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Article ; Online: Advances in Stroke: Treatments-Acute.

Broderick, Joseph P / Hill, Michael J

2022 Volume 53, Issue 3, Page(s) 999–1003

MeSH term(s)	Humans ; Stroke/surgery ; Stroke/therapy ; Thrombectomy ; Treatment Outcome
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.122.036976
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Article ; Online: Factors Associated With Premature Termination of Hyperacute Stroke Trials: A Review.

Aziz, Yasmin N / Sucharew, Heidi / Reeves, Mathew J / Broderick, Joseph P

Journal of the American Heart Association

2024 Volume 13, Issue 8, Page(s) e034115

Abstract: Background: We performed a review of acute stroke trials to determine features associated with premature termination of trial enrollment, defined by the authors as not meeting preplanned sample size.: Methods and results: MEDLINE was searched for ... ...

Abstract	Background: We performed a review of acute stroke trials to determine features associated with premature termination of trial enrollment, defined by the authors as not meeting preplanned sample size. Methods and results: MEDLINE was searched for randomized clinical stroke trials published in 9 major clinical journals between 2013 and 2022. We included randomized clinical trials that were phase 2 or 3 with a preplanned sample size ≥100 and a time-to-treatment within 24 hours of onset for transient ischemic attack, ischemic stroke, or intracerebral hemorrhage. Data were abstracted on trial features including trial design, inclusion criteria, imaging, location and number of sites, masking, treatment complexity, control group (standard therapy, placebo), industry involvement, and preplanned stopping rules (futility and efficacy). Least absolute shrinkage and selection operator regression was used to select the most important factors associated with premature termination; then, a multivariable logistic regression was fit including only the least absolute shrinkage and selection operator selected variables. Of 1475 studies assessed, 98 trials met eligibility criteria. Forty-five (46%) trials were prematurely terminated, of which 27% were stopped for benefit/efficacy, 20% for lack of money/slow enrollment, 18% for futility, 16% for newly available evidence, 17% for other reasons, and 4% due to harm. Complex trials (adjusted odds ratio [aOR], 2.76 [95% CI, 1.13-7.49]), presence of a futility rule (aOR, 4.43 [95% CI, 1.62-17.91]), and exclusion of prestroke dependency (none/slight disability only; aOR, 2.19 [95% CI, 0.84-6.72] versus dependency allowed) were identified as the strongest predictors. Conclusions: Nearly half of acute stroke trials were terminated prematurely. Broadening inclusion criteria and simplifying trial design may decrease the likelihood of unplanned termination, whereas planned futility analyses may appropriately terminate trials early, saving money and resources.
MeSH term(s)	Humans ; Stroke/therapy ; Stroke/drug therapy ; Ischemic Attack, Transient ; Cerebral Hemorrhage ; Ischemic Stroke ; Sample Size
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.124.034115
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid Quantification of Ammonium Nitrate and Urea Nitrate Using Liquid Chromatography-High-Resolution Orbitrap Mass Spectrometry.

Perez, Johnny J / Brady, John J / Broderick, Alicia / Horan, Andrew / Pedersen, Kevin / Wilkins, Benjamin P

Analytical chemistry

2024 Volume 96, Issue 4, Page(s) 1419–1426

Abstract: Resolution and sensitivity improvements in mass spectrometry technology have enabled renewed attempts at solving challenging analytical issues. One such issue involves the analysis of energetic ionic species. Energetic ionic species make up an important ... ...

Abstract	Resolution and sensitivity improvements in mass spectrometry technology have enabled renewed attempts at solving challenging analytical issues. One such issue involves the analysis of energetic ionic species. Energetic ionic species make up an important class of chemical materials, and a more robust and versatile analytical platform would provide tremendous value to the analytical community. Initial attempts at quantification of energetic ionic species employed high-resolution time-of-flight measurements with crown ether (CE) complexation and flow injection analysis (FIA). In this investigation, ammonium nitrate (AN) and urea nitrate (UN) in the presence of a crown ether complexation agent were explored by using high-resolution orbitrap mass spectrometry. Product ion scans of these signature complexes reveal positive identification of these energetic ionic species. Finally, quantification was demonstrated for both flow injection and liquid chromatography-mass spectrometry (LC-MS) analysis, suggesting the capability for routine and rapid analysis of these energetic ionic materials.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03245
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Article: Resting-state heart rate variability after stressful events as a measure of stress tolerance among elite performers.

Miyatsu, Toshiya / Smith, Briana M / Koutnik, Andrew P / Pirolli, Peter / Broderick, Timothy J

Frontiers in physiology

2023 Volume 13, Page(s) 1070285

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.1070285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Descriptive, real-world treatment patterns, resource use, and total cost of care among eculizumab- and ravulizumab-treated members with paroxysmal nocturnal hemoglobinuria.

