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Article ; Online: Innovative solutions: the C.O.R.E. to sociocultural care in nursing.

Preciado, Andrea / Vachhani, Ami / Gilbert, Amber / Cox, Jolene / Robles, Erick de Jesus Barraza / Thompson, John

Dimensions of critical care nursing : DCCN

2012 Volume 31, Issue 5, Page(s) 283–286

Abstract: Terminal weaning of patients follows a standardized medical care protocol. However, the evidence found for optimal terminal weaning protocols may lack individualization for the patient and family. As nursing students in the critical care unit, we have ... ...

Abstract	Terminal weaning of patients follows a standardized medical care protocol. However, the evidence found for optimal terminal weaning protocols may lack individualization for the patient and family. As nursing students in the critical care unit, we have designed a conceptual model that bridges the gap between cultural diversity and terminal weaning. This conceptual model integrates comfort, organization, rituals, and environment into the process of terminal weaning. The model assists nurses in all specialties, particularly critical care, to provide culturally appropriate end-of-life care for the patient and their family.
MeSH term(s)	Attitude to Death ; Cultural Diversity ; Humans ; Intensive Care Units ; Models, Nursing ; Nursing Care/methods ; Nursing Care/psychology ; Nursing Theory ; Terminal Care/methods ; Terminal Care/psychology
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632780-1
ISSN	1538-8646 ; 0730-4625
ISSN (online)	1538-8646
ISSN	0730-4625
DOI	10.1097/DCC.0b013e3182619987
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Article ; Online: Utilization of a novel autologous killed tri-vaccine (serogroups B [Typhimurium], C [Mbandaka] and E [Orion]) for Salmonella control in commercial poultry breeders.

Pavic, Anthony / Groves, Peter J / Cox, Julian M

Avian pathology : journal of the W.V.P.A

2010 Volume 39, Issue 1, Page(s) 31–39

Abstract: ... Salmonella serovars (Typhimurium - serogroup B, Mbandaka - serogroup C, and Orion - serogroup E) prevalent ... with autologous and heterologous serovars belonging to serogroup B (Typhimurium and Agona), serogroup C (Mbandaka ... and Infantis) and serogroup E (Orion and Zanzibar). Overall, vaccination resulted in a significant ...

Abstract	An autologous killed trivalent vaccine (3x10(8) colony-forming units [CFU]), based on three Salmonella serovars (Typhimurium - serogroup B, Mbandaka - serogroup C, and Orion - serogroup E) prevalent in the flocks of Australian poultry companies, was developed using Salenvac techniques. At 20 weeks, hens vaccinated at 12 and 17 weeks as well as non-vaccinated hens were challenged (250 microl of 10(7) CFU) with autologous and heterologous serovars belonging to serogroup B (Typhimurium and Agona), serogroup C (Mbandaka and Infantis) and serogroup E (Orion and Zanzibar). Overall, vaccination resulted in a significant difference in carriage of Salmonella between non-vaccinated and vaccinated commercial Cobb hens (P <0.05) for serogroups B and C. However, due to low colonization rates in the non-vaccinated birds, no significant difference (P>0.05) could be determined for serogroup E. All vaccinated flocks produced a significant antibody response (P<0.001) to the S. Typhimurium vaccine strain, measured using a S. Typhimurium enzyme-linked immunosorbent assay (Guildhay), which peaked at 20 weeks of age, with 39% of the hens positive. Maternal antibodies were detected in 16% of the yolks from eggs produced by these flocks. There was a significant difference after challenge with Salmonella (P <0.05) among 1-day-old chicks from vaccinated versus non-vaccinated parents, when challenged using 10(4) CFU but not when challenged with 10(8) CFU. The success of this trial resulted in the incorporation of this vaccine into a Salmonella control system in commercial broiler breeder production.
MeSH term(s)	Animal Husbandry ; Animals ; Antibodies, Bacterial ; Australia ; Chickens ; Egg Yolk/immunology ; Female ; Immunity ; Immunization Schedule ; Male ; Poultry Diseases/immunology ; Poultry Diseases/microbiology ; Poultry Diseases/prevention & control ; Salmonella Infections, Animal/immunology ; Salmonella Infections, Animal/microbiology ; Salmonella Infections, Animal/prevention & control ; Salmonella Vaccines/immunology ; Salmonella typhimurium/immunology ; Vaccines, Inactivated/immunology
Chemical Substances	Antibodies, Bacterial ; Salmonella Vaccines ; Vaccines, Inactivated
Language	English
Publishing date	2010-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1476380-1
ISSN	1465-3338 ; 0307-9457
ISSN (online)	1465-3338
ISSN	0307-9457
DOI	10.1080/03079450903454277
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Article: Comments on paper by C. E. Frangakis, D. B. Rubin and X.-H. Zhao.

