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  1. Article: COVID-19 and acute respiratory failure treated with CPAP.

    Kofod, Linette Marie / Nielsen Jeschke, Klaus / Kristensen, Morten Tange / Krogh-Madsen, Rikke / Monefeldt Albek, Carsten / Hansen, Ejvind Frausing

    European clinical respiratory journal

    2021  Volume 8, Issue 1, Page(s) 1910191

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834928-3
    ISSN 2001-8525 ; 1399-3003 ; 2001-8525 ; 0903-1936
    ISSN (online) 2001-8525 ; 1399-3003
    ISSN 2001-8525 ; 0903-1936
    DOI 10.1080/20018525.2021.1910191
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  2. Article: Hospital admission for COVID-19 pneumonitis - long-term impairment in quality of life and lung function.

    Vejen, Marie / Hansen, Ejvind Frausing / Al-Jarah, Bakir Nabil Ibrahim / Jensen, Casper / Thaning, Pia / Jeschke, Klaus Nielsen / Ulrik, Charlotte Suppli

    European clinical respiratory journal

    2022  Volume 9, Issue 1, Page(s) 2024735

    Abstract: Background and aim: Knowledge of long-term consequences of severe COVID-19 pneumonitis is of outmost importance. Our aim was, therefore, to assess the long-term impact on quality of life and lung function in adults hospitalized with severe COVID-19.: ... ...

    Abstract Background and aim: Knowledge of long-term consequences of severe COVID-19 pneumonitis is of outmost importance. Our aim was, therefore, to assess the long-term impact on quality of life and lung function in adults hospitalized with severe COVID-19.
    Methods: All patients hospitalized with COVID-19 pneumonitis at Copenhagen University Hospital-Hvidovre, Denmark, were invited to participate in the study 4-5 months after discharge. Of the 160 invited 128 responded positively (80%). Medical history and symptoms were assessed, and patients rated impact on quality of life and functional status with EuroQol-5D-5L and Post Covid Functional Scale. Lung function was assessed by dynamic spirometry and measurement of diffusing capacity.
    Results: Fatigue, dyspnea, cough and cognitive dysfunction were the most common symptoms. Of 128 patients, 85% had at least one symptom, and 51% reported two or more symptoms. Self-rated Quality of life was impaired assessed by EuroQol 5D-5L, with dimensions 'Pain or discomfort' (61%) and 'Usual activities' (54%) mostly affected. Functional status was significantly worse than before COVID-19 assessed by Post-COVID Functional Scale. Among lung function parameters, diffusing capacity was most affected, with 45% having diffusing capacity < 80% of predicted.
    Conclusion: Fatigue, respiratory symptoms and cognitive symptoms are highly common months after hospitalization for severe COVID-19. Compared to pre-COVID-19, functional status and usual activities continued to be impaired. In line with this, almost half of the patients were found to have impaired diffusing capacity.
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834928-3
    ISSN 2001-8525
    ISSN 2001-8525
    DOI 10.1080/20018525.2021.2024735
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  3. Article ; Online: [CPAP for patients with COVID-19].

    Kofod, Linette Marie / Jeschke, Klaus Nielsen / Krogh-Madsen, Rikke / Albek, Carsten Monefeldt / Hansen, Ejvind Frausing

    Ugeskrift for laeger

    2020  Volume 182, Issue 33

    Abstract: Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19). The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or ... ...

    Abstract Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19). The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or avoid intubation. This review describes the physiological rationale behind CPAP therapy for patients with COVID-19 and the clinical experience with CPAP, implemented in a medical ward without prior knowledge of the treatment. CPAP has the potential for reducing the burden on intensive care units if implemented on a medical ward by a multidisciplinary approach.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Continuous Positive Airway Pressure ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language Danish
    Publishing date 2020-08-14
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  4. Article: Guideline for the management of COVID-19 patients during hospital admission in a non-intensive care setting.

    Nielsen Jeschke, Klaus / Bonnesen, Barbara / Hansen, Ejvind Frausing / Jensen, Jens-Ulrik Stæhr / Lapperre, Therese Sophie / Weinreich, Ulla Møller / Hilberg, Ole

    European clinical respiratory journal

    2020  Volume 7, Issue 1, Page(s) 1761677

    Abstract: Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has presented health-care systems worldwide with novel challenges and experiences and evidence is emerging during the pandemic. Patients requiring hospitalization frequently ... ...

