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  1. Book ; Article ; Online: Conceptualizing women’s empowerment in agrifood systems governance

    Ragasa, Catherine / Kyle, Jordan / Kristjanson, Patricia M. / Eissler, Sarah

    A new framework

    2023  

    Abstract: This paper develops a new framework to measure and track women’s empowerment in governance ... of countries’ agrifood systems. All too often, women’s needs, priorities, and voices are missing ... preferences. The Women’s Empowerment in Agrifood Systems Governance (WEAGov) is an assessment framework ...

    Abstract This paper develops a new framework to measure and track women’s empowerment in governance of countries’ agrifood systems. All too often, women’s needs, priorities, and voices are missing from the policy process, even when women may be disproportionately affected by shocks or have distinct policy preferences. The Women’s Empowerment in Agrifood Systems Governance (WEAGov) is an assessment framework to help countries and stakeholders measure the extent of inclusion and leadership of women in agrifood systems governance and to identify gaps and opportunities for improvement. WEAGov looks across three stages of the policy cycle: policy design, policy implementation, and policy evaluation. At each stage of the policy cycle, WEAGov asks three questions central to women’s empowerment in governance: Are women considered? Are women included? And are women influencing? This paper describes the process of conceptualizing and developing the WEAGov assessment framework by drawing together evidence, experience, and lessons from the literature and from over 30 stakeholder consultations across several countries and sectors to develop a practical and theoretically grounded framework.
    Keywords gender ; women ; women's empowerment ; empowerment ; agrifood systems ; food systems ; governance ; assessment
    Language English
    Publishing date 2023-01-07T12:55:45Z
    Publisher International Food Policy Research Institute
    Publishing country fr
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: The genetic architecture of pain intensity in a sample of 598,339 U.S. veterans.

    Toikumo, Sylvanus / Vickers-Smith, Rachel / Jinwala, Zeal / Xu, Heng / Saini, Divya / Hartwell, Emily / Venegas, Mirko P / Sullivan, Kyle A / Xu, Ke / Jacobson, Daniel A / Gelernter, Joel / Rentsch, Christopher T / Stahl, Eli / Cheatle, Martin / Zhou, Hang / Waxman, Stephen G / Justice, Amy C / Kember, Rachel L / Kranzler, Henry R

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids ... ...

    Abstract Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids played a central role in precipitating the opioid crisis. Despite an estimated heritability of 25-50%, the genetic architecture of chronic pain is not well characterized, in part because studies have largely been limited to samples of European ancestry. To help address this knowledge gap, we conducted a cross-ancestry meta-analysis of pain intensity in 598,339 participants in the Million Veteran Program, which identified 125 independent genetic loci, 82 of which are novel. Pain intensity was genetically correlated with other pain phenotypes, level of substance use and substance use disorders, other psychiatric traits, education level, and cognitive traits. Integration of the GWAS findings with functional genomics data shows enrichment for putatively causal genes (n = 142) and proteins (n = 14) expressed in brain tissues, specifically in GABAergic neurons. Drug repurposing analysis identified anticonvulsants, beta-blockers, and calcium-channel blockers, among other drug groups, as having potential analgesic effects. Our results provide insights into key molecular contributors to the experience of pain and highlight attractive drug targets.
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.09.23286958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Untangling the sequence of events during the S

    Ibrahim, Mohamed / Fransson, Thomas / Chatterjee, Ruchira / Cheah, Mun Hon / Hussein, Rana / Lassalle, Louise / Sutherlin, Kyle D / Young, Iris D / Fuller, Franklin D / Gul, Sheraz / Kim, In-Sik / Simon, Philipp S / de Lichtenberg, Casper / Chernev, Petko / Bogacz, Isabel / Pham, Cindy C / Orville, Allen M / Saichek, Nicholas / Northen, Trent /
    Batyuk, Alexander / Carbajo, Sergio / Alonso-Mori, Roberto / Tono, Kensuke / Owada, Shigeki / Bhowmick, Asmit / Bolotovsky, Robert / Mendez, Derek / Moriarty, Nigel W / Holton, James M / Dobbek, Holger / Brewster, Aaron S / Adams, Paul D / Sauter, Nicholas K / Bergmann, Uwe / Zouni, Athina / Messinger, Johannes / Kern, Jan / Yachandra, Vittal K / Yano, Junko

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 23, Page(s) 12624–12635

    Abstract: ... structures of PS II in the four (semi)stable S-states, S ...

