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Article ; Online: Summary on a Systems Perspective on Growth.

Lampl, Michelle

Nestle Nutrition Institute workshop series

2018 Volume 89, Page(s) 55–61

MeSH term(s)	Adipocytes, White/physiology ; Adipose Tissue/growth & development ; Bone Development ; Child ; Child Development/physiology ; Child, Preschool ; Chondrocytes/physiology ; Female ; Fetal Development/physiology ; Growth/physiology ; Humans ; Infant ; Infant, Newborn ; Muscle, Skeletal/growth & development ; Nutritional Physiological Phenomena/physiology ; Osteoblasts/physiology ; Pregnancy
Language	English
Publishing date	2018-07-10
Publishing country	Switzerland
Document type	Journal Article
ISSN	1664-2155
ISSN (online)	1664-2155
DOI	10.1159/000486508
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Article ; Online: Implications of Growth as a Time-Specific Event.

Lampl, Michelle

Nestle Nutrition Institute workshop series

2018 Volume 89, Page(s) 1–11

Abstract: Nutritional influences on human growth are commonly assessed as weight or length/height outcomes, and adequacy is determined by reference to population-based growth charts. These approaches estimate gross effects only and are insensitive proxies for the ... ...

Abstract	Nutritional influences on human growth are commonly assessed as weight or length/height outcomes, and adequacy is determined by reference to population-based growth charts. These approaches estimate gross effects only and are insensitive proxies for the dynamic processes by which nutritional components affect tissue accrual. Weight provides information about calorie balance and/or hydration status, while offering little insight into functional physiology. Height is often attributed meaning in accordance with growth charts, a static group level statistical summary unrelated to individual skeletal dynamics. Evidence accumulates that the lifelong health consequences of early growth necessitate a better understanding of individual-level body composition and its developmental determinants. Empirical evidence documents that children's skeletal and head circumference growth occurs in time-specific saltations separated by intervals of no growth. These saltation events are accompanied by discrete increases and decreases in subcutaneous fat implying pulsatile metabolic changes that may or may not be reflected in weight. The mechanisms determining the timing of these saltatory growth events to emerge from stasis, as well as the required energy and chemical building blocks to fuel and support them, remain to be clarified. Their occurrence suggests that the present understanding of nutritional needs for growth is incomplete.
MeSH term(s)	Adolescent ; Age Factors ; Animals ; Body Composition/physiology ; Body Height ; Body Size ; Body Weight ; Bone Development ; Cell Physiological Phenomena ; Cells ; Cephalometry ; Child ; Child Development/physiology ; Child, Preschool ; Energy Metabolism/physiology ; Growth/physiology ; Growth Charts ; Humans ; Infant ; Nutritional Requirements ; Nutritional Status ; Organism Hydration Status ; Time Factors
Language	English
Publishing date	2018-07-10
Publishing country	Switzerland
Document type	Journal Article
ISSN	1664-2155
ISSN (online)	1664-2155
DOI	10.1159/000486488
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Article ; Online: Obituary for professor David Barker.

Lampl, Michelle

Annals of human biology

2014 Volume 41, Issue 2, Page(s) 187–190

MeSH term(s)	Chronic Disease ; Developmental Biology ; Health ; History, 20th Century ; History, 21st Century ; Humans ; Medicine ; Public Health
Language	English
Publishing date	2014-02-06
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.3109/03014460.2014.870277
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Article ; Online: Perspectives on modelling human growth: mathematical models and growth biology.

Lampl, Michelle

Annals of human biology

2012 Volume 39, Issue 5, Page(s) 342–351

Abstract: Context: James Tanner had a foundational role in promoting the modelling of growth data as an important step in further understanding the science of human growth.: Objective: A perspective on how growth models have determined the questions ... ...

Abstract	Context: James Tanner had a foundational role in promoting the modelling of growth data as an important step in further understanding the science of human growth. Objective: A perspective on how growth models have determined the questions researchers ask and the methods used to analyse data is historically informative. Alternatively, it is useful to review that mathematical models are representations of growth as a function of time and carry assumptions that require consideration in terms of the goals of a research inquiry. Methods: An overview of the history of the study of human growth models and modelling is summarized with reference to the important roles that these have played in the perceptions of the human growth process. Results: Growth models are important descriptive summaries, embody empirical evidence and provide the opportunity for hypotheses-testing that aides the understanding, explanation and prediction of growth processes and systems. These models are modified as novel data emerge. More frequent sampling protocols and the development of mathematical models has advanced mechanistic investigations of the human growth process. Conclusions: Technical advances in science are important to investigate potential underlying mechanisms of growth and develop interventions based on a more accurate model of growth biology.
MeSH term(s)	Developmental Biology ; Growth/physiology ; Humans ; Models, Biological
Language	English
Publishing date	2012-09
Publishing country	England
Document type	Journal Article
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.3109/03014460.2012.704072
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Article ; Online: How long bones grow children: Mechanistic paths to variation in human height growth.

