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  1. Article ; Online: New findings on brain actions of growth hormone and potential clinical implications.

    Donato, Jose / Kopchick, John J

    Reviews in endocrine & metabolic disorders

    2023  

    Abstract: Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth, lipolysis, and insulin resistance. The GH receptor (GHR) is ... ...

    Abstract Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth, lipolysis, and insulin resistance. The GH receptor (GHR) is expressed in numerous brain regions. Notably, a growing body of evidence indicates that GH-induced GHR signaling in specific neuronal populations regulates multiple physiological functions, including energy balance, glucose homeostasis, stress response, behavior, and several neurological/cognitive aspects. The importance of central GHR signaling is particularly evident when the organism is under metabolic stress, such as pregnancy, chronic food deprivation, hypoglycemia, and prolonged exercise. These particular situations are associated with elevated GH secretion. Thus, central GH action represents an internal signal that coordinates metabolic, neurological, neuroendocrine, and behavioral adaptations that are evolutionarily advantageous to increase the chances of survival. This review summarizes and discusses recent findings indicating that the brain is an important target of GH, and GHR signaling in different neuronal populations regulates essential physiological functions.
    Language English
    Publishing date 2023-12-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09861-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6069: Show issues Location:
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  2. Article ; Online: GH and IGF1 in cancer therapy resistance.

    Basu, Reetobrata / Kopchick, John J

    Endocrine-related cancer

    2023  Volume 30, Issue 9

    Abstract: Despite landmark advances in cancer treatments over the last 20 years, cancer remains the second highest cause of death worldwide, much ascribed to intrinsic and acquired resistance to the available therapeutic options. In this review, we address this ... ...

    Abstract Despite landmark advances in cancer treatments over the last 20 years, cancer remains the second highest cause of death worldwide, much ascribed to intrinsic and acquired resistance to the available therapeutic options. In this review, we address this impending issue, by focusing the spotlight on the rapidly emerging role of growth hormone action mediated by two intimately related tumoral growth factors - growth hormone (GH) and insulin-like growth factor 1 (IGF1). Here, we not only catalog the scientific evidences relating specifically to cancer therapy resistance inflicted by GH and IGF1 but also discuss the pitfalls, merits, outstanding questions and the future need of exploiting GH-IGF1 inhibition to tackle cancer treatment successfully.
    MeSH term(s) Humans ; Human Growth Hormone/therapeutic use ; Insulin-Like Growth Factor I/metabolism ; Neoplasms/drug therapy ; Growth Hormone/metabolism
    Chemical Substances Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6) ; IGF1 protein, human
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-22-0414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4192: Show issues Location:
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  3. Book: Laron Syndrome

    Laron, Zvi / Kopchick, John J.

    from man to mouse ; lessons from clinical and experimental experience

    2011  

    Author's details Zvi Laron ; John J. Kopchick
    Keywords Laron-Syndrom
    Language English
    Size XIV, 531 S. : Ill., graph. Darst., 260 mm x 193 mm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016648571
    ISBN 978-3-642-11182-2 ; 9783642111839 ; 3-642-11182-3 ; 3642111831
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 95 order for loan Magazin

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  4. Article ; Online: GH deficiency and insensitivity in children and adults.

    Johannsson, Gudmundur / Kopchick, John J

    Reviews in endocrine & metabolic disorders

    2021  Volume 22, Issue 1, Page(s) 1–2

    Abstract: This thematic review includes short reviews on GH deficiency and insensitivity in children and adults from basic science to clinical significance. ...

    Abstract This thematic review includes short reviews on GH deficiency and insensitivity in children and adults from basic science to clinical significance.
    MeSH term(s) Adult ; Child ; Growth Disorders/diagnosis ; Humans ; Insulin-Like Growth Factor I
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2021-02-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-021-09629-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Early Investigations of 20-kDa Human Placental GH Show Promise.

    List, Edward O / Berryman, Darlene E / List, Brian P / Kopchick, John J

    Endocrine, metabolic & immune disorders drug targets

    2023  Volume 23, Issue 13, Page(s) 1674–1677

    Language English
    Publishing date 2023-05-13
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530323666230515153130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5824: Show issues Location:
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  6. Article ; Online: Chasing Methuselah: adult inducible GHRKO mice.

    Kopchick, John J / Berryman, Darlene E / List, Edward O

    Aging

    2022  Volume 14, Issue 8, Page(s) 3331–3332

    MeSH term(s) Animals ; Longevity ; Mice ; Mice, Knockout ; Receptors, Somatotropin
    Chemical Substances Receptors, Somatotropin
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Lessons learned from studies with the growth hormone receptor.

    Kopchick, John J

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

    2016  Volume 28, Page(s) 21–25

    Abstract: Findings related to GH's biological activities have continued to be a fascinating topic over the past decade. Below, I will review several items related to the actions of GH including the GH/GHR interaction, pegvisomant (a GH receptor antagonist), GHR ... ...