    Abstract In oxygenic photosynthesis, light-driven oxidation of water to molecular oxygen is carried out by the oxygen-evolving complex (OEC) in photosystem II (PS II). Recently, we reported the room-temperature structures of PS II in the four (semi)stable S-states, S
    MeSH term(s) Hydrogen/metabolism ; Magnesium/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Photons ; Photosynthesis ; Photosystem II Protein Complex/chemistry ; Photosystem II Protein Complex/metabolism ; Quinones/metabolism ; Water/metabolism
    Chemical Substances Photosystem II Protein Complex ; Quinones ; Water (059QF0KO0R) ; Hydrogen (7YNJ3PO35Z) ; Magnesium (I38ZP9992A) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2000529117
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    Zs.A 1148: Show issues Location:
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  4. Article ; Online: S K-edge XAS of Cu

    Ha, Yang / Dille, Sara A / Braun, Augustin / Colston, Kyle / Hedman, Britt / Hodgson, Keith O / Basu, Partha / Solomon, Edward I

    Journal of inorganic biochemistry

    2022  Volume 230, Page(s) 111752

    Abstract: Reduced dithiolene ligands are bound to high valent Mo centers in the active site of the oxotransferase family of enzymes. Related model complexes have been studied with great insight by Prof. Holm and his colleagues. This study focuses on the other ... ...

    Abstract Reduced dithiolene ligands are bound to high valent Mo centers in the active site of the oxotransferase family of enzymes. Related model complexes have been studied with great insight by Prof. Holm and his colleagues. This study focuses on the other limit of dithiolene chemistry: an investigation of the 2-electron oxidized dithiolene bound to low-valent late transition metal (TM) ions (Zn
    MeSH term(s) Ligands ; Models, Molecular ; Oxidation-Reduction ; X-Ray Absorption Spectroscopy ; Zinc
    Chemical Substances Ligands ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2022.111752
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    Zs.B 1730: Show issues Location:
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  5. Article: Characterization of Senecavirus A Isolates Collected From the Environment of U.S. Sow Slaughter Plants.

    Hoffman, Kyle S / Humphrey, Nicki L / Korslund, John A / Anderson, Tavis K / Faaberg, Kay S / Lager, Kelly M / Buckley, Alexandra C

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 923878

    Abstract: ... in the U.S. The objectives of this investigation were to: (1) describe the environmental burden of SVA ...

    Abstract Vesicular disease caused by Senecavirus A (SVA) is clinically indistinguishable from foot-and-mouth disease (FMD) and other vesicular diseases of swine. When a vesicle is observed in FMD-free countries, a costly and time-consuming foreign animal disease investigation (FADI) is performed to rule out FMD. Recently, there has been an increase in the number of FADIs and SVA positive samples at slaughter plants in the U.S. The objectives of this investigation were to: (1) describe the environmental burden of SVA in sow slaughter plants; (2) determine whether there was a correlation between PCR diagnostics, virus isolation (VI), and swine bioassay results; and (3) phylogenetically characterize the genetic diversity of contemporary SVA isolates. Environmental swabs were collected from three sow slaughter plants (Plants 1-3) and one market-weight slaughter plant (Plant 4) between June to December 2020. Of the 426 samples taken from Plants 1-3, 304 samples were PCR positive and 107 were VI positive. There was no detection of SVA by PCR or VI at Plant 4. SVA positive samples were most frequently found in the summer (78.3% June-September, vs. 59.4% October-December), with a peak at 85% in August. Eighteen PCR positive environmental samples with a range of C
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.923878
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  6. Book ; Article ; Online: Conceptualizing women’s empowerment in agrifood systems governance

    Ragasa, Catherine / Kyle, Jordan / Kristjanson, Patricia / Eissler, Sarah

    A new framework

    2022  

    Abstract: This paper develops a new framework to measure and track women’s empowerment in governance ... of countries’ agrifood systems. All too often, women’s needs, priorities, and voices are missing ... preferences. The Women’s Empowerment in Agrifood Systems Governance (WEAGov) is an assessment framework ...