Lampl, Michelle / Schoen, Meriah

American journal of human biology : the official journal of the Human Biology Council

2017 Volume 29, Issue 2

Abstract: Objectives: Eveleth and Tanner's descriptive documentation of worldwide variability in human growth provided evidence of the interaction between genetics and environment during development that has been foundational to the science of human growth. There ...

Abstract	Objectives: Eveleth and Tanner's descriptive documentation of worldwide variability in human growth provided evidence of the interaction between genetics and environment during development that has been foundational to the science of human growth. There remains a need, however, to describe the mechanistic foundations of variability in human height growth patterns. Methods: A review of research documenting cellular activities at the endochondral growth plate aims to show how the unique microenvironment and cell functions during the sequential phases of the chondrocyte lifecycle affect long bone elongation, a fundamental source of height growth. Results: There are critical junctures within the chondrocytic differentiation cascade at which environmental influences are integrated and have the ability to influence progression to the hypertrophic chondrocyte phase, the primary driver of long bone elongation. Phenotypic differences in height growth patterns reflect variability in amplitude and frequency of discretely timed hypertrophic cellular expansion events, the cellular basis of saltation and stasis growth biology. Conclusions: Final height is a summary of the dynamic processes carried out by the growth plate cellular machinery. As these cell-level mechanisms unfold in an individual, time-specific manner, there are many critical points at which a genetic growth program can be enhanced or perturbed. Recognizing both the complexity and fluidity of this adaptive system questions the likelihood of a single, optimal growth pattern and instead identifies a larger bandwidth of saltatory frequencies for "normal" growth. Further inquiry into mechanistic sources of variability acting at critical organizational points of chondrogenesis can provide new opportunities for growth interventions.
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1025339-7
ISSN	1520-6300 ; 1042-0533
ISSN (online)	1520-6300
ISSN	1042-0533
DOI	10.1002/ajhb.22983
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Article ; Online: Human growth from the cell to the organism: saltations and integrative physiology.

Lampl, Michelle

Annals of human biology

2009 Volume 36, Issue 5, Page(s) 478–495

Abstract: The Society for the Study of Human Biology has been at the forefront in the scientific study of human growth. The documentation of variability in growth rate, size, and tempo across populations has provoked exploration for sources of this diversity, and ... ...

Abstract	The Society for the Study of Human Biology has been at the forefront in the scientific study of human growth. The documentation of variability in growth rate, size, and tempo across populations has provoked exploration for sources of this diversity, and the mechanisms by which environmental and genetic factors influence phenotypic expressions of growth biology. At a time when adult health and well-being are posited to reflect early development, the details of early growth patterns are increasingly sought as explanatory domains underlying lifespan health. A review of recent observations detailing events that occur in growth and differentiation during embryological and fetal development is considered for insights into mechanisms that may be operative in a putative cascade of growth biology operating across developmental ages. Cellular growth and differentiation are posited to be a process of integrative physiology, with increasing complexity in organismic growth achieved through modularity and temporally-differentiated signals. The flexible patterns of human growth are hypothesized to reflect the variability in timing and amount of growth saltations, which are the outcome of cross-talking signaling systems in an energy/immune integrating complex. This is an adaptive system, flexible and responsive to the challenges of developmental biology in changing environments.
MeSH term(s)	Adaptation, Biological ; Animals ; Cell Growth Processes/physiology ; Embryo, Mammalian/cytology ; Embryo, Mammalian/physiology ; Human Development/physiology ; Humans ; Immune System ; Longevity
Language	English
Publishing date	2009-09
Publishing country	England
Document type	Addresses
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.1080/03014460902911670
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Article ; Online: Commentary: The meaning of thrift.

Barker, David J P / Lampl, Michelle

International journal of epidemiology

2013 Volume 42, Issue 5, Page(s) 1229–1230

MeSH term(s)	Diabetes Mellitus, Type 2/etiology ; Humans ; Obesity/complications
Language	English
Publishing date	2013-10
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyt131
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Zs.A 893: Show issues

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Article ; Online: Historical approaches to human growth studies limit the present understanding of growth biology.

Lampl, Michelle / Mummert, Amanda

Annals of nutrition & metabolism

2014 Volume 65, Issue 2-3, Page(s) 114–120

Abstract: Background/aims: Measurements of children's size have (1) provided a biosensor of health and well-being in their environment; (2) provided references for clinical assessment, and (3) informed public health efforts to ameliorate living conditions. Size- ... ...

