandon / Boyd, Chad / Donnelly, Patrick / Karl, Jason / Kerby, Jay D / Maestas, Jeremy D / McIver, James D / Metz, Loretta J / Naugle, David E / Smith, Rob

Ecosphere. 2018 Sept., v. 9, no. 9

2018

Abstract: Innovations in machine learning and cloud‐based computing were merged with historical remote sensing and field data to provide the first moderate resolution, annual, percent cover maps of plant functional types across rangeland ecosystems to effectively ... ...

Abstract	Innovations in machine learning and cloud‐based computing were merged with historical remote sensing and field data to provide the first moderate resolution, annual, percent cover maps of plant functional types across rangeland ecosystems to effectively and efficiently respond to pressing challenges facing conservation of biodiversity and ecosystem services. We utilized the historical Landsat satellite record, gridded meteorology, abiotic land surface data, and over 30,000 field plots within a Random Forests model to predict per‐pixel percent cover of annual forbs and grasses, perennial forbs and grasses, shrubs, and bare ground over the western United States from 1984 to 2017. Results were validated using three independent collections of plot‐level measurements, and resulting maps display land cover variation in response to changes in climate, disturbance, and management. The maps, which will be updated annually at the end of each year, provide exciting opportunities to expand and improve rangeland conservation, monitoring, and management. The data open new doors for scientific investigation at an unprecedented blend of temporal fidelity, spatial resolution, and geographic scale.
Keywords	annuals ; artificial intelligence ; biodiversity ; climate ; ecosystem services ; ecosystems ; forbs ; grasses ; land cover ; Landsat ; meteorology ; monitoring ; perennials ; rangelands ; remote sensing ; shrubs ; Western United States
Language	English
Dates of publication	2018-09
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2572257-8
ISSN	2150-8925
ISSN	2150-8925
DOI	10.1002/ecs2.2430
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Article: Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins.

Tripp, Ralph A / Haynes, Lia M / Moore, Deborah / Anderson, Barbara / Tamin, Azaibi / Harcourt, Brian H / Jones, Les P / Yilla, Mamadi / Babcock, Gregory J / Greenough, Thomas / Ambrosino, Donna M / Alvarez, Rene / Callaway, Justin / Cavitt, Sheana / Kamrud, Kurt / Alterson, Harold / Smith, Jonathan / Harcourt, Jennifer L / Miao, Congrong /

Razdan, Raj / Comer, James A / Rollin, Pierre E / Ksiazek, Thomas G / Sanchez, Anthony / Rota, Paul A / Bellini, William J / Anderson, Larry J

Journal of virological methods

2004 Volume 128, Issue 1-2, Page(s) 21–28

Abstract: ... were developed and characterized for reactivity to SARS-CoV and SARS-CoV S, N, M, and E proteins using ... characterization. Five mAbs reacted against the S protein, two against the M protein, and one each against the N ... and E proteins. Two of five S protein mAbs neutralized SARS-CoV infection of Vero E6 cells and reacted ...

Abstract	Monoclonal antibodies (Mabs) against the Urbani strain of the SARS-associated coronavirus (SARS-CoV) were developed and characterized for reactivity to SARS-CoV and SARS-CoV S, N, M, and E proteins using enzyme-linked immunoabsorbent (ELISA), radioimmunoprecipitation, immunofluorescence, Western Blot and microneutralization assays. Twenty-six mAbs were reactive to SARS-CoV by ELISA, and nine were chosen for detailed characterization. Five mAbs reacted against the S protein, two against the M protein, and one each against the N and E proteins. Two of five S protein mAbs neutralized SARS-CoV infection of Vero E6 cells and reacted to an epitope within amino acids 490-510 in the S protein. While two of the three non-neutralizing antibodies recognized at second epitope within amino acids 270-350. The mAbs characterized should prove useful for developing SARS-CoV diagnostic assays and for studying the biology of infection and pathogenesis of disease.
MeSH term(s)	Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/immunology ; Antibody Specificity ; Cell Line ; Chlorocebus aethiops ; Epitope Mapping ; Humans ; Membrane Glycoproteins/immunology ; Neutralization Tests ; Nucleocapsid Proteins/immunology ; SARS Virus/immunology ; Severe Acute Respiratory Syndrome/virology ; Spike Glycoprotein, Coronavirus ; Vero Cells ; Viral Envelope Proteins/immunology ; Viral Matrix Proteins/immunology ; Viral Structural Proteins/immunology
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral ; E protein, SARS coronavirus ; M protein, Coronavirus ; MHV surface projection glycoprotein ; Membrane Glycoproteins ; Nucleocapsid Proteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; Viral Matrix Proteins ; Viral Structural Proteins ; nucleocapsid protein, Coronavirus ; spike glycoprotein, SARS-CoV
Keywords	covid19
Language	English
Publishing date	2004-01-29
Publishing country	Netherlands
Document type	Evaluation Study ; Journal Article
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2005.03.021
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Article ; Online: Scientific opinion on application EFSA-GMO-NL-2013-120 for authorisation of genetically modified soybean FG72 × A5547-127 for food and feed uses, import and processing submitted in accordance with Regulation (EC) No 1829/2003 by Bayer CropScience LP and M.S. Technologies LLC.

