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  1. Article ; Online: Commentary on a Case of Unexpected Hyperglycemia.

    Sacks, David B

    Clinical chemistry

    2021  Volume 67, Issue 8, Page(s) 1059–1060

    MeSH term(s) Humans ; Hyperglycemia/diagnosis
    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvab084
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  2. Article ; Online: Progress in the Early Detection of Risk of End-Stage Kidney Disease in Diabetes at Last?

    Berg, Anders H / Sacks, David B

    Clinical chemistry

    2023  Volume 69, Issue 7, Page(s) 673–675

    MeSH term(s) Humans ; Kidney Failure, Chronic/diagnosis ; Diabetic Nephropathies/diagnosis ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Risk Factors ; Kidney ; Disease Progression
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvac215
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  3. Article ; Online: Point-of-Care HbA1c in Clinical Practice: Caveats and Considerations for Optimal Use.

    Sacks, David B / Kirkman, M Sue / Little, Randie R

    Diabetes care

    2024  

    Abstract: Hemoglobin A1c (A1C) is widely used for the diagnosis and management of diabetes. Accurate measurement of A1C is necessary for optimal clinical value. Assay standardization has markedly improved the accuracy and consistency of A1C testing. Devices to ... ...

    Abstract Hemoglobin A1c (A1C) is widely used for the diagnosis and management of diabetes. Accurate measurement of A1C is necessary for optimal clinical value. Assay standardization has markedly improved the accuracy and consistency of A1C testing. Devices to measure A1C at point of care (POC) are commercially available, allowing rapid results when the patient is seen. In this review, we describe how standardization of A1C testing was achieved, leading to high-quality results in clinical laboratories. We address the use of POC A1C testing in clinical situations and summarize the advantages and disadvantages of POC A1C testing. We emphasize the importance of considering the limitations of these devices and following correct testing procedures to ensure that accurate A1C results are obtained for optimal care of patients.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dci23-0040
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  4. Article ; Online: Glycated Albumin: Added Value or Redundancy in Diabetes Care?

    Kirkman, M Sue / Sacks, David B

    Clinical chemistry

    2022  Volume 68, Issue 3, Page(s) 379–381

    MeSH term(s) Blood Glucose ; Diabetes Mellitus/therapy ; Glycated Hemoglobin A/analysis ; Glycation End Products, Advanced ; Humans ; Serum Albumin
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; Glycation End Products, Advanced ; Serum Albumin ; glycated serum albumin
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvab261
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  5. Article ; Online: Ca

    Sayedyahossein, Samar / Thines, Louise / Sacks, David B

    Cellular signalling

    2023  Volume 110, Page(s) 110846

    Abstract: The Hippo signaling pathway is a master regulator of organ size and tissue homeostasis. Hippo integrates a broad range of cellular signals to regulate numerous processes, such as cell proliferation, differentiation, migration and mechanosensation. ... ...

    Abstract The Hippo signaling pathway is a master regulator of organ size and tissue homeostasis. Hippo integrates a broad range of cellular signals to regulate numerous processes, such as cell proliferation, differentiation, migration and mechanosensation. Ca
    MeSH term(s) Hippo Signaling Pathway ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/physiology ; Cell Proliferation/physiology ; Cell Differentiation
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-08-06
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2023.110846
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  6. Article ; Online: IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins.

    Thines, Louise / Li, Zhigang / Sacks, David B

    Cells

    2023  Volume 12, Issue 3

    Abstract: The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple biological processes. The molecular mechanisms that underly spatial and temporal regulation of these interactions, which are crucial for proper cell functions, remain ... ...

    Abstract The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple biological processes. The molecular mechanisms that underly spatial and temporal regulation of these interactions, which are crucial for proper cell functions, remain poorly understood. The receptor tyrosine kinase MET phosphorylates IQGAP1 on Tyr
    MeSH term(s) Phosphotyrosine ; ras GTPase-Activating Proteins ; Phosphorylation ; Receptor Protein-Tyrosine Kinases
    Chemical Substances Phosphotyrosine (21820-51-9) ; IQ motif containing GTPase activating protein 1 ; ras GTPase-Activating Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12030483
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  7. Article ; Online: Antibody response to SARS-CoV-2 booster vaccines.

    Loving, Hanna S / Sacks, David B / Harb, Roa

    Clinical biochemistry

    2022  Volume 107, Page(s) 80–82

    MeSH term(s) Antibodies, Viral ; Antibody Formation ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Letter
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2022.06.004
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    Zs.A 624: Show issues Location:
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  8. Article ; Online: Establishing Pragmatic Analytical Performance Specifications for Blood Beta-Hydroxybutyrate Testing.

    Kilpatrick, Eric S / Butler, Alexandra E / Atkin, Stephen L / Sacks, David B

    Clinical chemistry

    2023  Volume 69, Issue 5, Page(s) 519–524

    Abstract: ... and (b) to be assured that a measured 0.5 mmol/L reduction in BOHB indicates the true concentration is ...