Berrington, A / Cox, D R

Biostatistics (Oxford, England)

2002 Volume 3, Issue 2, Page(s) 165–7; discussion 173–4

Language	English
Publishing date	2002-06
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2031500-4
ISSN	1465-4644
ISSN	1465-4644
DOI	10.1093/biostatistics/3.2.165
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Article: Utilization of a novel autologous killed tri-vaccine (serogroups B [Typhimurium], C [Mbandaka] and E [Orion]) for Salmonella control in commercial poultry breeders

Pavic, Anthony / Groves, Peter J / Cox, Julian M

Avian pathology. 2010 Feb., v. 39, no. 1

2010

Abstract	An autologous killed trivalent vaccine (3x10⁸ colony-forming units [CFU]), based on three Salmonella serovars (Typhimurium - serogroup B, Mbandaka - serogroup C, and Orion - serogroup E) prevalent in the flocks of Australian poultry companies, was developed using Salenvac techniques. At 20 weeks, hens vaccinated at 12 and 17 weeks as well as non-vaccinated hens were challenged (250 µl of 10⁷ CFU) with autologous and heterologous serovars belonging to serogroup B (Typhimurium and Agona), serogroup C (Mbandaka and Infantis) and serogroup E (Orion and Zanzibar). Overall, vaccination resulted in a significant difference in carriage of Salmonella between non-vaccinated and vaccinated commercial Cobb hens (P <0.05) for serogroups B and C. However, due to low colonization rates in the non-vaccinated birds, no significant difference (P>0.05) could be determined for serogroup E. All vaccinated flocks produced a significant antibody response (P<0.001) to the S. Typhimurium vaccine strain, measured using a S. Typhimurium enzyme-linked immunosorbent assay (Guildhay), which peaked at 20 weeks of age, with 39% of the hens positive. Maternal antibodies were detected in 16% of the yolks from eggs produced by these flocks. There was a significant difference after challenge with Salmonella (P <0.05) among 1-day-old chicks from vaccinated versus non-vaccinated parents, when challenged using 10⁴ CFU but not when challenged with 10⁸ CFU. The success of this trial resulted in the incorporation of this vaccine into a Salmonella control system in commercial broiler breeder production.
Keywords	broiler breeders ; poultry diseases ; Salmonella enterica subsp. enterica serovar Mbandaka ; Salmonella enterica subsp. enterica serovar Typhimurium ; Salmonella enterica subsp. enterica serovar Agona ; Salmonella enterica subsp. enterica serovar Infantis ; serotypes ; animal pathogenic bacteria ; inactivated vaccines ; vaccination ; disease incidence ; disease reservoirs ; microbial colonization ; immune response ; enzyme-linked immunosorbent assay ; temporal variation ; hens ; maternal immunity ; egg yolk ; disease control ; Australia
Language	English
Dates of publication	2010-02
Size	p. 31–39.
Document type	Article
ZDB-ID	1476380-1
ISSN	1465-3338 ; 0307-9457
ISSN (online)	1465-3338
ISSN	0307-9457
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Article: Drug susceptibility of subtypes A,B,C,D, and E human immunodeficiency virus type 1 primary isolates.

Palmer, S / Alaeus, A / Albert, J / Cox, S

AIDS research and human retroviruses

1998 Volume 14, Issue 2, Page(s) 157–162

Abstract: ... of human immunodeficiency virus type 1 (HIV-1) subtypes A, B, C, D, and E. Isolates from treated and untreated patients were ...

