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Article: An Expeditious Synthetic Access to β-(Z)-[(1-Propynyl)amino]enones and β-[(Z)-(1-Propynyl)amino]enoates

Gravestock, D. / Dovey, M. C.

2003 Volume 2003, Issue 09, Page(s) 1470–1470

Language	English
Publishing date	2003-01-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2033062-5
ISSN	1437-210X ; 0039-7881
ISSN (online)	1437-210X
ISSN	0039-7881
DOI	10.1055/s-2003-40198
Database	Thieme publisher's database

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Article ; Online: The influence of lifestyle changes (diet, exercise and stress reduction) on prostate cancer tumour biology and patient outcomes: A systematic review.

Dovey, Zach / Horowitz, Amir / Waingankar, Nikhil

BJUI compass

2023 Volume 4, Issue 4, Page(s) 385–416

Abstract: Background: The mostly indolent natural history of prostate cancer (PCa) provides an opportunity for men to explore the benefits of lifestyle interventions. Current evidence suggests appropriate changes in lifestyle including diet, physical activity (PA) ...

Abstract	Background: The mostly indolent natural history of prostate cancer (PCa) provides an opportunity for men to explore the benefits of lifestyle interventions. Current evidence suggests appropriate changes in lifestyle including diet, physical activity (PA) and stress reduction with or without dietary supplements may improve both disease outcomes and patient's mental health. Objective: This article aims to review the current evidence on the benefits of all lifestyle programmes for PCa patients including those aimed at reducing obesity and stress, explore their affect on tumour biology and highlight any biomarkers that have clinical utility. Evidence acquisition: Evidence was obtained from PubMed and Web of Science using keywords for each section on the affects of lifestyle interventions on (a) mental health, (b) disease outcomes and (c) biomarkers in PCa patients. PRISMA guidelines were used to gather the evidence for these three sections (15, 44 and Evidence synthesis: For lifestyle studies focused on mental health, 10/15 demonstrated a positive influence, although for those programmes focused on PA it was 7/8. Similarly for oncological outcomes, 26/44 studies demonstrated a positive influence, although when PA was included or the primary focus, it was 11/13. Complete blood count (CBC)-derived inflammatory biomarkers show promise, as do inflammatory cytokines; however, a deeper understanding of their molecular biology in relation to PCa oncogenesis is required (16 studies reviewed). Conclusions: Making PCa-specific recommendations on lifestyle interventions is difficult on the current evidence. Nevertheless, notwithstanding the heterogeneity of patient populations and interventions, the evidence that dietary changes and PA may improve both mental health and oncological outcomes is compelling, especially for moderate to vigorous PA. The results for dietary supplements are inconsistent, and although some biomarkers show promise, significantly more research is required before they have clinical utility.
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Access and socioeconomic status play an important role in outcomes for African American patients with prostate cancer.

Lundon, Dara J / Dovey, Zachary / Tewari, Ashutosh K

Cancer

2020 Volume 126, Issue 18, Page(s) 4257–4258

MeSH term(s)	African Americans ; European Continental Ancestry Group ; Health Services Accessibility ; Humans ; Male ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; Social Class
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.33063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of exercise on continence in prostate cancer patients post robotic assisted radical prostatectomy: a systematic review.

Razdan, Shirin / Pandav, Krunal / Altschuler, Joshua / Moody, Kate / Martin, Lily / Patel, Hiten D / Mohamed, Nihal / Dovey, Zachary / Tewari, Ashutosh K

American journal of clinical and experimental urology

2023 Volume 11, Issue 4, Page(s) 320–327

Abstract: Introduction: Urinary incontinence is one of the most common long term side effects after robotic prostatectomy (RALP), and significantly impacts patient quality of life. Pelvic floor muscle training (PFMT) has been a standard part of the urologist's ... ...

