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  1. Article ; Online: Epilepsy research at the Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez in Mexico.

    San-Juan, Daniel

    Epilepsy & behavior : E&B

    2021  Volume 116, Page(s) 107792

    MeSH term(s) Bibliometrics ; Epilepsy/therapy ; Hospitalization ; Humans ; Mexico
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2021.107792
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  2. Article ; Online: New Horizons of Brain Neuromodulation Therapies in Refractory Epilepsy.

    San-Juan, Daniel

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2021  Volume 38, Issue 6, Page(s) 470

    MeSH term(s) Brain ; Drug Resistant Epilepsy/therapy ; Humans ; Vagus Nerve Stimulation
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000841
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  3. Article ; Online: Cathodal Transcranial Direct Current Stimulation in Refractory Epilepsy: A Noninvasive Neuromodulation Therapy.

    San-Juan, Daniel

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2021  Volume 38, Issue 6, Page(s) 503–508

    Abstract: Summary: Epilepsy is a chronic disease of the brain that affects individuals of all ages and has a worldwide distribution. According to a 2006 World Health Organization report, 50 million people had epilepsy. Approximately 30% of people with epilepsy ... ...

    Abstract Summary: Epilepsy is a chronic disease of the brain that affects individuals of all ages and has a worldwide distribution. According to a 2006 World Health Organization report, 50 million people had epilepsy. Approximately 30% of people with epilepsy have refractory disease despite recent therapeutic developments. Consequently, new treatments are necessary. Transcranial direct current stimulation (tDCS) is a noninvasive method for cortical excitability modulation by subthreshold membrane depolarization or hyperpolarization (cathodal stimulation decreases cortical excitability, whereas anodal stimulation increases it), which has been shown to be safe, economical, and easy to use. The mechanism of action of tDCS is partially understood. Cathodal tDCS in vitro and in vivo animal studies have shown that direct current and cathodal tDCS can successfully induce suppression of epileptiform activity in EEG recordings. Cathodal tDCS has been used in heterogeneous clinical trials in pediatric and adult patients with refractory epilepsy and is well tolerated. A comprehensive review of the clinical trials based on their quality and biases shows evidence that cathodal tDCS in patients with epilepsy is potentially effective. However, additional randomized clinical trials are needed with other etiologies, special populations, additional concomitants therapies, long-term follow-up, and new parameters of stimulation.
    MeSH term(s) Animals ; Brain ; Child ; Drug Resistant Epilepsy/therapy ; Electrodes ; Epilepsy/therapy ; Humans ; Transcranial Direct Current Stimulation
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000717
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  4. Article ; Online: Letter to the Editor Concerning "Evolution and Medical Implications of Neurodiversity: Where Must We Go?"

    Miranda Ojeda, Raul / San-Juan, Daniel

    Journal of autism and developmental disorders

    2022  Volume 53, Issue 6, Page(s) 2529–2530

    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Letter
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-022-05556-5
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  5. Article ; Online: ACNS EEG Guidelines in Spanish: An International Collaboration.

    San-Juan, Daniel / Bermeo-Ovalle, Adriana

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2022  Volume 40, Issue 1, Page(s) 1

    MeSH term(s) Humans ; Electroencephalography
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000969
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  6. Article ; Online: A New Non-invasive Neuromodulation Technique for Super Refractory Status Epilepticus: Can We Consider tDCS for This Devastating Condition?

    San-Juan, Daniel / Stavropoulos, Ioannis / Valentin, Antonio

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2022  Volume 20, Issue 1, Page(s) 179–180

    MeSH term(s) Humans ; Transcranial Direct Current Stimulation ; Status Epilepticus/drug therapy ; Anticonvulsants/therapeutic use
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-022-01329-1
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  7. Article ; Online: Quantification of Mixed-Linkage β-Glucan (MLG) in Bacteria.

    Marchante, Juan Antonio / Ruiz-Sáez, Lucía / Muñoz, Socorro / Sanjuán, Juan / Pérez-Mendoza, Daniel

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2751, Page(s) 133–143

    Abstract: Prokaryotes are known to produce and secrete a broad range of biopolymers with a high functional and structural heterogeneity, often with critical duties in the bacterial physiology and ecology. Among these, exopolysaccharides (EPS) play relevant roles ... ...

