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  1. Book ; Online ; Thesis: Carl R. Rogers - Ein pädagogischer Klassiker? Biographische Rekonstruktionen

    Schlör, Joachim [Verfasser] / Bittner, Günther [Gutachter] / Zerfaß, Rolf [Gutachter]

    2021  

    Author's details Joachim Schlör ; Gutachter: Günther Bittner, Rolf Zerfaß
    Keywords Philosophie ; Philosophy
    Subject code sg100
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Ibrutinib- and bortezomib-extended R-CHOP induction in elderly higher-risk patients newly diagnosed with diffuse large B-cell lymphoma - first analysis of toxicity and efficacy signals.

    Denker, Sophy / Bittner, Aitomi / Frick, Mareike / Kase, Julia / Hoffmann, Jörg / Trenker, Corinna / Keller, Ulrich / Bogner, Christian / Hüttmann, Andreas / Dürig, Jan / Janz, Martin / Mathas, Stephan / Marks, Reinhard / Krohn, Ulrike / Na, Il-Kang / Bullinger, Lars / Schmitt, Clemens A

    Leukemia & lymphoma

    2021  Volume 63, Issue 1, Page(s) 84–92

    Abstract: ... of the patients will not be cured by standard Rituximab (R)-CHOP-like immune-chemotherapy, and ... R-CHOP with targeted agents failed in large randomized phase III trials. The addition of Ibrutinib ...

    Abstract Diffuse large-cell B-cell lymphoma (DLBCL) is the most common lymphoid malignancy. About 30-40% of the patients will not be cured by standard Rituximab (R)-CHOP-like immune-chemotherapy, and many of them experience relapse and eventually succumb to their disease. Enhancing first-line efficacy in patients at higher risk, among them many elderly, is key to improve long-term outcomes. Numerous attempts to combine R-CHOP with targeted agents failed in large randomized phase III trials. The addition of Ibrutinib enhanced survival in younger patients, but increased toxicity across all age groups, especially in the elderly. Older DLBCL patients impose particular challenges, since they often present with more advanced disease, and exhibit treatment-relevant comorbidities. ImbruVeRCHOP trial aims at identifying patients who need that benefit from rationally augmented first-line regimens without experiencing overt toxicity and detecting their molecular signatures of response. This first analysis presents encouraging feasibility, safety, and preliminary response data in elderly high-risk DLBCL patients.
    MeSH term(s) Adenine/analogs & derivatives ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bortezomib/therapeutic use ; Cyclophosphamide/adverse effects ; Doxorubicin/adverse effects ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Piperidines ; Prednisone/adverse effects ; Rituximab/adverse effects ; Vincristine/adverse effects
    Chemical Substances Piperidines ; ibrutinib (1X70OSD4VX) ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Bortezomib (69G8BD63PP) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Adenine (JAC85A2161) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2021-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1964024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
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  3. Article: A Phase I/II first-line study of R-CHOP plus B-cell receptor/NF-κB-double-targeting to molecularly assess therapy response.

    Denker, Sophy / Bittner, Aitomi / Na, Il-Kang / Kase, Julia / Frick, Mareike / Anagnostopoulos, Ioannis / Hummel, Michael / Schmitt, Clemens A

    International journal of hematologic oncology

    2019  Volume 8, Issue 4, Page(s) IJH20

    Abstract: The ImbruVeRCHOP trial is an investigator-initiated, multicenter, single-arm, open label Phase I/II study for patients 61-80 years of age with newly diagnosed ... ...

    Abstract The ImbruVeRCHOP trial is an investigator-initiated, multicenter, single-arm, open label Phase I/II study for patients 61-80 years of age with newly diagnosed CD20
    Language English
    Publishing date 2019-12-19
    Publishing country England
    Document type Clinical Trial Protocol
    ZDB-ID 2692801-2
    ISSN 2045-1407 ; 2045-1393
    ISSN (online) 2045-1407
    ISSN 2045-1393
    DOI 10.2217/ijh-2019-0010
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  4. Book ; Online ; E-Book: Laparo-endoscopic hernia surgery

    Bittner, Reinhard / Köckerling, Ferdinand / Fitzgibbons, Jr., Robert J.

    evidence based clinical practice

    2018  

    Author's details Reinhard Bittner, Ferdinand Köckerling, Robert J. Fitzgibbons, Jr., Karl A. LeBlanc, Sumeet K. Mittal, Pradeep Chowbey editors
    Keywords Medicine ; Abdominal surgery ; Surgery ; Minimally invasive surgery
    Subject code 617
    Language English
    Size 1 Online-Ressource (XVI, 483 Seiten), Illustrationen
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019761620
    ISBN 978-3-662-55493-7 ; 9783662554913 ; 3-662-55493-3 ; 3662554917
    DOI 10.1007/978-3-662-55493-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Viszeralmedizin in Fallstudien

    Bittner, Reinhard

    (Chirurgische Gastroenterologie interdisziplinär ; 22,2)

    2006  

    Author's details Hrsg. R. Bittner
    Series title Chirurgische Gastroenterologie interdisziplinär ; 22,2
    Chirurgische Gastroenterologie
    Collection Chirurgische Gastroenterologie
    Language German ; English
    Size S. 69 - 111 : Ill.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015703797
    ISBN 3-8055-8134-3 ; 978-3-8055-8134-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2103 -22- not available for loan Zeitschriften-Lesesaal

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  6. Book: Viszeralmedizin - state of the art

    Bittner, Reinhard

    (Chirurgische Gastroenterologie ; 22, Suppl. 1)

