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  1. Article ; Online: Antidiabetic agents and their hypothetical benefit on the risk of cardiac arrhythmias.

    Fauchier, Laurent

    Diabetes & metabolism

    2022  Volume 48, Issue 6, Page(s) 101406

    MeSH term(s) Humans ; Hypoglycemic Agents/therapeutic use ; Arrhythmias, Cardiac
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2022-11-17
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 1315751-6
    ISSN 1878-1780 ; 1262-3636 ; 0338-1684
    ISSN (online) 1878-1780
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/j.diabet.2022.101406
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1267: Show issues Location:
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  2. Article ; Online: Triple-Hormone-Receptor Agonist Retatrutide for Obesity.

    Bisson, Arnaud / Fauchier, Grégoire / Fauchier, Laurent

    The New England journal of medicine

    2023  Volume 389, Issue 17, Page(s) 1628

    MeSH term(s) Humans ; Obesity/drug therapy ; Hormones ; Gonadal Steroid Hormones
    Chemical Substances Hormones ; Gonadal Steroid Hormones
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2310645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of the Wearable Defibrillator in Heart Failure.

    Lenormand, Thibault / Bodin, Alexandre / Fauchier, Laurent

    Current heart failure reports

    2024  Volume 21, Issue 1, Page(s) 33–42

    Abstract: Purpose of review: Wearable cardioverter defibrillators (WCDs) have been developed as a temporary measure for protecting patients at risk for sudden cardiac death that do not meet the indication for implantable cardioverter defibrillator (ICD), most ... ...

    Abstract Purpose of review: Wearable cardioverter defibrillators (WCDs) have been developed as a temporary measure for protecting patients at risk for sudden cardiac death that do not meet the indication for implantable cardioverter defibrillator (ICD), most notably in the early stages of heart failure with reduced ejection fraction before reassessment of their left ventricular ejection fraction. In this review, we report available evidence in the literature and guidelines regarding WCD use in order to try to define the role WCDs may have in heart failure.
    Recent findings: In the last decade, most observational studies found WCDs to be both safe and effective in terminating ventricular arrhythmias in various indications, mostly centered around heart failure with reduced ejection fraction. The only available randomized controlled trial using WCD did not however show a benefit on patients' survival. Hence, recent guidelines only recommended its use in limited indications. Recent data also suggest a possible interest of WCD in monitoring patients, a finding that may prove useful in the context of new-onset heart failure. Data regarding WCD benefit is scarce, and definitive conclusions on its utility are hard to draw. In the context of heart failure, and particularly new-onset heart failure, WCD might find a role in a global comprehensive management of the disease, both acting as an educational tool, a monitoring tool, and, most importantly, a safe and effective tool in preventing sudden cardiac death. The low level of evidence however invites caution, and the decision of prescribing a WCD needs to be individualized and thoroughly discussed with the patient whose compliance is key with this device.
    MeSH term(s) Humans ; Heart Failure ; Stroke Volume ; Ventricular Function, Left ; Defibrillators, Implantable ; Death, Sudden, Cardiac/prevention & control ; Wearable Electronic Devices ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-023-00641-x
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  4. Article: Atrial Fibrillation Associated with Heart Failure: Perspectives from Recent Large Clinical Studies and Translational Research.

    Bentounes, Sid Ahmed / Bisson, Arnaud / Fauchier, Laurent

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Atrial fibrillation (AF) is a major public health issue [ ... ]. ...

    Abstract Atrial fibrillation (AF) is a major public health issue [...].
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155066
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  5. Article ; Online: Atrial fibrillation: better symptom control with rate and rhythm management.

    Gupta, Dhiraj / Rienstra, Michiel / van Gelder, Isabelle C / Fauchier, Laurent

    The Lancet regional health. Europe

    2024  Volume 37, Page(s) 100801

    Abstract: Atrial fibrillation (AF) is often associated with limiting symptoms, and with significant impairment in quality of life. As such, treatment strategies aimed at symptom control form an important pillar of AF management. Such treatments include a wide ... ...

    Abstract Atrial fibrillation (AF) is often associated with limiting symptoms, and with significant impairment in quality of life. As such, treatment strategies aimed at symptom control form an important pillar of AF management. Such treatments include a wide variety of drugs and interventions, including, increasingly, catheter ablation. These strategies can be utilised either singly or in combination, to improve and restore quality of life for patients, and this review covers the current evidence base underpinning their use. In this Review, we discuss the pros and cons of rate vs. rhythm control, while offering practical tips to non-specialists on how to utilise various treatments and counsel patients about all relevant treatment options. These include antiarrhythmic and rate control medications, as well as interventions such as cardioversion, catheter ablation, and pace-and-ablate.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2023.100801
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  6. Article ; Online: T Waves May Not Be What They Seem!