Abstract	Background/aims: Measurements of children's size have (1) provided a biosensor of health and well-being in their environment; (2) provided references for clinical assessment, and (3) informed public health efforts to ameliorate living conditions. Size-for-age measurements offer no information about the growth trajectories by which children achieve size, and growth trajectories offer no information on proximal mechanisms underlying growth biology. Increasing attention to the biological processes themselves, only estimated by anthropometric parameters and statistically based growth proxies, is needed. Methods: A literature overview of human growth measurement interpretations. Results: Aspects of study design, analysis and reliance on common conventions contribute to limitations in growth biology knowledge. Examples include conflating both the concepts of size and growth and incremental gains in either weight or length as manifestations of growth; nonuniformity in the use of growth trajectory-derived clinical categories, and conventional approaches to data collection and analysis. Conclusions: Intensive studies of individuals hold promise for expanding normal growth biology knowledge. Focusing on growth (not merely size), length (not weight alone) and individual growth patterns (not growth chart phenotypes) are important tactics. Benefits include clarification of mechanisms by which nutrition and metabolism influence growth, new solutions to abnormal growth states and improvements in long-term health consequences.
MeSH term(s)	Body Height ; Body Mass Index ; Body Weight ; Child ; Child Development/physiology ; Humans ; Nutritional Status
Language	English
Publishing date	2014
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	392341-1
ISSN	1421-9697 ; 0250-6807 ; 1018-9688
ISSN (online)	1421-9697
ISSN	0250-6807 ; 1018-9688
DOI	10.1159/000365015
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Article: Cellular life histories and bow tie biology.

Lampl, Michelle

American journal of human biology : the official journal of the Human Biology Council

2005 Volume 17, Issue 1, Page(s) 66–80

Abstract: Considering the life-long influences of fetal growth biology, it is of interest to further elucidate the nature of the fetal growth process itself. Previous analyses of longitudinal fetal ultrasound data led to the hypothesis that hypoxia signals were ... ...

Abstract	Considering the life-long influences of fetal growth biology, it is of interest to further elucidate the nature of the fetal growth process itself. Previous analyses of longitudinal fetal ultrasound data led to the hypothesis that hypoxia signals were important aspects of normal growth biology and directed attention to the place of oxygen as a basic nutrient. From the perspective of the cell, both hypoxia and lack of energy substrate trigger a common adaptive pathway through their effects on ATP availability. Comparative data from animal studies and cell culture provide evidence for an integrated energy/oxygen signaling system that acts redundantly and hierarchically with cellular differentiation programs, providing opportunities for developmental flexibility in response to variable ecologic or environmental challenge. The multinodal and interactive design of the fetal growth process suggests that it follows what has been described as the "bow tie" model of metabolism, with implications for robust and inventive approaches to cell, organ, and whole organism construction.
MeSH term(s)	Adaptation, Physiological/genetics ; Animals ; Developmental Biology ; Diabetes, Gestational ; Energy Metabolism/genetics ; Energy Metabolism/physiology ; Female ; Fetal Development/physiology ; Fetal Hypoxia/metabolism ; Gene Expression Regulation, Developmental ; Humans ; Hypoxia/complications ; Hypoxia/metabolism ; Maternal-Fetal Exchange/genetics ; Maternal-Fetal Exchange/physiology ; Models, Theoretical ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal Nutritional Physiological Phenomena/physiology
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1025339-7
ISSN	1520-6300 ; 1042-0533
ISSN (online)	1520-6300
ISSN	1042-0533
DOI	10.1002/ajhb.20094
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Article: Promoting Healthy Growth or Feeding Obesity? The Need for Evidence-Based Oversight of Infant Nutritional Supplement Claims.

Lampl, Michelle / Mummert, Amanda / Schoen, Meriah

Healthcare (Basel, Switzerland)

2016 Volume 4, Issue 4

Abstract: The Developmental Origins of Health and Disease (DOHaD) model recognizes growth in infancy and childhood as a fundamental determinant of lifespan health. Evidence of long-term health risks among small neonates who subsequently grow rapidly poses a ... ...

Abstract	The Developmental Origins of Health and Disease (DOHaD) model recognizes growth in infancy and childhood as a fundamental determinant of lifespan health. Evidence of long-term health risks among small neonates who subsequently grow rapidly poses a challenge for interventions aiming to support healthy growth, not merely drive weight gain. Defining healthy growth beyond "getting bigger" is essential as infant and young child feeding industries expand. Liquid-based nutritional supplements, originally formulated for undernourished children, are increasingly marketed for and consumed by children generally. Clarifying the nature of the evidentiary base on which structure/function claims promoting "healthy growth" are constructed is important to curb invalid generalizations. Evidence points to changing social beliefs and cultural practices surrounding supplementary feeding, raising specific concerns about the long-term health consequences of an associated altered feeding culture, including reduced dietary variety and weight gain. Reassessing the evidence for and relevance of dietary supplements' "promoting healthy growth" claims for otherwise healthy children is both needed in a time of global obesity and an opportunity to refine intervention approaches among small children for whom rapid subsequent growth in early life augments risk for chronic disease. Scientific and health care partnerships are needed to consider current governmental oversight shortfalls in protecting vulnerable populations from overconsumption. This is important because we may be doing more harm than good.
Language	English
Publishing date	2016-11-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare4040084
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