Abstract	Introduction: Urinary incontinence is one of the most common long term side effects after robotic prostatectomy (RALP), and significantly impacts patient quality of life. Pelvic floor muscle training (PFMT) has been a standard part of the urologist's armamentarium for maximizing continence outcomes post-op. Recently, aerobic and resistance exercises have been described as improving functional outcomes post RALP. We performed a systematic review to determine the influence of exercise, in the form of PFMT, aerobic exercise, and resistance training, on incontinence post-RALP. Materials and methods: This systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, with database searches performed on January 14, 2022 and again on August 10, 2022 to account for any new publications. The search identified 1675 papers. Of the 1675 papers, 1007 were found to be duplicates, leaving 668 total studies for screening. Of the 668 papers, nine met all inclusion criteria. Of the nine, four studies presented data from patients who had undergone RALP and were included in the final descriptive systematic review. Results: Sayilan et al. and Milios et al. showed postoperative PFMT and physical activity resulted in significantly improved continence outcomes at 1 and 6 months and 2, 6, and 12 weeks postoperatively, respectively. Heydenreich et al. combined PFMT with an oscillating rod therapy, which was found to significantly improve both postoperative urinary continence and health related quality of life compared to PFMT and relaxation techniques alone. On the contrary, Goode et al. examined delivery of exercise information and demonstrated no difference in continence outcomes between focused telehealth PFMT program and generic prostate cancer education. Conclusion: Pelvic floor muscle training, with or without adjunct therapies, results in improved continence outcomes post RALP. Supervised training programs may or may not accelerate this finding. There is no recent literature to support or refute the benefit of aerobic exercise or resistance training on reducing post-prostatectomy incontinence after RALP.
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article
ISSN	2330-1910
ISSN	2330-1910
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The potential role of precision medicine to alleviate racial disparities in prostate, bladder and renal urological cancer care.

Sindhu, Kunal K / Dovey, Zachary / Thompson, Marcher / Nehlsen, Anthony D / Skalina, Karin A / Malachowska, Beata / Hasan, Shaakir / Guha, Chandan / Tang, Justin / Salgado, Lucas Resende

BJUI compass

2024 Volume 5, Issue 4, Page(s) 405–425

Abstract: Background: Racial disparities in oncological outcomes resulting from differences in social determinants of health (SDOH) and tumour biology are well described in prostate cancer (PCa) but similar inequities exist in bladder (BCa) and renal cancers ( ... ...

Abstract	Background: Racial disparities in oncological outcomes resulting from differences in social determinants of health (SDOH) and tumour biology are well described in prostate cancer (PCa) but similar inequities exist in bladder (BCa) and renal cancers (RCCs). Precision medicine (PM) aims to provide personalized treatment based on individual patient characteristics and has the potential to reduce these inequities in GU cancers. Objective: This article aims to review the current evidence outlining racial disparities in GU cancers and explore studies demonstrating improved oncological outcomes when PM is applied to racially diverse patient populations. Evidence acquisition: Evidence was obtained from Pubmed and Web of Science using keywords prostate, bladder and renal cancer, racial disparity and precision medicine. Because limited studies were found, preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were not applied but rather related articles were studied to explore existing debates, identify the current status and speculate on future applications. Results: Evidence suggests addressing SDOH for PCa can reverse racial inequities in oncological outcomes but differences in incidence remain. Similar disparities in BCa and RCC are seen, and it would be reasonable to suggest achieving parity in SDOH for all races would do the same. Research applying a PM approach to different ethnicities is lacking although in African Americans (AAs) with metastatic castrate-resistant prostate cancer (mCRPCa) better outcomes have been shown with androgen receptor inhibitors, radium-223 and sipuleucel. Exploiting the abscopal effect with targeted radiation therapy (RT) and immunotherapy has promise but requires further study, as does defining actionable mutations in specific patient groups to tailor treatments as appropriate. Conclusion: For all GU cancers, the historical underrepresentation of ethnic minorities in clinical trials still exists and there is an urgent need for recruitment strategies to address this. PM is a promising development with the potential to reduce inequities in GU cancers, however, both improved understanding of race-specific tumour biology, and enhanced recruitment of minority populations into clinical trials are required. Without this, the benefits of PM will be limited.
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.323
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effectiveness of Dance Interventions on Psychological and Cognitive Health Outcomes Compared with Other Forms of Physical Activity: A Systematic Review with Meta-analysis.

Fong Yan, Alycia / Nicholson, Leslie L / Ward, Rachel E / Hiller, Claire E / Dovey, Kathryn / Parker, Helen M / Low, Lee-Fay / Moyle, Gene / Chan, Cliffton

Sports medicine (Auckland, N.Z.)

2024

Abstract: Background: Physical activity is known to improve psychological and cognitive outcomes. Learning dance sequences may challenge cognition, partnered or group dance may benefit social interactions, and the artistic aspect may improve psychological ... ...