    Abstract Findings related to GH's biological activities have continued to be a fascinating topic over the past decade. Below, I will review several items related to the actions of GH including the GH/GHR interaction, pegvisomant (a GH receptor antagonist), GHR gene disruptions in mice, and clinical consequences of human GHR gene mutations.
    Language English
    Publishing date 2016-06
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 1436781-6
    ISSN 1532-2238 ; 1096-6374
    ISSN (online) 1532-2238
    ISSN 1096-6374
    DOI 10.1016/j.ghir.2015.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3319: Show issues Location:
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  8. Article ; Online: The effects of growth hormone on therapy resistance in cancer.

    Basu, Reetobrata / Kopchick, John J

    Cancer drug resistance (Alhambra, Calif.)

    2019  Volume 2, Page(s) 827–846

    Abstract: Pituitary derived and peripherally produced growth hormone (GH) is a crucial mediator of longitudinal growth, organ development, metabolic regulation with tissue specific, sex specific, and age-dependent effects. GH and its cognate receptor (GHR) are ... ...

    Abstract Pituitary derived and peripherally produced growth hormone (GH) is a crucial mediator of longitudinal growth, organ development, metabolic regulation with tissue specific, sex specific, and age-dependent effects. GH and its cognate receptor (GHR) are expressed in several forms of cancer and have been validated as an anti-cancer target through a large body of
    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Journal Article
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2019.27
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: A review of renal GH/IGF1 family gene expression in chronic kidney diseases.

    Brittain, Alison L / Kopchick, John J

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

    2019  Volume 48-49, Page(s) 1–4

    Abstract: Despite decades of study on the contribution of growth hormone (GH) to the development of kidney disease, there remains the question of the relative contribution of elevated levels of GH to kidney damage in humans, particularly in diabetic nephropathy ... ...

    Abstract Despite decades of study on the contribution of growth hormone (GH) to the development of kidney disease, there remains the question of the relative contribution of elevated levels of GH to kidney damage in humans, particularly in diabetic nephropathy occurring in type 1 patients. In this study, we reviewed several publicly available datasets to examine transcription of twelve genes associated with the GH/IGF1 axis in several types of human and rodent kidney diseases. Our analyses revealed downregulation of renal GHR and IGF1 gene expression in several different chronic human kidney diseases, including diabetic nephropathy, with general upregulation of IGFBP6 in the same tissues and diseases. These findings were generally supported by a review of studies in rodent models. In healthy and diseased human kidneys, increased GHR gene expression was associated with increases in glomerular filtration rate (GFR) and decreases in serum creatinine. IGFBP6 gene expression demonstrated the opposite clinical correlation. Our results suggest the kidney may exhibit GH insensitivity due to low GHR gene expression during most chronic kidney diseases.
    MeSH term(s) Gene Expression Regulation ; Human Growth Hormone/metabolism ; Humans ; Insulin-Like Growth Factor I/metabolism ; Renal Insufficiency, Chronic/physiopathology
    Chemical Substances Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2019-07-16
    Publishing country Scotland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1436781-6
    ISSN 1532-2238 ; 1096-6374
    ISSN (online) 1532-2238
    ISSN 1096-6374
    DOI 10.1016/j.ghir.2019.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3319: Show issues Location:
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  10. Article ; Online: Mammary Tumor Growth and Proliferation Are Dependent on Growth Hormone in Female SV40 C3(1) T-Antigen Mice.

    Unterberger, Christopher J / McGregor, Stephanie M / Kopchick, John J / Swanson, Steven M / Marker, Paul C

    Endocrinology

    2022  Volume 164, Issue 2

    Abstract: Female SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH) signaling in these ...

    Abstract Female SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH) signaling in these tumors, genetic crosses were used to create cohorts of female mice that were homozygous for a floxed growth hormone receptor (Ghr) gene and carried one copy each of the Rosa-Cre-ERT2 transgene and the C3(1)/TAg transgene (Ghrflox/flox; Rosa-Cre-ERT2; C3(1)/TAg+/0 mice). When the largest mammary tumor reached 200 mm3, mice were treated with tamoxifen to delete Ghr or with vehicle as a control. An additional group of Ghrflox/flox; C3(1)/TAg+/0 mice were also treated with tamoxifen when the largest mammary tumor reached 200 mm3 as a control for the effects of tamoxifen. After 3 weeks, tumors in mice in which Ghr was deleted began to shrink while vehicle and tamoxifen treatment control mouse tumors continued to grow. Pathological analysis of tumors revealed similar growth patterns and varying levels of necrosis throughout all groups. A decrease in cancer cell proliferation in Ghr-/- tumors relative to controls was observed as measured by Ki67 immunohistochemistry labeling index. These data suggest that even established C3(1)/TAg mammary tumors are dependent on the GH/IGF-1 axis.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Antigens, Polyomavirus Transforming/genetics ; Cell Proliferation ; Growth Hormone/metabolism ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice, Transgenic ; Tamoxifen/pharmacology ; Receptors, Somatostatin/genetics
    Chemical Substances Antigens, Polyomavirus Transforming ; Growth Hormone (9002-72-6) ; Tamoxifen (094ZI81Y45) ; Receptors, Somatostatin
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqac174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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