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Article ; Online: Interactive patient blood management dashboards used in Western Australia.

Trentino, Kevin M / Swain, Stuart G / Geelhoed, Gary C / Daly, Frank F S / Leahy, Michael F

2016 Volume 56, Issue 12, Page(s) 3140–3141

Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.13854
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Zs.A 284: Show issues

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Article ; Online: The effectiveness of skilled breathing and relaxation techniques during antenatal education on maternal and neonatal outcomes: a systematic review.

Leutenegger, Vanessa / Grylka-Baeschlin, Susanne / Wieber, Frank / Daly, Deirdre / Pehlke-Milde, Jessica

BMC pregnancy and childbirth

2022 Volume 22, Issue 1, Page(s) 856

Abstract: Background: Several studies have investigated the relationship between antenatal education classes and pregnancy outcomes. These studies have shown positive effects on mothers, such as a lower epidural rate in the intervention groups. However, until now, ...

Abstract	Background: Several studies have investigated the relationship between antenatal education classes and pregnancy outcomes. These studies have shown positive effects on mothers, such as a lower epidural rate in the intervention groups. However, until now, the impact on outcomes for mothers and newborns of antenatal education classes that focus on breathing and relaxation techniques has not been examined. Aim: Investigate the effects of skilled breathing and relaxation techniques provided in antenatal education classes on maternal and neonatal birth outcomes. Methods: The protocol for this study was registered with PROSPERO (ID: CRD42020192289). A systematic literature search was undertaken and completed in January 2022, using the databases MEDLINE, CINAHL, clinicalTrials.gov, Cochrane Library, Embase and MIDIRS according to a priori formulated PICO criteria: population (pregnant women), intervention (antenatal education classes with integrated breathing and relaxation techniques), comparison (antenatal education classes that do not include skilled breathing and relaxation techniques), and outcome (maternal and neonatal outcomes). The quality of the studies was assessed by two reviewers using the standardised instruments RoB 2 and ROBINS-I. Results: Ten studies were included in this review, nine randomised controlled trials and one quasi-experimental study. The results indicate that skilled breathing and relaxation techniques may positively influence self-efficacy, the need for pharmacological support, specifically the use of epidural anaesthesia, and the memory of labour pain. No effects were found in relation to predefined neonatal outcomes. The quality of evidence on maternal and neonatal outcomes is inconsistent across studies, as different antenatal education classes with varying interventions, including breathing and relaxation techniques, were offered in the studies. Conclusions: Women who attended an antenatal education class with breathing and relaxation techniques appear to benefit from the intervention. This applies to the practical implementation and use of breathing and relaxation techniques during labour, increased self-confidence and self-efficacy, and a increased feeling of being in control during labour. This demonstrates the importance of information provision and a focus on breathing and relaxation techniques in antenatal education.
MeSH term(s)	Female ; Pregnancy ; Infant, Newborn ; Humans ; Prenatal Education ; Relaxation Therapy ; Labor, Obstetric ; Mothers/education ; Labor Pain ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-11-19
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-022-05178-w
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Article: Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage.

Westergaard, David / Steinthorsdottir, Valgerdur / Stefansdottir, Lilja / Rohde, Palle Duun / Wu, Xiaoping / Geller, Frank / Tyrmi, Jaakko / Havulinna, Aki S / Navais, Pol Sole / Flatley, Christopher / Ostrowski, Sisse Rye / Pedersen, Ole Birger / Erikstrup, Christian / Sørensen, Erik / Mikkelsen, Christina / Brun, Mie Topholm / Jensen, Bitten Aagaard / Brodersen, Thorsten / Ullum, Henrik /

medRxiv : the preprint server for health sciences

2023

Abstract: Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severity of these complications in ... ...

Abstract	Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severity of these complications in maternal-fetal health. Here, we investigated the genetic variation underlying aspects of pregnancy-associated bleeding and identified five loci associated with PPH through a meta-analysis of 21,512 cases and 259,500 controls. Functional annotation analysis indicated candidate genes,
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.10.23293932
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Article ; Online: Optimising research for neonates with encephalopathy: the role of core outcome sets.

Pediatric research

2024 Volume 95, Issue 4, Page(s) 869–870

MeSH term(s)	Infant, Newborn ; Humans ; Brain Diseases/therapy ; Hypothermia, Induced ; Outcome Assessment, Health Care ; Hypoxia-Ischemia, Brain/therapy ; Retrospective Studies
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-03006-1
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Article ; Online: Report on 7 Years' Experience Implementing an Undergraduate Medical Curriculum for Osteopathic Medical Students Using Entrustable Professional Activities.