    Abstract Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has presented health-care systems worldwide with novel challenges and experiences and evidence is emerging during the pandemic. Patients requiring hospitalization frequently suffer from respiratory failure of different severities.
    Aim: The aim of this guideline is the treatment of patients with SARS CoV-2 (COVID-19) in hospital; in particular, it addresses the treatment of respiratory failure treated in general Internal Medical- and Pulmonary Medical wards.
    Results: Elderly patients and patients with chronic disease are particularly vulnerable to COVID-19. Target oxygen saturation should be between 92% and 96% in patients without chronic lung diseases. Treatment with >5 L oxygen/min should be in close collaboration with intensive care colleagues and >15 l/min preferably in intensive care units. High-flow nasal canula (HFNC) and long-term Continuous Positive Airway Pressure (CPAP) are recommended for patients not responding to conventional oxygen therapy. Non-invasive ventilation (NIV) is only recommended for selected patients, such as those with a ceiling of treatment or patients presenting with hypercapnic failure. With the use of humidification protective equipment as FFP2-3 masks should be used. Nebulized medication should be avoided, and spacers should be used instead.
    Conclusion: Respiratory failure is frequently the cause of hospitalization in patients with COVID-19 and should be monitored closely.
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2834928-3
    ISSN 2001-8525
    ISSN 2001-8525
    DOI 10.1080/20018525.2020.1761677
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  5. Article ; Online: Guideline for the management of COVID-19 patients during hospital admission in a non-intensive care setting

    Nielsen Jeschke, Klaus / Bonnesen, Barbara / Hansen, Ejvind Frausing / Jensen, Jens-Ulrik Stæhr / Lapperre, Therese Sophie / Weinreich, Ulla Møller / Hilberg, Ole

    European Clinical Respiratory Journal

    2020  Volume 7, Issue 1, Page(s) 1761677

    Keywords covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2834928-3
    ISSN 2001-8525
    ISSN 2001-8525
    DOI 10.1080/20018525.2020.1761677
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: [Diagnostic approach and evaluation of hospitalized patients with COVID-19].

    Jeschke, Klaus Nielsen / Reiter, Nanna / Hvas, Anne-Mette / Rasmussen, Bodil Steen / Hansen, Ejvind Frausing / Marså, Kristoffer / Weinreich, Ulla Møller / Pedersen, Michael / Helleberg, Marie / Winding, Robert / Kirk, Ole / Dalager-Pedersen, Michael

    Ugeskrift for laeger

    2021  Volume 183, Issue 9

    Abstract: COVID-19 is the infectious disease caused by coronavirus SARS-CoV-2. The most common symptoms of COVID-19 are dry cough, tiredness and fever. Most patients recover from COVID-19 within a few weeks, but some patients have symptoms lasting for weeks or ... ...

    Abstract COVID-19 is the infectious disease caused by coronavirus SARS-CoV-2. The most common symptoms of COVID-19 are dry cough, tiredness and fever. Most patients recover from COVID-19 within a few weeks, but some patients have symptoms lasting for weeks or even months after recovery from acute illness, such as fatigue, shortness of breath and cough. This is a review of what we currently know about the clinical disease and its severity as well as which diagnostic strategies are recommended during and after hospital admission.
    MeSH term(s) COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Prognosis ; SARS-CoV-2
    Language Danish
    Publishing date 2021-03-18
    Publishing country Denmark
    Document type Journal Article ; Comment
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: [Clinical management of hospitalised patients with COVID-19].

    Jeschke, Klaus Nielsen / Reiter, Nanna / Hvas, Anne-Mette / Rasmussen, Bodil Steen / Hansen, Ejvind Frausing / Marså, Kristoffer / Weinreich, Ulla Møller / Pedersen, Michael / Helleberg, Marie / Winding, Robert / Kirk, Ole / Dalager-Pedersen, Michael

    Ugeskrift for laeger

    2021  Volume 183, Issue 9

    Abstract: COVID-19 is the infectious disease caused by SARS-CoV-2. This is a review of the current treatment strategies available for patients with COVID-19 during hospital admission. Patients requiring hospitalisation frequently suffer from respiratory failure ... ...