Abstract	We determined the susceptibility to antiviral drugs of clinical isolates of human immunodeficiency virus type 1 (HIV-1) subtypes A, B, C, D, and E. Isolates from treated and untreated patients were tested for sensitivity to zidovudine (ZDV), lamivudine (3TC), didanosine (ddI), nevirapine (NVP), foscarnet (PFA), and ritonavir (RNV). The susceptibility to these different drugs was broadly similar between the different subtypes of HIV-1. Isolates of subtype D showed a tendency toward slightly lower susceptibility to all the antiviral drugs, which could be related to the rapid growth characteristics of these isolates.
MeSH term(s)	Anti-HIV Agents/pharmacology ; Cell Line, Transformed ; Cells, Cultured ; Didanosine/pharmacology ; Foscarnet/pharmacology ; HIV Infections/virology ; HIV Protease Inhibitors/pharmacology ; HIV-1/drug effects ; HIV-1/isolation & purification ; Humans ; Lamivudine/pharmacology ; Leukocytes, Mononuclear/cytology ; Nevirapine/pharmacology ; Reverse Transcriptase Inhibitors/pharmacology ; Ritonavir/pharmacology ; Zidovudine/pharmacology
Chemical Substances	Anti-HIV Agents ; HIV Protease Inhibitors ; Reverse Transcriptase Inhibitors ; Lamivudine (2T8Q726O95) ; Foscarnet (364P9RVW4X) ; Zidovudine (4B9XT59T7S) ; Nevirapine (99DK7FVK1H) ; Didanosine (K3GDH6OH08) ; Ritonavir (O3J8G9O825)
Language	English
Publishing date	1998-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/aid.1998.14.157
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Article: Generation of (E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene from C-13-norisoprenoid precursors

Cox, A. / Skouroumounis, G. K. / Elsey, G. M. / Perkins, M. V. / Sefton, M. A.

Journal of Agricultural and Food Chemistry

2005 Volume 53, Issue 17, Page(s) 6777–6783

Abstract: ... under wine conservation conditions. After 173 days at 45 °C, approximately 4000-5000 ng/l of E-1-(2,3,6 ... E-1-(2,3,6 Trimethylphenyl)buta-1,3-diene is a wine component which was recently identified ... trihydroxymegastigma-5,7-diene, and the actinidols were shown to generate E-1-(2,3,6 Trimethylphenyl)buta-1,3-diene ...

Institution	Flinders Univ., School of Chemistry, Physics and Earth Sciences, Adelaide, SA 5001, Australia
Abstract	E-1-(2,3,6 Trimethylphenyl)buta-1,3-diene is a wine component which was recently identified in white wines. Tree C13-norisoprenoid compounds, 3,6,9-trihydroxymegastigma-4,7-diene, 3,4,9-trihydroxymegastigma-5,7-diene, and the actinidols were shown to generate E-1-(2,3,6 Trimethylphenyl)buta-1,3-diene under wine conservation conditions. After 173 days at 45 °C, approximately 4000-5000 ng/l of E-1-(2,3,6 Trimethylphenyl)buta-1,3-diene were formed from 1.0 mg/l of precursor, while at 25 °C more wine-like amounts (200-600 ng/l) were observed. Also hydrolysis of 4,5-dihydrovomifoliol-C9-\\beta\\-D-glucopyranoside produced E-1-(2,3,6 Trimethylphenyl)buta-1,3-diene, but in quantities insufficient to account for the levels observed in wine. 4,5-dihydrovomifoliol-C9-\\beta\\-D-glucopyranoside was isolated from grapevine leaves by multiplayer coil counter current chromatography (MLCCC). [18096] (C. Ancín Azpilicueta, Pamplona)
Keywords	WINE ; FLAVOUR ; METABOLISM
Language	English
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
Database	Viticulture and Oenology Abstracts

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Article: Cytochalasin E enhances the protein kinase C-dependent process of secretion.

Cox, A C

Biochemical and biophysical research communications

1988 Volume 150, Issue 2, Page(s) 745–751

Abstract: ... tetradecanoylphorbol acetate was enhanced by 10 microM cytochalasin E even in the absence of external calcium ions and ... by cytochalasin but the synergy between A23187 and phorbol ester was enhanced. Therefore, protein kinase C ... concentration or aggregation but is enhanced selectively by cytochalasin. Because the synergy between kinase C ...