Broderick, Kelly C / Burke, James P / Fishman, Jesse / Gleason, Patrick P

Journal of managed care & specialty pharmacy

2023 Volume 29, Issue 8, Page(s) 941–951

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Adult ; Female ; Humans ; Male ; Health Care Costs ; Hemoglobinuria, Paroxysmal/drug therapy ; Retrospective Studies ; United States
Chemical Substances	eculizumab (A3ULP0F556) ; ravulizumab (C3VX249T6L)
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article
ISSN	2376-1032
ISSN (online)	2376-1032
DOI	10.18553/jmcp.2023.29.8.941
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Article ; Online: More than words: Neurophysiological correlates of semantic dissimilarity depend on comprehension of the speech narrative.

Broderick, Michael P / Zuk, Nathaniel J / Anderson, Andrew J / Lalor, Edmund C

The European journal of neuroscience

2022 Volume 56, Issue 8, Page(s) 5201–5214

Abstract: Speech comprehension relies on the ability to understand words within a coherent context. Recent studies have attempted to obtain electrophysiological indices of this process by modelling how brain activity is affected by a word's semantic dissimilarity ... ...

Abstract	Speech comprehension relies on the ability to understand words within a coherent context. Recent studies have attempted to obtain electrophysiological indices of this process by modelling how brain activity is affected by a word's semantic dissimilarity to preceding words. Although the resulting indices appear robust and are strongly modulated by attention, it remains possible that, rather than capturing the contextual understanding of words, they may actually reflect word-to-word changes in semantic content without the need for a narrative-level understanding on the part of the listener. To test this, we recorded electroencephalography from subjects who listened to speech presented in either its original, narrative form, or after scrambling the word order by varying amounts. This manipulation affected the ability of subjects to comprehend the speech narrative but not the ability to recognise individual words. Neural indices of semantic understanding and low-level acoustic processing were derived for each scrambling condition using the temporal response function. Signatures of semantic processing were observed when speech was unscrambled or minimally scrambled and subjects understood the speech. The same markers were absent for higher scrambling levels as speech comprehension dropped. In contrast, word recognition remained high and neural measures related to envelope tracking did not vary significantly across scrambling conditions. This supports the previous claim that electrophysiological indices based on the semantic dissimilarity of words to their context reflect a listener's understanding of those words relative to that context. It also highlights the relative insensitivity of neural measures of low-level speech processing to speech comprehension.
MeSH term(s)	Auditory Perception/physiology ; Comprehension/physiology ; Electroencephalography ; Humans ; Semantics ; Speech/physiology ; Speech Perception/physiology
Language	English
Publishing date	2022-09-15
Publishing country	France
Document type	Journal Article
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15805
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Article ; Online: Mapping spatial frequency preferences across human primary visual cortex.

Broderick, William F / Simoncelli, Eero P / Winawer, Jonathan

Journal of vision

2022 Volume 22, Issue 4, Page(s) 3

Abstract: Neurons in primate visual cortex (area V1) are tuned for spatial frequency, in a manner that depends on their position in the visual field. Several studies have examined this dependency using functional magnetic resonance imaging (fMRI), reporting ... ...

Abstract	Neurons in primate visual cortex (area V1) are tuned for spatial frequency, in a manner that depends on their position in the visual field. Several studies have examined this dependency using functional magnetic resonance imaging (fMRI), reporting preferred spatial frequencies (tuning curve peaks) of V1 voxels as a function of eccentricity, but their results differ by as much as two octaves, presumably owing to differences in stimuli, measurements, and analysis methodology. Here, we characterize spatial frequency tuning at a millimeter resolution within the human primary visual cortex, across stimulus orientation and visual field locations. We measured fMRI responses to a novel set of stimuli, constructed as sinusoidal gratings in log-polar coordinates, which include circular, radial, and spiral geometries. For each individual stimulus, the local spatial frequency varies inversely with eccentricity, and for any given location in the visual field, the full set of stimuli span a broad range of spatial frequencies and orientations. Over the measured range of eccentricities, the preferred spatial frequency is well-fit by a function that varies as the inverse of the eccentricity plus a small constant. We also find small but systematic effects of local stimulus orientation, defined in both absolute coordinates and relative to visual field location. Specifically, peak spatial frequency is higher for pinwheel than annular stimuli and for horizontal than vertical stimuli.
MeSH term(s)	Animals ; Brain Mapping ; Humans ; Magnetic Resonance Imaging ; Neurons/physiology ; Photic Stimulation ; Primary Visual Cortex ; Visual Cortex/diagnostic imaging ; Visual Cortex/physiology ; Visual Fields
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2106064-2
ISSN	1534-7362 ; 1534-7362
ISSN (online)	1534-7362
ISSN	1534-7362
DOI	10.1167/jov.22.4.3
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Article ; Online: What Works When Treating Children and Adolescents With Low Back Pain?