Reynolds, Tristan S / Frothingham, Christopher / Carreiro, Jane E / Branda, Angela / Schuenke, Mark D / Tucker, Kerry L / Daly, Frank / Willard, Frank H

The Journal of the American Osteopathic Association

2020 Volume 120, Issue 8, Page(s) 529–539

Abstract: Calls for changes in undergraduate medical education and the advent of the single graduate medical education accreditation system have challenged the osteopathic medical profession to maintain its identity and distinctiveness while adapting to ... ...

Abstract	Calls for changes in undergraduate medical education and the advent of the single graduate medical education accreditation system have challenged the osteopathic medical profession to maintain its identity and distinctiveness while adapting to innovations. For the osteopathic medical profession to thrive, its colleges must provide students with an educational framework that solidifies their osteopathic identity. The authors developed an integrated anatomy-clinical skills course at the University of New England College of Osteopathic Medicine, Osteopathic Clinical Skills, that used the performance benchmarks of the Entrustable Professional Activities and the Osteopathic Core Competencies for Medical Students from the American Association of Colleges of Osteopathic Medicine. A primary tenet of osteopathic medicine is the relationship of structure and function; Osteopathic Clinical Skills fuses anatomical sciences with clinical skills and underscores this tenet in clinical diagnosis and treatment. This article describes the development and implementation of an educational framework that integrates anatomy, physical examination, history taking, and other clinical skills with osteopathic medicine principles and practice and osteopathic manipulative treatment.
MeSH term(s)	Clinical Competence ; Curriculum ; Education, Medical, Undergraduate ; Humans ; Osteopathic Medicine/education ; Osteopathic Physicians ; Students, Medical ; United States
Language	English
Publishing date	2020-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	410350-6
ISSN	1945-1997 ; 0003-0287 ; 0098-6151
ISSN (online)	1945-1997
ISSN	0003-0287 ; 0098-6151
DOI	10.7556/jaoa.2020.087
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Article ; Online: Optimizing Referral Timing of Patients With Fontan Circulatory Failure for Heart Transplant.

Griffeth, Elaine M / Burchill, Luke J / Dearani, Joseph A / Oberoi, Meher / Abdelrehim, Ahmed A / O'Leary, Patrick W / Edwards, Brooks S / Kushwaha, Sudhir S / Daly, Richard C / Cetta, Frank / Johnson, Jonathan N / Ameduri, Rebecca K / Stephens, Elizabeth H

Transplantation proceedings

2023 Volume 55, Issue 2, Page(s) 417–425

Abstract: Background: There are no criteria guiding the timing of heart transplant referral for Fontan patients, nor are there any characteristics of those deferred or declined listing reported. This study examines comprehensive transplant evaluations for Fontan ... ...

Abstract	Background: There are no criteria guiding the timing of heart transplant referral for Fontan patients, nor are there any characteristics of those deferred or declined listing reported. This study examines comprehensive transplant evaluations for Fontan patients of all ages, listing decisions, and outcomes to inform referral practices. Methods: Retrospective review of 63 Fontan patients formally assessed by the advanced heart failure service and presented at Mayo Clinic transplant selection committee meetings (TSM) January 2006 to April 2021. The study is compliant with the Helsinki Congress and Declaration of Istanbul and included no prisoners. Statistical analysis was performed with Wilcoxon Rank Sum and Fisher's Exact tests. Results: Median age at TSM was 26 years (17.5, 36.5). Most were approved (38/63 [60%]); 9 of 63 (14%) were deferred and 16 of 63 (25%) were declined. Approved patients more commonly were <18 years old at TSM (15/38 [40%] vs 1/25 [4%], P = .002) compared with those deferred/declined. Complications of Fontan circulatory failure were less common in approved vs deferred/declined patients: ascites (15/38 [40%] vs 17/25 [68%], P = .039), cirrhosis (16/38 [42%] vs 19/25 [76%], P = .01), and renal insufficiency (6/38 [16%] vs 11/25 [44%], P = .02). Ejection fraction and atrioventricular valve regurgitation did not differ between groups. Pulmonary artery wedge pressure was overall high normal (12 mm Hg [9,16]) but higher in deferred/declined vs approved patients, 14.5 (11, 19) vs 10 (8, 13.5) mm Hg, P = .015. Overall survival was significantly lower in deferred/declined patients (P = .0018). Conclusion: Fontan patient referral for heart transplant at younger age and before the onset of end-organ complications is associated with increased approval for transplant listing.
MeSH term(s)	Humans ; Adult ; Adolescent ; Heart Defects, Congenital/surgery ; Fontan Procedure/adverse effects ; Heart Transplantation/adverse effects ; Liver Cirrhosis/complications ; Retrospective Studies
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.02.014
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Article ; Online: Measuring the incidence of hospital-acquired complications and their effect on length of stay using CHADx.