Abstract	Background: Physical activity is known to improve psychological and cognitive outcomes. Learning dance sequences may challenge cognition, partnered or group dance may benefit social interactions, and the artistic aspect may improve psychological wellbeing. Dance is an equally effective form of physical activity compared with other structured physical activities to improve physical health, but it is unclear how effective dance could be for psychological and cognitive outcome measures. Objective: To systematically review the literature on the effectiveness of structured dance interventions, compared with structured exercise programmes, on psychological and cognitive outcomes across the lifespan. Methods: Eight databases were searched from earliest records to July 2022. Studies investigating a dance intervention lasting ≥ 4 weeks, including psychological and/or cognitive health outcomes, and having a structured exercise comparison group were included. Screening and data extraction were performed by two independent reviewers at all stages. All reviewer disagreements were resolved by the primary author. Where appropriate, meta-analysis was performed, or an effect size estimate generated. Results: Of 21,737 records identified, 27 studies met the inclusion criteria. Total sample size of included studies was 1392 (944 females, 418 males, 30 unreported). Dance was equally as effective as other physical activity interventions in improving quality of life for people with Parkinson's disease [mean difference 3.09; 95% confidence interval (CI) - 2.13 to 8.30; p = 0.25], reducing anxiety (standardised mean difference 2.26; 95% CI - 2.37 to 6.90; p = 0.34), and improving depressive symptoms (standardised mean difference 0.78; 95% CI - 0.92 to 2.48; p = 0.37). Preliminary evidence found dance to be superior to other physical activity interventions to improve motivation, aspects of memory, and social cognition and to reduce distress. Preliminary evidence found dance to be inferior to other physical activity interventions to improve stress, self-efficacy and language fluency. Conclusion: Undertaking structured dance of any genre is generally equally and occasionally more effective than other types of structured exercise for improving a range of psychological and cognitive outcomes. Trial registration: PROSPERO: CRD42018099637.
Language	English
Publishing date	2024-01-25
Publishing country	New Zealand
Document type	Systematic Review
ZDB-ID	605911-9
ISSN	1179-2035 ; 0112-1642
ISSN (online)	1179-2035
ISSN	0112-1642
DOI	10.1007/s40279-023-01990-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Review of the Pathophysiological Mechanisms Underlying Castration-resistant Prostate Cancer.

Crowley, Fionnuala / Sterpi, Michelle / Buckley, Conor / Margetich, Lauren / Handa, Shivani / Dovey, Zach

Research and reports in urology

2021 Volume 13, Page(s) 457–472

Abstract: Androgen deprivation therapy or ADT is one of the cornerstones of management of locally advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early response, most advanced prostate cancers progress into an androgen ... ...

Abstract	Androgen deprivation therapy or ADT is one of the cornerstones of management of locally advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early response, most advanced prostate cancers progress into an androgen unresponsive or castrate resistant state, which hitherto remains an incurable entity and the second leading cause of cancer-related mortality in men in the US. Recent advances have uncovered multiple complex and intermingled mechanisms underlying this transformation. While most of these mechanisms revolve around androgen receptor (AR) signaling, novel pathways which act independently of the androgen axis are also being discovered. The aim of this article is to review the pathophysiological mechanisms that help bypass the apoptotic effects of ADT to create castrate resistance. The article discusses castrate resistance mechanisms under two categories: 1. Direct AR dependent pathways such as amplification or gain of function mutations in AR, development of functional splice variants, posttranslational regulation, and pro-oncogenic modulation in the expression of coactivators vs corepressors of AR. 2. Ancillary pathways involving RAS/MAP kinase, TGF-beta/SMAD pathway, FGF signaling, JAK/STAT pathway, Wnt-Beta catenin and hedgehog signaling as well as the role of cell adhesion molecules and G-protein coupled receptors. miRNAs are also briefly discussed. Understanding the mechanisms involved in the development and progression of castration-resistant prostate cancer is paramount to the development of targeted agents to overcome these mechanisms. A number of targeted agents are currently in development. As we strive for more personalized treatment across oncology care, treatment regimens will need to be tailored based on the type of CRPC and the underlying mechanism of castration resistance.
Language	English
Publishing date	2021-06-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2649530-2
ISSN	2253-2447
ISSN	2253-2447
DOI	10.2147/RRU.S264722
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Tumor Microenvironment and Immunotherapy in Prostate and Bladder Cancer.