Abstract	Platelet dense body secretion, monitored as released serotonin, when induced by 20 nM tetradecanoylphorbol acetate was enhanced by 10 microM cytochalasin E even in the absence of external calcium ions and aggregation. Secretion induced by 500 nM A23187 in the presence of 15 microM indomethacin was not changed by cytochalasin but the synergy between A23187 and phorbol ester was enhanced. Therefore, protein kinase C-mediated secretion is not dependent on filipodal development, granule centralization, external calcium ion concentration or aggregation but is enhanced selectively by cytochalasin. Because the synergy between kinase C and A23187 is very rapid, the rate determining step in the slow secretion induced by phorbol ester alone appears to be the step accelerated by a rise in cytosolic Ca2+ concentration.
MeSH term(s)	Blood Platelets/drug effects ; Blood Platelets/physiology ; Cytochalasins/pharmacology ; Humans ; Kinetics ; Mycotoxins/pharmacology ; Platelet Aggregation/drug effects ; Protein Kinase C/blood ; Serotonin/blood ; Tetradecanoylphorbol Acetate/pharmacology
Chemical Substances	Cytochalasins ; Mycotoxins ; Serotonin (333DO1RDJY) ; cytochalasin E (36011-19-5) ; Protein Kinase C (EC 2.7.11.13) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	1988-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/0006-291x(88)90454-8
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Article: Generation of (E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene from C₁₃-norisoprenoid precursors

Cox, A / Skouroumounis, G.K / Elsey, G.M / Perkins, M.V / Sefton, M.A

Journal of agricultural and food chemistry. 2005 Aug. 24, v. 53, no. 17

2005

Abstract: ... All three were shown to generate (E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene (1) under wine conservation ... conditions. At 45 degrees C, approximately 4000-5000 ng/L of 1 was formed from 1.0 mg/L of precursor, after ... 173 days, while at 25 degrees C more wine-like amounts (200-600 ng/L) were observed. A glucoside, 4,5 ...

Abstract	Three C13-norisoprenoid compounds, 3,6,9-trihydroxymegastigma-4,7-diene (6), 3,4,9-trihydroxymegastigma-5,7-diene (4), and the actinidols (8), have all been synthesized and subjected to acid hydrolysis. All three were shown to generate (E)-1-(2,3,6-trimethylphenyl)buta-1,3-diene (1) under wine conservation conditions. At 45 degrees C, approximately 4000-5000 ng/L of 1 was formed from 1.0 mg/L of precursor, after 173 days, while at 25 degrees C more wine-like amounts (200-600 ng/L) were observed. A glucoside, 4,5-dihydrovomifoliol-C9-beta-D-glucopyranoside (9b), was isolated from grapevine leaves by multilayer coil countercurrent chromatography (MLCCC), and its stereochemistry was deduced as being (5R, 6S, 9R) by NMR and CD spectroscopy. Hydrolysis of this glucoside produced 1, but in quantities insufficient to account for the levels observed in wine.
Keywords	polyphenols ; odor compounds ; isoprenoids ; chemical reactions ; heat treatment ; wines ; stereochemistry
Language	English
Dates of publication	2005-0824
Size	p. 6777-6783.
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
Database	NAL-Catalogue (AGRICOLA)

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Article: Intake of vitamins E, C, and A and risk of lung cancer. The NHANES I epidemiologic followup study. First National Health and Nutrition Examination Survey.

Yong, L C / Brown, C C / Schatzkin, A / Dresser, C M / Slesinski, M J / Cox, C S / Taylor, P R

American journal of epidemiology

1997 Volume 146, Issue 3, Page(s) 231–243

Abstract: The relation between the dietary intake of vitamins E, C, and A (estimated by a 24-hour recall) and ... protective effect of supplements of vitamins E, C, and A beyond that provided through dietary intake. When vitamin E ... 0.74). These data provide support for a protective role of dietary vitamins E and C and ...