Trentino, Kevin M / Swain, Stuart G / Burrows, Sally A / Sprivulis, Peter C / Daly, Frank F S

The Medical journal of Australia

2013 Volume 199, Issue 8, Page(s) 543–547

Abstract: Objectives: To use an automated Classification of Hospital Acquired Diagnoses (CHADx) reporting system to report the incidence of hospital-acquired complications in inpatients and investigate the association between hospital-acquired complications and ... ...

Abstract	Objectives: To use an automated Classification of Hospital Acquired Diagnoses (CHADx) reporting system to report the incidence of hospital-acquired complications in inpatients and investigate the association between hospital-acquired complications and hospital length of stay (LOS) in multiday-stay patients. Design: Retrospective cross-sectional study for calendar years 2010 and 2011. Setting: South Metropolitan Health Service in Western Australia, which consists of two teaching and three non-teaching hospitals. Main outcome measures: Incidence of hospital-acquired complications and mean LOS for multiday-stay patients. Results: Of 436 841 inpatient separations, 29 172 (6.68%) had at least one hospital-acquired complication code assigned in the administrative data, and there were a total of 56 326 complication codes. The three most common complications were postprocedural complications; cardiovascular complications; and labour, delivery and postpartum complications. In the subset of data on multiday-stay patients, crude mean LOS was longer in separations for patients with hospital-acquired complications than in separations for those without such complications (17.4 days v 5.4 days). After adjusting for potential confounders, separations for patients with hospital-acquired complications had almost four times the mean LOS of separations for those without such complications (incident rate ratio, 3.84; 95% CI, 3.73-3.96; P < 0.001). Conclusions: An automated CHADx reporting system can be used to collect data on patients with hospital-acquired complications. Such data can be used to increase emphasis on patient safety and quality of care and identify potential opportunities to reduce LOS.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Diagnosis-Related Groups ; Female ; Humans ; Iatrogenic Disease/epidemiology ; Incidence ; International Classification of Diseases ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sex Factors
Language	English
Publishing date	2013-05-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja12.11640
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Book ; Online: Successful Kinetic Impact into an Asteroid for Planetary Defense

Daly, R. Terik / Ernst, Carolyn M. / Barnouin, Olivier S. / Chabot, Nancy L. / Rivkin, Andrew S. / Cheng, Andrew F. / Adams, Elena Y. / Agrusa, Harrison F. / Abel, Elisabeth D. / Alford, Amy L. / Asphaug, Erik I. / Atchison, Justin A. / Badger, Andrew R. / Baki, Paul / Ballouz, Ronald-L. / Bekker, Dmitriy L. / Bellerose, Julie / Bhaskaran, Shyam / Buratti, Bonnie J. /

Cambioni, Saverio / Chen, Michelle H. / Chesley, Steven R. / Chiu, George / Collins, Gareth S. / Cox, Matthew W. / DeCoster, Mallory E. / Ericksen, Peter S. / Espiritu, Raymond C. / Faber, Alan S. / Farnham, Tony L. / Ferrari, Fabio / Fletcher, Zachary J. / Gaskell, Robert W. / Graninger, Dawn M. / Haque, Musad A. / Harrington-Duff, Patricia A. / Hefter, Sarah / Herreros, Isabel / Hirabayashi, Masatoshi / Huang, Philip M. / Hsieh, Syau-Yun W. / Jacobson, Seth A. / Jenkins, Stephen N. / Jensenius, Mark A. / John, Jeremy W. / Jutzi, Martin / Kohout, Tomas / Krueger, Timothy O. / Laipert, Frank E. / Lopez, Norberto R.

2023

Abstract: ... the secondary member of the S-type binary near-Earth asteroid (65803) Didymos. This binary asteroid system was ...

Abstract	While no known asteroid poses a threat to Earth for at least the next century, the catalog of near-Earth asteroids is incomplete for objects whose impacts would produce regional devastation. Several approaches have been proposed to potentially prevent an asteroid impact with Earth by deflecting or disrupting an asteroid. A test of kinetic impact technology was identified as the highest priority space mission related to asteroid mitigation. NASA's Double Asteroid Redirection Test (DART) mission is the first full-scale test of kinetic impact technology. The mission's target asteroid was Dimorphos, the secondary member of the S-type binary near-Earth asteroid (65803) Didymos. This binary asteroid system was chosen to enable ground-based telescopes to quantify the asteroid deflection caused by DART's impact. While past missions have utilized impactors to investigate the properties of small bodies those earlier missions were not intended to deflect their targets and did not achieve measurable deflections. Here we report the DART spacecraft's autonomous kinetic impact into Dimorphos and reconstruct the impact event, including the timeline leading to impact, the location and nature of the DART impact site, and the size and shape of Dimorphos. The successful impact of the DART spacecraft with Dimorphos and the resulting change in Dimorphos's orbit demonstrates that kinetic impactor technology is a viable technique to potentially defend Earth if necessary. Comment: Accepted by Nature
Keywords	Astrophysics - Earth and Planetary Astrophysics
Subject code	306
Publishing date	2023-03-03
Publishing country	us
Document type	Book ; Online
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Article ; Online: Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group.