    Bisson, Arnaud / Bodin, Alexandre / Fauchier, Laurent / Clémenty, Nicolas

    JACC. Case reports

    2023  Volume 12, Page(s) 101778

    Abstract: A 39-year-old women who received a transvenous dual-chamber pacemaker in childhood developed 20 years later severe tricuspid valve stenosis induced by the leads and worsened by a pseudo-pacemaker syndrome. ( ...

    Abstract A 39-year-old women who received a transvenous dual-chamber pacemaker in childhood developed 20 years later severe tricuspid valve stenosis induced by the leads and worsened by a pseudo-pacemaker syndrome. (
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101778
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  7. Article ; Online: Empagliflozin in Heart Failure.

    Fauchier, Laurent / Fauchier, Grégoire / Angoulvant, Denis

    The New England journal of medicine

    2021  Volume 384, Issue 4, Page(s) 385

    MeSH term(s) Benzhydryl Compounds/adverse effects ; Glucosides/adverse effects ; Heart Failure/drug therapy ; Humans
    Chemical Substances Benzhydryl Compounds ; Glucosides ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2033669
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Heart failure with preserved ejection fraction and atrial fibrillation: recent advances and open questions.

    Fauchier, Laurent / Bisson, Arnaud / Bodin, Alexandre

    BMC medicine

    2023  Volume 21, Issue 1, Page(s) 54

    Abstract: Atrial fibrillation (AF) and heart failure (HF) are frequently associated and can be caused or exacerbated by each other through different mechanisms. AF is particularly common in patients with heart failure with preserved ejection fraction (HFpEF) ... ...

    Abstract Atrial fibrillation (AF) and heart failure (HF) are frequently associated and can be caused or exacerbated by each other through different mechanisms. AF is particularly common in patients with heart failure with preserved ejection fraction (HFpEF) defined as left ventricular ejection fraction (LVEF) ≥ 50%, with a prevalence ranging around 40-60%.In two recent trials, treatment with SGLT2 inhibitors resulted in a lower risk of worsening heart failure or cardiovascular death than placebo in patients with HFpEF, and SGLT2 inhibitors similarly improved prognosis whether patients had AF or not at enrolment. Analyses for subgroups of interest of patients with HFpEF likely to be at higher risk of AF (particularly those with older age or obesity) similarly indicated a consistent benefit with SGLT2 inhibitors. That subgroup in patients with HFpEF is those with a history of previous HF with LVEF ≤ 40%. The EAST-AFNET 4 trial indicated that early rhythm-control therapy was associated with a lower risk of adverse cardiovascular outcomes than usual care among patients with recent AF and cardiovascular conditions, including those with HF. In patients with AF and HF included in the CABANA trial, catheter ablation produced marked improvements in survival, freedom from AF recurrence, and quality of life compared to drug therapy. When strategies aiming at rhythm control eventually fail in patients with AF and HFpEF, a strategy of rate control with atrioventricular junction ablation and cardiac resynchronisation should be discussed since it may also reduce all-cause mortality.Finally, and in conclusion, considering that patients with AF and HFpEF may have a variety of cardiovascular and non-cardiovascular additional comorbidities, they are among those likely to have the highest clinical benefit being adherent to a holistic and integrated care management of AF following the ABC (Atrial Fibrillation Better Care) pathway.
    MeSH term(s) Humans ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Stroke Volume ; Ventricular Function, Left ; Heart Failure/epidemiology ; Heart Failure/therapy ; Heart Failure/complications ; Quality of Life ; Sodium-Glucose Transporter 2 Inhibitors ; Prognosis
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-023-02764-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Challenge of Minimizing Unnecessary ICD Shocks While Also Preventing Syncope.

    Stiles, Martin K / Fauchier, Laurent / Morillo, Carlos A / Wilkoff, Bruce L

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 9, Page(s) 2004

    MeSH term(s) Humans ; Tachycardia, Ventricular/prevention & control ; Ventricular Fibrillation/prevention & control ; Syncope/prevention & control ; Defibrillators, Implantable/adverse effects
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.06.014
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  10. Article ; Online: Pacemakers and implantable cardiac defibrillators: Must we fear hackers? Cybersecurity of implantable electronic devices.

    Chauvin, Michel / Piot, Olivier / Boveda, Serge / Fauchier, Laurent / Defaye, Pascal

    Archives of cardiovascular diseases

    2023  Volume 116, Issue 2, Page(s) 51–53

    MeSH term(s) Humans ; Defibrillators, Implantable ; Pacemaker, Artificial ; Heart ; Computer Security ; Fear
    Language English
    Publishing date 2023-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2022.12.002
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