    Abstract Background: Currently, no authoritative guidelines exist recommending the analytical performance specification (APS) of blood beta-hydroxybutyrate (BOHB) testing in order to meet the clinical needs of patients. This study has applied existing diabetic ketoacidosis (DKA) BOHB diagnostic thresholds and the recommended rates of fall in BOHB concentrations during DKA treatment to establish pragmatic APSs for BOHB testing.
    Methods: Required analytical performance was based on 2 clinical requirements: (a) to reliably distinguish between non-adjacent DKA BOHB diagnostic categories of <0.6, 0.6 to 1.5, 1.6 to 2.9, and ≥3 mmol/L, and (b) to be assured that a measured 0.5 mmol/L reduction in BOHB indicates the true concentration is at least falling (meaning >0 mmol/L decline).
    Results: An analytical coefficient of variation (CV) of <21.5% could reliably distinguish all non-adjacent diagnostic categories with >99% certainty, assuming zero bias. In contrast, within-day CVs of 4.9%, 7.0%, and 9.1% at 3 mmol/L BOHB were required to assure truly falling ketone concentrations with 99% (optimal), 95% (desirable), and 90% (minimal) probability, respectively. These CVs are larger at lower BOHB concentrations and smaller at higher concentrations.
    Conclusions: Reliable tracking of changes in BOHB during DKA treatment largely drives the requirement for analytical performance. These data can be used to guide minimal, desirable, and optimal performance targets for BOHB meters and laboratory assays.
    MeSH term(s) Humans ; 3-Hydroxybutyric Acid/therapeutic use ; Diabetic Ketoacidosis/diagnosis ; Hematologic Tests
    Chemical Substances 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad020
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  9. Article ; Online: IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins

    Louise Thines / Zhigang Li / David B. Sacks

    Cells, Vol 12, Iss 483, p

    2023  Volume 483

    Abstract: The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple biological processes. The molecular mechanisms that underly spatial and temporal regulation of these interactions, which are crucial for proper cell functions, remain ... ...

    Abstract The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple biological processes. The molecular mechanisms that underly spatial and temporal regulation of these interactions, which are crucial for proper cell functions, remain poorly understood. The receptor tyrosine kinase MET phosphorylates IQGAP1 on Tyr 1510 . Separately, Src homology 2 (SH2) domains mediate protein–protein interactions by binding specific phosphotyrosine residues. Here, we investigate whether MET-catalyzed phosphorylation of Tyr 1510 of IQGAP1 regulates the docking of SH2-containing proteins. Using a peptide array, we identified SH2 domains from several proteins, including the non-receptor tyrosine kinases Abl1 and Abl2, that bind to the Tyr 1510 of IQGAP1 in a phosphorylation-dependent manner. Using pure proteins, we validated that full-length Abl1 and Abl2 bind directly to phosphorylated Tyr 1510 of IQGAP1. In cells, MET inhibition decreases endogenous IQGAP1 phosphorylation and interaction with endogenous Abl1 and Abl2, indicating that binding is regulated by MET-catalyzed phosphorylation of IQGAP1. Functionally, IQGAP1 modulates basal and HGF-stimulated Abl signaling. Moreover, IQGAP1 binds directly to MET, inhibiting its activation and signaling. Collectively, our study demonstrates that IQGAP1 is a phosphotyrosine-regulated scaffold for SH2-containing proteins, thereby uncovering a previously unidentified mechanism by which IQGAP1 coordinates intracellular signaling.
    Keywords Abl ; IQGAP1 ; MET ; phosphorylation ; phosphotyrosine ; receptor tyrosine kinase ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling.

    Thines, Louise / Roushar, Francis J / Hedman, Andrew C / Sacks, David B

    The Journal of cell biology

    2023  Volume 222, Issue 6

    Abstract: The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G-protein coupled receptors, are common IQGAP1 binding partners. Interactions ... ...

    Abstract The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G-protein coupled receptors, are common IQGAP1 binding partners. Interactions with IQGAP1 modulate receptor expression, activation, and/or trafficking. Moreover, IQGAP1 couples extracellular stimuli to intracellular outcomes via scaffolding of signaling proteins downstream of activated receptors, including mitogen-activated protein kinases, constituents of the phosphatidylinositol 3-kinase pathway, small GTPases, and β-arrestins. Reciprocally, some receptors influence IQGAP1 expression, subcellular localization, binding properties, and post-translational modifications. Importantly, the receptor:IQGAP1 crosstalk has pathological implications ranging from diabetes and macular degeneration to carcinogenesis. Here, we describe the interactions of IQGAP1 with receptors, summarize how they modulate signaling, and discuss their contribution to pathology. We also address the emerging functions in receptor signaling of IQGAP2 and IQGAP3, the other human IQGAP proteins. Overall, this review emphasizes the fundamental roles of IQGAPs in coupling activated receptors to cellular homeostasis.
    MeSH term(s) Humans ; ras GTPase-Activating Proteins/genetics ; ras GTPase-Activating Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction
    Chemical Substances IQGAP2 protein, human ; IQGAP3 protein, human ; ras GTPase-Activating Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptors, G-Protein-Coupled ; IQ motif containing GTPase activating protein 1
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202205062
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