EFSA journal. European Food Safety Authority

2017 Volume 15, Issue 4, Page(s) e04744

Abstract: In this opinion, the EFSA Panel on Genetically Modified Organisms (GMO) assesses the two-event stack soybean FG72 × A5547-127 for food and feed uses, import and processing. The EFSA GMO Panel previously assessed the two single events combined to produce ... ...

Abstract	In this opinion, the EFSA Panel on Genetically Modified Organisms (GMO) assesses the two-event stack soybean FG72 × A5547-127 for food and feed uses, import and processing. The EFSA GMO Panel previously assessed the two single events combined to produce the two-event stack soybean FG72 × A5547-127 and did not identify safety concerns. No new data on the single events, leading to modification of the original conclusions on their safety, were identified. The molecular, agronomic, phenotypic and compositional data on soybean FG72 × A5547-127 did not give rise to safety concerns and no reason to expect interactions between the single events impacting on the food and feed safety of the two-event stack soybean was identified. Although the EFSA GMO Panel cannot conclude on forage composition, soybean forage is not expected to be imported in a significant amount for use as feed. Considering the routes of exposure and limited exposure levels, the EFSA GMO Panel concludes that soybean FG72 × A5547-127 would not give rise to safety concerns in the event of accidental release of viable seeds into the environment. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of soybean FG72 × A5547-127. The EFSA GMO Panel concludes that soybean FG72 × A5547-127 is as safe as the non-genetically modified (GM) comparator and non-GM soybean reference varieties with respect to potential effects on human and animal health and the environment.
Language	English
Publishing date	2017-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2017.4744
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Article: 1,2,3-triazolate-bridged tetradecametallic transition metal clusters [M14(L)6O6(OMe)18X6] (M=FeIII, CrIII and VIII/IV) and related compounds: ground-state spins ranging from S=0 to S=25 and spin-enhanced magnetocaloric effect.

Shaw, Rachel / Laye, Rebecca H / Jones, Leigh F / Low, David M / Talbot-Eeckelaers, Caytie / Wei, Qiang / Milios, Constantinos J / Teat, Simon / Helliwell, Madeleine / Raftery, James / Evangelisti, Marco / Affronte, Marco / Collison, David / Brechin, Euan K / McInnes, Eric J L

Inorganic chemistry

2007 Volume 46, Issue 12, Page(s) 4968–4978

Abstract: ... 6O6(OMe)18Cl6] (M=FeIII, CrIII) and [V14(L)6O6(OMe)18Cl6-xOx] (L=anion of 1,2,3-triazole or derivative ... complexes to have ground state electronic spins of SS=0 ground state despite having a very similar structure and all complexes being ...

Abstract	We report the synthesis, by solvothermal methods, of the tetradecametallic cluster complexes [M14(L)6O6(OMe)18Cl6] (M=FeIII, CrIII) and [V14(L)6O6(OMe)18Cl6-xOx] (L=anion of 1,2,3-triazole or derivative). Crystal structure data are reported for the {M14} complexes [Fe14(C2H2N3)6O6(OMe)18Cl6], [Cr14(bta)6O6(OMe)18Cl6] (btaH=benzotriazole), [V14O6(Me2bta)6(OMe)18Cl6-xOx] [Me2btaH=5,6-Me2-benzotriazole; eight metal sites are VIII, the remainder are disordered between {VIII-Cl}2+ and {VIV=O}2+] and for the distorted [FeIII14O9(OH)(OMe)8(bta)7(MeOH)5(H2O)Cl8] structure that results from non-solvothermal synthetic methods, highlighting the importance of temperature regime in cluster synthesis. Magnetic studies reveal the {Fe14} complexes to have ground state electronic spins of S<or=25, among the highest known, while in contrast the {Cr14} complex has an <mark>S=0 ground state despite having a very similar structure and all complexes being dominated by intramolecular antiferromagnetic exchange interactions. The {Fe14} complexes undergo a magnetic phase transition to long-range ordering at relatively high temperatures for molecular species, which are governed by the steric bulk of the triazole (TN=1.8 and 3.4 K for L=bta- and H2C2N3-, respectively). The huge spins of the {Fe14} complexes lead to very large magnetocaloric effects (MCE)-the largest known for any material below 10 K-which is further enhanced by spin frustration within the molecules due to the competing antiferromagnetic interactions. The largest MCE is found for [Fe14(C2H2N3)6O6(OMe)18Cl6] with an isothermal magnetic entropy change -DeltaSm of 20.3 J kg-1 K-1 at 6 K for an applied magnetic field change of 0-7 T.
MeSH term(s)	Chromium/chemistry ; Electrons ; Iron/chemistry ; Ligands ; Magnetics ; Organometallic Compounds/chemistry ; Temperature ; Transition Elements/chemistry ; Triazoles/chemistry ; Vanadium/chemistry
Chemical Substances	Ligands ; Organometallic Compounds ; Transition Elements ; Triazoles ; Vanadium (00J9J9XKDE) ; Chromium (0R0008Q3JB) ; Iron (E1UOL152H7)
Language	English
Publishing date	2007-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic070320k
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Article ; Online: Rapid emergence of blaCTX-M among Enterobacteriaceae in U.S. Medical Centers: molecular evaluation from the MYSTIC Program (2007).