Walton, Esther / Bernardoni, Fabio / Batury, Victoria-Luise / Bahnsen, Klaas / Larivière, Sara / Abbate-Daga, Giovanni / Andres-Perpiña, Susana / Bang, Lasse / Bischoff-Grethe, Amanda / Brooks, Samantha J / Campbell, Iain C / Cascino, Giammarco / Castro-Fornieles, Josefina / Collantoni, Enrico / D'Agata, Federico / Dahmen, Brigitte / Danner, Unna N / Favaro, Angela / Feusner, Jamie D /

Frank, Guido K W / Friederich, Hans-Christoph / Graner, John L / Herpertz-Dahlmann, Beate / Hess, Andreas / Horndasch, Stefanie / Kaplan, Allan S / Kaufmann, Lisa-Katrin / Kaye, Walter H / Khalsa, Sahib S / LaBar, Kevin S / Lavagnino, Luca / Lazaro, Luisa / Manara, Renzo / Miles, Amy E / Milos, Gabriella F / Monteleone, Alessio Maria / Monteleone, Palmiero / Mwangi, Benson / O'Daly, Owen / Pariente, Jose / Roesch, Julie / Schmidt, Ulrike H / Seitz, Jochen / Shott, Megan E / Simon, Joe J / Smeets, Paul A M / Tamnes, Christian K / Tenconi, Elena / Thomopoulos, Sophia I / van Elburg, Annemarie A / Voineskos, Aristotle N / von Polier, Georg G / Wierenga, Christina E / Zucker, Nancy L / Jahanshad, Neda / King, Joseph A / Thompson, Paul M / Berner, Laura A / Ehrlich, Stefan

Biological psychiatry

2022 Volume 92, Issue 9, Page(s) 730–738

Abstract: Background: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find ... ...

Abstract	Background: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and dependencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data. Methods: We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251). Results: In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of undernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients. Conclusions: The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.
MeSH term(s)	Anorexia Nervosa/diagnostic imaging ; Anorexia Nervosa/therapy ; Brain/diagnostic imaging ; Cerebral Cortex/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Multicenter Studies as Topic ; Prospective Studies ; Thinness
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2022.04.022
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Article ; Online: COHESION: a core outcome set for the treatment of neonatal encephalopathy.

Pediatric research

2023 Volume 95, Issue 4, Page(s) 922–930

Abstract: Background: Heterogeneity in outcomes reported in trials of interventions for the treatment of neonatal encephalopathy (NE) makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable ... ...

Abstract	Background: Heterogeneity in outcomes reported in trials of interventions for the treatment of neonatal encephalopathy (NE) makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable researchers to measure and report the same outcomes in future trials. This would minimise waste, ensure relevant outcomes are measured and enable evidence synthesis. Therefore, we aimed to develop a core outcome set for treating NE. Methods: Outcomes identified from a systematic review of the literature and interviews with parents were prioritised by stakeholders (n = 99 parents/caregivers, n = 101 healthcare providers, and n = 22 researchers/ academics) in online Delphi surveys. Agreement on the outcomes was achieved at online consensus meetings attended by n = 10 parents, n = 18 healthcare providers, and n = 13 researchers/ academics. Results: Seven outcomes were included in the final core outcome set: survival; brain injury on imaging; neurological status at discharge; cerebral palsy; general cognitive ability; quality of life of the child, and adverse events related to treatment. Conclusion: We developed a core outcome set for the treatment of NE. This will allow future trials to measure and report the same outcomes and ensure results can be compared. Future work should identify how best to measure the COS. Impact: We have identified seven outcomes that should be measured and reported in all studies for the treatment of neonatal encephalopathy. Previously, a core outcome set for neonatal encephalopathy treatments did not exist. This will help to reduce heterogeneity in outcomes reported in clinical trials and other studies, and help researchers identify the best treatments for neonatal encephalopathy.
MeSH term(s)	Infant, Newborn ; Child ; Humans ; Quality of Life ; Research Design ; Cerebral Palsy ; Consensus ; Outcome Assessment, Health Care/methods ; Treatment Outcome
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02938-y
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