    Abstract Prokaryotes are known to produce and secrete a broad range of biopolymers with a high functional and structural heterogeneity, often with critical duties in the bacterial physiology and ecology. Among these, exopolysaccharides (EPS) play relevant roles in the interaction of bacteria with eukaryotic hosts. EPS can help to colonize the host and assist in bacterial survival, making this interaction more robust by facilitating the formation of structured biofilms. In addition, they are often key molecules in the specific recognition mechanisms involved in both beneficial and pathogenic bacteria-host interactions. A novel EPS known as MLG (Mixed-Linkage β-Glucan) was recently discovered in rhizobia, where it participates in bacterial aggregation and biofilm formation and is required for efficient attachment to the roots of their legume host plants. MLG is the first and, so far, the only reported linear Mixed-Linkage β-glucan in bacteria, containing a perfect alternation of β (1 → 3) and β (1 → 4) bonds. A phylogenetic study of MLG biosynthetic genes suggests that far from being exclusive of rhizobia, different soil and plant-associated bacteria likely produce MLG, adding this novel polymer to the plethora of surface polysaccharides that help bacteria thrive in the changing environment and to establish successful interactions with their hosts.In this work, a quantification method for MLG is proposed. It relays on the hydrolysis of MLG by a specific enzyme (lichenase), and the subsequent quantification of the released disaccharide (laminaribiose) by the phenol-sulfuric acid method. The protocol has been set up and optimized for its use in 96-well plates, which makes it suitable for high-throughput screening (HTS) approaches. This method stands out by its fast processing, technical simplicity, and capability to handle multiple samples and biological replicates at a time.
    MeSH term(s) Phylogeny ; Bacteria ; Prokaryotic Cells ; Rhizobium ; Biofilms
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3617-6_9
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  8. Article ; Online: Epilepsy and education: A case-control analysis of the impact of an intensive epilepsy training program on undergraduate medical students.

    Diaz-Peregrino, Roberto / San-Juan, Daniel / Arritola-Uriarte, Aleida / Contreras-Salazar, Álvaro / Del Moral-Bastida, Jesús / Miranda-Ojeda, Raúl

    Epilepsy & behavior : E&B

    2024  Volume 153, Page(s) 109717

    Abstract: Aims: To evaluate the knowledge, attitudes, and practical skills of students submitted to a 6-week intensive training in epilepsy compared to students without any training but mandatory neurology classes.: Methods: It is a case-control study. After ... ...

    Abstract Aims: To evaluate the knowledge, attitudes, and practical skills of students submitted to a 6-week intensive training in epilepsy compared to students without any training but mandatory neurology classes.
    Methods: It is a case-control study. After completing a 6-week intensive Academic, Clinical, and Research Program in epilepsy, TUMSs answered a validated Knowledge Attitudes and Practices (KAP) questionnaire. The control group, composed of undergraduate students who shared the same age, academic year, and compulsory hours for learning about epilepsy as TUMSs, was also assessed through the KAP instrument. Answers from both groups were submitted to Fisher exact and the χ
    Results: TUMSs displayed better results in theoretical knowledge such as the definition and causes of epilepsy, and the application of paraclinical studies essential for diagnosing epilepsy. From their perspective, people with epilepsy encounter restricted opportunities for preserving their social life and employment and they are more prone to workplace accidents. They are convinced that facing epilepsy presents a notable risk due to the difficulties linked with diagnosis, considering epilepsy a challenging disease for general practitioners to identify and follow up. Likewise, they exhibited improvement in treatment adjustment and treatment monitoring of patients with epilepsy, mainly in pregnancy cases. Finally, they had greater knowledge about what to do when they witness a person experiencing a seizure.
    Conclusion: Our study showed that a 6-week intensive education program in epilepsy increased the knowledge and practical skills and changed the attitude toward patients with epilepsy of undergraduate students.
    MeSH term(s) Humans ; Students, Medical ; Case-Control Studies ; Epilepsy/therapy ; Seizures ; Educational Status ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2024.109717
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  9. Article ; Online: Response to "Difficulty of Comparing the Multiple Heterogeneous Approaches: Comment to Transcranial Direct Current Stimulation in Epilepsy".

    San-Juan, Daniel

    Brain stimulation

    2016  Volume 9, Issue 3, Page(s) 462

    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2016.03.002
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  10. Article ; Online: MindReader

    Rivas-Carrillo, Salvador Daniel / Akkuratov, Evgeny E / Valdez Ruvalcaba, Hector / Vargas-Sanchez, Angel / Komorowski, Jan / San-Juan, Daniel / Grabherr, Manfred G

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: Electroencephalogram (EEG) interpretation plays a critical role in the clinical assessment of neurological conditions, most notably epilepsy. However, EEG recordings are typically analyzed manually by highly specialized and heavily trained personnel. ... ...

    Abstract Electroencephalogram (EEG) interpretation plays a critical role in the clinical assessment of neurological conditions, most notably epilepsy. However, EEG recordings are typically analyzed manually by highly specialized and heavily trained personnel. Moreover, the low rate of capturing abnormal events during the procedure makes interpretation time-consuming, resource-hungry, and overall an expensive process. Automatic detection offers the potential to improve the quality of patient care by shortening the time to diagnosis, managing big data and optimizing the allocation of human resources towards precision medicine. Here, we present
    MeSH term(s) Humans ; Electroencephalography/methods ; Epilepsy/diagnosis ; Neural Networks, Computer ; Fourier Analysis ; Unsupervised Machine Learning
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23062971
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