Castanheira, Mariana / Mendes, Rodrigo E / Rhomberg, Paul R / Jones, Ronald N

Microbial drug resistance (Larchmont, N.Y.)

2008 Volume 14, Issue 3, Page(s) 211–216

Abstract: ... in U.S. medical centers during the MYSTIC Program 2007 were evaluated to determine the presence ... of selected beta-lactamase genes. CTX-M-encoding genes, considered rare in the United States, were detected ... observed in 80.0% of the participating hospitals. CTX-M-14 and -15 were found in multiple institutions ...

Abstract	A total of 220 gram-negative isolates showing distinct beta-lactam resistance profiles recovered in U.S. medical centers during the MYSTIC Program 2007 were evaluated to determine the presence of selected beta-lactamase genes. CTX-M-encoding genes, considered rare in the United States, were detected in 38.8% (28/70; three species) of the extended spectrum beta-lactamase-positive isolates and were observed in 80.0% of the participating hospitals. CTX-M-14 and -15 were found in multiple institutions (eight and nine medical centers, respectively), and CTX-M-3 was detected in only one isolate. The OXA-2 and -10 were identified in nine Enterobacteriaceae strains, and plasmid-mediated AmpC enzymes CMY-2 and FOX-5 were identified in six and four isolates, respectively, displaying negative clavulanate inhibition. Genes encoding OXA-23 and -24 were detected in 30.0% (15/50) of carbapenem-resistant Acinetobacter spp. strains. Retrospective sampling showed that these OXA enzymes were present since 2004 in the MYSTIC Program isolates. The KPC serine carbapenemases were observed in the majority of the carbapenem-resistant Enterobacteriaceae (usually Klebsiella pneumoniae), confirming an epidemic problem in the New York City area. The association of beta-lactamase production and transferable quinolone resistance genes (qnr; 6.7%) in Enterobacteriaceae strains was higher than previously reported. This study illustrates the emergence and rapid dissemination of some beta-lactamases, such as CTX-M, broad-spectrum oxacillinases, and serine carbapenemases, that compromised the treatment of gram-negative infections in numerous U.S. hospitals participating in the MYSTIC Program in 2007.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Drug Resistance, Bacterial/genetics ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/isolation & purification ; Enterobacteriaceae Infections/enzymology ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Genes, Bacterial ; Hospitals ; Humans ; Microbial Sensitivity Tests ; Retrospective Studies ; United States/epidemiology ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; oxacillinase (EC 3.5.2.6)
Language	English
Publishing date	2008-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1290490-9
ISSN	1931-8448 ; 1076-6294
ISSN (online)	1931-8448
ISSN	1076-6294
DOI	10.1089/mdr.2008.0827
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Article: A reply to the comments of S.M. Tavantzis

Jones, A.T / Cooper, J.I

Phytopathology. 1984. v. 74 (4)

1984

Title variant	Reply to the comments of S.M. Tavantzis [Terminology used in plant response to viruses, tolerance, sensitivity, immunity]
Keywords	immunity
Language	English
Size	p. 381.
Document type	Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
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Article: Recognising the R.N.M.S.

Jones, A

Nursing mirror and midwives journal

1966 Volume 122, Issue 12, Page(s) 257

MeSH term(s)	Humans ; Intellectual Disability/nursing ; Nurses ; Nursing
Language	English
Publishing date	1966-06-17
Publishing country	England
Document type	Journal Article
ZDB-ID	603413-5
ISSN	0143-2524
ISSN	0143-2524
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