Nair, Sujit S / Weil, Rachel / Dovey, Zachary / Davis, Avery / Tewari, Ashutosh K

The Urologic clinics of North America

2021 Volume 47, Issue 4S, Page(s) e17–e54

Abstract: Bladder cancer has been successfully treated with immunotherapy, whereas prostate cancer is a cold tumor with inadequate immune-related treatment response. A greater understanding of the tumor microenvironment and methods for harnessing the immune system ...

Abstract	Bladder cancer has been successfully treated with immunotherapy, whereas prostate cancer is a cold tumor with inadequate immune-related treatment response. A greater understanding of the tumor microenvironment and methods for harnessing the immune system to address tumor growth will be needed to improve immunotherapies for both prostate and bladder cancer. Here, we provide an overview of prostate and bladder cancer, including fundamental aspects of the disease and treatment, the elaborate cellular makeup of the tumor microenvironment, and methods for exploiting relevant pathways to develop more effective treatments.
MeSH term(s)	Antineoplastic Agents, Immunological/immunology ; Antineoplastic Agents, Immunological/therapeutic use ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Combined Modality Therapy ; Female ; Humans ; Immunologic Factors/immunology ; Immunologic Factors/therapeutic use ; Immunotherapy/methods ; Male ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/therapy ; Receptors, Androgen/immunology ; Signal Transduction/immunology ; Tumor Escape/immunology ; Tumor Microenvironment/immunology ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Antineoplastic Agents, Immunological ; Cancer Vaccines ; Immunologic Factors ; Receptors, Androgen
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	192293-2
ISSN	1558-318X ; 0094-0143
ISSN (online)	1558-318X
ISSN	0094-0143
DOI	10.1016/j.ucl.2020.10.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current strategies to improve erectile function in patients undergoing radical prostatectomy - preoperative scenario.

Pedraza, Adriana M / Pandav, Krunal / Menon, Mani / Khera, Mohit / Wagaskar, Vinayak / Dovey, Zachary / Mohamed, Nihal / Parekh, Sneha / Tewari, Ashutosh K

Urologic oncology

2022 Volume 40, Issue 3, Page(s) 72–78

Abstract: Radical prostatectomy (RP) is a common procedure for localized and locally advanced prostate cancer (PCa). Despite advances in the technique with the introduction of robotic surgery, erectile dysfunction (ED) remains a major drawback. Therefore, a ... ...

Abstract	Radical prostatectomy (RP) is a common procedure for localized and locally advanced prostate cancer (PCa). Despite advances in the technique with the introduction of robotic surgery, erectile dysfunction (ED) remains a major drawback. Therefore, a personalized evaluation that considers the patient's expectations and cultural background, baseline erectile function (EF), health status, and tumoral extension is important to optimize outcomes. Since EF has a tremendous impact on the quality of life of the patient and the intimate partner, it is timely to review multidisciplinary approaches to be implemented in the preoperative setting. Here we propose various strategies divided into two main categories, namely, comprehensive preoperative planning and prehabilitation (Figure 1.).
MeSH term(s)	Erectile Dysfunction/etiology ; Humans ; Male ; Penile Erection ; Prostate ; Prostatectomy/adverse effects ; Prostatectomy/methods ; Prostatic Neoplasms/surgery ; Quality of Life ; Recovery of Function
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2021.12.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current strategies to improve erectile function in patients undergoing radical prostatectomy - postoperative scenario.

Pedraza, Adriana M / Pandav, Krunal / Menon, Mani / Khera, Mohit / Wagaskar, Vinayak / Dovey, Zachary / Mohamed, Nihal / Parekh, Sneha / Tewari, Ashutosh K

Urologic oncology

2022 Volume 40, Issue 3, Page(s) 87–94

Abstract: In order to optimize functional outcomes following radical prostatectomy (RP), early rehabilitation programs should be stablished in the clinical practice. A multidisciplinary approach to assess the patient's mental, physical and social well-being are as ...

Abstract	In order to optimize functional outcomes following radical prostatectomy (RP), early rehabilitation programs should be stablished in the clinical practice. A multidisciplinary approach to assess the patient's mental, physical and social well-being are as important as the implementation of pharmacological and mechanical interventions. In current article of the seminar, we focus on strategies to improve erectile function (EF) after surgery. These strategies have been grouped into 4 main categories: pharmacologic and mechanical interventions, psychosocial interventions, hormonal assessment and a final section dedicated to strategies under research.
MeSH term(s)	Erectile Dysfunction ; Humans ; Male ; Penile Erection ; Postoperative Period ; Prostatectomy/adverse effects ; Recovery of Function
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2021.12.002
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