    Abstract COVID-19 is the infectious disease caused by SARS-CoV-2. This is a review of the current treatment strategies available for patients with COVID-19 during hospital admission. Patients requiring hospitalisation frequently suffer from respiratory failure and may require oxygen therapy. Insufficient response to oxygen may be an indication, that other modalities such as high-flow nasal cannula, continuous positive airway pressure or mechanical ventilation are needed. The only medical treatments currently being used are remdesivir and dexamethasone.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/therapy ; Humans ; Inpatients ; Oxygen Inhalation Therapy/methods ; Respiration, Artificial/methods ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; SARS-CoV-2
    Language Danish
    Publishing date 2021-03-01
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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    In stock of ZB MED Cologne/Königswinter

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  8. Article: [CPAP for patients with COVID-19]

    Kofod, Linette Marie / Jeschke, Klaus Nielsen / Krogh-Madsen, Rikke / Albek, Carsten Monefeldt / Hansen, Ejvind Frausing

    Ugeskrift for laeger

    Abstract: Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19) The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or ... ...

    Abstract Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19) The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or avoid intubation This review describes the physiological rationale behind CPAP therapy for patients with COVID-19 and the clinical experience with CPAP, implemented in a medical ward without prior knowledge of the treatment CPAP has the potential for reducing the burden on intensive care units if implemented on a medical ward by a multidisciplinary approach
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #720281
    Database COVID19

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  9. Article ; Online: Guideline for the management of COVID-19 patients during hospital admission in a non-intensive care setting

    Nielsen Jeschke, Klaus / Bonnesen, Barbara / Hansen, Ejvind Frausing / Jensen, Jens Ulrik Stæhr / Lapperre, Therese Sophie / Weinreich, Ulla Møller / Hilberg, Ole

    Nielsen Jeschke , K , Bonnesen , B , Hansen , E F , Jensen , J U S , Lapperre , T S , Weinreich , U M & Hilberg , O 2020 , ' Guideline for the management of COVID-19 patients during hospital admission in a non-intensive care setting ' , European Clinical Respiratory Journal , vol. 7 , no. 1 , 1761677 . https://doi.org/10.1080/20018525.2020.1761677

    2020  

    Keywords corona virus ; COVID-19 ; CPAP ; Guideline ; HFNC ; high Flow ; hospital ; NIV ; oxygen ; SARS-CoV-2 ; covid19
    Language English
    Publishing date 2020-07-01
    Publishing country dk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Management of COVID-19-Associated Acute Respiratory Failure with Alternatives to Invasive Mechanical Ventilation: High-Flow Oxygen, Continuous Positive Airway Pressure, and Noninvasive Ventilation.

    Bonnesen, Barbara / Jensen, Jens-Ulrik Stæhr / Jeschke, Klaus Nielsen / Mathioudakis, Alexander G / Corlateanu, Alexandru / Hansen, Ejvind Frausing / Weinreich, Ulla Møller / Hilberg, Ole / Sivapalan, Pradeesh

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: Patients admitted to hospital with coronavirus disease 2019 (COVID-19) may develop acute respiratory failure (ARF) with compromised gas exchange. These patients require oxygen and possibly ventilatory support, which can be delivered via different devices. ...

    Abstract Patients admitted to hospital with coronavirus disease 2019 (COVID-19) may develop acute respiratory failure (ARF) with compromised gas exchange. These patients require oxygen and possibly ventilatory support, which can be delivered via different devices. Initially, oxygen therapy will often be administered through a conventional binasal oxygen catheter or air-entrainment mask. However, when higher rates of oxygen flow are needed, patients are often stepped up to high-flow nasal cannula oxygen therapy (HFNC), continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP), or invasive mechanical ventilation (IMV). BiPAP, CPAP, and HFNC may be beneficial alternatives to IMV for COVID-19-associated ARF. Current evidence suggests that when nasal catheter oxygen therapy is insufficient for adequate oxygenation of patients with COVID-19-associated ARF, CPAP should be provided for prolonged periods. Subsequent escalation to IMV may be implemented if necessary.
    Language English
    Publishing date 2021-12-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11122259
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