Leite, Mariana N / Kamper, Steven J / Broderick, Carolyn / Yamato, Tié P

The Journal of orthopaedic and sports physical therapy

2022 Volume 52, Issue 7, Page(s) 419–424

Abstract: Background: Low back pain is a common health condition for all ages. One quarter to a third of children report persistent pain, including low back pain.: Clinical question: The aim of this Clinical Commentary is to provide an overview of evidence- ... ...

Abstract	Background: Low back pain is a common health condition for all ages. One quarter to a third of children report persistent pain, including low back pain. Clinical question: The aim of this Clinical Commentary is to provide an overview of evidence-based treatment approaches for children and adolescents with low back pain. Key results: Physical, psychological, and pharmacological interventions are effective in reducing pain intensity and disability. Interdisciplinary and patient- and family-centered treatment approaches are the gold standard for persistent pain in children and adolescents. Communication between health professionals, children, and parents is a key part of a therapeutic alliance. The use of holistic and complementary therapies is not supported by compelling evidence. Clinical application: Physical interventions can be delivered alone or as a component of other interventions. The interventions are delivered over 8 to 12 weeks. Psychological therapies are mostly delivered as a component of a multidisciplinary treatment program: cognitive behavioral therapy is most often used, and interventions usually run from 4 to 10 weeks. Pharmacological interventions should be delivered in combination with physical and psychological interventions. Tailor family-centered interventions to personal aspects, such as age, gender, and family structure. When communicating with children and adolescents, use simple language that is clear and direct. Aim to support trust between health professionals and parents to facilitate family decision making.
MeSH term(s)	Adolescent ; Child ; Cognitive Behavioral Therapy ; Humans ; Low Back Pain/therapy ; Pain Measurement ; Parents/psychology
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2022.10768
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Article ; Online: Multicentre pilot randomised control trial of a self-directed exergaming intervention for poststroke upper limb rehabilitation: research protocol.

Broderick, Michelle / Burridge, Jane / Demain, Sara / Johnson, Louise / Brereton, Joe / O'Shea, Robert / Bentley, Paul

BMJ open

2024 Volume 14, Issue 1, Page(s) e077121

Abstract: Introduction: Technology-facilitated, self-directed upper limb (UL) rehabilitation, as an adjunct to conventional care, could enhance poststroke UL recovery compared with conventional care alone, without imposing additional resource burden. The proposed ...

Abstract	Introduction: Technology-facilitated, self-directed upper limb (UL) rehabilitation, as an adjunct to conventional care, could enhance poststroke UL recovery compared with conventional care alone, without imposing additional resource burden. The proposed pilot randomised controlled trial (RCT) aims to assess whether stroke survivors will engage in self-directed UL training, explore factors associated with intervention adherence and evaluate the study design for an RCT testing the efficacy of a self-directed exer-gaming intervention for UL recovery after stroke. Methods and analysis: This is a multicentre, internal pilot RCT; parallel design, with nested qualitative methods. The sample will consist of stroke survivors with UL paresis, presenting within the previous 30 days. Participants randomised to the intervention group will be trained to use an exergaming device and will be supported to adopt this as part of their self-directed rehabilitation (ie, without formal support/supervision) for a 3-month period. The primary outcome will be the Fugl Meyer Upper Extremity Assessment (FM-UE) at 6 months poststroke. Secondary outcomes are the Action Research Arm Test (ARAT), the Barthel Index and the Modified Rankin Scale. Assessment time points will be prior to randomisation (0-1 month poststroke), 3 months and 6 months poststroke. A power calculation to inform sample size required for a definitive RCT will be conducted using FM-UE data from the sample across 0-6 months time points. Semistructured qualitative interviews will examine factors associated with intervention adoption. Reflexive thematic analysis will be used to code qualitative interview data and generate key themes associated with intervention adoption. Ethics and dissemination: The study protocol (V.1.9) was granted ethical approval by the Health Research Authority, Health and Care Research Wales, and the London- Harrow Research Ethics Committee (ref. 21/LO/0054) on 19 May 2021. Trial results will be submitted for publication in peer-reviewed journals, presented at national and international stroke meetings and conferences and disseminated among stakeholder communities. Trial registration number: NCT04475692.
MeSH term(s)	Humans ; Stroke Rehabilitation/methods ; Exergaming ; Pilot Projects ; Stroke/complications ; Upper Extremity ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-077121
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Article: Neisseria meningitidis

Mc Carthy, A / Broderick, J M / Molloy, A P

Case reports in infectious diseases

2020 Volume 2020, Page(s) 8431019

Abstract: One of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another ... ...

Abstract	One of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another infection source. In this case, a 72-year-old female presented with symptoms of septic arthritis seven years after her original arthroplasty surgery. At presentation, she denied trauma and any comorbidity which would predispose her to infection. Culturing of samples taken revealed the patient was infected with
Language	English
Publishing date	2020-03-10
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2627642-2
ISSN	2090-6633 ; 2090-6625
ISSN (online)	2090-6633
ISSN	2090-6625
DOI	10.1155/2020/8431019
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