    Abstract This paper develops a new framework to measure and track women’s empowerment in governance of countries’ agrifood systems. All too often, women’s needs, priorities, and voices are missing from the policy process, even when women may be disproportionately affected by shocks or have distinct policy preferences. The Women’s Empowerment in Agrifood Systems Governance (WEAGov) is an assessment framework to help countries and stakeholders measure the extent of inclusion and leadership of women in agrifood systems governance and to identify gaps and opportunities for improvement. WEAGov looks across three stages of the policy cycle: policy design, policy implementation, and policy evaluation. At each stage of the policy cycle, WEAGov asks three questions central to women’s empowerment in governance: Are women considered? Are women included? And are women influencing? This paper describes the process of conceptualizing and developing the WEAGov assessment framework by drawing together evidence, experience, and lessons from the literature and from over 30 stakeholder consultations across several countries and sectors to develop a practical and theoretically grounded framework.

    Non-PR

    IFPRI1; 1 Fostering Climate-Resilient and Sustainable Food Supply; 5 Strengthening Institutions and Governance; G Cross-cutting gender theme; women’s empowerment in agrifood governance (weagov)

    DSGD
    Keywords WORLD ; gender ; women ; women's empowerment ; empowerment ; agrifood systems ; food systems ; governance ; assessment ; assessment framework ; assessment tool
    Subject code 360
    Language English
    Publisher International Food Policy Research Institute (IFPRI)
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Article ; Online: Claim-making under India’s Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA)

    Kosec, Katrina / Kyle, Jordan / Narayanan, Sudha / Raghunathan, Kalyani / Ray, Soumyajit

    Barriers and opportunities for women’s voice and agency over asset selection

    2024  

    Abstract: Poverty, Gender, and Inclusion (PGI); Development Strategies and Governance (DSG) ...

    Abstract Poverty, Gender, and Inclusion (PGI); Development Strategies and Governance (DSG)
    Keywords social protection
    Language English
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Rabies postexposure prophylaxis: What the U.S. emergency medicine provider needs to know.

    Gibbons, Kyle / Dvoracek, Kyle

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2023  Volume 30, Issue 11, Page(s) 1144–1149

    Abstract: Approximately 55,000 patients per year in the United States are exposed to potentially rabid animals and receive rabies postexposure prophylaxis (PEP) and these patients commonly present to the emergency department (ED) for wound care and PEP. Despite ... ...

    Abstract Approximately 55,000 patients per year in the United States are exposed to potentially rabid animals and receive rabies postexposure prophylaxis (PEP) and these patients commonly present to the emergency department (ED) for wound care and PEP. Despite the number of rabies exposures seen in EDs each year, there appears to be a knowledge gap among health care providers with regard to prescribing and administering rabies PEP. The following review aims to bridge that knowledge gap by discussing the importance of obtaining a comprehensive exposure history to determine the category of the encounter, the type of animal, and the location of the bite and of consulting outside expert resources to determine whether the rabies PEP series is indicated. In addition, this article will discuss dosing, administration, and schedule of the rabies vaccine and human rabies immune globulin to ensure patients are fully protected from developing rabies. Lastly, this article discusses the potential cost associated with rabies PEP and provides information on managing this barrier.
    MeSH term(s) Animals ; Humans ; United States ; Rabies/prevention & control ; Rabies Vaccines ; Immunoglobulins/therapeutic use ; Post-Exposure Prophylaxis ; Emergency Medicine ; Bites and Stings
    Chemical Substances Rabies Vaccines ; Immunoglobulins
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14755
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    Zs.A 4479: Show issues Location:
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  9. Article ; Online: One-step site-specific S-alkylation of full-length caveolin-1: Lipidation modulates the topology of its C-terminal domain.

    Julien, Jeffrey A / Rousseau, Alain / Perone, Thomas V / LaGatta, David M / Hong, Chan / Root, Kyle T / Park, Soohyung / Fuanta, René / Im, Wonpil / Glover, Kerney Jebrell

    Protein science : a publication of the Protein Society

    2023  Volume 32, Issue 11, Page(s) e4791

    Abstract: ... which could have structural and topological implications. Herein, a reliable preparation of full-length S-alkylated ... analysis of the constructs revealed that S-alkylation does not significantly affect the global helicity ... was altered positively or negatively by S-alkylation. In addition, the simulations showed ...