    2006  

    Author's details Reinhard Bittner ... (Hrsg.)
    Series title Chirurgische Gastroenterologie ; 22, Suppl. 1
    Collection
    Language German
    Size 64 S. : Ill.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015017734
    ISBN 3-8055-8257-9 ; 978-3-8055-8257-5 ; 9783825782575 ; 3825782573
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2103 -22,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  7. Book: Chirurgie der Leistenhernie

    Bittner, Reinhard

    minimalinvasive Operationstechniken ; 64 Tabellen

    2006  

    Author's details Hrsg. Reinhard Bittner
    Keywords Leistenhernie ; Minimal-invasive Chirurgie ; Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren ; MIC ; Minimal invasive surgery ; Mikro-invasive Chirurgie ; Endoskopische Chirurgie ; Operative Endoskopie ; Chirurgische Endoskopie ; Therapeutische Endoskopie ; Video-assistierte Telechirurgie ; Schlüssellochchirurgie ; Knopflochchirurgie ; Less invasive surgery ; Leistenbruch ; Hernia inguinalis ; Inguinalhernie
    Language German
    Size IX, 346 S. : zahlr. Ill.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Accompanying material 1 DVD
    HBZ-ID HT014419345
    ISBN 3-8055-7557-2 ; 978-3-8055-7557-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 A 2485 order for loan Magazin
    2006 MO 693 <<[Begleitmaterial]>> order for loan Magazin

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  8. Book: Hauptthema Minimal invasive Chrirgie in der Onkologie

    Bittner, Reinhard

    eingeladene Beiträge

    (Chirurgische Gastroenterologie interdisziplinär ; 21,1)

    2005  

    Title variant Minimal invasive Chrirgie in der Onkologie
    Author's details R. Bittner ... (Hrsg.)
    Series title Chirurgische Gastroenterologie interdisziplinär ; 21,1
    Chirurgische Gastroenterologie
    Collection Chirurgische Gastroenterologie
    Language German ; English
    Size 97 S. : Ill.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT014958285
    ISBN 3-8055-7954-3 ; 978-3-8055-7954-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2103 -21- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: Acute Respiratory Distress Syndrome, Mechanical Ventilation, and Inhalation Injury in Burn Patients.

    Bittner, Edward / Sheridan, Robert

    The Surgical clinics of North America

    2023  Volume 103, Issue 3, Page(s) 439–451

    Abstract: Respiratory failure occurs with some frequency in seriously burned patients, driven by a combination of inflammatory and infection factors. Inhalation injury contributes to respiratory failure in some burn patients via direct mucosal injury and indirect ... ...

    Abstract Respiratory failure occurs with some frequency in seriously burned patients, driven by a combination of inflammatory and infection factors. Inhalation injury contributes to respiratory failure in some burn patients via direct mucosal injury and indirect inflammation. In burn patients, respiratory failure leading to acute respiratory distress syndrome, with or without inhalation injury, is effectively managed using principles evolved for non-burn critically ill patients.
    MeSH term(s) Humans ; Respiration, Artificial ; Burns/complications ; Burns/therapy ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Critical Illness/therapy ; Respiratory Insufficiency
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2023.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.75: Show issues Location:
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  10. Article: Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes.

    Deslandes, Laurent / Olivier, Jocelyne / Theulieres, Frederic / Hirsch, Judith / Feng, Dong Xin / Bittner-Eddy, Peter / Beynon, Jim / Marco, Yves

    Proceedings of the National Academy of Sciences of the United States of America

    2002  Volume 99, Issue 4, Page(s) 2404–2409

    Abstract: ... recessive (RRS1-R) alleles from susceptible and resistant accessions encode highly similar predicted ... of some plant transcriptional factors. Although genetically defined as a recessive allele, RRS1-R behaves ... homozygous intragenic recombinant lines indicates that several domains of RRS1-R are essential ...

    Abstract The identification of two Arabidopsis thaliana genes involved in determining recessive resistance to several strains of the causal agent of bacterial wilt, Ralstonia solanacearum, is reported. Dominant (RRS1-S) and recessive (RRS1-R) alleles from susceptible and resistant accessions encode highly similar predicted proteins differing in length and which present a novel structure combining domains found in plant Toll-IL-1 receptor-nucleotide binding site-leucin-rich repeat resistance proteins and a WRKY motif characteristic of some plant transcriptional factors. Although genetically defined as a recessive allele, RRS1-R behaves as a dominant resistance gene in transgenic plants. Sequence analysis of the RRS1 genes present in two homozygous intragenic recombinant lines indicates that several domains of RRS1-R are essential for its resistance function. Additionally, RRS1-R-mediated resistance is partially salicylic acid- and NDR1-dependent, suggesting the existence of similar signaling pathways to those controlled by resistance genes in specific resistance.
    MeSH term(s) Alleles ; Amino Acid Sequence ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins ; Cloning, Molecular ; Genes, Recessive ; Gram-Negative Aerobic Rods and Cocci/pathogenicity ; Immunity, Innate/genetics ; Models, Genetic ; Molecular Sequence Data ; Plant Diseases/genetics ; Plant Proteins/genetics ; Protein Structure, Tertiary ; Recombinant Proteins/metabolism ; Recombination, Genetic ; Salicylic Acid/metabolism ; Sequence Homology, Amino Acid ; Time Factors ; Transcription Factors/physiology
    Chemical Substances Arabidopsis Proteins ; NDR1 protein, Arabidopsis ; Plant Proteins ; Recombinant Proteins ; Transcription Factors ; Salicylic Acid (O414PZ4LPZ)
    Language English
    Publishing date 2002-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.032485099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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