Abstract	The relation between the dietary intake of vitamins E, C, and A (estimated by a 24-hour recall) and lung cancer incidence was examined in the First National Health and Nutrition Examination Survey Epidemiologic Followup Study cohort of 3,968 men and 6,100 women, aged 25-74 years. During a median follow-up period of 19 years (from 1971-1975 to 1992), 248 persons developed lung cancer. Adjusted for potential confounders using Cox proportional hazards regression methods with age as the underlying time variable, the relative risk of lung cancer for subjects in the highest quartile of vitamin C intake compared with those in the lowest quartile was 0.66 (95% confidence interval (CI) 0.45-0.96). For vitamin A intake, a protective effect was observed only for its fruit and vegetable component (carotenoids) among current smokers (relative risk = 0.49, 95% CI 0.29-0.84), but this was modified by the intensity of smoking (a statistically significant effect (relative risk = 0.33, 95% CI 0.13-0.84) was observed only for those in the lowest tertile of pack-years of smoking). The vitamin E intake-lung cancer relation was modified by the intensity of smoking with a significant protective effect confined to current smokers in the lowest tertile of pack-years of smoking (relative risk = 0.36, 95% CI 0.16-0.83). Overall, there was no additional protective effect of supplements of vitamins E, C, and A beyond that provided through dietary intake. When vitamin E, vitamin C, and carotenoid intakes were examined in combination, a strong protective effect was observed for those in the highest compared with those in the lowest quartile of all three intakes (relative risk = 0.32, 95% CI 0.14-0.74). These data provide support for a protective role of dietary vitamins E and C and of carotenoids against lung cancer risk but with a modification in effects by the intensity of cigarette exposure. While smoking avoidance is the most important behavior to reduce lung cancer risk, the daily consumption of a variety of fruits and vegetables that provides a combination of these nutrients and other potential protective factors may offer the best dietary protection against lung cancer.
MeSH term(s)	Adult ; Aged ; Alcohol Drinking ; Ascorbic Acid/administration & dosage ; Carotenoids/administration & dosage ; Female ; Follow-Up Studies ; Fruit ; Humans ; Lung Neoplasms/epidemiology ; Lung Neoplasms/prevention & control ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Smoking/adverse effects ; Vegetables ; Vitamin A/administration & dosage ; Vitamin E/administration & dosage
Chemical Substances	Vitamin A (11103-57-4) ; Vitamin E (1406-18-4) ; Carotenoids (36-88-4) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	1997-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/oxfordjournals.aje.a009258
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Article: Interaction between variant apolipoproteins C-II and E that affects plasma lipoprotein concentrations.

Hegele, R A / Breckenridge, W C / Cox, D W / Maguire, G F / Little, J A / Connelly, P W

Arteriosclerosis and thrombosis : a journal of vascular biology

1991 Volume 11, Issue 5, Page(s) 1303–1309

Abstract: The genes for apolipoprotein (apo) C-II, a cofactor for activation of lipoprotein lipase, and apo E ... of the complete absence of lipoprotein lipase activity and were homozygous for a DNA frameshift mutation of apo C ... the presence of a single apo E allele encoding the E4 isoform occurring in individuals with a single mutant apo ...

Abstract	The genes for apolipoprotein (apo) C-II, a cofactor for activation of lipoprotein lipase, and apo E, a ligand for receptor-mediated uptake of triglyceride-rich lipoproteins, are physically linked on chromosome 19q13.1. In a large Caribbean Caucasian family, several individuals had clinical features of the complete absence of lipoprotein lipase activity and were homozygous for a DNA frameshift mutation of apo C-II, imparting functional inactivity to the mutant protein. Plasma from heterozygous carriers of this mutation, when compared with plasma from relatives who were noncarriers, had significantly diminished capacity to activate lipoprotein lipase in vitro. We also observed in heterozygotes for this mutation a wide range of serum lipid and lipoprotein levels. When age and sex were taken into account, the presence of a single apo E allele encoding the E4 isoform occurring in individuals with a single mutant apo C-II allele was strongly associated with higher levels of cholesterol, triglycerides, very low density lipoprotein cholesterol, and non-high density lipoprotein cholesterol when compared with those of relatives who carried neither or only one variant allele. This suggests that a single genetic mutation that usually has a recessive effect on lipoprotein metabolism can have an interactive effect on lipid phenotype when it is coinherited with a single mutation at another gene whose product affects the same metabolic pathway.
MeSH term(s)	Adult ; Aged ; Apolipoprotein C-II ; Apolipoproteins C/blood ; Apolipoproteins C/genetics ; Apolipoproteins E/blood ; Apolipoproteins E/genetics ; Cholesterol, HDL/blood ; Cholesterol, VLDL/blood ; Chromosome Deletion ; Chromosomes, Human, Pair 19 ; Female ; Genetic Linkage ; Heterozygote ; Humans ; Hyperlipoproteinemia Type V/blood ; Hyperlipoproteinemia Type V/genetics ; Male ; Middle Aged ; Phenotype ; Triglycerides/blood
Chemical Substances	Apolipoprotein C-II ; Apolipoproteins C ; Apolipoproteins E ; Cholesterol, HDL ; Cholesterol, VLDL ; Triglycerides
Language	English
Publishing date	1991-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063375-3
ISSN	1049-8834
ISSN	1049-8834
DOI	10.1161/01.atv.11.5.1303
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