    Abstract Caveolin-1 is an integral membrane protein that is known to acquire a number of posttranslational modifications upon trafficking to the plasma membrane. In particular, caveolin-1 is palmitoylated at three cysteine residues (C133, C143, and C156) located within the C-terminal domain of the protein which could have structural and topological implications. Herein, a reliable preparation of full-length S-alkylated caveolin-1, which closely mimics the palmitoylation observed in vivo, is described. HPLC and ESI-LC-MS analyses verified the addition of the C16 alkyl groups to caveolin-1 constructs containing one (C133), two (C133 and C143), and three (C133, C143, and C156) cysteine residues. Circular dichroism spectroscopy analysis of the constructs revealed that S-alkylation does not significantly affect the global helicity of the protein; however, molecular dynamics simulations revealed that there were local regions where the helicity was altered positively or negatively by S-alkylation. In addition, the simulations showed that lipidation tames the topological promiscuity of the C-terminal domain, resulting in a disposition within the bilayer characterized by increased depth.
    MeSH term(s) Caveolin 1/genetics ; Caveolin 1/chemistry ; Caveolin 1/metabolism ; Cysteine/metabolism ; Membrane Proteins/chemistry ; Cell Membrane/metabolism ; Alkylation
    Chemical Substances Caveolin 1 ; Cysteine (K848JZ4886) ; Membrane Proteins
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4791
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    Zs.A 3407: Show issues Location:
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    Zs.MO 1: Show issues

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  10. Article ; Online: In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction.

    D'Alessandro, Angelo / Nouraie, S Mehdi / Zhang, Yingze / Cendali, Francesca / Gamboni, Fabia / Reisz, Julie A / Zhang, Xu / Bartsch, Kyle W / Galbraith, Matthew D / Gordeuk, Victor R / Gladwin, Mark T

    American journal of hematology

    2023  Volume 98, Issue 7, Page(s) 1017–1028

    Abstract: Despite a wealth of exploratory plasma metabolomics studies in sickle cell disease (SCD), no study to date has evaluate a large and well phenotyped cohort to compare the primary erythrocyte metabolome of hemoglobin SS, SC and transfused AA red blood ... ...

    Abstract Despite a wealth of exploratory plasma metabolomics studies in sickle cell disease (SCD), no study to date has evaluate a large and well phenotyped cohort to compare the primary erythrocyte metabolome of hemoglobin SS, SC and transfused AA red blood cells (RBCs) in vivo. The current study evaluates the RBC metabolome of 587 subjects with sickle cell sickle cell disease (SCD) from the WALK-PHaSST clinical cohort. The set includes hemoglobin SS, hemoglobin SC SCD patients, with variable levels of HbA related to RBC transfusion events. Here we explore the modulating effects of genotype, age, sex, severity of hemolysis, and transfusion therapy on sickle RBC metabolism. Results show that RBCs from patients with Hb SS genotypes-compared to AA RBCs from recent transfusion events or SC RBCs-are characterized by significant alterations of RBC acylcarnitines, pyruvate, sphingosine 1-phosphate, creatinine, kynurenine and urate metabolism. Surprisingly, the RBC metabolism of SC RBCs is dramatically different from SS, with all glycolytic intermediates significantly elevated in SS RBCs, with the exception of pyruvate. This result suggests a metabolic blockade at the ATP-generating phosphoenolpyruvate to pyruvate step of glycolysis, which is catalyzed by redox-sensitive pyruvate kinase. Metabolomics, clinical and hematological data were collated in a novel online portal. In conclusion, we identified metabolic signatures of HbS RBCs that correlate with the degree of steady state hemolytic anemia, cardiovascular and renal dysfunction and mortality.
    MeSH term(s) Humans ; Hemoglobin, Sickle/metabolism ; Erythrocytes/metabolism ; Anemia, Sickle Cell ; Sickle Cell Trait ; Pyruvates/metabolism
    Chemical Substances Hemoglobin, Sickle ; Pyruvates
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26923
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